Category: chlorides-buliding-blocks

Yi, Xiaofeng; Wang, Di; Li, Fan; Zhang, Jian; Zhang, Lei published the artcile< Molecular bixbyite-like In12-oxo clusters with tunable functionalization sites for lithography patterning applications>, Recommanded Product: Indium(III) chloride tetrahydrate, the main research area is indium oxo cluster mol bixbyite lithog patterning application.

Indium oxides have been widely applied in many technol. areas, but their utilization in lithog. has not been developed. Herein, we illustrated a family of unprecedented In12-oxo clusters with a general formula [In12(Μ4-O)4(Μ2-OH)2(OCH2CH2NHCH2CH2O)2(OR)4X4]X2 (where X = Cl or Br; R = CH3, C6H4NO2 or C6H4F), which not only present the largest size record in the family of indium-oxo clusters (InOCs), but also feature the first mol. model of bixbyite-type In2O3. Moreover, through the labile coordination sites of the robust diethanolamine-stabilized In12-oxo core, these InOCs can be accurately functionalized with different halides and alc. or phenol derivatives, producing tunable solubility Based on the high solution stability as confirmed by ESI-MS anal., homogeneous films can be fabricated using these In12-oxo clusters by the spin-coating method, which can be further used for electron beam lithog. (EBL) patterning studies. Accordingly, the above structural regulations have significantly influenced their corresponding film quality and patterning performance, with bromide or p-nitrophenol functionalized In12-oxo clusters displaying better performance of sub-50 nm lines. Thus, the here developed bixbyite-type In12-oxo cluster starts the research on indium-based patterning materials and provides a new platform for future lithog. radiation mechanism studies.

Chemical Science published new progress about Atomic force spectroscopy. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Recommanded Product: Indium(III) chloride tetrahydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Derand, Renaud; Bulteau-Pignoux, Laurence; Mettey, Yvette; Zegarra-Moran, Olga; Howell, L. Daniel; Randak, Christoph; Galietta, Luis J. V.; Cohn, Jonathan A.; Norez, Caroline; Romio, Leila; Vierfond, Jean-Michel; Joffre, Michel; Becq, Frederic published the artcile< Activation of G551D CFTR channel with MPB-91: regulation by ATPase activity and phosphorylation>, Synthetic Route of 2905-54-6, the main research area is cystic fibrosis transmembrane conductance regulator mutant activation MPB91 preparation; benzoquinolizinium derivative preparation activation CFTR chloride channel mutant.

We have designed and synthesized benzo[c]quinolizinium derivatives and evaluated their effects on the activity of G551D cystic fibrosis transmembrane conductance regulator (CFTR) expressed in Chinese hamster ovary and Fisher rat thyroid cells. We demonstrated, using iodide efflux, whole cell patch clamp, and short-circuit recordings, that 5-butyl-6-hydroxy-10-chlorobenzo[c]quinolizinium chloride (MPB-91) restored the activity of G551D CFTR (EC50 = 85 μM) and activated CFTR in Calu-3 cells (EC50 = 47 μM). MPB-91 has no effect on the ATPase activity of wild-type and G551D NBD1/R/GST fusion proteins or on the ATPase, GTPase, and adenylate kinase activities of purified NBD2. The activation of CFTR by MPB-91 is independent of phosphorylation because (1) kinase inhibitors have no effect and (2) the compound still activated CFTR having 10 mutated protein kinase A sites (10SA-CFTR). The new pharmacol. agent MPB-91 may be an important candidate drug to ameliorate the ion transport defect associated with CF and to point out a new pathway to modulate CFTR activity.

American Journal of Physiology published new progress about CFTR (cystic fibrosis transmembrane conductance regulator) Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, Synthetic Route of 2905-54-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Yang, Yang; Ohnoutek, Lukas; Ajmal, Saira; Zheng, Xiuzhen; Feng, Yiqing; Li, Kejian; Wang, Tao; Deng, Yue; Liu, Yangyang; Xu, Dong; Valev, Ventsislav K.; Zhang, Liwu published the artcile< ""Hot edges"" in an inverse opal structure enable efficient CO2 electrochemical reduction and sensitive in situ Raman characterization>, COA of Formula: Cl3H8InO4, the main research area is carbon dioxide electrochem reduction sensitivity inverse opal structure.

Conversion of CO2 into fuels and chems. via electroreduction has attracted significant interest. Via mesostructure design to tune the elec. field distribution in the electrode, it is demonstrated that the Cu-In alloy with an inverse opal (CI-1-IO) structure provides efficient electrochem. CO2 reduction and allows for sensitive detection of the CO2 reduction intermediates via surface-enhanced Raman scattering. The significant enhancement of Raman signals of the intermediates on the CI-1-IO surface can be attributed to elec. field enhancement on the “”hot edges”” of the inverse opal structure. Addnl., a highest CO2 reduction faradaic efficiency (FE) of 92% (sum of formate and CO) is achieved at -0.6 V vs. RHE on the CI-1-IO electrode. The diffuse reflectance IR Fourier transform spectroscopy (DRIFTS) results show that the Cu-In alloy with an inverse opal structure has faster adsorption kinetics and higher adsorption capacity for CO2. The “”hot edges”” of the bowl-like structure concentrate elec. fields, due to the high curvature, and also concentrate K+ on the active sites, which can lower the energy barrier of the CO2 reduction reaction. This research provides new insight into the design of materials for efficient CO2 conversion and the detection of intermediates during the CO2 reduction process.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Current density. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, COA of Formula: Cl3H8InO4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Yan; Wang, Zhenbo; Ding, Caifeng; Luo, Xiliang published the artcile< Ratiometric antifouling electrochemiluminescence biosensor based on bi-functional peptides and low toxic quantum dots>, Recommanded Product: Indium(III) chloride tetrahydrate, the main research area is quantum dot peptide antifouling electrochemiluminescence biosensor.

It is a great challenge to detect the target selectively and accurately in complex biol. samples. A ratiometric signal amplification strategy based on antifouling peptide is proposed to detect thrombin (TB) in this work. The electrode is modified with conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and Au@Luminol. Then the bi-functional peptide anchors to the modified electrode and captures the low toxic electrochemiluminescence (ECL) probe. The bi-functional peptide includes a new antifouling sequence (DRDRDRDR) and a TB recognizable sequence (SGRPVLG), while the former can greatly reduce the non-specific adsorption in complex samples and the latter can be cleaved by TB. The new self-enhanced luminescence probe labeled as PAMAM-QDs is composed of low toxic and water-soluble CuInZnS/ZnS quantum dots (CIZS/ZnS QDs) and polyamidoamine (PAMAM) via amide bonds. Concentration of TB can be obtained via the ratio of the signals of ECLQDs/ECLAu@Luminol accurately and sensitively. The ECL biosensor with the detection line 1.82 fM can work from 10 fM to 1 nM. Thanks to the antifouling property of the designed peptide and the amplification of the new ECL probe, the biosensor can be used for quantifying TB in practical complex samples with high selectivity and sensitivity.

Sensors and Actuators, B: Chemical published new progress about Bioelectric current, current-potential relationship. 22519-64-8 belongs to class chlorides-buliding-blocks, and the molecular formula is Cl3H8InO4, Recommanded Product: Indium(III) chloride tetrahydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Xiaohong; Liu, Xiaoguang; Martinez, Jenny S.; Mohr, Justin T. published the artcile< Practical regioselective halogenation of vinylogous esters: synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols>, Electric Literature of 42413-03-6, the main research area is regioselective halogenation vinylogous ester; synthesis differentiated haloresorcinol polyhalogenated resorcinol.

A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodol. to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications.

Tetrahedron published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (vinylogous). 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, Electric Literature of 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nishii, Yuji; Ikeda, Mitsuhiro; Hayashi, Yoshihiro; Kawauchi, Susumu; Miura, Masahiro published the artcile< Triptycenyl Sulfide: A Practical and Active Catalyst for Electrophilic Aromatic Halogenation Using N-Halosuccinimides>, COA of Formula: C4H4ClNO2, the main research area is arene triptycenyl sulfide catalyst electrophilic aromatic halogenation halosuccinimide regioselective; aryl halide preparation.

A Lewis base catalyst Trip-SMe (Trip = triptycenyl) for electrophilic aromatic halogenation using N-halosuccinimides (NXS) is introduced. In the presence of an appropriate activator (as a noncoordinating-anion source), a series of unactivated aromatic compounds were halogenated at ambient temperature using NXS. This catalytic system was applicable to transformations that are currently unachievable except for the use of Br2 or Cl2: e.g., multihalogenation of naphthalene, regioselective bromination of BINOL, etc. Controlled experiments revealed that the triptycenyl substituent exerts a crucial role for the catalytic activity, and kinetic experiments implied the occurrence of a sulfonium salt [Trip-S(Me)Br][SbF6] as an active species. Compared to simple dialkyl sulfides, Trip-SMe exhibited a significant charge-separated ion pair character within the halonium complex whose structural information was obtained by the single-crystal X-ray anal. A preliminary computational study disclosed that the π system of the triptycenyl functionality is a key motif to consolidate the enhancement of electrophilicity.

Journal of the American Chemical Society published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, COA of Formula: C4H4ClNO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kalani, Komal; Chaturvedi, Vinita; Trivedi, Priyanka; Tondon, Sudeep; Srivastava, Santosh Kumar published the artcile< Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents>, Application of C9H7ClO, the main research area is Mycobacterium dihydroartemisinin antitubercular agent; Anti-tubercular activity; Dihydroartemisinin; Semi-synthetic derivatives; Synergistic effect Artemisia annua; Tuberculosis..

Chem. transformation of dihydroartemisinin for anti-tubercular lead optimization. Dihydroartemisinin, a metabolite of artemisinin was chem. converted into eight acyl derivatives and were evaluated for anti-tubercular potential against H37Rv virulent strain of Mycobacterium tuberculosis by agar-based proportion assay. Further, synergistic activity of 12-O-m-anisoyl dihydroartemisinin was also studied with the front-line anti-TB drugs, isoniazid and rifampicin. Results: The results showed that all the derivatives were active but out of eight, 12-O-m-anisoyl dihydroartemisinin and 12-O-p-anisoyl dihydroartemisinin were significantly active (MIC 25.0μg/mL). In synergistic activity evaluation, the 12-O-m-anisoyl dihydroartemisinin derivative showed reduction in MIC (by 1/8th, i.e. 3.12μg/mL and that of rifampicin by 1/4th, i.e. 0.05μg/mL) with the front-line anti-TB drug, rifampicin. The sumfractional inhibitory concentration (Σ FIC) was 0.375. These results suggested a synergistic effect of the 12-O-m-anisoyl dihydroartemisinin with rifampicin and established its base for the development of anti-tubercular agents from an in-expensive and non-toxic natural product. To the best of our knowledge this is the first ever report on the anti-tubercular potential of dihydroartemisinin and its derivatives

Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about Mycobacterium tuberculosis. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application of C9H7ClO.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Harmsen, S.; Meijerman, I.; Beijnen, J. H.; Schellens, J. H. M. published the artcile< Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor>, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate, the main research area is pregnane X receptor cytochrome P450 3A4 colon adenocarcinoma anticancer.

Induction of cytochrome P 450 (CYP) 3A4, an enzyme that is involved in the biotransformation of more than 50% of all drugs, by xenobiotics is an important cause of pharmacokinetic drug-drug interactions in oncol. In addition to rifampicin and hyperforin, the anticancer drug paclitaxel has also been shown to be an inducer of CYP3A4 via activation of the pregnane X receptor (PXR). We therefore screened 18 widely used anticancer drugs for their ability to activate PXR-mediated CYP3A4 induction. A CYP3A4 reporter gene assay was employed to identify PXR agonists among the eighteen anticancer drugs. Subsequently CYP3A4 mRNA and protein expression following treatment with these PXR agonists was assessed. Finally, the effect of pre-treatment with these agents on the 1′-hydroxylation of midazolam (a specific CYP3A4 probe) was determined Paclitaxel, erlotinib, tamoxifen, ifosfamide, flutamide and docetaxel are able to activate PXR, while only strong PXR activation leads to significant induction of CYP3A4 activity. The identified PXR agonists may have the propensity to cause clin. relevant drug-drug interactions as a result of CYP3A4 induction.

Cancer Chemotherapy and Pharmacology published new progress about Antitumor agents. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Name: 2-(Bis(2-chloroethyl)amino)-1,3,2-oxazaphosphinane 2-oxide hydrate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Giorgianni, Giuliana; Nori, Valeria; Baschieri, Andrea; Palombi, Laura; Carlone, Armando published the artcile< Organocatalyzed Michael addition to nitroalkenes via masked acetaldehyde>, Reference of 5153-70-8, the main research area is nitroaldehyde preparation enantioselective; acetaldehyde nitroalkene Michael addition organocatalyst.

A novel and safe reaction protocol for the enantioselective enamine-catalyzed addition of acetaldehyde to nitroalkenes R1CH=CHNO2 (R1 = Bu, 4-chloropheny, 2-phenylethyl, etc.) is presented; this protocol makes use of a safe acetaldehyde precursor to access important intermediates R/S-R1CH(CH2C(O)H)CH2NO2 to Active Pharmaceutical Ingredients (APIs), and allows the use of fewer equivalent of acetaldehyde and lower catalyst loadings. The reaction developed proved to be suitable to be performed on gram-scale and to produce key intermediates, such as (R)-5-methyl-3-(nitromethyl)hexanal for the synthesis of pharmacol. active compounds such as pregabalin.

Catalysts published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (nitro). 5153-70-8 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClNO2, Reference of 5153-70-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Blazejewski, Jean Claude; Dorme, Regine; Wakselman, Claude published the artcile< Chlorous acid oxidation of trifluoromethylphenols: cyclopentenolones by benzilic acid ring contraction>, Formula: C7H4ClF3O, the main research area is oxidation fluoromethylphenol chlorous acid; chlorohydroxyoxotrifluoromethylcyclopentenecarboxylic acid preparation decarboxylation; cyclopentenecarboxylic acid chloro hydroxy oxo fluoromethyl; cyclopentanedione chloro fluoromethyl.

HClO2 oxidation of 2- and 3-F3CC6H4OH initially gives isolable (trifluoromethyl)cyclopentenecarboxylic acid I, which decarboxylates upon heating to give 2-chloro-2-(trifluoromethyl)-1,3-cyclopentanedione.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Oxidation. 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Formula: C7H4ClF3O.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics