Tag: 100-200

Nickel-Catalyzed C-S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers was written by Yang, Yu-Zhong;Li, Yang;Lv, Gui-Fen;He, De-Liang;Li, Jin-Heng. And the article was included in Organic Letters in 2022.Recommanded Product: 6294-17-3 The following contents are mentioned in the article:

A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C-S reductive cross-coupling with alkyl halides to manage an electrophilic alkyl group onto the electrophilic sulfur atom and then construct a C(sp3)-S bond, and features exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biol. relevant mols. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis and Cytotoxic Activities of Pyrazole-Perimidine Hybrids was written by Guemues, Mehmet;Guemues, Nisa;Eroglu, Halil Erhan;Koca, Irfan. And the article was included in ChemistrySelect in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Nine perimidine-pyrazole hybrids I [R = H, Me, Cl; Ar = Ph, 4-MeC₆H₄, 2-MeOC₆H₄, 4-FC₆H₄, 4-BrC₆H₄] were designed and synthesized. Genotoxic, mutagenic and carcinogenic effects of two of the synthesized compounds I [R = H, Ar = 4-MeC₆H₄; R = Me, Ar = 4-BrC₆H₄] were evaluated. The tested compounds could cause chromosomal damage by genotoxic potential and mitotic delay by cytotoxic potential at high concentrations (25-100μM). This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparative studies of novel triazole derivative having chiral center and their antimicrobial activities was written by Mistry, Bhavnaben D.;Desai, Kishor R.;Intwala, Sanket M.. And the article was included in Pharma Chemica in 2013.Formula: C9H10ClNO2 The following contents are mentioned in the article:

The compounds 1,2,4-triazole-3-thiol derivatives (-) and (+)-I [R = H, 3-CH₃, 2-OH, 3,5-(NH₂)₂] have been synthesized by the reaction of 1,3,4-oxadiazole-2-thiol derivatives (-) and (+)-II with concentrate H₂SO₄, L-(+) tartaric acid, D-(-) tartaric acid, hydrazine hydrate, carbon disulfide and various aromatic amine resp.. The synthesized compounds have been screened for their antibacterial and antifungal activities against different microorganisms. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Formula: C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemo-enzymatic approach to the synthesis of the antithrombotic clopidogrel was written by Ferraboschi, Patrizia;De Mieri, Maria;Galimberti, Fiorella. And the article was included in Tetrahedron: Asymmetry in 2010.Recommanded Product: 141109-14-0 The following contents are mentioned in the article:

The (S)-2-chlorophenylglycine moiety is well recognized in the structure of (S)-clopidogrel, a known antithrombotic drug. An enantiomerically pure chiral building block was prepared via an enzyme-catalyzed resolution of (RS)-N-Boc-2-chlorophenylglycine Me ester. The best results were obtained by means of an immobilized subtilisin, the cross-linked enzyme aggregate (Alcalase-CLEA). The high enantiomeric excess of the synthon obtained remained the same over the course of clopidogrel synthesis; the simplicity of the process makes this pathway suitable for large-scale preparation This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Iron-Catalyzed Borylation of Alkyl Electrophiles was written by Atack, Thomas C.;Lecker, Rachel M.;Cook, Silas P.. And the article was included in Journal of the American Chemical Society in 2014.Product Details of 6294-17-3 The following contents are mentioned in the article:

The use of low-cost iron(III) acetoacetate (Fe(acac)₃) and tetramethylethylenediamine (TMEDA) enables the direct cross-coupling of alkyl halides with bis(pinacolato)diboron. This approach allows for the borylation of activated or unactivated primary, secondary, and tertiary bromides. Moreover, even the borylation of benzylic or allylic chlorides, tosylates, and mesylates are possible. The reactions proceed under mild conditions at room temperature and show broad functional-group compatibility and “robustness” as measured by a modified Glorius robustness screen. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photoredox B-H functionalization to selective B-N(sp³) coupling of nido-carborane with primary and secondary amines was written by Huang, Ronghui;Zhao, Weijia;Xu, Shengwen;Xu, Jingkai;Li, Chunxiao;Lu, Changsheng;Yan, Hong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Access to nido-carborane site-selective B-N(sp³) coupling by photoredox catalyzed B-H activation has been achieved for the first time, which leads to the synthesis of a series of nitrogen-containing nido-carboranes with moderate to good yields. This protocol is applicable to primary and secondary amines containing alkyl, or heteroaryl groups as well as sulfonamides. Furthermore, the open to air and metal-free conditions with excellent site-selectivity represent a significant improvement for B-H functionalization of nido-carboranes with organic functionalities. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Category: chlorides-buliding-blocks).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Copper-Catalyzed Cross-Coupling Reaction of Allyl Boron Ester with 1°/2°/3°-Halogenated Alkanes was written by Wang, Guang-Zu;Jiang, Jian;Bu, Xiao-Song;Dai, Jian-Jun;Xu, Jun;Fu, Yao;Xu, Hua-Jian. And the article was included in Organic Letters in 2015.Related Products of 6294-17-3 The following contents are mentioned in the article:

The cross-coupling reaction of allyl boron ester with 1°/2°/3°-halogenated alkanes in the presence of copper has been developed for the first time, which provides a mild and efficient method for the construction of saturated C(sp³)-C(sp³) bonds. E.g., in presence of CuI and LiOCMe₃ in DMF, cross-coupling of allylboronic acid pinacol ester with 1-(4-bromobutyl)indole gave 87% I. This protocol shows excellent compatibility with the nonactivated primary, secondary, and even tertiary halogenated alkanes under mild conditions. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Related Products of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and antibacterial activities of newly synthesized coumarin derivatives was written by Chavhan, J. V.;Patil, S. S.. And the article was included in International Journal of Pharmaceutical, Chemical and Biological Sciences in 2017.Reference of 95-88-5 The following contents are mentioned in the article:

In this work, substituted coumarin based flavones I (R = OCH₃, NO₂) have been synthesized via chalcone. The study was conducted with two primary objectives. The first objective was to synthesize coumarin based flavones and second objective was to study antimicrobial activity of synthesized compounds The structures of the compounds were elucidated by elemental and spectral (IR, 1HNMR, and MS) anal. The reactions are easy to conduct, under mild conditions, and form coumarine substituted flavones in moderate to excellent yields. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Reference of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Reference of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 2-(pyrrolidin-1-yl)pyrimidines by reactions of N-(4,4-diethoxybutyl)pyrimidin-2-amine with (hetero)aromatic C-nucleophiles was written by Smolobochkin, Andrey V.;Rizbayeva, Tanzilya S.;Gazizov, Almir S.;Voronina, Julia K.;Chugunova, Elena A.;Akylbekov, Nurgali I.;Appazov, Nurbol O.;Burilov, Alexander R.;Pudovik, Michael A.. And the article was included in Chemistry of Heterocyclic Compounds in 2019.Application of 95-88-5 The following contents are mentioned in the article:

A method was developed for the synthesis of 2-(pyrrolidin-1-yl)pyrimidines I•CF₃CO₂H [R = 2,4-di-OH-5-ClC₆H₂, 2-hydroxy-1-naphthyl, 6-hydroxy-1,3-benzodioxol-5-yl, etc.] and 2-[(4,4-diarylbutyl)amino]pyrimidine by reactions of (hetero)aromatic C-nucleophiles with N-(4,4-diethoxybutyl)pyrimidin-2-amine in the presence of trifluoroacetic acid. The structures of the obtained products were confirmed by methods of IR spectroscopy, ¹H and ¹³C NMR spectroscopy and X-ray structural anal. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors was written by Li, Gudong;Zhang, Wei;Xie, Yuting;Li, Yang;Cao, Rao;Zheng, Guojun;Huang, Niu;Zhou, Yu. And the article was included in Journal of Chemical Information and Modeling in 2020.Product Details of 6294-17-3 The following contents are mentioned in the article:

Pim-1 kinase has been widely regarded as an attractive target for anticancer drugs. Here, we reported our continued efforts in structure-based optimization of compound 10-DEBC, a previously identified micromolar Pim-1 inhibitor. Guided by the Site Identification by Ligand Competitive Saturation (SILCS) method, we quickly obtained a series of 10-DEBC derivatives with significantly improved activity and selectivity. In particular, compound 26 exhibited an IC₅₀ value of 0.9 nM, as well as 220- and 8-fold selectivity over Pim-2 and Pim-3 kinases, resp. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics