Tag: M.W=150-200

Wang, Chen; Wang, Yongli; Yin, Qiuxiang; Xu, Zhao; Bao, Ying; Hou, Baohong; Liu, Wei; Hao, Hongxun published the artcile< Solubilities of 3-Chlorophthalic Anhydride and 4-Chlorophthalic Anhydride in Different Pure Solvents>, Name: 5-Chloroisobenzofuran-1,3-dione, the main research area is solubility chlorophthalic anhydride pure solvent.

To help the development of separation technol. for the mixture of 3-chlorophthalic anhydride and 4-chlorophthalic anhydride, the solubility data of 3-chlorophthalic anhydride and 4-chlorophthalic anhydride in tert-amyl alc., carbon tetrachloride, cyclohexane, methanol, Me acetate, and acetonitrile were measured at of 283.15 K to 328.15 K by a static method. The solubilities of both 3-chlorophthalic anhydride and 4-chlorophthalic anhydride increased with the increase of temperature The exptl. solubility data in six pure solvents were correlated by the modified Apelblat equation, the van’t Hoff equation, the λh (Buchowski) equation, and the NRTL model, among which the modified Apelblat equation can give better correlation results than other models. In addition, the dissolution thermodn. properties, including enthalpy, entropy, and Gibbs energy were determined The exptl. data would be of great significance for the design and optimization of the crystallization processes of 3-chlorophthalic anhydride and 4-chlorophthalic anhydride.

Journal of Chemical & Engineering Data published new progress about Entropy (of solution). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Name: 5-Chloroisobenzofuran-1,3-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sasaki, Tadashi; Kanematsu, Ken; Minamoto, Katsumaro published the artcile< Morphine-like analgesics. II. Aminohydrophenanthrene derivatives>, Product Details of C10H9ClO2, the main research area is CHEMISTRY, PHARMACEUTICAL; EXPERIMENTAL LAB STUDY; MORPHINE; PHENANTHRENES.

A solution of 10 g. 2-phenylcyclohexanone in 25 ml. C6H6 is added dropwise to a solution of 1.5 g. 50% NaH (in oil) in 35 ml. C6H6 and the whole kept 5 hrs., refluxed 20 min., cooled, and refluxed with 12.5 g. MeI and 10 ml. C6H6 8 hrs. to give 7 g. 2-methyl-2-phenylcyclohexanone (I), b2 110°; 2,4-dinitrophenylhydrazone m. 175-6°. A mixture of 31.3 g. I, 14.3 g. malononitrile, 2.7 g. AcONH4, 1.5 ml. AcOH, and 60 ml. C6H6 is refluxed 13 hrs. to give 14 g. 2-methyl-2-phenyl-Δ1,α -cyclohexanemalononitrile (II), b0.1 150-1°. A solution of 4.5 g. II in 40 ml. MeOH is subjected to catalytic reduction using 0.2 g. PtO2 under high pressure at room temperature, and the oily product (4.6 g.) in 55 ml. BuOH refluxed with 14.8 g. KOH (150-60°) 12 hrs. to give 3 g. 2-methyl-2-phenylcyclohexaneacetic acid (III), m. 130-1° (EtOH). A mixture of 3.9 g. III and 56 g. polyphosphoric acid is heated 2 hrs. at 110° to give 3.5 g. 4α-methyl-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrone (IV), b2 140°. To a solution of 3 g. IV in 17 ml. dioxane are added 3.5 ml. Am nitrite and a solution of 0.36 g. Na in EtOH, the whole kept 6 hrs. at 0-5° and then 40 hrs. at 10°, Et2O added, and the pH adjusted to 5.0 to give 2.4 g. 4a-methyl-10-isonitroso-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrone (V), oil; 2,4-dinitrophenylhydrazone m. 226-7°. Catalytic reduction of 1.2 g. V in 30 ml. EtOH over 0.1 g. Pd-C (autoclave) gives 90% 4a-methyl-10-amino-1,2,3,4,4a,10a-hexahydro-9(10H)-phenanthrone (VI); hydrochloride m. 173-5°; it exhibits morphine-like analgesic activity.

Yakugaku Zasshi published new progress about Analgesics. 90940-40-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C10H9ClO2, Product Details of C10H9ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Habibi, Davood; Marvi, Omid published the artcile< Montmorillonite KSF and montmorillonite K-10 clays as efficient catalysts for the solventless synthesis of bismaleimides and bisphthalimides using microwave irradiation>, Reference of 118-45-6, the main research area is bismaleimide bisphthalimide microwave irradiation montmorillonite clay catalyst solventless.

Different bismaleimides and bisphthalimides were synthesized in a simple and environmentally benign method from the condensation reaction of maleic and phthalic anhydrides with different diamines on montmorillonite KSF and montmorillonite K-10 clays as solid acidic catalysts by microwave irradiations under the solvent-free conditions in good yields and short reaction times.

ARKIVOC (Gainesville, FL, United States) published new progress about Microwave irradiation. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Reference of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ma, Yu-Hong; He, Xiao-Yu; Wang, Long; Yang, Qing-Qing published the artcile< PPh3-Triggered Tandem Synthesis of 2,3-Disubstituted Benzofuran Derivatives from o-Quinone Methides with Acyl Chlorides>, SDS of cas: 17082-09-6, the main research area is benzofuran preparation; quinone methide acyl chloride phospha Michael acylation intramol Wittig.

A PPh3-triggered tandem strategy for the efficient synthesis of valuable 2,3-disubstituted benzofuran derivatives in generally good to high yields from aryl or alkyl acyl chlorides and o-quinone methides has been developed. This method features mild reaction conditions, simple operation, and a broad substrate scope.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, SDS of cas: 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lei, Tianmeng; Wang, Yefei; Zhang, Heng; Cao, Jie; Xiao, Chuanmin; Ding, Mingchen; Chen, Wuhua; Chen, Mifa; Zhang, Zhenyu published the artcile< Preparation and performance evaluation of a branched functional polymer for heavy oil recovery>, COA of Formula: C9H7ClO, the main research area is functional polymer heavy oil viscosity reduction synergistic effect.

To solve the problem of chromatog. separation encountered in surfactant-polymer composite systems, a branched functional polymer (PEM) was prepared from acrylamide, acrylic acid, polyethyleneimine, and a newly synthesized functional monomer (XN) to realize high efficient displacement of heavy oil in oil reservoir conditions. Proton NMR (1HNMR) anal., elemental anal., and Fourier-transform IR spectroscopy verified the synthesis of PEM. The thickening performance, salt resistance, interfacial activity, ability of heavy oil viscosity reduction by emulsification, and core-flooding performance of PEM were systematically studied, with linear functional polymer PXM containing XN and conventional polymer HPAM as the control group. Under the synergistic effect of functional monomer XN and the branched structure, PEM demonstrated better thickening performance and more ideal heavy oil viscosity reduction compared with those of PXM and HPAM. The branched structure of PEM enhanced the interaction between mols. and the strength of the spatial network structure; notably, the thickening performance of PEM improved by 34.6% and 141.7%, and the salt resistance performance improved by 31.5% and 89.4%, compared with those of PXM and HPAM, resp. Furthermore, PEM formed a relatively tight interfacial adsorption layer at the oil-water interface, leading to the reduction of interfacial tension. The heavy oil viscosity reduction rate of PEM (87.0%) was higher than that of PXM (79.5%). The emulsion formed was more stable than PXM, and the oil-water separation rate was slower. Owing to the better heavy oil viscosity reduction effect of PEM, the recovery factor of PEM (21.4%) was higher than that of PXM (17.2%) under the same polymer viscosity condition. These findings indicate that PEM and its functional mechanism are suitable for the enhancement of heavy oil recovery.

Journal of Molecular Liquids published new progress about Dehydration process. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, COA of Formula: C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chetty, Sarentha; Armstrong, Tom; Kharkwal, Shalu Sharma; Drewe, William C.; De Matteis, Cristina I.; Evangelopoulos, Dimitrios; Bhakta, Sanjib; Thomas, Neil R. published the artcile< New InhA inhibitors based on expanded triclosan and Di-triclosan analogues to develop a new treatment for tuberculosis>, COA of Formula: C7H7ClO2, the main research area is triclosan preparation InhA Inhibition mol docking SAR; InhA; Mycobacterium bovis BCG; Mycobacterium tuberculosis; isoniazid; molecular modelling; structure-based drug-design; triazole; triclosan; tuberculosis.

This work aimed to design new ‘direct’ InhA inhibitors that obviate the need for activation by KatG, circumventing pre-existing resistance. In silico mol. modeling was used as part of a rational structure-based drug-design approach involving inspection of protein crystal structures of InhA:inhibitor complexes, including the broad spectrum antibiotic triclosan (TCS). One crystal structure exhibited the unusual presence of two triclosan mols. within the Mycobacterium tuberculosis InhA binding site. This became the basis of a strategy for the synthesis of novel inhibitors. A series of new, flexible ligands were designed and synthesized, expanding on the triclosan structure. Low Min. Inhibitory Concentrations (MICs) were obtained for benzylphenyl compounds I [R = MeO, acetoxy, acetyl; R1 = MeO, methanesulfonyloxy; X = F, Cl, Br; Y =NH, O] and di-triclosan derivative II [R2 = MeO, R3 = Me], against Mycobacterium bovis BCG although these may also be inhibiting other enzymes. The ether linked di-triclosan derivative II [R2 = OH, R3 = 4-chloro-2-hydroxyphenyl] displayed excellent in-vitro isolated enzyme inhibition results comparable with triclosan, but at a higher MIC (125μg mL-1). These compounds offered good opportunities as leads for further optimization.

Pharmaceuticals published new progress about Drug design. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, COA of Formula: C7H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Akutsu, Hiroshi; Ito, Mifuyu; Kawada, Masahiro; Nakashima, Kosuke; Hirashima, Shin-ichi; Miura, Tsuyoshi published the artcile< Organocatalytic asymmetric conjugate addition of substituted 5-benzylfurfurals to nitroalkenes based on stereocontrol of trienamine>, HPLC of Formula: 5153-70-8, the main research area is nitroalkene benzylfurfural organocatalyst enantioselective diastereoselective regioselective alkylation; furan derivative preparation.

Asym. ε-alkylation reaction of substituted 5-benzylfurfural derivatives to nitroalkenes by controlling the stereochem. of the trienamine intermediate resulted in corresponding ε-regioselective addition products, e.g., I, in high yields, diastereoselectivities, and enantioselectivities.

Tetrahedron Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, HPLC of Formula: 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yoom, Hoonsik; Shin, Jaedon; Ra, Jiwoon; Son, Heejong; Ryu, Dongchoon; Kim, Changwon; Lee, Yunho published the artcile< Transformation of methylparaben during water chlorination: Effects of bromide and dissolved organic matter on reaction kinetics and transformation pathways>, Product Details of C8H7ClO3, the main research area is paraben water chlorination bromide dissolved organic matter disinfection byproduct; Bromide; Bromine; Chlorination; Disinfection byproducts; Paraben; Transformation products.

The reaction kinetics, products, and pathways of methylparaben (MeP) during water chlorination with and without bromide (Br-) were investigated to better understand the fate of parabens in chlorinated waters. During the chlorination of MeP-spiked waters without Br-, MeP was transformed into mono-Cl-MeP and di-Cl-MeP with apparent second-order rate constants (kapp) of 64 M-1s-1 and 243 M-1s-1 at pH 7, resp., while further chlorination of di-Cl-MeP was relatively slower (kapp = 1.3 M-1s-1 at pH 7). With increasing Br- concentration, brominated MePs, such as mono-Br-MeP, Br-Cl-MeP, and di-Br-MeP, became major transformation products. The di-halogenated MePs (di-Cl-MeP, Br,Cl-MeP, and di-Br-MeP) showed relatively low reactivity to chlorine at pH 7 (kapp = 1.3-4.6 M-1s-1) and bromine (kapp = 32-71 M-1s-1), which explains the observed high stability of di-halogenated MePs in chlorinated waters. With increasing pH from 7 to 8.5, the transformation of di-halogenated MePs was further slowed due to the decreasing reactivity of di-MePs to chlorine. The formation of the di-halogenated MePs and their further transformation become considerably faster at Br- concentrations higher than 0.5 μM (40 μg/L). Nonetheless, the accelerating effect of Br- diminishes in the presence of dissolved organic matter (DOM) extract (Suwannee River humic acid (SRHA)) due to a more rapid consumption of bromine by DOM than chlorine. The effect of Br- on the fate of MeP was less in the tested real water matrixes, possibly due to a more rapid bromine consumption by the real water DOM compared to SRHA. A kinetic model was developed based on the determined species-specific second-order rate constants for chlorination/bromination of MeP and its chlorinated and brominated MePs and the transformation pathway information, which could reasonably simulate the transformation of MePs during the chlorination of water in the presence of Br- and selected DOM.

Science of the Total Environment published new progress about Bromination. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fu, Duo; Dong, Jun; Du, Hongguang; Xu, Jiaxi published the artcile< Methanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide>, Category: chlorides-buliding-blocks, the main research area is dimethyl sulfoxide benzyl halide phenyltrimethylammonium tribromide sulfinylation nucleophilic substitution; benzyl methyl sulfoxide preparation.

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a “”S(O)Me”” source, thus providing a convenient method for the efficient and direct synthesis of various benzyl Me sulfoxides.

Journal of Organic Chemistry published new progress about Benzyl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Garba, Zaharaddeen N.; Ibrahim, I.; Abdul Rahim, Afidah published the artcile< Equilibrium isotherms and kinetics modelling for an efficient removal of 4-chloro-2-methoxyphenol from aqueous solution using optimal activated carbon>, Synthetic Route of 16766-30-6, the main research area is activated carbon adsorbent chloromethoxyphenol kinetic model adsorption wastewater treatment.

A surface area of 1085.92 m2/g and a monolayer adsorption capacity of 497.66 mg/g were obtained from the optimum activated carbon derived using Prosopis africana seed hulls (PASH-AC) at the activation temperature of 795°C, activation time of 62 min, and impregnation ratio of 2.45. Five different forms of the linearized Langmuir equations along with two other models (Freundlich and Temkin) were tested on the adsorption data. The best adsorption model was selected using correlation coefficient (R2) and chi-square (χ2) was used for assessing the validity of each isotherm model. Langmuir-2 along and pseudo-second-order models were found to be the most suitable model for describing the equilibrium and kinetic processes, resp.

Avicenna Journal of Environmental Health Engineering published new progress about Adsorbents. 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, Synthetic Route of 16766-30-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics