Tag: 100-200

Synthesis and anticancer activity of open-resorcinarene conjugates was written by Daniel Pedro-Hernandez, Luis;Hernandez-Montalban, Carlos;Martinez-Klimova, Elena;Ramirez-Apan, Teresa;Martinez-Garcia, Marcos. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

The first example of conjugation of open-resorcinarenes with chlorambucil, ibuprofen, naproxen and indomethacin are presented. The cytotoxic properties of the obtained conjugates were tested against the cancer cell lines U-251, PC-3, K-562, HCT-15, MCF-7 and SKLU-1. It was found that the conjugate with chlorambucil, naproxen or indomethacin (having 8 moieties) was toxic towards cancer cell lines U-251 and K-562, with no activity against non-cancerous COS-7 cells. The conjugates with naproxen and indomethacin showed high selectivity towards U-251 tumor cells. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Category: chlorides-buliding-blocks).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Transition Metal Free Stannylation of Alkyl Halides: The Rapid Synthesis of Alkyltrimethylstannanes was written by Li, Songyi;Lian, Chang;Yue, Guanglu;Zhang, Jianning;Qiu, Di;Mo, Fanyang. And the article was included in Journal of Organic Chemistry in 2022.Electric Literature of C6H12BrCl The following contents are mentioned in the article:

A transition metal free stannylation reaction of alkyl bromides and iodides with hexamethyldistannane was developed. This protocol is operationally convenient and features a rapid reaction and good functional group tolerance. A wide range of functionalized primary and secondary alkyl and benzyl tri-Me stannanes were prepared in moderate to excellent yields. The success of the gram-scale procedure and tandem Stille coupling reaction has allowed this protocol to demonstrate potential for application in organic synthesis. Both exptl. and theor. studies reveal the mechanistic details of this stannylation reaction. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Electric Literature of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heat Capacity of α,ω-Bromochloroalkanes and α,ω-Dibromoalkanes: Their Dependence on the Hydrocarbon Chain Length and Temperature (285.15 to 355.15) K was written by Goralski, Pawel;Tkaczyk, Mariola. And the article was included in Journal of Chemical & Engineering Data in 2012.SDS of cas: 6294-17-3 The following contents are mentioned in the article:

The heat capacities at constant pressure of some α,ω-bromochloroalkanes (from C2 to C6) and α,ω-dibromoalkanes (from C2 to C12, without C7 and C10) were measured within the temperature range of (285.15 to 355.15) K. The measurements were performed by means of a Micro DSC III (Setaram) differential scanning calorimeter. The dependence of molar heat capacity on temperature and hydrocarbon chain length was described by the group additivity method. The densities of α,ω-bromochloroalkanes within the temperature range (288.15 to 318.15) K and their volumetric expansion coefficients at 298.15 K were also determined This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.SDS of cas: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Electrochemical B-H Nitrogenation: Access to Amino Acid and BODIPY-Labeled nido-Carboranes was written by Yang, Long;Bongsuiru Jei, Becky;Scheremetjew, Alexej;Kuniyil, Rositha;Ackermann, Lutz. And the article was included in Angewandte Chemie, International Edition in 2021.Electric Literature of C4H12ClN The following contents are mentioned in the article:

Electrocatalyzed oxidative B-H nitrogenations of nido-carborane (nido-7,8-C₂B₉H₁₂^–) with N-heterocycles have been established, enabling the preparation of various N-substituted nido-carboranes without chem. oxidants or metal catalyst under ambient conditions. The electrolysis manifold occurred with high levels of efficiency as well as chemo- and position- selectivity, employing sustainable electricity as the sole oxidant. The strategy set the stage for a user-friendly access to novel amino acid and fluorogenic boron-dipyrrin (BODIPY)-labeled nido-carborane hybrids. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Electric Literature of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Electric Literature of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

3-Benzo[b]furyl- and 3-benzo[b]thienylaminobutyric acids as GABA_B ligands. Synthesis and structure-activity relationship studies was written by Ansar, M.;Ebrik, S. Al Akoum;Mouhoub, R.;Berthelot, P.;Vaccher, C.;Vaccher, M. P.;Flouquet, N.;Caignard, D. H.;Renard, P.. And the article was included in European Journal of Medicinal Chemistry in 1996.Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde The following contents are mentioned in the article:

Baclofen (β-p-chlorophenyl GABA) is one of the selective agonists for the bicuculline-insensitive GABA_B receptors. In the search for new compounds that bind to GABA_B receptors it is very important to clarify the structural requirements. The syntheses of the binding studies on various 3-heteroaromatic (benzo[b]furyl- and benzo[b]thienyl)aminobutyric acids is reported. 4-Amino-3-(7-methyl-benzo[b]furan-2-yl)butanoic acid (I) is a potent and specific ligand for GABA_B receptors, with an IC₅₀ value of 5.4 μM in the displacement of [³H]GABA. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 3-Chloro-2-hydroxy-5-methylbenzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

R₄NHal/NOHSO₄: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and Beyond was written by Bondarenko, Oksana B.;Karetnikov, Georgy L.;Komarov, Arseniy I.;Pavlov, Aleksandr I.;Nikolaeva, Svetlana N.. And the article was included in Journal of Organic Chemistry in 2021.Related Products of 75-57-0 The following contents are mentioned in the article:

A new convenient and versatile halogenating system (R₄NHal/NOHSO₄), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Related Products of 75-57-0).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 75-57-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Opening the Third Century of Polyhalide Chemistry: Thermally Stable Complex with “Trapped” Dichlorine was written by Usoltsev, Andrey N.;Adonin, Sergey A.;Kolesov, Boris A.;Novikov, Alexander S.;Fedin, Vladimir P.;Sokolov, Maxim N.. And the article was included in Chemistry – A European Journal in 2020.Computed Properties of C4H12ClN The following contents are mentioned in the article:

Unlike polyhalides of heavier halogens, polychlorides still remain exotic curiosities. Herein, authors report preparation and investigation of complexes Cat₂{[TeCl₆](Cl₂)} (cat = 1-methylpyridinium (1) and tetramethylammonium (2)) where dichlorine units are “trapped” by chlorotellurate(IV) anions via a system of non-covalent Cl···Cl interactions. Complex 2 reveals a record thermal stability (>100°) for inclusion compounds with Cl₂, indications that such compounds can be used as solid Cl₂ source. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Computed Properties of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Green Synthesis of 3-Substituted-4-arylmethylideneisoxazol-5(4H)-one Derivatives Catalyzed by Salicylic Acid was written by Mosallanezhad, Asiyeh;Kiyani, Hamzeh. And the article was included in Current Organocatalysis in 2019.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The efficient and environmental friendliness procedure for the synthesis of isoxazol-5(4H)-ones was introduced. Salicylic acid was used as an inexpensive, easy to handle and safe catalyst for the synthesis of title compounds 3-Substituted-4-arylmethylideneisoxazol-5(4H)-ones were obtained from readily available aryl/heteroaryl aldehydes and β-keto esters via the cyclocondensation reaction without using thermal, microwave or ultrasound conditions. It must be highlighted that the procedure is operationally mild and simple, and the desired small heterocycles were obtained in good to high yields. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An asymmetric synthesis of clopidogrel hydrogen sulfate was written by Sashikanth, Suthrapu;Raju, Veeramalla;Somaiah, Sripathi;Rao, Peddi Srinivasa;Reddy, Karnati Venugopal. And the article was included in Synthesis in 2013.Electric Literature of C9H10ClNO2 The following contents are mentioned in the article:

An asym. synthesis of (S)-(+)-clopidogrel hydrogen sulfate was developed through application of a Strecker reaction with [(1S)-1-(4-methoxyphenyl)ethyl]amine.HCl (I) as a chiral auxiliary. Addition of 2-ClC₆H₄CHO to a solution of NaCN and I gave diastereoisomerically pure (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile.HCl. Cleavage of the chiral auxiliary and concomitant hydrolysis of the nitrile group then gave enantiomerically pure (2S)-2-(2-chlorophenyl)glycine.HCl, a key intermediate for (S)-(+)-clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Electric Literature of C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis was written by Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A.. And the article was included in Catalysis Communications in 2019.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

Zn_1-xTi_xO NPs were efficiently synthesized using a simple solution free mechanochem. method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn_1-xTi_xO catalysts were pos. correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodol. was also extended to sulfone-fluorescein dye synthesis. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics