Category: chlorides-buliding-blocks

Adouama, Cherif published the artcileRoom-Temperature and Transition-Metal-Free Intramolecular α-Arylation of Ketones: A Mild Access to Tetracyclic Indoles and 7-Azaindoles, SDS of cas: 145349-62-8, the publication is Organic Letters (2019), 21(1), 320-324, database is CAplus and MEDLINE.

A novel approach for the synthesis of tetracyclic indoles and 7-azaindoles is reported. The strategy involves four steps, with a fast rt intramol. α-arylation of ketones as key step. The reaction was inspected synthetically to achieve the synthesis of 11 novel tetracyclic structures with moderate to very good yields (39-85%). Theor. combined with exptl. studies led us to propose a probable polar mechanism (concerted S_NAr).

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kubyshkin, Vladimir published the artcileExploring hydrophobicity limits of polyproline helix with oligomeric octahydroindole-2-carboxylic acid, Synthetic Route of 42074-68-0, the publication is Journal of Peptide Science (2018), 24(4-5), n/a, database is CAplus and MEDLINE.

The polyproline-II helix is the most extended naturally occurring helical structure and is widely present in polar, exposed stretches and “unstructured” denatured regions of polypeptides. Can it be hydrophobic. In this study, we address this question using oligomeric peptides formed by a hydrophobic proline analog, (2S,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic). Previously, we found the mol. principles underlying the structural stability of the polyproline-II conformation in these oligomers, whereas the hydrophobicity of the peptide constructs remains to be examined Therefore, we investigated the octan-1-ol/water partitioning and inclusion in detergent micelles of the oligo-Oic peptides. The results showed that the hydrophobicity is remarkably enhanced in longer oligomeric sequences, and the oligo-Oic peptides with 3 to 4 residues and higher are specific towards hydrophobic environments. This contrasts significantly to the parent oligoproline peptides, which were moderately hydrophilic. With these findings, we have demonstrated that the polyproline-II structure is compatible with nonpolar media, whereas addnl. manipulations of the terminal functionalities feature solubility in extremely nonpolar solvents such as hexane.

Journal of Peptide Science published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Synthetic Route of 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Blaschette, Armand published the artcileVibrational spectra of some trimethyl-h9(and d9)-sulfoxonium halides, Formula: C3H9ClOS, the publication is Inorganic and Nuclear Chemistry Letters (1969), 5(8), 639-42, database is CAplus.

The ir and Raman spectra of Me3SO)X (X = Cl, Br, I) and [(CD3)3SO]X1 (X1 = Cl, I) are reported; assignment of the vibrational bands are given. The size of the anions has a definite yet slight influence on the positions of the ir bands. Similarly as with trimethylphosphine oxide and silanolate, the deuteration changes the character of several vibrations.

Inorganic and Nuclear Chemistry Letters published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tryniszewski, Michal published the artcileReductive Condensation of a Nitro Group with Carboxylic Acids Promoted by Phosphorus(III) Compounds: A Short Route to 5 H -Dibenzo[b,e][1,4]diazepin-11(10 H )-ones, HPLC of Formula: 60091-87-4, the publication is Synthesis (2020), 52(20), 3086-3094, database is CAplus.

Tributyl- or triphenylphosphine promoted a one-pot, three-step method for the synthesis of differently substituted dibenzodiazepinones such as I [R = H, n-Bu; R¹ = H, 8-Cl, 7-OMe, etc.; R² = 2-Me, 2-CN; Z = N, CH; Y = S, NCH, HCCH] from N-aryl-2-nitroanilines. Pyridine analogs I [R = H; R¹ = 9-Cl; R² = H; Z = CH; Y = NCH] and the corresponding thiazepinones could also be formed using this method. The process involved deoxygenation of the nitro group, then formation of an iminophosphorane intermediate and its intramol. condensation with a carboxyl group placed in the N-aryl group. The role of the carboxyl group in the formation of the iminophosphorane and the mode of cyclization were discussed.

Synthesis published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C12H17BO4S, HPLC of Formula: 60091-87-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tryniszewski, Michal published the artcileDirect Reductive Cyclocondensation of the Nitro Group with the Amido Group: Key Role of the Iminophosphorane Intermediate in the Synthesis of 1,4-Dibenzodiazepine Derivatives, Application of 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Journal of Organic Chemistry (2019), 84(4), 2277-2286, database is CAplus and MEDLINE.

A class of dialkylamino-substituted dibenzodiazepines and their hetero analogs was synthesized by the intramol. aza-Wittig condensation of the amido group with iminophosphoranes. The one-pot, two-step procedure includes reductive synthesis of the intermediate iminophosphoranes from the corresponding nitroamides and tributylphosphine.

Journal of Organic Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C12H17BO4S, Application of 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Price, Charles C. published the artcileHydrolysis and oxidation of mustard gas and related compounds in aqueous solution, Formula: C4H8Cl2S2, the publication is Journal of Organic Chemistry (1947), 238-48, database is CAplus and MEDLINE.

cf. following abstract The hydrolysis and oxidation of S(CH₂CH₂Cl)₂ (I) are studied to evaluate its hazard as a H₂O contaminant. To 400 cc. H₂O through which O containing O₃ is bubbled, 40 cc. Cellosolve containing 1.6 cc. I is added dropwise over a period of 1 hr. The solution is evaporated to dryness to give 53% OS(CH₂CH₂Cl)₂ (II), m. 105-8°. When to 100 cc. H₂O containing 0.25 mol. NaOCl, adjusted to pH 7.5, 25 cc. MeOH containing 2 cc. I is added, 57% II, m. 105-8°, is isolated. I and chloramine-T (III) give 83% N-(p-tolylsulfonyl) – S,S’ – bis(2-chloroethyl) sulfilimine, m. 139-42°. I and Halazone (p-HO₂CC₆H₄SO₂NCl₂) (IV) give 40% II, m. 104-7°. When II is shaken with NaHCO₃, Cl is very slowly split off. II and NaOCl in NaHCO₃-buffered solution give 37% O₂S(CH₂CH₂Cl)₂ (V), m. 54-6°. To 200 g. II in 7.5 l. H₂O, 4.5 l. 0.612 N NaOCl contg: 100 g. NaHCO₃ is added with stirring, and the mixture kept overnight and extracted exhaustively with CHCl₃. From the residue of the CHCl₃ extract (205 g.), 37 g. II, m. 103-7°, is filtered off. The filtrate is subjected to a rapid vacuum distillation, giving a distillate (VI), b₁ 73-145°, and leaving 30 g. residue from which 9 g. light tan crystals, m. 107-8°, are isolated. VI is fractionally distilled through a 12-in. column and the presence of OS(CH:CH₂)₂, b₁₆ 81°, n_D²⁰ 1.5100, O₂S(CH:CH₂)₂ (VII), b₁₆ 109°, n_D²⁰ 1.4782, CH₂:CHSOCH₂CH₂Cl, b₁₅ 126°, n_D²⁰ 1.5232, and CH₂:CHSO₂CH₂CH₂Cl, b₁₆ 143°, n_D²⁰ 1.4952, is indicated. V, after repeated crystallization from EtOH, m. 55-5.2° and dissolves in H₂O to 1.115%. When 10 g. V in 1 l. H₂O containing 16.8 g. NaHCO₃ is kept overnight and the mixture extracted 16 hrs. with ether, 1.6 g. VII, b₁₇ 110°, n_D²⁰ 1.4750, is isolated. O₂S(CH₂CH₂OH)₂ (VIII) could not be prepared according to Gilman and Beaber (C.A. 19, 1850) from S(CH₂CH₂OH)₂ (IX) and H₂O₂ in AcOH, as distillation of the reaction product gave thioxane sulfone (X), m. 129-30°, b₁ 130-40°. Following the method of Levin (C.A. 24, 4257), VIII, m. 54-5°, is obtained. Into a solution of 1.6 g. IX in 100 cc. H₂O, O containing 2.5% O₃ is passed at a rate of 200 cc./min. After 0.02 mol. O₃ has been introduced, 95% OS(CH₂CH₂OH)₂ (XI), m. 106-8°, is obtained. On further treatment of XI with O₃, VIII, m. 36-43°, is formed. When IX is treated with III, 50% XI, m. 108°, is obtained. IX and IV give 76% XI, m. 106-8°. IX and NaOCl at pH 7 give 60% XI. On treatment of IX with Cl, neutralizing the reaction mixture with NaHCO₃, evaporating to dryness in vacuo, and extracting with dioxane, X is obtained in good yield. For the detection of sulfonium salt [(HOCH₂CH₂)₂S⁺CH₂CH₂]₂S 2Cl^– (XII) in H₂O, a solution of 26 g. KI and 45 g. HgI₂ in 20 cc. H₂O is used. Addition of 0.02 cc. of this solution to 2 cc. of a solution of 10 g. XII in 1 l. H₂O causes a white cloudiness after 5-10 sec. Oxidation of 20 g. XII with 5.7 g. 30% H₂O₂ gives [(HOCH₂CH₂)₂S⁺CH₂CH₂]₂SO 2Cl^–, rosettes of needles, m. 63.5-5° (sealed tube). When XII is treated with III, 92% p-toluenesulfonamide, m. 133-4°, is formed. When 20 g. XII is treated with 17 g. 30% H₂O₂ and the mixture evaporated at room temperature, an oil is obtained which is dried in vacuo over P₂O₅. The oil does not crystallize and its aqueous solution gives a heavy oily precipitate (XIII) with KHgI₃. Assuming the composition of XIII to be XIIIa, the yield of XIII is 97%. Attempts to prepare crystalline salts of XIII with picric acid, etc., failed. When 1 g. IX is shaken with 3,5-(O₂N)₂C₆H₃COCl with dropwise addition of 0.7 g. NaOH in 10 cc. H₂O, bis[2-(3,5-dinitrobenzoxy)ethyl] sulfide, m. 161-2°, is formed; the corresponding sulfoxide, crystals from BuOH, m. 185-6°. Oxidation of 10 g. IX with an excess of 30% H₂O₂ according to G. and B. (cf. loc. cit.) and treating the resulting oil with Ac₂O give bis(2-hydroxyethyl) sulfone diacetate (XIV), b₂ 170-5°, in addition to a small amount of X, m. 130°. XIV is readily saponified Distillation of washed Levinstein mustard gas (XV) in vacuo gives 69.5% almost pure I, b₁ 59°, n_D²⁰ 1.5281, and 9% fairly pure (ClCH₂CH₂)₂S₂ (XVI) in addition to a small amount of dithiane, m. 110-11°. Distillation of 750 g. unwashed XV gives 432 g. I, b_0.13 57°, n_D²⁰ 1.5273-1.5278, of a yellow-brown color, in addition to some higher-boiling material. The decomposition of XV in H₂O and the Cl demand of XVI, (ClCH₂CH₂)₂S₃, and (ClCH₂CH₂)₂S₅ in aqueous solution with III are studied and the results given in tables.

Journal of Organic Chemistry published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kovtunyak, N. A. published the artcileEffect of decamethoxin, decamine and levorin on the content of cholesterol, phospholipids and triglycerides in the liver of white rats, Synthetic Route of 38146-42-8, the publication is Farmakologiya i Toksikologiya (Moscow) (1983), 46(5), 72-5, database is CAplus.

I.m. injection, of quaternary ammonium compounds (decamethoxin (I) [38146-42-8] and decamine  [522-51-0]) and levorin  [11014-70-3] changed the content of cholesterol  [57-88-5], phospholipids, and triglycerides in the liver of rats. Decamethoxin decreased the content of phospholipids and cholesterol and raised the concentration of triglycerides. Decamine decreased the level of phospholipids and raised the content of cholesterol and triglycerides, while levorin minimized the content of phospholipids, cholesterol, and triglycerides.

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kovtunyak, N. A. published the artcileEffect of decamethoxin, decamine and levorin on the content of carbohydrate-protein components in the connective tissue of the rat liver, Application In Synthesis of 38146-42-8, the publication is Farmakologiya i Toksikologiya (Moscow) (1980), 43(1), 88-91, database is CAplus.

Decamethoxin [38146-42-8] (0.5 mg/kg/day) injected i.m. into rats for 10 days increased the concentration of hexosamines and hexuronic acid [62446-36-0] in the liver. Decamine [522-51-0] (1.0 mg/kg/day) decreased the levels of hexosamines and hexoses. Levorin [1403-17-4] (1.0 mg/kg/day) decreased the biosynthesis of hydroxyproline [51-35-4] and hexosamine.

Farmakologiya i Toksikologiya (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Das, Arup Jyoti published the artcileSwitching of regioselectivity in base-mediated diastereoselective annulation of 2,3-epoxy tosylates and their N-tosylaziridine analogs with 2-mercaptobenzimidazole, HPLC of Formula: 7080-50-4, the publication is Organic & Biomolecular Chemistry (2020), 18(3), 441-449, database is CAplus and MEDLINE.

A base-mediated dinucleophilic cyclization of readily accessible 2,3-epoxy tosylates such as I with 2-mercaptobenzimidazole has been developed for the one-pot diastereoselective synthesis of benzimidazole-based tricyclic compounds such as II equipped with two stereogenic centers. With trans-substrates such as I bearing an aryl or alkyl substituent at the C3 position, the reaction involves an initial S-C1 bond-forming intermol. alkylation followed by an N-C3 bond-forming, endo-selective intramol. epoxide ring-opening cyclization reaction. A spectacular regioselectivity switching (tandem S-C3 and N-C1 bond formation reactions) was observed with related trans-N-tosylaziridine substrates III (R = H, F). Wide substrate scope, complete diastereoselectivity, high to complete regioselectivity and mild transition metal-free conditions render this protocol particularly efficient and practical.

Organic & Biomolecular Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, HPLC of Formula: 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ramazani, A. published the artcileIn silico analysis and development of anti-malarial compounds against dihydroorotate dehydrogenase using chem-bioinformatic tools, Category: chlorides-buliding-blocks, the publication is International Journal of Pharma and Bio Sciences (2011), 2(2), 122-131, database is CAplus.

Computational studies have been developed to unravel the mechanism of action of the anti-malarial drugs and to give guidelines for the development of new derivatives with improved efficiency. In this study, dihydroorotate dehydrogenase (DHOD), a key enzyme in de novo pyrimidine biosynthesis and the major source of electrons for the mitochondrial electron transport chain of intraerythrocytic malaria parasites, was selected as a target for potential inhibitors. Beginning with the natural inhibitors found in crystallographed mols. representing *.pdb file, a general similarity search were done in PDB, NCI and PUBMED databases resemble probable anti-malarial compounds This made it possible to dock these ligand libraries with DHOD by FlexX 3.2, 2007 software and comparing the inter-mol. interactions and scores which are given to them by the software. The highest absolute value of interactions energies were considered be the best and proper ligands. These ligands were used for second 95% similarity search in PUBCHEM for proposed anti-malarial compound which have the same mechanism as A26. As an interesting point among 400 found mols. was presence of quinolines. This could propose a new mechanism for these important anti-malarial agents.

International Journal of Pharma and Bio Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics