Tag: M.W=250-300

Munjal, Bhushan; Zode, Sandeep S.; Bansal, Arvind K. published the artcile< Crystallization of Cyclophosphamide Monohydrate During Lyophilization>, Related Products of 6055-19-2, the main research area is crystallization cyclophosphamide monohydrate lyophilization; crystallization; dehydration; freeze-drying; hydrates; lyophilization; processing.

The purpose of this study was to investigate the phase behavior of cyclophosphamide (CPA) during various stages of lyophilization, with special emphasis on obtaining crystalline CPA monohydrate (CPA-MH) in the lyophilized product. Subambient differential scanning calorimetry and low-temperature X-ray diffractometry (LTXRD) were used to study the phase behavior of CPA solution (3.7% w/v). In situ lyophilization in LTXRD chamber was used to monitor the phase transitions occurring during the drying stages. Finally, the implications of these findings were confirmed by freeze-drying the aqueous solution in a laboratory-scale freeze-dryer. The results suggested that CPA remains amorphous during freeze concentration, with a Tg’ of -50°C. However, its crystallization as CPA-MH can be induced by annealing the frozen solution between -5°C and -10°C. In situ lyophilization in LTXRD showed that the CPA-MH crystallized during annealing, rapidly dehydrated during primary drying, thereby causing structural collapse. The dehydration of CPA-MH can be prevented by lowering the escaping tendency of water mols. from the crystal lattice of CPA-MH by maintaining the chamber pressure to 300, 400, or 500 mTorr. This study highlights the relationship of process parameters used during lyophilization with the solid form of lyophilized CPA.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Crystallization. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Related Products of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ding, Su-Ying; Yu, Si-Qi; Wang, Xiao-Xia; Wu, Zi-Hua; Li, Wen-Qin; Jia, Wei; Xie, Hua-Qing published the artcile< Fabrication of buffer-window layer system for Cu(ln, Ga)Se2 thin film devices by chemical bath deposition and Sol-Gel methods>, HPLC of Formula: 22519-64-8, the main research area is fabrication buffer window layer system copper indium gallium selenium; thin film device chem bath deposition Soluble gel method.

Recently, nontoxic fabrication for Cu(ln, Ga)Se2 thin films gained increasing popularity. In this work, chem. bath deposition and Sol-gel methods were utilized in the fabrication of an environmentally buffer-window (ZnS-ZnO/ZnO:AI) layer system for Cu(ln, Ga)Se2 thin film devices. The influences of conditions like annealing temperature, coating times, and Al-doping amount were investigated. The surface morphol. and optical properties illustrated a compact and uniform ZnS film with a band-gap of 3.78, which can be a good alternative to CdS film. Resistivity of 0.35 ω.cm for the ZnO/ZnO:AI film was achieved by the ideal condition of 9 coating times and 5 Al-doping amounts A cross-sectional view of the complete Cu(ln, Ga)Se2 thin film was obtained, and the structure status was analyzed.

Journal of Nanoelectronics and Optoelectronics published new progress about Absorbents. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, HPLC of Formula: 22519-64-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhao, Bin; Lu, Yafei; Yuan, Boheng; Wang, Zhenyu; Han, Xiaogang published the artcile< Preparation of free-standing Li3InCl6 solid electrolytes film with infiltration-method enable roll-to-roll manufacture>, Product Details of Cl3H8InO4, the main research area is lithium indium chlorine glass fiber secondary battery electrolyte.

All-solid-state Li batteries (ASSLBs) have attracted more and more attention due to their potential energy d. and safety benefits. For practical application, searching for a preparation method of solid-state electrolyte that is compatible with mature Li-ion-batteries technologies and enable scale-up production is important. In this work, an infiltration method is proposed for the preparation of Li3InCl6/glass-fiber solid composite electrolyte (LIC-SCE) film. Roll pressing method is adopted to obtain compact LIC-SCE with good mech. strength, showing great promising to roll-to-roll manufacture platform. The LIC-SCE shows a high ionic conductivity of 5.4×10-4 S cm-1 at room temperature Further, ASSLBs are successfully assembled with LiCoO2 (LCO) cathode.

Materials Letters published new progress about Activation energy. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Product Details of Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Xishan; Shen, Hui; Zhang, Yan; Wang, Chao; Li, Qiu; Zhang, Cheng; Zhuang, Xiaoxi; Li, Chenchang; Shi, Yudan; Xing, Yanli; Xiang, Qiuping; Xu, Jinxin; Wu, Donghai; Liu, Jinsong; Xu, Yong published the artcile< Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist>, Formula: C7H7ClO4S2, the main research area is benzimidazole derivative XY123 ROR gamma inverse agonist.

Receptor-related orphan receptor γ (RORγ) has emerged as an attractive therapeutic target for the treatment of cancer and inflammatory diseases. Herein, we report our effort on the discovery, optimization, and evaluation of benzothiazole and benzimidazole derivatives as novel inverse agonists of RORγ. The representative compound 27h (designated as XY123) (I) potently inhibited the RORγ transcription activity with a half-maximal inhibitory concentration (IC50) value of 64 nM and showed excellent selectivity against other nuclear receptors. 27H also potently suppressed cell proliferation, colony formation, and the expression of androgen receptor (AR)-regulated genes in AR-pos. prostate cancer cell lines. In addition, 27h demonstrated good metabolic stability and a pharmacokinetic property with reasonable oral bioavailability (32.41%) and moderate half-life (t1/2 = 4.98 h). Significantly, oral administration of compound 27h achieved complete and long-lasting tumor regression in the 22Rv1 xenograft tumor model in mice. Compound 27h may serve as a new valuable lead compound for further development of drugs for the treatment of prostate cancer.

Journal of Medicinal Chemistry published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Formula: C7H7ClO4S2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Xishan; Shen, Hui; Zhang, Yan; Wang, Chao; Li, Qiu; Zhang, Cheng; Zhuang, Xiaoxi; Li, Chenchang; Shi, Yudan; Xing, Yanli; Xiang, Qiuping; Xu, Jinxin; Wu, Donghai; Liu, Jinsong; Xu, Yong published the artcile< Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist>, Formula: C7H7ClO4S2, the main research area is benzimidazole derivative XY123 ROR gamma inverse agonist.

Receptor-related orphan receptor γ (RORγ) has emerged as an attractive therapeutic target for the treatment of cancer and inflammatory diseases. Herein, we report our effort on the discovery, optimization, and evaluation of benzothiazole and benzimidazole derivatives as novel inverse agonists of RORγ. The representative compound 27h (designated as XY123) (I) potently inhibited the RORγ transcription activity with a half-maximal inhibitory concentration (IC50) value of 64 nM and showed excellent selectivity against other nuclear receptors. 27H also potently suppressed cell proliferation, colony formation, and the expression of androgen receptor (AR)-regulated genes in AR-pos. prostate cancer cell lines. In addition, 27h demonstrated good metabolic stability and a pharmacokinetic property with reasonable oral bioavailability (32.41%) and moderate half-life (t1/2 = 4.98 h). Significantly, oral administration of compound 27h achieved complete and long-lasting tumor regression in the 22Rv1 xenograft tumor model in mice. Compound 27h may serve as a new valuable lead compound for further development of drugs for the treatment of prostate cancer.

Journal of Medicinal Chemistry published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 5335-40-0 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO4S2, Formula: C7H7ClO4S2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jiang, Xiaoqing; Wu, Hongping; Yu, Hongwei; Hu, Zhanggui; Wang, Jiyang; Wu, Yicheng published the artcile< Metal halide In(Ba3Cl3F6) - a novel infrared-transparent molecular sieve constructed by halides>, Name: Indium(III) chloride tetrahydrate, the main research area is metal halide manufacture barium indium chloride fluoride mol sieve.

Mol. sieves are of increasing importance in catalysis, the oil industry, and biomedicine. Traditional mol. sieves are generally oxides that inevitably show some absorption in the mid- and far-IR range due to the vibrations of metal-oxygen bonds, which are unfavorable for the in situ observation of the reactions in mol. sieves through IR techniques. In this study, a new metal halide In[Ba3Cl3F6] has been synthesized. It exhibits a quite transparent window from 0.366 to 22 μm and good adsorption and desorption processes.

Chemical Communications (Cambridge, United Kingdom) published new progress about Halides Role: IMF (Industrial Manufacture), PREP (Preparation). 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Name: Indium(III) chloride tetrahydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sirenko, Oksana; Cromwell, Evan F.; Crittenden, Carole; Wignall, Jessica A.; Wright, Fred A.; Rusyn, Ivan published the artcile< Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity>, Application In Synthesis of 6055-19-2, the main research area is cardiotoxicity cardiomyocyte beating pluripotency stem cell; AUC; BMC; Calcium flux; Cardiotoxicity; DMSO; EC(50); Phenotypic screening; Predictive toxicology; area under the curve; benchmark concentration; dimethyl sulfoxide; effective concentration at 50% of the maximum response; hERG; iPSC; induced pluripotent stem cell.

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes show promise for screening during early drug development. Here, we tested a hypothesis that in vitro assessment of multiple cardiomyocyte physiol. parameters enables predictive and mechanistically-interpretable evaluation of cardiotoxicity in a high-throughput format. Human iPSC-derived cardiomyocytes were exposed for 30 min or 24 h to 131 drugs, pos. (107) and neg. (24) for in vivo cardiotoxicity, in up to 6 concentrations (3 nM to 30 uM) in 384-well plates. Fast kinetic imaging was used to monitor changes in cardiomyocyte function using intracellular Ca2+ flux readouts synchronous with beating, and cell viability. A number of physiol. parameters of cardiomyocyte beating, such as beat rate, peak shape (amplitude, width, raise, decay, etc.) and regularity were collected using automated data anal. Concentration-response profiles were evaluated using logistic modeling to derive a benchmark concentration (BMC) point-of-departure value, based on one standard deviation departure from the estimated baseline in vehicle (0.3% DMSO)-treated cells. BMC values were used for cardiotoxicity classification and ranking of compounds Beat rate and several peak shape parameters were found to be good predictors, while cell viability had poor classification accuracy. In addition, we applied the Toxicol. Prioritization Index (ToxPi) approach to integrate and display data across many collected parameters, to derive “”cardiosafety”” ranking of tested compounds Multi-parameter screening of beating profiles allows for cardiotoxicity risk assessment and identification of specific patterns defining mechanism-specific effects. These data and anal. methods may be used widely for compound screening and early safety evaluation in drug development.

Toxicology and Applied Pharmacology published new progress about Anti-inflammatory agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Application In Synthesis of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rouissi, Kamel; Hamrita, Bechr; Kouidi, Soumaya; Messai, Yosra; Jaouadi, Bassem; Hamden, Khaled; Medimegh, Imen; Ouerhani, Slah; Cherif, Mohamed; Elgaaied, Amel Benammar published the artcile< In vivo prevention of bladder urotoxicity: purified hydroxytyrosol ameliorates urotoxic effects of cyclophosphamide and buthionine sulfoximine in mice>, Formula: C7H17Cl2N2O3P, the main research area is hydroxytyrosol bladder urotoxicity antioxidant cyclophosphamide monohydrate BSO.

Urotoxicity is a troublesome complication associated with cyclophosphamide (CP) and L-buthionine-SR-sulfoximine (BSO) treatment in chemotherapy. With this concern in mind, the present study investigated the potential effects of a hydroxytyrosol extract from olive mill waste (OMW) on urotoxicity induced by acute CP and BSO doses using a Swiss albino mouse model. Toxicity modulation was evaluated by measuring lipid peroxidation (LPO) and antioxidants in urinary bladder. The findings revealed that the hydroxytyrosol extract exerted a protective effect not only on LPO but also on enzymic antioxidants. When compared to the controls, the CP-treated animals underwent significant decreases in the glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GP), and catalase (CAT) activities. The level of glutathione (GSH) was also reduced with increased doses of LPO in the CP-treated animals. L-Buthionine-SR-sulfoximine treatment exerted an additive toxic effect on the CP-treated animals. Interestingly, pretreatment with the hydroxytyrosol extract restored the activities of all enzymes back to normal levels and exhibited an overall protective effect on the CP- and BSO-induced toxicities in urinary bladder. The restoration of GSH through the treatment with the hydroxytyrosol extract can play an important role in reversing CP-induced apoptosis and free radical-mediated LPO.

International Journal of Toxicology published new progress about Antioxidants. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shim, Soon-Mi; Bae, Eunkyung; Kim, Gun-Hee published the artcile< Single-dose oral acute toxicity and mutagenic effects of methanol extracts of Cirsium japonicum>, Electric Literature of 6055-19-2, the main research area is Cirsium acute oral toxicity mutagenicity chromosome flavone.

The purpose of this study was to evaluate safety on Cirsium japonicum extracts containing flavones by examining acute oral toxicity, bacterial reverse mutation and the chromosome aberration test. Mutagenicity of extracts were evaluated by a bacterial reverse mutation assay using Salmonella typhimurium TA98, TA100, TA102, TA1535, TA1537 and Escherichia coli (WP2uvrA) with and without metabolic activation. An in vitro chromosome aberration test in Chinese hamster lung cells was conducted at the concentrations of 0, 1,250, 2,500 and 5,000 μg/mL. No significant adverse effects on body weight, mortality and gross findings were observed for 15 days after a single dose (2,000 mg of extracts/kg body weight) of administration. In the bacterial reverse mutation assay, C. japonicum extracts ranging from 156 to 5,000 μg/plate did not induce base-pair substitution or frame shift. Any significant increase in structural aberration as well as reduction of cell cycle progression was not observed in the chromosome.

Journal of Food Biochemistry published new progress about Chromosome aberrations. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Electric Literature of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Corton, J. Christopher; Witt, Kristine L.; Yauk, Carole L. published the artcile< Identification of p53 Activators in a Human Microarray Compendium>, Reference of 6055-19-2, the main research area is p53 activation human microarray DNA damage.

Biomarkers predictive of mol. and toxicol. effects are needed to interpret emerging high-throughput transcriptomic data streams. The previously characterized 63 gene TGx-DDI biomarker that includes 20 genes known to be regulated by p53 was previously shown to accurately predict DNA damage in chem.-treated cells. The authors comprehensively evaluated whether the mol. basis of the DDI predictions was based on a p53-dependent response. The biomarker was compared to microarray data in a compendium derived from human cells using the Running Fisher test, a nonparametric correlation test. Using the biomarker, the authors identified conditions that led to p53 activation, including exposure to the chem. nutlin-3 which disrupts interactions between p53 and the neg. regulator MDM2 or by knockdown of MDM2. The expression of most of the genes in the biomarker (75%) were found to depend on p53 activation status based on gene behavior after TP53 overexpression or knockdown. The biomarker identified DDI chems. that were strong inducers of p53 in wild-type cells; these p53 responses were decreased or abolished in cells after p53 knockdown by siRNAs. Using the biomarker, the authors screened ∼1950 chems. in ∼9800 human cell line chem. vs. control comparisons and identified ∼100 chems. that caused p53 activation. Among the pos. chems. were many that are known to activate p53 through direct and indirect DNA damaging mechanisms. These results contribute to the evidence that the TGx-DDI biomarker is useful for identifying chems. that cause DDI and activate p53.

Chemical Research in Toxicology published new progress about Algorithm. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Reference of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics