Tag: M.W=150-200

Masuda, Takeshi published the artcileSugar-induced stereoselectivity in the Fe³⁺-complexation of boronic acid-appended trihydroxamate-type artificial siderophores, Synthetic Route of 332154-58-2, the publication is Supramolecular Chemistry (2000), 11(4), 301-314, database is CAplus.

Two linear- and two tripodal-trihydroxamate siderophore mimics, suspending phenylboronic acid as the sugar-binding site, have been newly prepared These siderophore mimics strongly bind Fe³⁺ ions to give rise to the ligand-Fe³⁺ 1:1 complexes over a wide range of pH 2 to 11. CD spectra of these complexes in the presence of a sugar, D-fructose, exhibit moderately strong bisignate Cotton effects of first neg. and second pos. signs in aqueous alk. media. The sign and extent of the observed CD signals depend largely on the solution pH and the concentration and absolute configuration of the bound sugars, implying that the phenylboronate-sugar covalent interactions are capable of inducing a chirality around the metal center.

Supramolecular Chemistry published new progress about 332154-58-2. 332154-58-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,acyl chloride,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (3-(Chlorocarbonyl)phenyl)boronic acid, and the molecular formula is C7H6BClO3, Synthetic Route of 332154-58-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pedreira, Julia G. B. published the artcileBioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors, Application In Synthesis of 620-20-2, the publication is Journal of Medicinal Chemistry (2020), 63(13), 7347-7354, database is CAplus and MEDLINE.

The recent disclosure of type I 1/2 inhibitors for p38α MAPK demonstrated how the stabilization of the R-spine can be used as a strategy to greatly increase the target residence time (TRT) of inhibitors. Herein, for the first time, we describe N-acylhydrazone and selenophene residues as spine motifs, yielding metabolically stable inhibitors with high potency on enzymic, NanoBRET, and whole blood assays, improved metabolic stability, and prolonged TRT.

Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application In Synthesis of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kikuchi, Mikio published the artcilePredicting changes in aquatic toxicity of chemicals resulting from solvent or dispersant use as vehicle, Application of 3-Chloro-4-fluoronitrobenzene, the publication is Chemosphere (2016), 34-39, database is CAplus and MEDLINE.

The influence of two vehicles (N,N-dimethylformamide [DMF] as solvent and polyoxyethylene hydrogenated castor oil [HCO-40] as a dispersant) on the acute toxicity of eight hydrophobic chems. with a non-specific mode of action to Daphnia magna was investigated according to the OECD Guidelines for the Testing of Chems., Number 202. An increased 48-h EC₅₀ value for D. magna or reduced toxicity resulting from the addition of HCO-40 to the test medium was observed for five of the eight chems. examined Each of eight chems. was dissolved in water at a concentration of either 10 mg/L or 1.0 mg/L, with or without DMF or HCO-40. Silicone film as a model of a biol. membrane was then immersed in each solution, and the concentration of each chem. in the water was monitored until equilibrium was reached for each test substance, after which the adsorbed amount of each chem. was determined The amounts of p-pentylphenol and four other substances with log P_ow (1-octanol/water partition coefficient) values greater than 3.4 adsorbed onto the silicone film decreased with increasing concentrations of HCO-40. However, 3-chloro-4-fluoronitrobenzene and two other substances with log P_ow values less than 2.6 demonstrated no changes in adsorption with either increasing HCO-40 concentration or the addition of DMF. The reduced adsorption in the presence of a vehicle on the silicone film correlated closely with changes in toxicity. These results indicate that the methodol. developed in this study enables the prediction of changes in toxicity resulting from the addition of vehicles to a test system.

Chemosphere published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Application of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Arisawa, Mieko published the artcileRhodium-catalyzed synthesis of benzofurans by the reaction of ketones and o-difluorobenzenes, Quality Control of 350-30-1, the publication is Heterocycles (2012), 86(2), 1103-1118, database is CAplus.

In the presence of catalytic amounts of RhH(PPh₃)₄ and 1,2-bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The α-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7-trifluorobenzofuranes.

Heterocycles published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Quality Control of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cross, R. Matthew published the artcileSynthesis, Antimalarial Activity, and Structure-Activity Relationship of 7-(2-Phenoxyethoxy)-4(1H)-quinolones, Computed Properties of 209919-30-2, the publication is Journal of Medicinal Chemistry (2011), 54(24), 8321-8327, database is CAplus and MEDLINE.

Me 6-butyl-2-methyl-4-oxo-7-(2-phenoxyethoxy)-1,4-dihydroquinoline-3-carboxylate (I, ICI 56,780) displayed causal prophylactic and blood schizonticidal activity (ED₅₀ = 0.05 mg/kg) in rodent malaria models but produced rapid acquisition of parasitol. resistance in P. berghei infected mice. Herein we describe the synthesis of analogs of I with EC₅₀ as low as 0.15 nM against multidrug resistant P. falciparum. Optimal activity with low cross-resistance indexes (RI) to atovaquone was achieved by introducing ortho-substituted aryl moieties at the 3-position of the 7-(2-phenoxyethoxy)-4(1H)-quinolone core.

Journal of Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Computed Properties of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Jinpeng published the artcileChemoselective methylene oxidation in aromatic molecules, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Nature Chemistry (2019), 11(3), 213-221, database is CAplus and MEDLINE.

Despite significant progress in the development of site-selective aliphatic C-H oxidations over the past decade, the ability to oxidize strong methylene C-H bonds in the presence of more oxidatively labile aromatic functionalities remains a major unsolved problem. Such chemoselective reactivity is highly desirable for enabling late-stage oxidative derivatizations of pharmaceuticals and medicinally important natural products that often contain such functionality. Here, we report a simple manganese small-mol. catalyst Mn(CF₃-PDP) system that achieves such chemoselectivity via an unexpected synergy of catalyst design and acid additive. Preparative remote methylene oxidation is obtained in 50 aromatic compounds housing medicinally relevant halogen, oxygen, heterocyclic and biaryl moieties. Late-stage methylene oxidation is demonstrated on four drug scaffolds, including the ethinylestradiol scaffold where other non-directed C-H oxidants that tolerate aromatic groups effect oxidation at only activated tertiary benzylic sites. Rapid generation of a known metabolite (piragliatin) from an advanced intermediate is demonstrated.

Nature Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C7H3Cl2F3O2S, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pendem, Venkata Bhavanarushi published the artcileIron Mediated Desulfurization and C-N Bond Formation: Strategy for the Synthesis of Thioureas, Application of 1-(4-Chlorophenyl)thiourea, the publication is Letters in Organic Chemistry (2018), 15(12), 1025-1029, database is CAplus.

A highly efficient and simple protocol for the construction of aromatic and aliphatic thioureas from their resp. amines in the presence of cheap, readily available and air-stable iron catalyst in one-pot three-step reaction is described [e.g., aniline + CS₂ + NH₃ → PhNHC(:S)NH₂ (99%) in presence of Fe(NO₃)₃ and NaHCO₃ in DMF]. All the reactions were carried out under optimized reaction conditions to get the target products in good to excellent yields and shorter reaction time.

Letters in Organic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nakajima, Yusuke published the artcileAuxin transport and response requirements for root hydrotropism differ between plant species, Synthetic Route of 33697-81-3, the publication is Journal of Experimental Botany (2017), 68(13), 3441-3456, database is CAplus and MEDLINE.

The direction of auxin transport changes in gravistimulated roots, causing auxin accumulation in the lower side of horizontally reoriented roots. This study found that auxin was similarly involved in hydrotropism and gravitropism in rice and pea roots, but hydrotropism in Lotus japonicus roots was independent of both auxin transport and response. Application of either auxin transport inhibitors or an auxin response inhibitor decreased both hydrotropism and gravitropism in rice roots, and reduced hydrotropism in pea roots. However, Lotus roots treated with these inhibitors showed reduced gravitropism but an unaltered or an enhanced hydrotropic response. Inhibiting auxin biosynthesis substantially reduced both tropisms in rice and Lotus roots. Removing the final 0.2 mm (including the root cap) from the root tip inhibited gravitropism but not hydrotropism in rice seedling roots. These results suggested that modes of auxin involvement in hydrotropism differed between plant species. In rice roots, although auxin transport and responses were required for both gravitropism and hydrotropism, the root cap was involved in the auxin regulation of gravitropism but not hydrotropism. Hydrotropism in Lotus roots, however, may be regulated by a novel mechanism that is independent of both auxin transport and the TIR1/AFBs auxin response pathway.

Journal of Experimental Botany published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Synthetic Route of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V. published the artcileNitrogen-Doped Graphene-Activated Iron-Oxide-Based Nanocatalysts for Selective Transfer Hydrogenation of Nitroarenes, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is ACS Catalysis (2015), 5(3), 1526-1529, database is CAplus.

Nanoscaled iron oxides on carbon were modified with nitrogen-doped graphene (NGr) and found to be excellent catalysts for the chemoselective transfer hydrogenation of nitroarenes to anilines. Under standard reaction conditions, a variety of functionalized and structurally diverse anilines, which serve as key building blocks and central intermediates for fine and bulk chems., were synthesized in good to excellent yields.

ACS Catalysis published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gokanapalli, Anusha published the artcileBenzimidazole bearing Pd-PEPPSI complexes catalyzed direct C2-arylation/heteroarylation of N-substituted benzimidazoles, SDS of cas: 620-20-2, the publication is Applied Organometallic Chemistry (2020), 34(10), e5869, database is CAplus.

A convenient and highly efficient palladium-catalyzed direct C2-arylation/heteroarylation of N-substituted benzimidazole derivatives such as N-benzyl/3-chlorobenzyl/2,4,6-trimethylbenzyl/2,4,6-triisopropylbenzyl/aryl benzimidazoles I (R = H; R¹ = Bn, 4-chlorophenyl, (2,4,6-trimethylphenyl)methyl, etc.) with various aryl/heteroaryl bromides R²Br (R² = Ph, thiophen-3-yl, phenanthren-9-yl, etc.) in the presence of Pd-PEPPSI (palladium-pyridine enhanced pre-catalyst preparation stabilization and initiation) complexes is reported. A series of different sym. and unsym. N,N’-diaralkyl benzimidazole-bearing Pd-PEPPSI complexes II (R = 5-Me, 5,6-dimethyl; R³ = Me, 4-fluorophenyl, (2,4,6-trimethylphenyl)methyl, etc.) was prepared Among all of the prepared complexes, II = (R = 5,6-di-Me, R¹ = R³ = [2,4,6-tris(propan-2-yl)phenyl]methyl) effectively tuned the reaction at a relatively higher rate under mild reaction conditions in an ethanol-water system. In addition, the catalytic process avoids the use of external ligand and additives. Further the reactivity was compared with com. available copper-N-heterocyclic carbene catalyst, but the reaction was less successful. With the optimized reaction conditions, a wide range of 2-aryl/heteroaryl-N-substituted benzimidazoles were synthesized in good to excellent yields via Csp²-H/Csp²-X biaryl cross-coupling.

Applied Organometallic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics