Tag: M.W=150-200

Sano, Mitsuji published the artcileIdentification of carpronium chloride and its metabolite in human urine by field desorption mass spectrometry using deuterium labeling, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biomedical Mass Spectrometry (1979), 6(11), 467-71, database is CAplus and MEDLINE.

After oral administration of carpronium chloride [13254-33-6], it and a major metabolite N-(3-carbohydroxypropyl)trimethylammonium chloride [6249-56-5] were identified in urine by field desorption mass spectrometry using D labeling. Purification from urine included ion pair extraction with an iodine reagent.

Biomedical Mass Spectrometry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sauerberg, Per published the artcileIdentification and Synthesis of a Novel Selective Partial PPARδ Agonist with Full Efficacy on Lipid Metabolism In Vitro and In Vivo, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Medicinal Chemistry (2007), 50(7), 1495-1503, database is CAplus and MEDLINE.

The aim was to identify a novel selective PPARδ agonist with full efficacy on free fatty acid (FFA) oxidation in vitro and plasma lipid correction in vivo. Using the triple PPARα,γ,δ agonist 1 (I) as the structural starting point, we wanted to investigate the possibility of obtaining selective PPARδ agonists by modifying only the acidic part of 1, while holding the lipophilic half of the mol. constant The structure-activity relationship was guided by in vitro transactivation data using the human PPAR receptors, FFA oxidation efficacy performed in the rat muscle L6 cell line, and in vivo rat pharmacokinetic properties. Compound 7 ([4-[3,3-bis-(4-bromo-phenyl)-allylthio]-2-chloro-phenoxy]-acetic acid) was identified as a selective, partial agonist with good oral pharmacokinetic properties in rat. Chronic treatment of high fat fed ApoB100/CETP-Tgn mice with 7 corrected the plasma lipid parameters and improved insulin sensitivity. These data suggest that selective PPARδ agonists have the potential to become a novel treatment of dyslipidemia.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aspuria, E. T. published the artcileGFP accumulation controlled by an auxin-responsive promoter as a non-destructive assay to monitor early auxin response, HPLC of Formula: 33697-81-3, the publication is Plant Cell Reports (2002), 21(1), 52-57, database is CAplus.

We have constructed transgenic Arabidopsis lines that contain a gene for green fluorescent protein (GFP) under the control of auxin-responsive domains A and B of the promoter from the pea PS-IAA4/5 gene. The chimeric transgene was named BA-mgfp5-ER. GFP was detected after the application of indole-3-acetic acid at concentrations as low as 100 nM in epidermal cells in the root elongation zone. The induction of the reporter gene was highly specific to auxin and was correlated with the auxin-induced change in epidermal cell shape. No GFP accumulation was observed in the lateral root meristem that was formed as a result of exogenous auxin application. These results suggest that auxin signals were transmitted through several distinct pathways depending on the cell type. The intensity of the GFP signal was strong enough to be observed through the plastic lid of the culture dish using a dissecting microscope, thereby enabling GFP expression to be monitored in an aseptic environment. Thus, the BA-mgfp5-ER transgenic plant can be a powerful tool for screening mutants that are defective in auxin signaling and the expression of early auxin-response genes.

Plant Cell Reports published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, HPLC of Formula: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Perez-Rodriguez, Santiago published the artcileHighly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles, SDS of cas: 33697-81-3, the publication is European Journal of Medicinal Chemistry (2009), 44(6), 2434-2446, database is CAplus and MEDLINE.

I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) and II (R = H, MeOCH₂CH₂OCH₂) are prepared as novel adamantyl biaryl arotinoids with decreased binding to retinoic acid receptors but with anticancer activity (by selective induction of apoptosis in cancer cells). I and II are prepared using Suzuki coupling reactions of an adamantylphenylboronic acid with a trifloxyphenylacetate, a trifloxycinnamate, and a trifloxynaphthoate. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH) show significant antiproliferative activity in several human cancer cell lines, with the anticancer activity correlated to the induction of apoptosis as measured by caspase activity. I (R = H, MeOCH₂CH₂OCH₂; R¹ = R² = H; R¹R² = CH:CH), while devoid of retinoic acid receptor binding capacity, transactivate the retinoid X receptor α.

European Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Raimundo, Brian C. published the artcileIntegrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: An Approach for Inhibiting Protein-Protein Interactions, Recommanded Product: 2-Chloro-4-hydroxyphenylboronic acid, the publication is Journal of Medicinal Chemistry (2004), 47(12), 3111-3130, database is CAplus and MEDLINE.

Fragment assembly has shown promise for discovering small-mol. antagonists for difficult targets, including protein-protein interactions. Here, the authors describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα) interaction. By use of fragment-based approaches, a compound with millimolar affinity was evolved to a hit series with low micromolar activity, and these compounds were optimized into a lead series with nanomolar affinity. Fragment assembly was useful not only for hit identification, but also for lead optimization. Throughout the discovery process, biophys. methods and structural biol. demonstrated that compounds bound reversibly to IL-2 at the IL-2 receptor binding site.

Journal of Medicinal Chemistry published new progress about 766549-26-2. 766549-26-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 2-Chloro-4-hydroxyphenylboronic acid, and the molecular formula is C6H6BClO3, Recommanded Product: 2-Chloro-4-hydroxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pravardhan Reddy, E. published the artcileBenzyl chlorides as aldehyde surrogates in the Prins cyclization: Direct access to 2-aryl-4-chlorotetrahydropyrans, Formula: C8H6ClF3, the publication is Tetrahedron Letters (2022), 153746, database is CAplus.

An efficient synthesis of 2-aryl-4-chloro-tetrahydropyrans was accomplished from benzyl chlorides and homoallylic alcs. using FeCl₃ as a promoter through a sequential oxidation/Prins cyclization in high yields. This was the first report on the use of benzyl chlorides as surrogates for aldehydes in the Prins cyclization.

Tetrahedron Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Geethanjali, Y. published the artcileSynthesis and antimicrobial activity of 7-(β-t-alkylaminoalkoxy)-8-benzoyl-4-methyl coumarins, Synthetic Route of 4584-49-0, the publication is Indian Journal of Heterocyclic Chemistry (1995), 4(4), 307-8, database is CAplus.

Title compounds were prepared by reaction of 7-hydroxy-8-benzoyl-4-methylcoumarin with various alkylaminoalkyl chloride hydrochlorides and were screened for antimicrobial activity. 7-(3-Piperidinopropoxy)-8-benzoyl-4-methylcoumarin showed marked antifungal and antibacterial activity.

Indian Journal of Heterocyclic Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Synthetic Route of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shimamura, Satoshi published the artcileEffects of anti-auxins on secondary aerenchyma formation in flooded soybean hypocotyls, SDS of cas: 33697-81-3, the publication is Plant Production Science (2016), 19(1), 154-160, database is CAplus.

In flooded hypocotyl of soybean (Glycine max), cell division in phellogen and the elongation of these cells are enhanced, and thereby a secondary aerenchyma with high porosity is produced. Auxin controls cell division and cell elongation in many plants, so we studied its role in secondary aerenchyma development. Soybean plants with fully expanded unifoliolate leaves were flooded for 6 d with solutions (100μM each) of seven anti-auxins. TIBA, NPA, HFCA, 1-NOA, or CHPAA did not restrict the secondary aerenchyma formation, while MH moderately suppressed the aerenchyma development, and PCIB strongly inhibited the development of phellogen and secondary aerenchyma. However, the endogenous IAA concentrations in the flooded hypocotyls did not increase or decrease relative to the controls until 72 h, when a secondary aerenchyma was observed From these results, it is unclear whether auxin plays an important role in the process of secondary aerenchyma formation under flooding.

Plant Production Science published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C7H8BFO2, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kitaoka, Satoshi published the artcilePyridinium-based ionic liquids incorporating disulfide bond: reversible control of phase separation property with water, Name: 1,2-Bis(2-chloroethyl)disulfane, the publication is Chemistry Letters (2018), 47(3), 362-364, database is CAplus.

Water-insoluble pyridinium-based ionic liquids with a disulfide bond were prepared Reduction of these ionic liquids using sodium hydrosulfite changed the water solubilities of the ionic liquids because the structural exchange of disulfide into thiol groups increased their polarities. Such a structural change by oxidation-reduction enabled reversible control of the phase separation property of ionic liquids with water.

Chemistry Letters published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Name: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chung, Woojung published the artcileTime-Resolved Observation of Chiral-Index-Selective Wrapping on Single-Walled Carbon Nanotube with Non-Aromatic Polysilane, Product Details of C7H16Cl2Si, the publication is Journal of the American Chemical Society (2013), 135(6), 2374-2383, database is CAplus and MEDLINE.

In the present paper, we ascertain two novel findings on chiral-index-selective binding/separating of single-walled carbon nanotubes (SWNTs) with a nonaromatic polymer, poly(dialkylsilane) (PSi). PSi is a typical σ-conjugated polymer, composed of alkyl side chains attached to the silicon (Si)-catenated main chain. First, PSi’s with linear alkyl side chains showed significant diameter-selective wrapping for SWNTs with ca. 0.9 nm in diameter, resulting in the selective separation of (7,6) and (9,4) SWNTs. Its driving force was demonstrated to be cooperative CH-π interactions among the alkyl side chains of PSi’s and the curved graphene of SWNTs. Second, the dynamic wrapping behavior of PSi’s onto SWNTs was elucidated with time-resolved UV spectroscopy. Highly anisotropic UV absorption of PSi along the Si main chain was utilized as a “chromophoric indicator” to monitor the global/local conformations, which enabled us to track kinetic structural changes of PSi’s on SWNTs. Consequently, we concluded that upon wrapping, flexible/helical PSi with an average dihedral angle (φ) of 145° and Kuhn’s segment length (λ^-1) of 2.6 nm interconverted to the more stiffer/planar conformation with 170° and λ^-1 of 7.4 nm. Furthermore, through kinetic analyses of the time-course UV spectra, we discovered the fact that PSi’s involve three distinct structural changes during wrapping. That is, (i) the fast adsorption of several segments within dead time of mixing (<30 ms), following (ii) the gradual adsorption of loosely wrapped segments with the half-maximum values (τ₁) of 31.4 ms, and (iii) the slow rearrangement of the entire chains with τ₂ of 123.1 ms, coupling with elongation of the segment lengths. The present results may be useful for rational design of polymers toward chiral-index-selective binding/separating of desired (n,m) SWNTs.

Journal of the American Chemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Product Details of C7H16Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics