Tag: M.W=150-200

Sudo, Yu; Kawai, Ryuki; Nabae, Yuta; Hayakawa, Teruaki; Kakimoto, Masa-aki published the artcile< Self-condensing vinyl polymerization of a switchable chain transfer monomer for facile synthesis of star-shaped block copolymers>, Reference of 1592-20-7, the main research area is star polymer switchable chain transfer agent.

Reversible addition-fragmentation chain transfer-self-condensing vinyl polymerization (RAFT-SCVP) is a versatile methodol. for synthesizing hyperbranched polymers with a large number of chain transfer termini. Also, this method easily provides star-shaped block copolymers by another sequence of RAFT polymerizations The design of such block copolymers, however, is still limited because the structure of chain transfer groups needed to be selected in accordance with the activity of monomers. This paper proposes a new class of styrene-type monomer, namely (4-vinyl)benzyl-N-methyl-N-(4-pyridyl)dithiocarbamate (VPDC), as a universal chain transfer monomer for facile synthesis of star-shaped block copolymers. VPDC effectively works as a chain transfer monomer for RAFT-SCVP in protonated form, providing hyperbranched polystyrene (PVPDC). The RAFT polymerization of a more-activated monomer (MAM), in this case N-isopropylacrylamide, was demonstrated from the same RAFT agent, whereas that of a less-activated monomer (LAM), namely vinyl acetate, was also achieved after switching the activity of the termini by deprotonation of the chain transfer agent (CTA). All in all, we believe that the current findings will enable facile synthesis of more varied star-shaped block copolymers with flexible design.

Applied Surface Science published new progress about Branched polymers, star-branched Role: SPN (Synthetic Preparation), PREP (Preparation). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hansch, Corwin; Coubeils, Jean Louis; Leo, A. published the artcile< Antimicrobial structure-activity relation in esters of 4-hydroxybenzoic acid>, Application of C8H7ClO3, the main research area is methyl hydroxybenzoate antimicrobiol activity; ethyl hydroxybenzoate antimicrobiol activity.

Equations of the type log 1/c = alog p + b were derived to correlate the molar concn (C) of 4-hydroxybenzoates (such as methyl 4-hydroxybenzoate [99-76-3] and ethyl 4-hydroxybenzoate [120-47-8]) causing a standard antimicrobial response with their relative lipophilic character (P) for fungi, gram-pos., and gram-neg. bacteria. Thus, hydroxybenzoates were found to be .sim.30-fold as toxic to fungi as to gram-pos. cells, while gram-neg. cells showed an intermediate toxicity.

Chimica Therapeutica published new progress about Fungicides. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Application of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brodskii, E. S.; Kluev, N. A.; Zhil’nikov, V. G.; Bocharov, B. V.; Dovgilevich, A. V.; Mel’nikova, N. P.; Grandberg, I. I. published the artcile< Photodegradation of the herbicide Goal>, Synthetic Route of 35852-58-5, the main research area is herbicide Goal photolysis product.

Photodegradation products of the herbicide Goal active ingredient were obtained with a xenon lamp and analyzed using direct inlet mass spectrometry (MS), MS/MS and gas chromatog./MS. A number of products were identified and their generation pathways were established to be mainly Ar-O bond cleavage, dechlorination and photocyclization. The latter process gives chlorinated and unchlorinated dibenzofurans some of which may be toxic.

Toxicological and Environmental Chemistry published new progress about Herbicides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Synthetic Route of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

do Carmo, Lucas F.; Silva, Simone C.; Machado, Matheus V.; Prata, Paloma S.; Junior, Alberto Wisniewski; Vidal, Diogo M.; Villar, Jose Augusto F. P. published the artcile< The role of L-proline and co-catalysts in the enantioselectivity of OXA-Michael-Henry reactions>, Application In Synthesis of 5153-70-8, the main research area is nitrophenyl chromene preparation enantioselective; salicylaldehyde nitrostyrene Michael Henry tandem proline catalyst.

In this work, a study of the OXA-Michael-Henry reactions between salicylaldehyde and β-nitrostyrenes 2-R1-3-R2-4-R3C6H2CH=CHNO2 (R1 = R2 = H, R3 = Cl; R1 = R2 = H, R3 = Br; R1 = R2 = 2,3-Cl2, R3 = H, etc.), catalyzed by proline derivatives e.g., L-proline was described. The corresponding (R)-3-nitro-2-phenyl-2H-chromenes I were obtained in 55% enantiomeric excess (ee, 20 mol% L-proline) and 70% ee (stoichiometric amount) employing Ti(OiPr)4 as Lewis acid. Despite the ee obtained, this result represents the highest enantioselectivity obtained in this reaction. Therefore, this work demonstrated that it is possible to obtain considerable enantiomeric excesses in OXA-Michael-Henry reactions using L-proline, an inexpensive and accessible amino acid.

Journal of the Brazilian Chemical Society published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Application In Synthesis of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Takahashi, Kimio; Shimizu, Sumio; Ogata, Masaru published the artcile< Syntheses of phenolic metabolites of an antifungal imidazole derivative (cloconazole hydrochloride)>, Reference of 3964-57-6, the main research area is cloconazole fungicide phenolic metabolite; imidazole benzyloxystyryl phenolic metabolite; benzyloxystyrylimidazole fungicide phenolic metabolite.

Phenolic compounds I (R = OH, R1 = H) and I (R = H, R1 = OH) were prepared, and they are proposed metabolites of cloconazole I (R = R1 = H), a fungicide (no data). Phenolic compound II was etherified by 3-ClC6H4CH2Cl and NaH to yield I (R = THPO, R1 = H) and the latter was deprotected by oxalic acid to give I (R = OH, R1 = H).

Heterocycles published new progress about 3964-57-6. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Reference of 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gao, Hui; Zhang, Xia; Pu, Xiao-Jia; Zheng, Xi; Liu, Bei; Rao, Gao-Xiong; Wan, Chun-Ping; Mao, Ze-Wei published the artcile< 2-Benzoylbenzofuran derivatives possessing piperazine linker as anticancer agents>, Reference of 17082-09-6, the main research area is benzofuranylcarbonylphenyl piperazinylmethylcarbonyl piperazine antitumor antiinflammatory cytotoxicity apoptosis structure activity; 2-Benzoylbenzofuran; Anticancer activity; Apoptosis; Cytotoxicity.

A series of novel 2-benzoylbenzofuran derivatives possessing a piperazine linker, I [R = H, COCH2Cl, cyclopropylsulfonyl, COC6H4CF3-4, etc.], were prepared, and their in-vitro anticancer activity against a panel of human tumor cell lines by MTT assay was evaluated. The results demonstrated that tertiary amine derivatives exhibited better cytotoxic activity, and the SAR study revealed that electron-donating substituents on the Ph ring of the derivatization functionality contributed to potent anticancer activities. Among them, compounds I [R = H, COC6H3Cl2-3,5, COCH:CHPh, CH2C6H4CH:CHCO2Me-4, CH2COMe, CH2COC6H4OMe-4] displayed both better antitumor activity and lower cytotoxic effect on human normal liver cell L02. Further apoptosis anal. showed that compound I [R = CH2C6H4CH:CHCO2Me-4] significantly induced apoptosis in A549 cell, which was considered as the most potent anticancer agent.

Bioorganic & Medicinal Chemistry Letters published new progress about Amides Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Reference of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Moon, Jihyeon; Kang, Chaewon; Kang, Hyo published the artcile< Vertical alignment of liquid crystals on phenylphenoxymethyl-substituted polystyrene-PS derivatives structurally similar to LC molecules>, Product Details of C9H9Cl, the main research area is liquid crystal phenylphenoxymethyl polystyrene surface energy property; 4-phenylphenol; alignment layer; liquid crystal; polystyrene; precursor.

A series of polystyrene derivatives containing precursors of liquid crystal (LC) mols., phenylphenoxymethyl-substituted polystyrene (PPHE#; # = 5, 15, 25, 50, 75, and 100)-where # is the molar content of 4-phenylphenol using polymer modification reactions-were prepared in order to examine the effect of the polymer film, which possess similar LC mol. structure on the LC alignment properties. It was found that the Tg values of the PPHE# were higher than 100°C due to their aromatic structure in the biphenyl-based PHE moiety. The LC cells fabricated with PPHE5 and PPHE15 films exhibited planar LC alignment. Conversely, LC mols. showed a vertical alignment in LC cells made using the polymer films with phenylphenoxymethyl side groups in the range of 25-100 mol %. The polar surface energies on the PPHE# films can be associated with the vertical LC alignment on the PPHE# films. For example, vertical LC alignment was exhibited when the polar surface energy of the polymer films was less than approx. 4.2 mJ/m2. Aligning stability was observed at 200°C and UV irradiation of 20 J/cm2 for LC cells made using the PPHE100 film. Therefore, it was found that biphenyl, one of the LC precursors, modified polystyrene derivatives and can produce a next-generation vertical LC alignment system.

Polymers (Basel, Switzerland) published new progress about Contact angle. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Product Details of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jun, Joonhong; Baek, Jihyun; Yang, Songyi; Moon, Hyungwoo; Kim, Hyejin; Cho, Hyunwook; Hah, Jung-Mi published the artcile< Discovery of a Potent and Selective JNK3 Inhibitor with Neuroprotective Effect Against Amyloid β-Induced Neurotoxicity in Primary Rat Neurons>, Quality Control of 27841-33-4, the main research area is amyloid beta neurotoxicity Jun terminal kinase inhibitor neuroprotective effect; Alzheimer’s disease (AD); JNK3; SAR; benzimidazole; neurodegenerative diseases; neuroprotection.

As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biol. processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerative diseases such as Alzheimer′s disease (AD) and Parkinson′s disease (PD). In this study, we prepared a series of five 6-dihydroxy-1H-benzo[d]imidazoles as JNK3 inhibitors and found them have potential as neuroprotective agents. Following a previous lead scaffold, benzimidazole moiety was modified with various aryl groups and hydroxylation, and the resulting compounds exhibited JNK3 inhibitory activity with improved potency and selectivity. Out of 37 analogs synthesized, (S)-cyclopropyl(3-((4-(2-(2,3-dihydrobenzo[b][1,4]dioxin -6-yl)-5,6-dihydroxy-1H-benzo[d]imidazol-1-yl)pyrimidin-2-yl)amino) piperidin-1-yl)methanone (35b) demonstrated the highest JNK3 inhibition (IC50 = 9.7 nM), as well as neuroprotective effects against Aβ-induced neuronal cell death. As a protein kinase inhibitor, it also showed excellent selectivity over other protein kinases including isoforms JNK1 (>1000 fold) and JNK2 (-10 fold).

International Journal of Molecular Sciences published new progress about Cell viability. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Quality Control of 27841-33-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Wenhui; Shi, Yali; Gao, Lihong; Liu, Jiemin; Cai, Yaqi published the artcile< Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools>, SDS of cas: 3964-57-6, the main research area is paraben hydroxybenzoic acid environmental exposure swimming pool; Chlorinated parabens; Human exposure assessment; PHBA; Parabens; Swimming pool.

As an emerging group of endocrine-disrupting chems., parabens have attracted growing attention due to their potential effects on human health. In the present study, the occurrence and distribution of eight parabens, four chlorinated parabens, and their common hydrolysis product, p-hydroxybenzoic acid (PHBA), were investigated in 39 swimming pools in Beijing, China. Me paraben and Pr paraben were the predominant compounds in swimming pools, accounting for 91.2 % of the total parabens. It is noteworthy that octyl paraben, a paraben with longer chain, was firstly detected in this study. There were several factors affecting the levels of parabens among the 39 swimming pools. The concentrations of parabens and chlorinated derivatives detected in indoor pools (144 ng L-1) were roughly 20-fold higher than those in outdoor pools (6.78 ng L-1). Hotel pools appear to present higher level of target compounds (361 ng L-1) than that in health club (228 ng L-1), municipal (130 ng L-1), school (75.6 ng L-1), and community pools (63.0 ng L-1). Moreover, the level of these compounds in pools during weekends (174 ng L-1) was much higher than that during weekdays (52.3 ng L-1). The dynamics of target compounds were also investigated to provide a general trend of the level of parabens in a school indoor swimming pool during a 14-wk period. Human exposure assessment was conducted to estimate the potential risk of exposure to parabens and their chlorinated derivatives in swimming pools. Considering the total exposure dose of multiple parabens, human exposure to parabens from the water of swimming pools is negligible. However, the threat of these parabens to children in swimming pool should be concerned.

Environmental Science and Pollution Research published new progress about Occupational safety. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vishe, Mahesh; Johnston, Jeffrey N. published the artcile< The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis>, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene, the main research area is amino amide synthesis enantioselective diastereoselective; oxime preparation reduction; dinitro alkane preparation amine umpolung; ethane nitro styrene Michael addition enantioselective.

A stereocontrolled synthesis of β2,3-amino amides I [R = Me, Ph, 4-MeC6H4; R1 = Ph, 4-MeOC6H4; R2 = Ac, Cbz, Fmoc] was reported. Innovation was encapsulated by the first use of nitroalkenes to achieve double umpolung in enantioselective β2,3-amino amide synthesis. Step economy was also fulfilled by the use of umpolung Amide Synthesis (UmAS) in the second step, delivering the amide product without intermediacy of a carboxylic acid or activated derivative Molybdenum oxide-mediated hydride reduction provided the anti-β2,3-amino amides I with high selectivity.

Chemical Science published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Name: (E)-1-Chloro-4-(2-nitrovinyl)benzene.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics