Tag: M.W=150-200

Xia, Rongjiao; Guo, Tao; Chen, Mei; Su, Shijun; He, Jun; Tang, Xu; Jiang, Shichun; Xue, Wei published the artcile< Synthesis, antiviral and antibacterial activities and action mechanism of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety>, Category: chlorides-buliding-blocks, the main research area is antiviral antibacterial pentadienone oxime ether.

A series of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety were synthesized and their antibacterial and antiviral activities were evaluated. Bioassay activity indicated that some of the compounds displayed significant antibacterial and antiviral activities. In particular, some title compounds were found to show remarkable antiviral activities against Tobacco mosaic virus (TMV). Compound 6i showed remarkable curative, protective and inactivation activity against TMV, with a 50% effective concentration (EC50) of 287.1, 157.6 and 133.0μg mL-1, resp. These results were better than or comparable to those of ningnanmycin (356.3, 233.7 and 121.6μg mL-1, resp.). Microscale thermophoresis (MST) also showed that the binding of compound 6i to TMV coat protein (TMV-CP) gave a Kd value of 0.115 ± 0.092μmol L-1, which was better than that of ningnanmycin (0.523 ± 0.254μmol L-1). Meanwhile, the EC50 values of compound 6k against Xanthomonas axonopodis pv. Citri (Xac) and Xanthomonas oryzae pv. oryzae (Xoo) were 16.8 and 33.4μg mL-1 resp., and that of compound 6i against Ralstonia solanacearum (Rs) was 33.9μg mL-1. These results were better than those of bismerthiazol (44.3, 42.5 and 62.4μg mL-1, resp.). The mechanism of antibacterial action of compound 6k against Xac was analyzed through SEM (SEM). This study indicated that the title compounds are valuable in the search for novel agrochems.

New Journal of Chemistry published new progress about Antibacterial agents. 611-19-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Takada, Tomoya; Ushiromura, Ryoga; Fushiki, Takuto published the artcile< Fractal dimensional analysis on dispersion/aggregation state of MWCNT in poly(4-chloromethyl)styrene: effect of UV-induced polymer-MWCNT chemical bond formation and its influence on electrical conductivity of their composites>, Reference of 1592-20-7, the main research area is polychloromethyl styrene MWCNT composite chem bond elec conductivity.

The effects of UV-induced chem. bond formation on the dispersion/aggregation state of multi-walled carbon nanotubes (MWCNTs) in poly(4-chloromethyl)styrene/MWCNT composites and their elec. conductivity were examined using transmission electron microscopy (TEM) and fractal dimensional anal. of the TEM images. The composites prepared with UV irradiation exhibited lower elec. conductivity and denser aggregation of the trapped MWCNTs than those observed for unirradiated composites. Fractal dimensional anal. of the TEM images indicated that the difference in the dispersion/aggregation state associated with elec. conductivity could be correlated to the fractal dimension calculated by the box-counting method.

International Journal of Polymer Analysis and Characterization published new progress about Carbon nanotubes (multiwalled). 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Reference of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Armstrong, Tom; Lamont, Malcolm; Lanne, Alice; Alderwick, Luke J.; Thomas, Neil R. published the artcile< Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives>, COA of Formula: C7H7ClO2, the main research area is triclosan triazole preparation regioselective InhA inhibitor docking; InhA; Isoniazid; Mycobacterium tuberculosis; TB; Triazole; Triclosan.

A library of new 1,5-triazoles I [R = H, Me, pyrrolidin-1-yl, etc.], designed to mimic the structures of both triclosan mols. uniquely bound to InhA was synthesized. The inhibitory activity of these compounds was evaluated using isolated enzyme assays with I [R = 4-chloro-2-hydroxyphenoxy] exhibiting an IC50 of 5.6μM. Whole-cell evaluation was also performed, with I [R = cyclopropylmethoxy] showing the greatest potency, with an MIC99 of 12.9μM against M. bovis.

Bioorganic & Medicinal Chemistry published new progress about Alkynes, aryl Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 16766-30-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H7ClO2, COA of Formula: C7H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Brotschi, Christine; Bolli, Martin H.; Gatfield, John; Heidmann, Bibia; Jenck, Francois; Roch, Catherine; Sifferlen, Thierry; Treiber, Alexander; Williams, Jodi T.; Boss, Christoph published the artcile< From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs>, HPLC of Formula: 85740-98-3, the main research area is insomnia disorders orexin receptor antagonist metabolic stability orally brain; drug design; dual orexin receptor antagonists; insomnia; sleep disorders; structure-activity relationships.

The orexin system is responsible for regulating the sleep-wake cycle. Suvorexant, a dual orexin receptor antagonist (DORA) is approved by the FDA for the treatment of insomnia disorders. Herein, we report the optimization efforts toward a DORA, where our starting point was (5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}methanone (6), a compound which emerged from our inhouse research program. Compound 6 was shown to be a potent, brain-penetrating DORA with in vivo efficacy similar to suvorexant in rats. However, shortcomings from low metabolic stability, high plasma protein binding (PPB), low brain free fraction (fu brain), and low aqueous solubility, were identified and hence, compound 6 was not an ideal candidate for further development. Our optimization efforts addressing the above-mentioned shortcomings resulted in the identification of (4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}l-methanone (42), a DORA with improved in vivo efficacy compared to 6.

ChemMedChem published new progress about Blood proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (plasma protein binding). 85740-98-3 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, HPLC of Formula: 85740-98-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Albano, Gianluigi; Interlandi, Salvatore; Evangelisti, Claudio; Aronica, Laura Antonella published the artcile< Polyvinylpyridine-Supported Palladium Nanoparticles: A Valuable Catalyst for the Synthesis of Alkynyl Ketones via Acyl Sonogashira Reactions>, Quality Control of 17082-09-6, the main research area is alkynyl ketone preparation; acetylene acid chloride Sonogashira polyvinylpyridine supported palladium nanocatalyst.

Palladium nanoparticles (NP) immobilized on metal scavengers (Smopex-234, Smopex-111, PVPy, 1% weight/weight) were tested in the synthesis of alkynyl ketones R1C(O)C≡CR2 [R1 = t-Bu, Ph, 2-naphthyl, etc.; R2 = Ph, 1-naphthyl, 2-NCC6H4, etc.] with different stereoelectronic properties via acyl Sonogashira reaction between terminal acetylenes and acid chlorides. Preliminary tests seemed to indicate that Pd/PVPy could act as a reservoir of very active palladium NP which are partially released during the reaction and then recaptured from the resin at the end of the process, thus ensuring the possibility of reuse of the catalyst.

Catalysis Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Quality Control of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Du, Weixin; Liu, Yufeng; Sun, Junjun; Wang, Haiying; Yang, Guoping; Zhang, Dongdi published the artcile< Three rare-earth incorporating 6-peroxotantalo-4-selenates and catalytic activities for imidation reaction>, HPLC of Formula: 118-45-6, the main research area is preparation rare earth peroxotantaloselenate complex; crystal structure rare earth peroxotantaloselenate complex; imidation reaction catalyst rare earth peroxotantaloselenate complex.

Functionalization with belt lanthanide groups allows for the crystallization and structural characterization of homometallic selenotantalates, CsK[Ln(H2O)6Se4(TaO2)6(OH)3O18]·nH2O (Ln = Eu/Gd, n = 14 (STD-Eu, STD-Gd) and Ln = Lu, n = 12 (STD-Lu)). The basket-shaped {Se4(TaO2)6} archetype is assembled in a simple one-pot reaction of Na2SeO3 and K8[Ta6O19]·17H2O in acidic aqueous medium (pH 2) and in the presence of hydrogen peroxide. This unit was proven to be an effective precursor for the preparation of a range of new POMs containing the {Se4(TaO2)6} unit. The lanthanide derivatives STD-Eu, STD-Gd and STD-Lu were fully characterized with single-crystal X-ray diffraction, IR spectroscopy, TGA and PXRD in the solid state. The photoluminescence and lifetime decay behaviors of STD-Eu were studied at room temperature, and the photoluminescence spectrum displays the characteristic emission of the Eu3+ cation. In addition, the catalytic activities of STD-Eu, STD-Gd and STD-Lu on the reaction of phthalic anhydride with phenylamines were studied. STD-Eu shows good catalytic activities for imidation reactions.

Dalton Transactions published new progress about Crystal structure. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, HPLC of Formula: 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Zhu, Linglong; Hu, Haiwen; Qi, Liang; Zheng, Yi; Zhong, Weihui published the artcile< Enantioselective Allylic Substitution of Morita-Baylis-Hillman Adducts Catalyzed by Chiral Bifunctional Ferrocenylphosphines>, Application In Synthesis of 31166-29-7, the main research area is enantioselective allylic substitution Morita Baylis Hillman adduct ferrocenylphosphine catalyst.

A series of air-stable chiral ferrocenylphosphines (LB1-LB4) were prepared and used in the asym. allylic substitution of Morita-Baylis-Hillman (MBH) adducts with phthalimide under mild reaction conditions; the (R,SFc)-ferrocenylphosphine LB4 afforded the desired amination products in moderate yields with excellent enantioselectivities. The absolute configuration of (R)-N-[2-Methoxycarbonyl-1-(2,4-dichlorophenyl)allyl]-phthalimide was confirmed by x-ray anal.

European Journal of Organic Chemistry published new progress about Allylic substitution reaction. 31166-29-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C5H2Cl2O2S, Application In Synthesis of 31166-29-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Naganawa, Atsushi; Saito, Tetsuji; Nagao, Yuuki; Egashira, Hiromu; Iwahashi, Maki; Kambe, Tohru; Koketsu, Masatoshi; Yamamoto, Hiroshi; Kobayashi, Michiyoshi; Maruyama, Takayuki; Ohuchida, Shuichi; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki published the artcile< Discovery of new chemical leads for selective EP1 receptor antagonists>, COA of Formula: C8H7ClO3, the main research area is prostanoid receptor antagonist phenylsulfonyl benzoate preparation SAR.

A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids were identified as functional PGE2 antagonists with selectivity for the EP1 receptor subtype starting from a chem. lead I, which was found while screening our inhouse compound library. Discovery of the optimized analogs is presented here and structure-activity relationships (SAR) are also discussed.

Bioorganic & Medicinal Chemistry published new progress about Prostanoid receptor PTGER4 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, COA of Formula: C8H7ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Lingling; Xiong, Zhi; Dang, Yijing; Li, Yang; Zhang, Ao; Ding, Chunyong; Xu, Zhiai; Zhang, Wen published the artcile< A red-emissive D-A-D type fluorescent probe for lysosomal pH imaging>, Product Details of C8H12N2O2, the main research area is red emissive type fluorescent probe lysosome pH.

Visual detection of pH changes in lysosomes is critical because lysosomes not only play an important role in diverse cellular functions but also are closely related to various physiol. and pathol. processes. Herein, we disclose a donor-acceptor-donor (D-A-D) type fluorescent probe DBTD for detecting pH fluctuation in lysosomes. DBTD was rationally designed by using benzothiadiazole as the electron acceptor and N,N-diethylamino groups as the electron donor. Owing to its unique D-A-D structure, DBTD displayed a red-emission centered at 614 nm. It showed a sensitive and a linear response to pH from 4.5 to 5.2 with a pKa of 5.0, which is very suitable for lysosomal pH imaging. The response was based on the intramol. charge transfer (ICT) effect owing to the protonation of the diethylamino group. Furthermore, DBTD could accurately monitor lysosomal pH variations in SGC-7901 cells. More importantly, it was able to image the pH change in lysosomes during the autophagy process successfully, suggesting the great potential of DBTD acting as a powerful tool for monitoring lysosomal pH-related biol. processes.

Analytical Methods published new progress about Autophagy. 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Product Details of C8H12N2O2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Lin; Li, Miao; Chi, Huiwei; Yang, Jichun; Li, Zhinian; Liu, Changling published the artcile< Discovery of flufenoxystrobin: Novel fluorine-containing strobilurin fungicide and acaricide>, HPLC of Formula: 35852-58-5, the main research area is flufenoxystrobin fluorine strobilurin preparation fungicide acaricide.

To discover new strobilurin analogs with high activity, a series of new fluorine-containing strobilurin derivatives were synthesized utilizing intermediate derivatization methods (IDM). The compounds were identified by 1H and 19F NMR, IR and elemental anal. Preliminary bioassays in greenhouse indicated that compounds (I) (SYP-3759, flufenoxystrobin) and (II) exhibited excellent fungicidal activities against Erysiphe graminis protecting wheat at 1.56 mg L-1 concentration and compounds 2a showed a moderately high acaricidal activity at 10 mg L-1. Field trials showed the fungicidal activities of compounds I and II is almost equivalent to that of pyraclostrobin, higher than that of triadimefon and the acaricidal activity of compound I is almost equivalent to that of pyidaben, but lower than that of fluacrypyrim. The preliminary mammalian toxicol. results showed compound I was a low-toxicity compound In conclusion compound I is a promising candidate for further development; mammalian toxicol. and ecotoxicol. with compound I are in progress.

Journal of Fluorine Chemistry published new progress about Acaricides. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, HPLC of Formula: 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics