Tag: 100-200

On May 19, 2022, Sabbah, Dima A.; Samarat, Hla H.; Al-Shalabi, Eveen; Bardaweel, Sanaa K.; Hajjo, Rima; Sweidan, Kamal; Khalaf, Reema Abu; Al-Zuheiri, Aya M.; Abushaikha, Ghassan published an article.Name: 2-Amino-4-chlorobenzoic acid The title of the article was Design, Synthesis, and Biological Examination of N-Phenyl-6-fluoro-4-hydroxy-2-quinolone-3-carboxamides as Anticancer Agents. And the article contained the following:

Cancer is one of the leading causes of death worldwide, and it has a major impact on public health. Phosphatidylinositol 3-kinase (PI3Kα) has been recognized as a promising drug target for developing anticancer agents. Herein, a series of N-phenyl-6-fluoro-4-hydroxy-2-quinolone-3-carboxamides was developed to target PI3Kα. All synthesized compounds were characterized using FT-IR, NMR (1H and 13C) and elemental anal. All synthesized chem. analogs exerted distinctive anticancer activity. They inhibited the growth of human epithelial colorectal adenocarcinoma (Caco-2) with IC50 values between 48.63-378 μM, and human colon cancer (HCT-116) cell lines with IC50 values between 44-664 μM. Computational modeling studies provided important biol. insight. Induced-fit docking (IFD) studies showed that the synthesized chem. analogs fit the kinase catalytic domains and form a significant H-bond interaction network with key amino acids at the biding site. Furthermore, cheminformatics analyses indicated that all synthesized compounds were drug-like permitting further animal testing or clin. development. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid

The Article related to phenylfluoro hydroxyquinolone carboxamide anticancer agent clin development, Placeholder for records without volume info and other aspects.Name: 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 15, 2021, Abdulwahab, Muhammad Kumayl; Tan, Ke Han; Dzulkeflee, Rashidi; Leong, Kok Hoong; Heh, Choon Han; Ariffin, Azhar published an article.Safety of 2-Amino-4-chlorobenzoic acid The title of the article was In-silico Studies of the Antiproliferative Activity of New Anilinoquinazoline Derivatives Against NSCLC Cells.. And the article contained the following:

The current reversible epidermal growth factor (EGFR) tyrosine kinase inhibitors of non-small cell lung cancer (NSCLC) have been resisted by T790M mutation, while the irreversible inhibitors introduced to overcome the mutation have faced resistance from C979S mutation. In the effort to discover potentially improved reversible EGFR inhibitors, a series of new anilinoquinazoline derivatives with modification on the 2nd carbon on the aniline ring was synthesized. The derivatives were tested for their antiproliferative activity against NSCLC cell lines with wild-type (A549), exon 19 deletion mutated (H1650) and L858R+T790M (H1975) mutated EGFR kinases. Three derivatives (4-6) performed better than the standard drug, gefitinib, in all cell lines. Derivative 5 recorded the lowest IC50 values in all cell lines (A549: 24.60 ± 0.75 μM, H1650: 14.83 ± 0.54 μM, H1975: 21.72 ± 1.21 μM). A mol. docking study followed by mol. dynamics simulations was performed on derivative 5 and gefitinib using wild-type EGFR kinase (WT-EGFR) and L858R+T790M mutated kinase (LRTM-EGFR) to provide an understanding of their binding mechanisms. In WT-EGFR kinase, derivative 5 recorded better hydrogen bonding occupancy with MET793 (94.16%) and binding energy profile (-35.287 kcal/mol) as compared to gefitinib (91.80%, -26.071 kcal/mol). In LRTM-EGFR kinase, derivative 5 recorded better hydrogen bonding occupancy with MET793 (93.68%) as compared to gefitinib (91.48%). Derivative 5 also recorded addnl. hydrogen bonding interactions with ASP855, with a total of 60.61% occupancy as well as a better energy profile (-42.867 kcal/mol) as compared to gefitinib (-41.778 kcal/mol). The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Safety of 2-Amino-4-chlorobenzoic acid

The Article related to anilinoquinazolin antiproliferative activity kinase inhibitor mol docking, Placeholder for records without volume info and other aspects.Safety of 2-Amino-4-chlorobenzoic acid

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 10, 2019, Hobbs, Heather; Bravi, Gianpaolo; Campbell, Ian; Convery, Maire; Davies, Hannah; Inglis, Graham; Pal, Sandeep; Peace, Simon; Redmond, Joanna; Summers, Declan published an article.Safety of trimethyloxosulphonium chloride The title of the article was Correction to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway [Erratum to document cited in CA171:311735]. And the article contained the following:

There are errors in Figures 4 and 5 as well as the corresponding article and Supporting Information text; the corrections are provided here. The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Safety of trimethyloxosulphonium chloride

The Article related to morpholine isostere pi3k akt mtor pathway inhibitor conformation erratum, Placeholder for records without volume info and other aspects.Safety of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Rosenbach, Dominic; Krimalowski, Alexander; Erabhoina, Harimohan; Thelakkat, Mukundan published an article in 2022, the title of the article was Solid polymer electrolytes from polyesters with diester sidechains for lithium metal batteries.Formula: C7H11ClO3 And the article contains the following content:

A series of polymethacrylates and polyacrylates carrying diester side chain moieties with varying alkyl spacer lengths are designed, synthesized, and evaluated as solid polymer electrolytes (SPEs) in lithium metal batteries (LMBs). These amorphous polymers with glass transition temperatures in the range of -58 to +32 °C are tested as SPEs in combination with LiTFSI or LiFSI. At an optimum salt concentration of 25 wt%, ionic conductivities up to 10-4 S cm-1 at 70 °C are achieved. These SPEs reveal high lithium transport numbers (0.5-0.7) and high electrochem. stability (5.4 V vs. Li/Li+) as determined by LSV. In combination with an ultrathin polyimide membrane and 10 wt% TiO2 nanoparticles, dendrite-free plating/stripping at 40 and 70 °C is realized in sym. Li|SPE|Li cells. Detailed extended distribution of relaxation times (eDRT) anal. of impedance measurements is employed for understanding the diverse cell processes. In solvent-free LMBs comprising a polyimide membrane soaked with the nanocomposite polyester electrolyte, lithium metal foil as the anode and an optimized LiFePO4 cathode, a very high initial specific discharge capacity of 152 mA h g- 1 (at 0.2C, 70 °C), excellent capacity retention of 94% after 100 cycles (at 1C, 70 °C) and negligible capacity fading even at 2C (96% retention after 300 cycles) are demonstrated. These novel polyester-based SPEs exhibit high cycling stability at 40 °C, making them highly attractive for room temperature applications. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Formula: C7H11ClO3

The Article related to titanium oxide polyester solid polymer electrolyte lithium metal battery, Placeholder for records without volume info and other aspects.Formula: C7H11ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On September 30, 2021, Soraggi Battagin, Tiago; Nicolas Caccalano, Mario; Dilarri, Guilherme; Felipe Cavicchia Zamuner, Caio; Alleoni, Natalia; Leonardo Saldanha, Luiz; Bacci, Mauricio Jr.; Ferreira, Henrique published an article.Application of 35444-44-1 The title of the article was Syzygium aromaticum (clove) essential oil: An alternative for the sanitization of citrus fruit in packinghouses. And the article contained the following:

Citrus canker is a quarentenary disease caused by Xanthomonas citri subsp. citri (X. citri). Thus, sanitization of fresh fruit is a necessary measure before any com. activity. Therefore, we evaluated the clove essential oil (CEO), as an alternative sanitizer for the disinfection of citrus fruit in packinghouses. Tests in vitro and in vivo were carried out to determine the cell inhibitory concentration and to verify the efficacy of the oil for the disinfection of citrus fruits. In in vitro tests, CEO was able to inhibit X. citri when used at 0.75% (volume/volume). In experiments that simulate the sanitization process used in packinghouses, 5% CEO was as effective as the recommended sanitization product based on sodium hypochlorite. GC-MS results showed a high presence of eugenol derivatives as the major compounds of CEO. All results proved that CEO is a potential sanitizer that could be used as an alternative to sodium hypochlorite. Novelty impact statement : Exptl. evidence shows that the clove essential oil (CEO) has the same sanitization efficacy as sodium hypochlorite, which makes of CEO an alternative sanitizer for the decontamination of citrus fruits to be exported to the European Union. CEO is a safer and more sustainable sanitizer for the postharvest disinfection of citrus fruit. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Application of 35444-44-1

The Article related to syzygium aromaticum essential oil citrus fruit packing sanitization, Placeholder for records without volume info and other aspects.Application of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ding, Shunmin; Cheng, Dan; Xiao, Weiming; Ma, Xiaohua; Zeng, Rong; Liu, Senqun; Liang, Sanqi; Chen, Chao; Song, Wei-Guo published an article in , the title of the article was Nickel Nanoparticles Encapsulated in Carbon Nanotubes as an Efficient and Robust Catalyst for Hydrogenation of Nitroarenes.Reference of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:

Catalytic hydrogenation of nitroarenes is an efficient and commonly used route for preparing aromatic amines. The cost-effective metallic Ni catalyst prefers to be used for its superior hydrogenation activity, but they generally are not stable enough and usually show poor reusability. In this work, carbon nanotube encapsulating metallic Ni catalysts were prepared by simple ball milling and calcining the mixture of poss-octaphenyl and nickel (II) acetate tetrahydrate. The as-prepared metallic nickel encapsulated catalyst Ni@CNT-800 exhibited excellent stability in the hydrogenation reaction, no any activity decrease was observed after ten runs whether at high conversion or low conversion. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Reference of 2-Chloro-4-methyl-1-nitrobenzene

The Article related to nickel carbon nanotube hydrogenation activation energy stability, Placeholder for records without volume info and other aspects.Reference of 2-Chloro-4-methyl-1-nitrobenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 5, 2022, Ahmad, Iqrar; Akand, Sazedur Rahman; Shaikh, Matin; Pawara, Rahul; Manjula, S. N.; Patel, Harun published an article.COA of Formula: C7H6ClNO2 The title of the article was Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity. And the article contained the following:

In the current research, methaqualone derivatives were synthesized and assessed for their anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti-convulsant activities with ED50 values of 132.23 mg/kg, 120.34 mg/kg, 100.78 mg/kg, 145.89 mg/kg, and 148.46 mg/kg, resp. The toxicity profiling (TD50) of these compounds (3, 4, 6, 7 and 11) demonstrated that these drugs caused only a minor neurol. impairment. The PI scores of these compounds (3, 4, 6, 7 and 11) were higher than the reference drug (methaqualone PI: 1.99). The acetylcholinesterase enzyme level is significantly reduced in these compounds, indicating the enhancement of cognition activity. Pharmacophoric modeling and mol. docking studies against the human GABA-A receptor are in close agreement with each other. Mol. dynamic simulation of compound 6 indicates that it remains stable with the human GABA-A receptor for a 100 ns time span. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).COA of Formula: C7H6ClNO2

The Article related to methaqualone anticonvulsant cognition neurotoxicity mol docking, Placeholder for records without volume info and other aspects.COA of Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kaliraj, S.; Jeyalakshmi, R.; Kathiravan, M. K.; Madhavan, T.; Devi, Arikketh published an article in 2021, the title of the article was Design, molecular docking and biological evaluation of fused thienopyrimidines and quinazoline.Electric Literature of 89-77-0 And the article contains the following content:

The anticancer activity of the condensed pyrimidine and quinazoline moieties are pronounced with a different pathway. Thienopyrimidine is considered as ring equivalent bioisosteres of quinazolines and present in other heterocyclic compounds including thienopyrimidine. The present investigation focused on the synthesis of thienopyrimidine and quinazoline derivatives for their anticancer activity against the human oral squamous carcinoma-3 (HSC-3) cell line. The synthesized compound confirmed for their structural characteristics from spectral anal. and tested for anti-proliferative activity from MTT assay. The electron-withdrawing group in 4-chloro thienopyrimidines and amino ester derivate/facilitate the inhibition of cancer cells. Further probing by docking studies revealed that the compounds exhibit possible interactions with VEGF, FGFR and c-Met proteins, which are known to have a role in the pathogenesis of oral squamous cell carcinoma. Among the derivatives a moderate activity demonstrated by substituted 4-chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]-pyrimidine (4a) and Et 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1a) derivatives Lack of chirality and the presence of bulky substituents in few of the compounds were found to be the cause for lower potency. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Electric Literature of 89-77-0

The Article related to fused thienopyrimidine quinazoline mol docking biol evaluation, Placeholder for records without volume info and other aspects.Electric Literature of 89-77-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 28, 2022, Elfeky, Sherin M.; Almehmadi, Samar J.; Tawfik, Samar S. published an article.Synthetic Route of 89-77-0 The title of the article was Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents. And the article contained the following:

Through a two-step procedure, 3-amino-7-chloro-2-methylquinazolin-4(3H)-one was synthesized from 2-amino-4-chlorobenzoic acid as a starting material. The latter reacted with chloro acetylchloride, then nucleophilically substituted with various secondary amines to produce acetamide derivatives (5a-e), or underwent condensation reaction with various aldehydes to produce arylidine derivatives (6a-e). In-silico study of drug-likeness and ADME descriptors was conducted for all compounds Compounds showed good oral bioavailability, as well as good gastrointestinal absorption potential and no symptoms of liver or CNS adverse effects. In-vitro cytotoxic activity of the compounds was moderate to good when compared to staurosporine in three cell lines: HCT, MCF-7, and HepG-2. Compound 5c showed the highest cytotoxic activity against the HCT cell line (IC50 = 8.00 ± 0.33 μM), Compound 5d showed the highest cytotoxic activity against the HepG-2 cell line (IC50 = 17.78 ± 0.58 μM). Acetamide derivatives revealed higher cytotoxic activity compared to arylidine derivatives Compound 5d had the highest enzyme inhibition activity in the in-vitro PI3k-δ enzyme inhibition assay (IC50 = 1.24 ± 0.03 μM) followed by 5c (IC50 = 8.27 ± 0.19 μM). Both 5c and 5d were able to bind at the ATP binding site of the PI3k-δ enzyme in a mode similar to the native ligand where they formed H-bond interactions with the hinge region amino acid Val828 and hydrophobic interactions with other amino acids indicating an agreement between mol. docking simulation study and the biol. screening. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0

The Article related to chloro methylquinazolinone pik inhibitor cytotoxic agent, Placeholder for records without volume info and other aspects.Synthetic Route of 89-77-0

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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Prasad, Bagineni; Doimo, Mara; Andreasson, Maans; L′Hote, Valentin; Chorell, Erik; Wanrooij, Sjoerd published an article in 2022, the title of the article was A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells.Product Details of 35444-44-1 And the article contains the following content:

G-quadruplex (G4) DNA structures are implicated in central biol. processes and are considered promising therapeutic targets because of their links to human diseases such as cancer. However, functional details of how, when, and why G4 DNA structures form in vivo are largely missing leaving a knowledge gap that requires tailored chem. biol. studies in relevant live-cell model systems. Towards this end, we developed a synthetic platform to generate complementary chem. probes centered around one of the most effective and selective G4 stabilizing compounds, Phen-DC3. We used a structure-based design and substantial synthetic devlopments to equip Phen-DC3 with an amine in a position that does not interfere with G4 interactions. We next used this reactive handle to conjugate a BODIPY fluorophore to Phen-DC3. This generated a fluorescent derivative with retained G4 selectivity, G4 stabilization, and cellular effect that revealed the localization and function of Phen-DC3 in human cells. To increase cellular uptake, a second chem. probe with a conjugated cell-penetrating peptide was prepared using the same amine-substituted Phen-DC3 derivative The cell-penetrating peptide conjugation, while retaining G4 selectivity and stabilization, increased nuclear localization and cellular effects, showcasing the potential of this method to modulate and direct cellular uptake e.g. as delivery vehicles. The applied approach to generate multiple tailored biochem. tools based on the same core structure can thus be used to advance the studies of G4 biol. to uncover mol. details and therapeutic approaches. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Product Details of 35444-44-1

The Article related to cervical cancer g quadruplex dna structure chem probe, Placeholder for records without volume info and other aspects.Product Details of 35444-44-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics