Chlorides-buliding-blocks

Zheng, Zhi-gang published the artcileThree-dimensional control of the helical axis of a chiral nematic liquid crystal by light, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Nature (London, United Kingdom) (2016), 531(7594), 352-356, database is CAplus and MEDLINE.

Chiral nematic liquid crystals – otherwise referred to as cholesteric liquid crystals (CLCs) – are self-organized helical superstructures that find practical application in, for example, thermog., reflective displays, tuneable color filters and mirrorless lasing. Dynamic, remote and three-dimensional control over the helical axis of CLCs is desirable, but challenging. For example, the orientation of the helical axis relative to the substrate can be changed from perpendicular to parallel by applying an alternating-current elec. field, by changing the anchoring conditions of the substrate, or by altering the topog. of the substrate’s surface; sep., in-plane rotation of the helical axis parallel to the substrate can be driven by a direct-current field. Here we report three-dimensional manipulation of the helical axis of a CLC, together with inversion of its handedness, achieved solely with a light stimulus. We use this technique to carry out light-activated, wide-area, reversible two-dimensional beam steering-previously accomplished using complex integrated systems and optical phased arrays. During the three-dimensional manipulation by light, the helical axis undergoes, in sequence, a reversible transition from perpendicular to parallel, followed by in-plane rotation on the substrate surface. Such reversible manipulation depends on exptl. parameters such as cell thickness, surface anchoring condition, and pitch length. Because there is no thermal relaxation, the system can be driven either forwards or backwards from any light-activated intermediate state. We also describe reversible photocontrol between a two-dimensional diffraction state, a one-dimensional diffraction state and a diffraction ‘off’ state in a bilayer cell.

Nature (London, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C39H35N5O8, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fan, Jing published the artcileLight-Directing Omnidirectional Circularly Polarized Reflection from Liquid-Crystal Droplets, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2015), 54(7), 2160-2164, database is CAplus and MEDLINE.

Constructing and tuning self-organized 3-dimensional (3D) superstructures with tailored functionality is crucial in the nanofabrication of smart mol. devices. A self-organized, phototunable 3D photonic superstructure was fabricated from monodisperse droplets of 1-dimensional cholesteric liquid crystal (CLC) containing a photosensitive chiral mol. switch with high helical twisting power. The droplets are obtained by a glass capillary microfluidic technique by dispersing into PVA solution that facilitates planar anchoring of the liquid-crystal mols. at the droplet surface, as confirmed by the observation of normal incidence selective circular polarized reflection in all directions from the core of individual droplet. Photoirradiation of the droplets furnishes dynamic reflection colors without thermal relaxation, whose wavelength can be tuned reversibly by variation of the irradiation time. The results provided clear evidence on the phototunable reflection in all directions.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Ke published the artcileSynthesis and in vitro cytotoxic activities of sorafenib derivatives, Quality Control of 33697-81-3, the publication is Chinese Chemical Letters (2014), 25(5), 702-704, database is CAplus.

A series of novel sorafenib derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested in three tumor cell lines. Most of the compounds showed potent antiproliferative activity against the tested cell lines with IC₅₀ = 0-20 μmol/L. Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines. Among them, one of the compounds demonstrated significant inhibitory activity against A549, ACHN, and MDA-MB-231 cell lines with IC₅₀ values of 1.29, 1.99, 3.11 μmol/L, resp.

Chinese Chemical Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C21H24O8, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileMulti-modulated photochromic behavior of a D-A type dithienylethene, Computed Properties of 219537-97-0, the publication is Dyes and Pigments (2019), 712-720, database is CAplus.

The development of multiresponsive photochromic materials is of increasing interest for their potential application in the complicated chem. and biol. environment. Here, a novel D-A type dithienylethene derivative NDM, in which dimethylamino group acted as both electron donor (D) and recognition moiety for H⁺, and the dicyanovinyl group functioned as electron acceptor (A) and responsed to cyanide anion, has been designed and synthesized. Its structure was confirmed by ¹H NMR, ¹³C NMR and HRMS (ESI). As expected, dithienylethene NDM exhibited distinctive multi-modulated photochromic properties by solvent, acid and cyanide anion stimulation. Moreover, NDM can be acted as a potential fluorescent turn-on pH-sensor and colorimetric sensor for CN^– in biol. field.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Song published the artcileDMSO-catalysed late-stage chlorination of (hetero)arenes, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Nature Catalysis (2020), 3(2), 107-115, database is CAplus.

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications.

Nature Catalysis published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C19H14O2, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tan, Wen-Juan published the artcileA photochromic diarylethene dyad based on perylene diimide, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Dyes and Pigments (2011), 89(3), 260-265, database is CAplus.

A new photochromic diarylethene dyad based on perylene diimide (PDI-DTE) was synthesized. The photochromic reaction of PDI-DTE induced the significant change of the absorption spectra and fluorescence intensity. The color of PDI-DTE in THF solution was not changed obviously upon UV irradiation, while the fluorescence intensity is increased unexpectedly with the photochromic cyclization of the diarylethene units. With not visible change of color accompanied to the enhanced fluorescence, PDI-DTE can be potentially applied to anti-counterfeiting technol.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C8H8BNO2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Teng published the artcilePhotoresponsive Supramolecular Assemblies Based on a C₃-Symmetric Benzene-1,3,5-tricarboxamide Anchored Diarylethene, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Advanced Optical Materials (2016), 4(6), 840-847, database is CAplus.

This article describes about photoresponsive supramol. assemblies based on a C₃-sym. benzene-1,3,5-tricarboxamide anchored diarylethene. This article describes about a functional C3-sym. BTA anchored diarylethene (C3-BTE) mol. that evolved into ordered superstructures with tunable morphol. properties both in different solvent and via alternative light stimuli.

Advanced Optical Materials published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yan, Yu-Hang published the artcileStructure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors, Category: chlorides-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2022), 113965, database is CAplus and MEDLINE.

X-ray structure-guided optimization of 1H-imidazole-2-carboxylic acid (ICA) derivatives, I [R¹ = cyclopropyl, 4-pyridylmethyl, 2-(1-methyltetrazol-5-yl)sulfanylethyl, etc.; R² = R³ = Me, cyclopropyl, Ph, etc.] was reported by considering how to engage with the active-site flexible loops and improve penetration into Gram-neg. bacteria. Structure-activity relationship studies revealed the importance of appropriate substituents at ICA 1-position to achieve potent inhibition to class B1 MBLs, particularly the Verona Integron-encoded MBLs (VIMs), mainly by involving ingenious interactions with the flexible active site loops as observed by crystallog. analyses. Of the tested ICA inhibitors, I [R¹ = 4-pyridylmethyl, R² = R³ = H] displayed potent synergistic antibacterial activity with meropenem against engineered Escherichia coli strains and even intractable clin. isolated Pseudomonas aeruginosa producing VIM-2 MBL. The morphol. and internal structural changes of bacterial cells after treatment further demonstrated that I [R¹ = 4-pyridylmethyl, R² = R³ = H] crossed the outer membrane and reversed the activity of meropenem. Moreover, I [R¹ = 4-pyridylmethyl, R² = R³ = H] showed good pharmacokinetic and safety profile in vivo, which could be a potential candidate for combating VIM-mediated Gram-neg. carbapenem resistance.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C3H6O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Huang, Hong-Gui published the artcileTrifluoromethanesulfonyl azide as a bifunctional reagent for metal-free azidotrifluoromethylation of unactivated alkenes, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Science (2021), 12(9), 3210-3215, database is CAplus and MEDLINE.

A simple and metal-free method that rapidly provides these building blocks, e.g., I from abundant alkenes RR¹C=CR²R³ (R = 3-[(pyridin-3-yl)carbonyloxy]propyl, C₈H₁₇, CH₂C₆H₅, etc.; R¹ = H, Me, n-Pr; R² = R³ = H, Me) and trifluoromethanesulfonyl azide (N₃SO₂CF₃). This unprecedented two-component reaction employs readily available N₃SO₂CF₃ as a bifunctional reagent to concurrently incorporate both CF₃ and N₃ groups, which avoids the use of their expensive and low atom economic precursors. A wide range of functional groups, including bio-relevant heterocycles and amino acids, was tolerated. Application of this method was further demonstrated by scale-up synthesis (5 mmol), product derivatization to CF₃-containing medicinal chem. motifs, as well as late-stage modification of natural products, e.g., 5-(2,2,2-trifluoroethyl)pyrrolidin-2-one and drug derivatives

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Sheng published the artcileStimuli-Responsive Copolymer and Uniform Polymeric Nanoparticles with Photochromism and Switchable Emission, Application In Synthesis of 219537-97-0, the publication is ChemPhotoChem (2019), 3(7), 568-574, database is CAplus.

An efficient approach to make a fluorescent polymer both photoswitchable and stimuli-responsive was successfully developed by rationally introducing a photochromic bisthienylethene derivative (BTE) and fluorescent 4-dicyanomethylene-2,6-distyryl-4H-pyran derivative (DPC) units in the side chains via copolymerization Benefiting from the reversible photocyclization of BTE and the intermol. Foerster Resonance Energy Transfer (FRET) effect from DPC to the closed form of BTE, the emission signatures of the polymer both in solution in organic solvents and in thin films could be tuned by the alternating irradiation of UV and visible light. Moreover, uniform polymeric nanoparticles (NPs) with reversibly photoswitchable fluorescence properties were synthesized using a facile one-step mini-emulsion polymerization This polymer could act as a smart material for photoresponsive polymer illuminants and offers new platform for multifunctional mol. switching and multi-responsive materials.

ChemPhotoChem published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C13H26N2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics