Tag: M.W=200-300

Related Products of 54932-72-8, A common heterocyclic compound, 54932-72-8, name is 4-Bromo-1-chloro-2-methylbenzene, molecular formula is C7H6BrCl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0422] A mixture of 2-chloro-5-methyl-pyrimidin-4-ylamine (0.34 g, 2.34 mmol), 4- bromo-l-chloro-2-methyl-benzene (0.58 g, 2.8 ?1), Pd2(dba)3 (0.21 g, 0.23 mmol), Xantphos (0.47 g, 0.47 mmol) and cesium carbonate (2.3 g, 7 mmol) were suspended in dioxane (9 mL) microwaved at 160 0C for 20 min. The reaction mixture was cooled to room temperature and centrifuged down. Solvents were then decanted and evaporated. Resulting residue was purified by flash chromatography on silica gel to afford title compound as yellow solids (0.24 g, 38%).

The synthetic route of 54932-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN, INC.; WO2007/53452; (2007); A1;,
Chloride – Wikipedia,
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Reference of 13918-92-8, The chemical industry reduces the impact on the environment during synthesis 13918-92-8, name is 2,4-Difluorobenzene-1-sulfonyl chloride, I believe this compound will play a more active role in future production and life.

A mixture of 4.0 g (21.4 mmol) C-3, 4.3 mL (32.1 mmol) 2,4-difluorobenzenesulfonyl chloride, 5.2 mL (64.2 mmol) pyridine and 50 mL DCM is stirred at RT for 5 h. After completion of the reaction, the solvent is removed under reduced pressure, the crude product is taken up in 50 mL water and extracted twice with 100 mL DCM. The combined organic layers are dried over MgSO4 and the solvent is removed under reduced pressure. The crude product can be used without further purification. Yield: 7.88 g (91%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Difluorobenzene-1-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; KRAEMER, Oliver; van der VEEN, Lars; US2013/23533; (2013); A1;,
Chloride – Wikipedia,
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Electric Literature of 328-72-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 328-72-3, name is 3,5-Bis(trifluoromethyl)chlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 10 Synthesis of 3,5-bis(trifluoromethyl)cinnamide (Method II) 0.181 g (2.55 mmol) of acrylamide, 9.7 mg (30 mumol) of NBu4Br, 0.675 mg (3 mumol) of palladium acetate and 2.67 mg (12 mumol) of phenyldi(t-butyl)phosphine are weighed into a Schlenk vessel. 0.542 g (3 mmol) of 3,5-bis(trifluoromethyl)chlorobenzene and 0.637 ml (3 mmol) of dicyclohexylmethylamine and also 2.5 ml of dimethylacetamide are then added. The Schlenk vessel is placed in a heating bath at 130 C. and the contents are stirred. After 3 hours, the yield is determined by means of HPLC: 99% (TON=723, TOF=241/h).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Bis(trifluoromethyl)chlorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Rampf, Florian; Eckert, Markus; US2003/105353; (2003); A1;,
Chloride – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-2,3-dichlorobenzene

Intermediate 40:[0172] A well-dried flask was first charged with l-bromo-2,3-dichlorobenzene (10 g, 44 mmol) and piperazine (4.55 g, 53 mmol), which was evacuated and backfilled with N2 through a balloon under gentle warming (40C). Toluene was charged and the mixture was bubbled with N2 for 10 min, then BINAP (822 mg, 1.32 mmol) and Pd2dba3 (403 mg, 0.44 mmol) were added to the mixture. After the addition of DBU (8.0 mL), the solution was warmed at 60-70C while a fine powder of ffluONa (7.39 g, 66 mmol) was added in one portion to start the amination. After the reaction mixture cooled to rt, (Boc)20 (24 g, 110 mmol) was dissolved in DCM and added dropwise to the reaction mixture, then stirred at rt for 3 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined EtOAc layers were washed with brine, dried over anhydrous Na2S04, concentrated in vacuo and purified by flash chromatography on silica gel column (elution with PE/EtOAc = 10:1) to give tert-butyl 4-(2,3-dichlorophenyl)piperazine-l- carboxylate (intermediate 40) (11.1 g, 76%) as a white solid.

The synthetic route of 56961-77-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen; WO2012/3418; (2012); A2;,
Chloride – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14490-19-8 as follows. category: chlorides-buliding-blocks

A pressure vessel was charged with l,4-dichloropyrido[4,3-d]pyridazine (prepared according to the procedures in WO2009/035568A1) (66 mg, 0.33 mmol, 1.0 eq.), 3-trifluoromethyl aniline (0.05 mL, 0.39 mmol, 1.2 eq.) and l-methyl-2-pyrrolidinone (0.1 mL). The reaction was sealed and was heated to 105 C for 1 h. Analysis showed mono- addition as the major product with a minor amount of bis-addition product. Regioisomeric mono-addition products were not observed. The reaction was then cooled to room temperature and was diluted with water and saturated sodium bicarbonate solution. The mixture was extracted with ethyl acetate (2X). The combined organic layer was dried with sodium sulfate, was filtered and was concentrated to give the crude product. The product was purified by column chromatography (eluted with hexanes:ethyl acetate = 4: 1 to 1 : 1) to afford l-chloro-N-(3- (trifluoromethyl)phenyl)pyrido[4,3-d]pyridazin-4-amine (41 mg, 38% yield). MS (EI) for C14H8CIF3 4: 325 (MH+), Chlorine isotope pattern.

According to the analysis of related databases, 14490-19-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EXELIXIS, INC.; ANAND, Neel, Kumar; BROWN, S., David; TESFAI, Zerom; ZAHARIA, Cristiana, A.; WO2012/37132; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

2770-11-8, name is 2-(4-Chlorophenoxy)aniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2770-11-8

General procedure: To a stirred and cooled solution of 2-(4-chlorophenoxy)aniline (330 mg, 1.50 mmol) and triethylamine (230 muL, 1.65 mmol) in toluene (5 mL), the appropriate acid chloride (pivaloyl chloride, 2,2-dimethylbutyryl chloride, 3-methylbutyryl chloride, propyl chloride, cyclopropanecarbonyl chloride, cyclobutanecarbonyl chloride, methyl succinyl chloride, 4-methoxybenzoyl chloride) (1.65 mmol) was added. Subsequently the reaction mixture was allowed to warm to room temperature. The progress of the reaction was monitored by TLC. After 2-9 h the reaction mixture was extracted with a saturated sodium hydrogen carbonate solution, with a hydrogen chloride solution (10%), with brine and finally with water. Afterwards the organic solution was dried over sodium sulfate and evaporated under reduced pressure. The residue was further purified by recrystallization or column chromatography over silica gel.

The synthetic route of 2770-11-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Weidner, Thomas; Nasereddin, Abed; Preu, Lutz; Gruenefeld, Johann; Dzikowski, Ron; Kunick, Conrad; Molecules; vol. 21; 2; (2016);,
Chloride – Wikipedia,
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Electric Literature of 61881-19-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61881-19-4, name is 2,2,2-Trifluoro-N-phenylacetimidoyl chloride belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

3,4,6-Tri-O-benzyl-2-deoxy-2-trichloroacetamido-alpha/beta-D-galactopyranosyl N-phenyltrifluoroacetimidate (181). The hemiacetal (1.85 g, 3.11 mmol), obtained from the thioglycoside 24, was dissolved in acetone (31 mL). N-(phenyl)trifluoroacetimidoyl chloride (1.29 g, 6.22 mmol) and Cs2CO3 (1.12 g, 3.42 mmol, 1.1 equiv.) were added to the solution. The mixture was stirred for 4 h at rt. The reaction mixture was filtered and concentrated. The residue was purified by flash chromatography (Chex/EtOAc 85:15 to 7:3 + 1% Et3N) to give N-phenyltrifluoroacetimidate 181 (2.10 g, 88%) as a light yellow oil. 1H NMR (CDCl3), delta 7.61-7.09 (m, 18H, HAr), 6.77 (d, 2H, J = 7.6 Hz, HAr), 6.48 (do, 1H, JNH,2 = 7.7 Hz, NH), 6.47 (bso, 1H, H-1), 4.97 (d, 1H, J = 11.4 Hz, HBn), 4.76 (dpo, 1H, J = 11.9 Hz, HBn), 4.73 (m, 1H, H-2), 4.64 (d, 1H, HBn), 4.57-4.48 (m, 3H, HBn), 4.20 (bs, 1H, H-4), 4.07 (pt, 1H, H-5), 3.88 (dd, 1H, J2,3 = 11.0 Hz, J3,4 = 1.4 Hz, H-3), 3.72 (pt, 1H, J5,6a = 7.8 Hz, H-6a), 3.62 (dd, 1H, J5,6b = 5.7 Hz, J6a,6b = 9.1 Hz, H-6b). 13C NMR (CDCl3), delta 161.8 (NHCO), 143.1, 138.0, 137.7, 137.0 (4C, CIVAr), 129.4-119.3 (20C, CAr), 94.3 (C-1, 1JCH = 162.9 Hz), 92.3 (CCl3), 75.5 (C-3), 74.8, 73.7 (2C, CBn), 72.5 (C-5), 71.6 (C-4), 71.3 (CBn), 68.1 (C-6), 50.6 (C-2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-phenylacetimidoyl chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INSTITUT PASTEUR; Centre National de la Recherche Scientifique; Institut National De La Sante Et De La Recherche Medicale; UNIVERSITE PARIS DESCARTES; Mulard, Laurence; Chassagne, Pierre; Sansonetti, Philippe; EP2724730; (2014); A1;,
Chloride – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 19752-55-7

3,5-dichlorobromobenzene (2.3 g, 10 mmol), 9-phenylcarbazole-3-boronic acid (2.5 g, 11 mmol) Sodium carbonate (5.1 g, 48 mmol), Pd2 (dba) 3 (0.4 g, 0.4 mmo 1), Toluene, ethanol, water 50ml in turn added to the reaction bottle, The reaction was refluxed under nitrogen for 10 hours, Cooled to room temperature, separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated brine and water respectively. The organic layer was dried over magnesium sulfate, filtered, The column was silica gel to give 3.0 g of product, HPLC purity 99.2percent.

The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Li Chong; Yu Kaichao; Zhang Zhaochao; (42 pag.)CN107098918; (2017); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51419-59-1, name is p-Tolylmethanesulfonyl chloride, A new synthetic method of this compound is introduced below., Product Details of 51419-59-1

Potassium tert-butoxide (93.8 mg, 836 mumol) was added to a solution of 2-amino-5-(benzyloxy)-N,1-dimethyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide (110 mg, 380 mumol) in THF (10 ml) in DMF (2 ml) [Comment: please check]. After 10 min., the reaction mixture was cooled by an ice bath and then a solution of (4-methylphenyl)methanesulfonyl chloride (93.7 mg, 458 mumol) in THF (2 ml) was added. After 70 min., EtOAc and 1 N NaOH aqueous solution were added. The organic phase was extracted with EtOAc and then with DCM. The combined organic phases were washed with water, and brine, dried over Na2SO4 and evaporated to dryness. Chromatography (silica gel, 0 to 2percent MeOH in DCM) provided the title compound as a pale yellow solid (0.080 g; 46percent). LCMS: m/z=457 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; F. HOFFMANN-LA ROCHE AG; BUSCHMANN, Helmut; WOLKERSTORFER, Andrea; SZOLAR, Oliver; HANDLER, Norbert; CUSACK, Stephen; SMITH, Mark; SO, Sung-Sau; US2014/38990; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electric Literature of 16799-05-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16799-05-6, name is 3-Chlorophenethyl Bromide belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 57; (3R)-1-[2-(3-Chlorophenyl)ethyl]-3-{[2-piperidin-1-yl-2-(2-thienyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane bromide (Isomer 1); (3R)-1-Azabicyclo[2.2.2]oct-3-yl 2-piperidin-1-yl-2-(2-thienyl)propanoate (Example 57b, Isomer 1, 0.5 g) in acetonitrile (3 mL) was treated with 1-(2-bromoethyl)-3-chlorobenzene (0.35 g) and the mixture stirred and heated at 80 C. for 4 h. The mixture was concentrated to dryness, and the residue purified on silica gel eluting with 5% methanol in dichloromethane. The product from the column was triturated with ether to afford title compound as a colourless solid (160 mg).m/e 487 [M]30 1H NMR (400 MHz, DMSO) delta 7.51 (1H, dd), 7.48-7.44 (1H, m), 7.41-7.32 (2H, m), 7.32-7.27 (1H, m), 7.10 (1H, dd), 6.97 (1H, dd), 5.17-5.13 (1H, m), 3.95-3.88 (1H, m), 3.65-3.56 (1H, m), 3.50-3.40 (4H, m), 3.33-3.26 (1H, m), 3.24-3.16 (1H, m), 3.04-2.97 (2H, m), 2.51-2.42 (2H, m), 2.41-2.32 (2H, m), 2.31-2.23 (1H, m), 2.04-1.83 (4H, m), 1.62 (3H, s), 1.56-1.38 (6H, m).; Preparation of Example 57 Bromide; (3R)-1-[2-(3-Chlorophenyl)ethyl]-3-{[2-piperidin-1-yl-2-(2-thienyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane bromide (Isomer 1) Crystalline Form A; (3R)-1-Azabicyclo[2.2.2]oct-3-yl 2-piperidin-1-yl-2-(2-thienyl)propanoate (Example 57b, Isomer 1, 0.5 g) in acetonitrile (3 mL) was treated with 1-(2-bromoethyl)-3-chlorobenzene (0.35 g) and the mixture stirred and heated at 80 C. for 4 h. The mixture was concentrated to dryness, and the residue purified on silica gel eluting with 5% methanol in dichloromethane. The product from the column was triturated with diethyl ether to afford title compound as a colourless solid (160 mg).m/e 487 [M]+ 1H NMR (400 MHz, DMSO) delta 7.51 (1H, dd), 7.48-7.44 (1H, m), 7.41-7.32 (2H, m), 7.32-7.27 (1H, m), 7.10 (1H, dd), 6.97 (1H, dd), 5.17-5.13 (1H, m), 3.95-3.88 (1H, m), 3.65-3.56 (1H, m), 3.50-3.40 (4H, m), 3.33-3.26 (1H, m), 3.24-3.16 (1H, m), 3.04-2.97 (2H, m), 2.51-2.42 (2H, m), 2.41-2.32 (2H, m), 2.31-2.23 (1H, m), 2.04-1.83 (4H, m), 1.62 (3H, s), 1.56-1.38 (6H, m).

The synthetic route of 3-Chlorophenethyl Bromide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ford, Rhonan; Mete, Antonio; Millichip, Ian; Teobald, Barry; US2010/113510; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics