Tag: M.W=150-200

Kajimoto, Chihiro; Yamada, Shigeyuki; Konno, Tsutomu published the artcile< Novel multi-functionalized fluorine-containing organometallics: Preparation and applications of tetrafluoroethylenated zinc reagent>, Application In Synthesis of 17082-09-6, the main research area is bromotetrafluorobutene zinc bromide preparation acid chloride copper coupling reaction; bromo tetrafluoropentenone preparation; iodoarene bromotetrafluorobutene zinc bromide cross coupling reaction; tetrafuoro bromo arylbutene preparation.

On treating 2,4-dibromo-3,3,4,4-tetrafluorobut-1-ene, readily prepared from com. available 4-bromo-3,3,4,4-tetrafluorobut-1-ene, with 2.0 equivalent of zinc-silver alloy at 40 C in CH3CN, zinc insertion at the terminal C(sp3)-Br site proceeded selectively, giving the corresponding (3-bromo-1,1,2,2-tetrafluorobut-3-en-1-yl)zinc bromide in high yield. This organozinc reagent was found to be thermally stable and easily handled. It was found that this organozinc reagent was participated in the cross-coupling reaction with various acyl chlorides or iodoarenes to give the corresponding CF2CF2-containing organic mols. in good yields. It was also revealed that Suzuki-Miyaura cross-coupling reactions at the C(sp2)-Br site of these CF2CF2-substituted products also proceeded in good to excellent yields.

Journal of Fluorine Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chouliaras, Thanasis; Vollas, Aristofanis; Ioannides, Theophilos; Deimede, Valadoula; Kallitsis, Joannis published the artcile< Synthesis of imidazolium based PILs and investigation of their blend membranes for gas separation>, COA of Formula: C9H9Cl, the main research area is acrylic acid vinyl benzyl chloride imidazolium gas separation property; PILs; blends; imidazolium based PILs; membranes, gas separation; pyridinium based PIL (PILPyr).

Polymeric (ionic liquid) (PIL) copolymers bearing cationic imidazolium pendants and polar acrylic acid groups (P(VBCImY-co-AAx)), which both favor the interaction with CO2 mols., have been synthesized and blended with film forming, high glass transition temperature aromatic polyether-based pyridinium PILs (PILPyr). The blend membranes based on the above combination have been prepared and characterized in respect to their thermal and morphol. behavior as well as to their gas separation properties. The used copolymers and blends showed a wide range of glass transition temperatures from 32 to 286°, while blends exhibited two phase morphol. despite the presence of polar groups in the blend components that could participate in specific interactions. Finally, the membranes were studied in terms of their gas separation behavior. It revealed that blend composition, counter anion type and acrylic acid molar percentage affect the gas separation properties. In particular, PILPyr-TFSI/P(VBCImTFSI-co-AA20) blend with 80/20 composition shows CO2 permeability of 7.00 Barrer and quite high selectivity of 103 for the CO2/CH4 gas pair. Even higher CO2/CH4.selectivity of 154 was achieved for PILPyr-BF4/P(VBCImBF4-co-AA10) blend with composition 70/30.

Membranes (Basel, Switzerland) published new progress about Anion exchangers. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Jianchang; Liu, Chang; Li, Bo; Gu, Fenglong; Zhang, Luozheng; Hu, Manman; Deng, Xiang; Qiao, Yuan; Mao, Yongyun; Tan, Wenchang; Tian, Yanqing; Xu, Baomin published the artcile< Side-Chain Polymers as Dopant-Free Hole-Transporting Materials for Perovskite Solar Cells-The Impact of Substituents' Positions in Carbazole on Device Performance>, Formula: C9H9Cl, the main research area is perovskite solar cell hole transporting material dopant free; side chain polymer substituent position carbazole; dopant-free; hole-transporting material; perovskite solar cells; side-chain polymer; substituents’ positions in carbazole.

Side-chain polymers have the potential to be excellent dopant-free hole-transporting materials (HTMs) for perovskite solar cells (PSCs) because of their unique characteristics, such as tunable energy levels, high charge mobility, good solubility, and excellent film-forming ability. However, there has been less research focusing on side-chain polymers for PSCs. Here, two side-chain polystyrenes with triphenylamine substituents on carbazole moieties were designed and characterized. The properties of the side-chain polymers were tuned finely, including the photophys. and electrochem. properties and charge mobilities, by changing the positions of triphenylamine substituents on carbazole. Owing to the higher mobility and charge extraction ability, the polymer P2 with the triphenylamine substituent on the 3,6-positions of the carbazole unit showed higher performance with power conversion efficiency (PCE) of 18.45%, which was much higher than the PCE (16.78%) of P1 with 2,7-positions substituted. These results clearly demonstrated that side-chain polymers can act as promising HTMs for PSC applications and the performance of side-chain polymers could be optimized by carefully tuning the structure of the monomer, which provides a new strategy to design new kinds of side-chain polymers and obtain high-performance dopant-free HTMs.

ACS Applied Materials & Interfaces published new progress about Hole transport. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kushch, Olga; Hordieieva, Iryna; Novikova, Katerina; Litvinov, Yurii; Kompanets, Mykhailo; Shendrik, Alexander; Opeida, Iosip published the artcile< Kinetics of N-oxyl Radicals' Decay>, COA of Formula: C8H3ClO3, the main research area is imide phthalimide nitroxide radical decomposition kinetics.

N-oxyl radicals of various structures were generated by oxidation of corresponding N-hydroxy compounds with iodobenzene diacetate, [bis(trifluoroacetoxy)]iodobenzene, and ammonium cerium(IV) nitrate in acetonitrile. The decay rate of N-oxyl radicals follows first-order kinetics and depends on the structure of N-oxyl radicals, reaction conditions, and the nature of the solvent and oxidant. The values of the self-decay constants change within 1.4 x 10-4 s-1 for the 3,4,5,6-tetraphenylphthalimide-N-oxyl radical to 1.4 x 10-2 s-1 for the 1-benzotriazole-N-oxyl radical. It was shown that the rate constants of the phthalimide-N-oxyl radicals’ self-decay with different electron-withdrawing or -donor substituents in the benzene ring are higher than that of the unsubstituted phthalimide-N-oxyl radical in most cases. The solvent effect on the process of phthalimide-N-oxyl radical self-decomposition was investigated. The dependence of the rate constants on the Gutmann donor numbers was shown.

Journal of Organic Chemistry published new progress about Cyclic imides Role: FMU (Formation, Unclassified), PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), FORM (Formation, Nonpreparative), PROC (Process), RACT (Reactant or Reagent) (N-oxyl radicals of). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, COA of Formula: C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Bertrand, Sophie M.; Ancellin, Nicolas; Beaufils, Benjamin; Bingham, Ryan P.; Borthwick, Jennifer A.; Boullay, Anne-Benedicte; Boursier, Eric; Carter, Paul S.; Chung, Chun-wa; Churcher, Ian; Dodic, Nerina; Fouchet, Marie-Helene; Fournier, Charlene; Francis, Peter L.; Gummer, Laura A.; Herry, Kenny; Hobbs, Andrew; Hobbs, Clare I.; Homes, Paul; Jamieson, Craig; Nicodeme, Edwige; Pickett, Stephen D.; Reid, Iain H.; Simpson, Graham L.; Sloan, Lisa A.; Smith, Sarah E.; Somers, Donald O’N.; Spitzfaden, Claus; Suckling, Colin J.; Valko, Klara; Washio, Yoshiaki; Young, Robert J. published the artcile< The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits>, Name: 4-Chloro-2-methoxybenzaldehyde, the main research area is mitochondria aminotransferase inhibitor.

The hybridization of hits, identified by complementary fragment and high throughput screens, enabled the discovery of the first series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a 2-benzylamino-pyrazolo[1,5-a]pyrimidinone-3-carbonitrile template. Structure-guided growth enabled rapid optimization of potency with maintenance of ligand efficiency, while the focus on physicochem. properties delivered compounds with excellent pharmacokinetic exposure that enabled a proof of concept experiment in mice. Oral administration of I significantly raised the circulating levels of the branched-chain amino acids leucine, isoleucine, and valine in this acute study.

Journal of Medicinal Chemistry published new progress about Crystal structure. 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, Name: 4-Chloro-2-methoxybenzaldehyde.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shin, Hyunshun; Gennadios, Heather A.; Whittington, Douglas A.; Christianson, David W. published the artcile< Amphipathic benzoic acid derivatives: Synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC>, HPLC of Formula: 3964-57-6, the main research area is benzoate derivative preparation zinc deacetylase LpxC inhibitor.

The first committed step in lipid A biosynthesis is catalyzed by uridine diphosphate-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase (LpxC), a zinc-dependent deacetylase, and inhibitors of LpxC may be useful in the development of antibacterial agents targeting a broad spectrum of Gram-neg. bacteria. Here, the authors report the design of amphipathic benzoic acid derivatives that bind in the hydrophobic tunnel in the active site of LpxC. The hydrophobic tunnel accounts for the specificity of LpxC toward substrates and substrate analogs bearing a 3-O-myristoyl substituent. Simple benzoic acid derivatives bearing an aliphatic tail bind in the hydrophobic tunnel with micromolar affinity despite the lack of a glucosamine ring like that of the substrate. However, although these benzoic acid derivatives each contain a neg. charged carboxylate group intended to coordinate to the active site zinc ion, the 2.25 Å resolution x-ray crystal structure of LpxC complexed with 3-(heptyloxy)benzoate reveals backward binding in the hydrophobic tunnel, such that the benzoate moiety does not coordinate to zinc. Instead, it binds at the outer end of the hydrophobic tunnel. Interestingly, these ligands bind with affinities comparable to those measured for more complicated substrate analog inhibitors containing glucosamine ring analogs and hydroxamate groups that coordinate to the active site zinc ion. The authors conclude that the intermol. interactions in the hydrophobic tunnel dominate enzyme affinity in this series of benzoic acid derivatives

Bioorganic & Medicinal Chemistry published new progress about Conformation. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, HPLC of Formula: 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mushtaq, Nafeesa; Chen, Guofei; Sidra, Lala Rukh; Liu, Yang; Fang, Xingzhong published the artcile< Synthesis and crosslinking study of isomeric poly(thioether ether imide)s containing pendant nitrile and terminal phthalonitrile groups>, HPLC of Formula: 118-45-6, the main research area is isomeric polythioether ether imide pendant nitrile terminal phthalonitrile group.

Two novel series of highly organosol. and curable polyimides containing pendant nitrile groups PI (a-d) and phthalonitrile-terminated polyimides PN-PI (a-d) were prepared by solution polycondensation of isomeric bis(chlorophthalimides)s and 2,6-dichlorobenzonitrile with 4,4′-thiobisbenzenethiol. The inherent viscosities of these copolymers were in the range of 0.37-0.59 dL g-1 in N-methyl-2-pyrrolidone (NMP) at 30 °C. The phthalonitrile and pendant nitrile groups in isomeric poly(thioether-ether-imide)s were thermally crosslinked without a catalyst through thermal curing up to 280-360 °C, which led to the transformation from thermoplastic polymers to thermosetting polymers. All PIs before and after crosslinking were characterized by gel permeation chromatog. (GPC), differential scanning calorimetry (DSC) and Fourier transform IR (FT-IR) spectroscopy. PN-PI (a-d) and PI (a-d) were found to be highly soluble in some solvents, such as chloroform, dimethylacetamide, m-cresol, dimethlyformamide and N-methyl-2-pyrrolidone, while the crosslinked polymers were insoluble in all tested solvents. The crosslinking results of pendant nitrile and terminal phthalonitrile groups are also compared. Both series of PIs showed high thermal stability based on 5% weight loss temperature (T5%) in the range of 471-509 °C and increased up to 35 °C after thermal curing. Polyimides showed high glass transition temperatures (Tgs) ranging from 191-213 °C as determined by DSC, but no detectable Tg was observed after thermal heating, indicating the crosslinked structure of PIs. The mech. properties also enhanced after the crosslinking of the copolymers. The tensile modulus and strength of the cured PI films were in the range of 3.3-4.7 GPa and 68-122 MPa, resp., which were up to 62% and 35% higher than the uncured films.

Polymer Chemistry published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jeon, Hyojin; Ko, Soo-Byung; Lee, Sunwoo published the artcile< Palladium-catalyzed decarboxylative gem-selective addition of alkynoic acids to terminal alkynes>, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid, the main research area is gem enyne preparation regioselective DFT study; alkynoic acid terminal alkyne decarboxylative addition palladium catalyst.

The regioselective palladium-catalyzed decarboxylative head-to-tail addition of alkynoic acid derivatives to terminal alkynes furnished gem-1,3-enynes. Both aryl- and alkyl-substituted alkynoic acids showed favorable reactivity and high selectivity. The proposed method provided good yields and showed broad functional group tolerance. In addition, the reaction of alkynoic acids with propiolic acid provided the corresponding gem-1,3-enynes via double decarboxylation. This is the first example of propiolic acid being employed as an acetylene surrogate for the formation of gem-1,3-enynes. D. functional theory calculations were conducted to rationalize the high selectivity observed in the formation of head-to-tail addition products.

Organic Chemistry Frontiers published new progress about Addition reaction (decarboxylative). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Recommanded Product: 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Wen-Ke; Guo, Jia-Ming; Chen, Zhao-Dan; Si, Chang-Mei; Wei, Bang-Guo published the artcile< Titanium Tetrachloride-Mediated Approach to Access 2-Chloro-2-Substituted Isoindolin-1-ones through the Addition of Alkynes to Acyliminium ions>, Computed Properties of 118-45-6, the main research area is isoindolinone chlorovinyl hydroxyethyl preparation diastereoselective; oxazoloidoindole ring opening addition chlorination terminal alkyne titanium tetrachloride.

An asym. approach to access 2-substituted isoindolin-1-ones I (R1 = R2 = H, MeO; R1 = Cl, R2 = H; R = n-pentyl, cyclopropyl, Ph, 4-FC6H4, 2-MeC6H4, 2-naphthyl, etc.) through TiCl4-mediated addition-chlorination of N,O-acetals II with terminal alkynes RCCH has been developed. A range of substrates were amenable to this transformation and the desired substituted isoindolin-1-ones were obtained in moderate to good yields with moderate diastereoselectivities.

European Journal of Organic Chemistry published new progress about Addition reaction, stereoselective. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Computed Properties of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Limin; Wang, Zhengjie; Gao, Chao; Dai, Honglin; Si, Xiaojie; Zhang, Yang; Meng, Yaqi; Zheng, Jiaxin; Ke, Yu; Liu, Hongmin; Zhang, Qiurong published the artcile< Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives>, SDS of cas: 611-19-8, the main research area is trifluoromethyl benzyl thio pyrimidin preparation SAR antitumor mol docking; Antitumor activity; Pyrimidine derivatives; Synthesis; Trifluoromethyl moiety.

In order to find efficient new antitumor drugs, a series of novel trifluoromethyl-substituted pyrimidine derivatives were designed and synthesized and the bioactivity against four human tumor cells (PC-3, MGC-803, MCF-7 and H1975) was evaluated by MTT assay. Compound I displayed potent anti-proliferative activity on H1975 (IC50 = 2.27 μM), which was better than the pos. control 5-FU (IC50 = 9.37 μM). Further biol. evaluation studies showed that compound I apoptosis of H1975 cells and arrested the cell cycle at G2/M phase. Furthermore, compound I induced H1975 cells apoptosis through increasing the expression of pro-apoptotic proteins Bax and p53 and down-regulating the anti-apoptotic protein Bcl-2. In addition, compound I was able to be tightly embedded in the active pocket of EGFR. These results demonstrated that compound I has a potential as a lead compound for further investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, SDS of cas: 611-19-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics