Tag: 100-200

Design and synthesis of a novel PLK1 inhibitor scaffold using a hybridized 3D-QSAR model was written by Oh, Youri;Jung, Hoyong;Kim, Hyejin;Baek, Jihyun;Jun, Joonhong;Cho, Hyunwook;Im, Daseul;Hah, Jung-Mi. And the article was included in International Journal of Molecular Sciences in 2021.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify addnl. effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reactivity in Nickel-Catalyzed Multi-component Sequential Reductive Cross-Coupling Reactions was written by Chen, Haifeng;Yue, Huifeng;Zhu, Chen;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and Et chloroformate is described. Et chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Exptl. and DFT mechanistic studies highlight the complexity of the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile synthesis of polymerized ionic liquids with high thermal stability was written by Hsieh, Yu-Nung;Kuei, Chun-Hsiung;Chou, Yu-Kai;Liu, Chia-Chyuan;Leu, Kuen-Lin;Yang, Tasi-Hsiu;Wang, Mei-Ying;Ho, Wen-Yueh. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Twelve main-chain-type polymerized ionic liquids that have alkylimidazolium cation units were prepared using simple synthetic processes. The polymers were prepared using the self-polymerization of a single monomer; no polymerization initiators were required. The thermal stability and solvent miscibility of these polymers were studied. Results show that the combined anions greatly influence the solubility and thermal stability of the polymers. Among these polymers, poly-alkylimidazolium bis(trifluoromethyl sulfonyl)imide polymers exhibited the highest thermal stability (> 400°), which makes them candidates for many applications. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New visible light excitable donor-acceptor 7-hydroxy-coumarins as blue fluorescent probes for selective staining of vacuoles in yeasts and L. donovani was written by Raghuvanshi, Ashutosh;Kumar Jha, Ajay;Kathuria, Manoj;Priya Awasthi, Bhanu;Purohit, Deepak;Mitra, Kalyan;Goel, Atul. And the article was included in Journal of Materials Chemistry B in 2017.Application of 95-88-5 The following contents are mentioned in the article:

In order to address the existing limitations of the com. available fluorescent probe CMAC (7-amino-4-chloromethylcoumarin), a new series of highly fluorescent donor-acceptor 7-hydroxy-coumarin derivatives was prepared and these derivatives were used as vacuole specific fluorescent probes for live cell imaging of unicellular parasitic protozoa L. donovani promastigotes and yeast cells S. pombe and S. cerevisiae. The synthesized 7-hydroxy-coumarins exhibited interesting photophys. properties and have advantages such as excitation in the visible region, good water solubility, photo-stability, good quantum yield and low cytotoxicity. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzylamines: synthesis and evaluation of antimycobacterial properties was written by Meindl, Wolfgang R.;Von Angerer, Erwin;Schoenenberger, Helmut;Ruckdeschel, Gotthard. And the article was included in Journal of Medicinal Chemistry in 1984.Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine The following contents are mentioned in the article:

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra were described. The most active compounds: I.HCl (MIC 10.2 μg/mL), II. HCl (MIC 10.2 μg/mL), and III.HCl (MIC 6.4 μg/mL), also had a marked inhibitory effect on M. marinum and M. lufu. The combination of II with aminosalicylic acid, streptomycin, or dapsone had marked supra-additive effects on M. tuberculosis H 37 Ra. This study involved multiple reactions and reactants, such as 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine (cas: 90390-34-4Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine).

1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine (cas: 90390-34-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxygenated Cyclopentenones via the Pauson-Khand Reaction of Silyl Enol Ether Substrates was written by Shaw, Paul;Hassell-Hart, Storm J.;Douglas, Gayle E.;Malcolm, Andrew G.;Kennedy, Alan R.;White, Gemma V.;Paterson, Laura C.;Kerr, William J.. And the article was included in Organic Letters in 2022.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:

Here the application of silyl enol ether moieties as efficient alkene coupling partners within cobalt-mediated intramol. Pauson-Khand reactions is reported. This cyclization strategy delivers synthetically valuable oxygenated cyclopentenone products, e.g., I, in yields of ≤93% from both ketone- and aldehyde-derived silyl enol ethers, e.g., II, incorporates both terminal and internal alkyne partners, and delivers a variety of decorated systems, including more complex tricyclic structures. Facile removal of the silyl protecting group reveals oxygenated sites for potential further elaboration. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Access to 3-alkylselenindoles by multicomponent reaction of indoles, selenium powder and unactivated alkyl halides under transition-metal-free conditions was written by Liu, Huan;Cai, Zhong-Jian;Ji, Shun-Jun. And the article was included in Chinese Chemical Letters in 2022.Product Details of 6294-17-3 The following contents are mentioned in the article:

Herein, a convenient and efficient multicomponent reaction of indoles, selenium powder and unactivated alkyl halides is reported. This protocol provides a practical, and facile approach for the synthesis of 3-alkylselenindole derivatives The advantages of this strategy include mild and transition-metal-free conditions, broad functional group tolerance, the use of simple and easily accessible selenium powder and alkyl halides as coupling partners. More importantly, the reaction proceeded smoothly with a large scale (> 10 g, > 90% yield), which further highlighted the potential application of this selenation strategy. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Aromaticity and Extrusion of Benzenoids Linked to [o-COSAN]^–: Clar Has the Answer was written by Poater, Jordi;Vinas, Clara;Olid, David;Sola, Miquel;Teixidor, Francesc. And the article was included in Angewandte Chemie, International Edition in 2022.HPLC of Formula: 75-57-0 The following contents are mentioned in the article:

Benzene and pyrene can be condensed to 8,8′-positions of 3,3′-cobaltabis[1,2-carborane], while naphthalene and anthracene undergo ring contraction yielding 8,8′-indenylmethylene and 8,8′-benzo[f]indenylmethylene derivatives Benzene and pyrene can be synthetically linked to [o-COSAN]^– keeping their aromaticity. In contrast, naphthalene and anthracene are extruded in the same reaction. We have proven that extrusion is only favorable if the number of Clar’s π-sextets remains constant Thus, Clar has the answer to whether an attached polycyclic aromatic hydrocarbon to [o-COSAN]^– is extruded or not. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0HPLC of Formula: 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper(I)-Catalyzed Direct Oxidative Annulation of 1,3-Dicarbonyl Compounds with Maleimides: Access to Polysubstituted Dihydrofuran Derivatives was written by Wang, Wen-Kang;Tan, Hong-Ru;Wang, Ning-Ning;Ruan, Hong-Li;Zhao, Sheng-Yin. And the article was included in Journal of Organic Chemistry.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:

An efficient annulation method for the synthesis of polysubstituted dihydrofurans I [R¹ = H, Me, Bn, etc.] from 1,3-dicarbonyl compounds and maleimides was described. The reactions could afford furo[2,3-c]pyrrole derivatives with satisfactory yields. The developed strategy realized the direct oxidative double C(sp³)-H functionalization in the presence of copper(I) salts and 2-(tert-butylperoxy)-2-methylpropane. Meanwhile, this protocol featured a mild reaction condition and simple catalytic system. A reaction mechanism involving a single electron oxidation was also proposed. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Intramolecular Nucleophilic Substitution of ω-Haloalkylphosphine Derivatives was written by Woznicki, Pawel;Korzeniowska, Ewelina;Stankevic, Marek. And the article was included in Journal of Organic Chemistry in 2017.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

ω-Haloalkylphosphine derivatives undergo the intramol. nucleophilic substitution reaction upon treatment with a strong base, yielding either cycloalkylphosphine derivatives or heterocyclic phosphine derivatives The selectivity of the cyclization of (ω-haloalkyl)alkylarylphosphine derivatives depends strongly on the distance between the electrophilic and nucleophilic C atoms and the structure of the P moiety. The desymmetrization of dimethylphenylphosphine sulfide followed by haloalkylation and cyclization led to the enantiomerically enriched tertiary phosphine sulfide, possessing a cyclohexyl fragment at the P. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics