Tag: M.W=150-200

Shang, Jia-Qi; Fu, Hong; Li, Yi; Yang, Tao; Gao, Chuanzhu; Li, Ya-Min published the artcile< Copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide>, Safety of 3-(4-Chlorophenyl)propiolic acid, the main research area is copper catalyzed decarboxylation cycloaddition cascade alkynoic acid azide; triazole synthesis decarboxylation cycloaddition cascade alkynoic acid azide.

A copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide has been developed [e.g., phenylpropiolic acid + (azidomethyl)trimethylsilane → 4-phenyl-1-[(trimethylsilyl)methyl]-1H-1,2,3-triazole (97%) in presence of Cu2O in MeCN]. This reaction exhibits good functional group tolerance and wide substrate scope, provides an efficient way to construct 1,4-disubstituted 1,2,3-triazoles.

Tetrahedron published new progress about 1,3-Dipolar cycloaddition reaction. 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Safety of 3-(4-Chlorophenyl)propiolic acid.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Jing, Ze; Xiu, Kemao; Sun, Yuyu published the artcile< Amide-Based Cationic Polymeric N-Halamines: Synthesis, Characterization, and Antimicrobial and Biofilm-Binding Properties>, Formula: C9H9Cl, the main research area is amide cationic polymer N halamine antimicrobial biofilm.

A series of amide-based N-halamine precursors, poly 3-(4′-vinylbenzyl) – 5, 5-dimethylhydantoin-co-trimethyl-2-methacryloxyethylammonium chloride (PVPT), were synthesized by copolymerizing 3-(4′-vinylbenzyl) – 5, 5-dimethylhydantoin (VBDMH) and trimethyl-2-methacryloxyethylammonium chloride (TMAC) with different compositions Chlorine bleach treatment was used to transform the VBDMH moieties in the copolymers into amide N-halamines (Cl-PVPT). 1H-NMR, FT-IR, and dynamic light scattering (DLS) anal. were used to characterize the copolymers. With lower than 50% of VBDMH, the Cl-PVPT copolymers could be dissolved in water, and provided powerful antimicrobial function in killing Gram-pos. as well as Gram-neg. bacteria. Furthermore, Cl-PVPTs rapidly bound onto preexisting bacterial biofilms and eradicated adherent bacteria. The biofilm-binding kinetics were studied, and the parameters of the kinetics were provided.

Industrial & Engineering Chemistry Research published new progress about Antibacterial agents. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gensini, Martina; Altamura, Maria; Dimoulas, Tula; Fedi, Valentina; Giannotti, Danilo; Giuliani, Sandro; Guidi, Antonio; Harmat, Nicholas J. S.; Meini, Stefania; Nannicini, Rossano; Pasqui, Franco; Tramontana, Manuela; Triolo, Antonio; Maggi, Carlo Alberto published the artcile< Modulation on C- and N-Terminal Moieties of a Series of Potent and Selective Linear Tachykinin NK2 Receptor Antagonists>, Synthetic Route of 22717-55-1, the main research area is tachykinin NK2 receptor antagonist preparation structure activity.

Herein we describe the synthesis of a series of new potent tachykinin NK2 receptor antagonists by the modulation of the C- and N-terminal moieties of ibodutant (MEN 15596, 1). The N-terminal benzo[b]thiophene ring was replaced by different substituted naphthalenes and benzofurans, while further modifications were evaluated at the C-terminal tetrahydropyran moiety. Most compounds demonstrated a high affinity for the human NK2 receptor and high in vitro antagonist potency, indicating that a wide range of substituents at both termini can be incorporated in the mol. without detrimental effects on the interactions with the NK2 receptor. Selected compounds were tested in vivo confirming their activity as NK2 antagonists. In particular, after both iv and id administration to guinea pig, compound 61 b was able to antagonize NK2-induced colonic contractions with a potency and duration-of-action fully comparable to the reference compound 1 (MEN 15596, ibodutant).

ChemMedChem published new progress about Colon (contractions). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Synthetic Route of 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Simpson, Harold N.; Hancock, C. Kinney; Meyers, Edward A. published the artcile< The correlation of the electronic spectra, acidities, and polarographic oxidation half-wave potentials of 4-substituted 2-chlorophenols with substituent constants>, Related Products of 3964-57-6, the main research area is .

The electronic spectra, pKA values, and polarographic oxidation half-wave potentials of a series of 4-substituted 2-chlorophenols (I) have been measured. Correlations of these data have been made and compared with correlations previously reported for a series of 4-substituted 2-nitrophenols (II) and a series of 5-substituted 2-nitrophenols (III). For all three of these series, there are excellent correlations between pKA and σ, with the ρ value of -2.22 for I agreeing closely with that of -2.16 for II but being much more positive than that of -3.01 for III. As with II and III, there is a good correlation between νB and νA, but the relationship between Δν and pKA is unsatisfactory. Excellent correlations exist between E1/2 and σ and between E1/2 and pKA. These and other relationships are discussed.

Journal of Organic Chemistry published new progress about 3964-57-6. 3964-57-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Related Products of 3964-57-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Qingrui; Yin, Yunnian; Li, Yabo; Zhang, Jianye; Huang, Mengmeng; Kim, Jung Keun; Wu, Yangjie published the artcile< A simple approach to indeno-coumarins via visible-light-induced cyclization of aryl alkynoates with diethyl bromomalonate>, Product Details of C9H5ClO2, the main research area is indenochromene preparation regioselective; aryl alkynoate diethyl bromomalonate cyclization reaction photocatalyst.

Visible-light-induced triple-domino cyclization between aryl alkynoates R1C6H4OC(O)CCC6H4R2 (R1 = H, 2-Cl, 3-tert-Bu, etc.; R2 = H, 4-Me, 4-Cl, 4-F, 4-OMe) and di-Et bromomalonate was developed for the synthesis of indeno-coumarins I (R3 = H, 1-Cl, 4-tert-Bu, 2-tert-Bu, etc.; R4 = H, 9-Me, 9-F, 9-Cl, 9-MeO). This one-pot method substantially simplified the production process for indeno-coumarins I and a series of indeno-coumarins could be isolated in moderate to high yields. It was found that the obtained indeno-coumarins I could be used as addnl. photosensitizers to initiate this transformation. A possible radical mechanism accompanying the processes of electron transfer and energy transfer is proposed based on the results of ESI-MS anal., cyclic voltammetry, Stern-Volmer quenching experiments and control experiments The photoluminescence properties (emission spectra and quantum yields) of the obtained indeno-coumarins I were investigated.

Organic Chemistry Frontiers published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3240-10-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H5ClO2, Product Details of C9H5ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, RongRong; Du, CunBin; Han, Shuo; Wang, Jian; Yao, GanBing; Zhao, HongKun published the artcile< Saturated vapor pressure of 4-fluorophthalic anhydride and 4-chlorophthalic anhydride and isobaric vapor-liquid phase equilibrium of 4-fluorophthalic anhydride + 4-chlorophthalic anhydride: Measurement and modeling>, Category: chlorides-buliding-blocks, the main research area is fluorophthalic chlorophthalic anhydride isobaric liquid phase equilibrium vapor pressure.

The saturated vapor pressures of 4-fluorophthalic anhydride and 4-chlorophthalic anhydride at various temperatures ranging from T = (426 to 560) K, and the isobaric vapor-liquid phase equilibrium data for binary system of 4-fluorophthalic anhydride (1) + 4-chlorophthalic anhydride (2) at pressures of 21.33 kPa, 41.33 kPa, 61.33 kPa and 81.33 kPa were measured exptl. by means of an inclined ebulliometer. The relationship between saturated vapor pressure and temperature was fitted by using two Antoine equations and the Antoine constants were acquired for 4-fluorophthalic anhydride and 4-chlorophthalic anhydride, resp. The semi-empirical method, Herington method was employed to test thermodn. consistency of the vapor-liquid equilibrium data. The isobaric vapor-liquid phase equilibrium data were fitted with three thermodn. models, which corresponded to Wilson, NRTL and UNIQUAC. The parameters of the three activity coefficient models were obtained by the method of nonlinear least-square regression. The calculated vapor-liquid phase equilibrium data with the three activity coefficient models agree very well with the exptl. values.

Fluid Phase Equilibria published new progress about Antoine equation. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Capparelli, Clara; Fernandez Pulido, Carlos R.; Lopez-Hallman, Raymond; Geise, Geoffrey M.; Hickner, Michael A. published the artcile< Anion Exchange Membranes with Dynamic Redox-Responsive Properties>, Application of C9H9Cl, the main research area is anion exchange membrane dynamic redox; anion exchange membranes; redox-responsive membranes; stimuli-responsive membranes; transport properties; viologen.

Redox-responsive anion exchange membranes were developed using photoinitiated free-radical polymerization and reversible oxidation and reduction of viologen. The membranes were formulated using poly(ethylene glycol diacrylate) and diurethane dimethacrylate oligomers, dipentaerythritol penta-/hexa-acrylate cross-linker, photoinitiators, and 4-vinylbenzyl chloride as precursors for functionalization. In the membrane, 4,4′-bipyridine reacted with the 4-vinylbenzyl chloride residues, and subsequently, unreacted amines were methylated with iodomethane to obtain viologen as both the ion carrier and redox-responsive group. Upon oxidation, viologen supports two cations, where the reduced form only contains one cation. Thus, the redox responsiveness changed the membrane ionicity by a factor of 2. The area-specific resistance of the membranes in the oxidized, +2, state was lower than in the reduced, +1, state. The resistance increased between 40.6 ± 0.1 and 111.6 ± 0.1%, depending on membrane thickness, with the most significant increment being a resistance change from 4.88 × 10-4 Ω m2 in the oxidized state to 1.03 × 10-3 Ω m2 in the reduced state. Membrane permselectivity in the reduced, +1, state was between 15.9 ± 0.1 and 26.5 ± 0.01% lower than in the oxidized, +2, state, with no change in water uptake, spanning an average of 0.87 ± 0.02 in the oxidized state to an average of 0.7 ± 0.01 in the reduced state. Upon reduction, membrane ion-exchange capacity decreases, increasing ionic resistance and decreasing membrane permselectivity due to a reduction in fixed charge concentration without a measurable change in water uptake. This trend is not generally observed for ion-exchange membranes and explains that the changes in transport properties result from changes in ionicity, not water uptake or domain size. The reversibility and stability of the stimuli responsiveness were confirmed by the absence of transport property changes after redox cycling.

ACS Applied Materials & Interfaces published new progress about Absorption (of water). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application of C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Peng; Ji, Min; Sha, Fei published the artcile< An efficient and facile process for synthesis of 4,5-dichlorothiophene-2-carboxylic acid using N-chlorosuccinimide>, Synthetic Route of 31166-29-7, the main research area is dichlorothiophene carboxylic acid preparation.

The compound 4,5-Dichlorothiophene-2-carboxylic acid was obtained from the starting material thiophene-2-carboxylic acid via esterification, chlorination and hydrolysis. The chlorination reaction was achieved using N-chlorosuccinimide as the chlorinating agent with high selectivity and yield. The advantages of this synthesis route were mild reaction conditions, simplified operational procedure and the raw materials were easy to obtain. It could be applied to industrial production

Journal of Chemical Research published new progress about Thiophenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Synthetic Route of 31166-29-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Mori, Nobuo; Asano, Yuzuru; Tsuzuki, Yojiro published the artcile< Intramolecular hydrogen bonds. XIV. Correlation of the hydroxyl and the carbonyl frequencies of methyl salicylates with Hammett substituent constants>, SDS of cas: 22717-55-1, the main research area is salicylates Hammett constant; Hammett constant salicylates.

The ir OH and C(O) stretching spectra of methyl 4- or 5-substituted salicylates were measured in dilute CCl4, and the resp. peak-frequencies correlated with ordinary Hammett σ-constant The best linear relation was established between the γOH and the (σOH-0.38 σCO2Me) values and between the γC(O) and the (σCO2Me-0.49σOH) values, where σOH and σCO2Me are the σ-constant of a substituent with respect to the OH and the CO2Me group, resp. Besides, in other internally bonded phenol systems, including o-bromophenols, 2,6-dihalophenols, and salicylic acids, the plotting of the OH frequencies against the (σOH-Aσx) values gave the best linear relation, where A is a constant depending on the kind of proton acceptor, X. The value of A can be a measure of the electronic effects of the substituent, influencing the bonded OH frequency through X.

Bulletin of the Chemical Society of Japan published new progress about Hydrogen bond. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, SDS of cas: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Svalova, Tatiana S.; Medvedeva, Margarita V.; Saigushkina, Anna A.; Kozitsin, Ivan V.; Malysheva, Natalya N.; Zhdanovskikh, Valeria O.; Okhokhonin, A. V.; Kozitsina, Alisa N. published the artcile< A label-free impedimetric immunosensor based on covalent immobilization of anti-E. Coli antibody via a copper-catalyzed azide-alkyne cycloaddition reaction>, COA of Formula: C9H9Cl, the main research area is impedimetry immunosensor antibody immobilization; Antibody covalent immobilization; Copper-catalyzed azide-alkyne cycloaddition; E. coli; Label-free impedimetric immunosensor.

An original method is proposed for address and covalent immobilization of anti-E. coli antibodies on a screen-printed electrode (SPE). The method is based on a copper-catalyzed “”click”” reaction between a polyvinylbenzylazide (PVBA) film electrochem. deposited on the electrode surface and acetylene fragments of propargyl-N-hydroxysuccinimide ester. The products of electrochem. oxidation of copper particles incorporated in the polymer film on the electrode were first used for catalysis of the click reaction. This approach allowed the authors to reduce the immobilization time from a few hours for conventional methods to just 30 min, and to prevent denaturation of the immunoreceptor. The modified electrodes were characterized by SEM, electrochem. impedance spectroscopy (EIS), and cyclic voltammetry (CV). Based on the results obtained, a label-free impedimetric immunosensor for E. coli detection was developed. The detection limit of the immunosensor was estimated as 6.3 CFU/mL, with a linear range of 103-106 CFU/mL. The immunosensor demonstrated good stability during 30 days of storage in phosphate buffer solution (PBS, pH 7) and selectivity toward excess Staphylococcus aureus bacteria.

Analytical and Bioanalytical Chemistry published new progress about Antibodies and Immunoglobulins Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), TEM (Technical or Engineered Material Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study) (anti-E.coli). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, COA of Formula: C9H9Cl.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics