Category: chlorides-buliding-blocks

Carle, Joergen S. published the artcileDogger Bank itch. The allergen is (2-hydroxyethyl)dimethylsulfoxonium ion, Formula: C3H9ClOS, the publication is Journal of the American Chemical Society (1980), 102(15), 5107-8, database is CAplus.

The causative agent of Dogger Bank Itch, an allergic contact dermatitis caused by exposure to Alcyonidium gelatinosum, was characterized and synthesized. This allergen is (2-hydroxyethyl)dimethylsulfoxonium ion.

Journal of the American Chemical Society published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baj, Stefan published the artcileNew and efficient technique for the synthesis of ε-caprolactone using KHSO₅ as an oxidizing agent in the presence of a phase transfer catalyst, Quality Control of 23616-79-7, the publication is Applied Catalysis, A: General (2011), 395(1-2), 49-52, database is CAplus.

A new method for the synthesis of ε-caprolactone based on the Baeyer-Villiger oxidation of cyclohexanone was developed. In the proposed reaction, potassium peroxomonosulfate was used as an oxidizing agent under phase transfer catalysis conditions. The effects of the reaction parameters, including the type of phase transfer catalyst, the concentration of the oxidizing agent, the type of organic solvent and temperature, were investigated. When dichloromethane was used as an organic solvent and an adequate amount of water was added to the reaction mixture, the highest yield and selectivity for ε-caprolactone were achieved at 40°.

Applied Catalysis, A: General published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Quality Control of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Peng published the artcileNovel promising 4-anilinoquinazoline-based derivatives as multi-target RTKs inhibitors: Design, molecular docking, synthesis, and antitumor activities in vitro and vivo, Quality Control of 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2019), 27(20), 114938, database is CAplus and MEDLINE.

4-Anilinoquinazoline derivatives I [R = 2-OBn, 3-OBn, 4-OBn, 2-O(4-NO₂Bn), etc.; n = 0, 1, 2] were designed and synthesized using a binding model with multi-target receptor tyrosine kinases and assessed their antitumor activity against five human tumor cell lines (HepG2, A549, MCF-7, DU145, SH-SY5Y). The majority of the compounds inhibited the proliferation of all the cancer cell types, with some compounds displaying selective inhibition. Compounds I [R = 3-OBn, n = 0], I [R = 4-O(4-NO₂Bn), n = 0] and I [R = 2-OBn, n = 1] displayed IC₅₀ values of 7.588, 8.619 and 6.936μM, resp., for A549 cells, which were much lower than that of Gefitinib (14.803μM). Compound I [R = 3-O(4-CF₃Bn), n = 1] displayed an IC₅₀ value of 2.756μM for DU145 cells. The representative compound I [R = 3-O(4-CF₃Bn), n = 1] had unexceptionable broad-spectrum inhibition for all cancer cell types, and demonstrate inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived growth factor receptor beta (PDGFR-β), and epidermal growth factor receptor (EGFR) with IC₅₀ values of 46.4, 673.6 and 384.8 nM, resp., which were similar to those of Sorafenib for VEGFR-2 and PDGFR-β (140.6 and 582.7 nM, resp.). Mol. docking results supported the mol. level assay results. Data for production of reactive oxygen species and assessment of matrix metalloproteinase corroborated the strong anti-proliferative effect of compound I [R = 3-O(4-CF₃Bn), n = 1]. The compound also displayed robust antitumor efficacy and relativity lower toxicity in a xenograft model. These attributes were similar to those of Sorafenib.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H15NO, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fan, Ao published the artcilePhosphonium ionic liquids as highly thermal stable and efficient phase transfer catalysts for solid-liquid Halex reactions, SDS of cas: 350-30-1, the publication is Catalysis Today (2012), 198(1), 300-304, database is CAplus.

Trihexyl (tetradecyl) phosphonium tetrafluoroborate was found to be an active catalyst for the introduction of fluoride by nucleophilic aromatic substitution. With a decomposition temperature above 300 °C, this ionic liquid is suitable for reactions at high temperatures The addition of 1 mol% of the ionic liquid relative to KF increased the initial rate for the fluorination of 1,2-dichloro-4-nitrobenzene six-fold compared to the uncatalyzed reaction. The highest reaction rate was observed at 20 mol% ionic liquid relative to KF. Ease of handling without the need for stringent drying conditions and reuseability make this ionic liquid a useful phase transfer catalyst.

Catalysis Today published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, SDS of cas: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Curtis, Michael P. published the artcileThe discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattle, Quality Control of 864725-22-4, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(21), 5011-5014, database is CAplus and MEDLINE.

Hematobia irritans (horn fly) infestation in cattle is responsible for over a billion dollars a year in global economic loss due to decreased milk production and lower feed conversion. There is significant need for new insecticidal agents since current treatments such as organophosphates and pyrethroids suffer from field resistance. Isoxazoline oxime ethers represent a new class of γ-aminobutyric acid (GABA) receptor channel blockers which show good activity (LD⁹⁰ = 1.0 μg/mL) against horn flies in an in vitro feed assay and have demonstrated efficacy (>90% reduction at 1.0 mg/kg) as a topical treatment in a field study.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Quality Control of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qian, Bo published the artcileIron-Catalyzed Carboamination of Olefins: Synthesis of Amines and Disubstituted β-Amino Acids, SDS of cas: 1263414-46-5, the publication is Journal of the American Chemical Society (2017), 139(37), 13076-13082, database is CAplus and MEDLINE.

Intermol. carboamination of olefins with general alkyl groups is an unsolved problem. Diastereoselective carboamination of acyclic olefins represents an addnl. challenge in intermol. carboaminations. We have developed a general alkylamination of vinylarenes and the unprecedented diastereoselective anti-carboamination of unsaturated esters, generating amines and unnatural β-amino acids. This alkylamination is enabled by difunctional alkylating reagents and the iron catalyst. Alkyl diacyl peroxides, readily synthesized from aliphatic acids, serve as both alkylating reagents and internal oxidizing agents. A computational study suggests that addition of a nitrile to the carbocation is the diastereoselectivity-determining step, and hyperconjugation is proposed to account for the highly diastereoselective anti-carboamination.

Journal of the American Chemical Society published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, SDS of cas: 1263414-46-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Peng published the artcileChemoselective Borono-Catellani Arylation for Unsymmetrical Biaryls Synthesis, COA of Formula: C13H18BClO2, the publication is Organic Letters (2019), 21(9), 3323-3327, database is CAplus and MEDLINE.

In the presence of Pd(OAc)₂ and a norbornenedicarboxylate, arylpinacolboronates such as 2-methylphenyl pinacolboronate underwent chemoselective aerobic borono-Catellani reactions with aryl bromides such as Me 2-bromobenzoate and alkenes (including α,β-unsaturated esters) such as tert-Bu acrylate to yield unsym. biaryl alkenes such as biphenylpropenoate I. In the absence of alkene, a bromophenylcarbamate underwent coupling and cyclization with 2-naphthylpinacolboronate to yield a mixture of benzocarbazoles in 45% combined yield; a bromophenol underwent coupling without cyclization.

Organic Letters published new progress about 1030832-75-7. 1030832-75-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic acid and ester, name is 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C18H35NO, COA of Formula: C13H18BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Zhaomeng published the artcileFluoroform: an Efficient Precursor for the Trifluoromethylation of Aromatic Esters by Sodium Diisopropylamide with Trialkylamines, HPLC of Formula: 5860-95-7, the publication is European Journal of Organic Chemistry (2019), 2019(29), 4658-4661, database is CAplus.

The trifluoromethanide anion is the postulated key intermediate in nucleophilic trifluoromethylation reactions. It is believed to be incompatible with Na⁺ cation due to the strong Na-F bond. However, herein we demonstrate that it could be prepared for the first time. Trialkylamines can be used as cation chelating agents to stabilize the isolated ^–CF₃ ion to realize trifluoromethylation reaction. With this strategy, trifluoromethyl aromatic ketones could be effectively synthesized from fluoroform and aromatic esters with diisopropyl aminosodium (NaDA) and trialkylamines.

European Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, HPLC of Formula: 5860-95-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Xianfeng published the artcileDesign and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone Deacetylase 6 Inhibitors, Recommanded Product: Methyl 4-bromo-3-chlorobenzoate, the publication is Journal of Medicinal Chemistry (2015), 58(6), 2809-2820, database is CAplus and MEDLINE.

Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule dynamics and chaperone activities. There is growing interest in identifying HDAC6-selective inhibitors as chem. biol. tools and ultimately as new therapeutic agents. Herein we report the design, synthesis, and phenotypic screening of a novel class of 3-aminopyrrolidinone-based hydroxamic acids as HDAC6 inhibitors. In particular, the α-methyl-substituted enantiomer I (3-S) showed significant in-cell tubulin acetylation (Tub-Ac) with an EC₅₀ of 0.30 μM but limited impact on p21 levels at various concentrations In enzyme inhibition assays, I demonstrated high selectivity for HDAC6 with an IC₅₀ of 0.017 μM and selectivity indexes of 10 against HDAC8 and over 4000 against HDAC1-3 isoforms. Moreover, I has suitable drug metabolism and pharmacokinetics properties compared with other hydroxamic acid-based HDAC inhibitors, warranting further biol. studies and development as a selective HDAC6 inhibitor.

Journal of Medicinal Chemistry published new progress about 117738-74-6. 117738-74-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Ester, name is Methyl 4-bromo-3-chlorobenzoate, and the molecular formula is C8H6BrClO2, Recommanded Product: Methyl 4-bromo-3-chlorobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Xiaoguang published the artcileCopper-Catalyzed γ-Sulfonylation of α,β-Unsaturated Carbonyl Compounds by Means of Silyl Dienol Ethers, Computed Properties of 21286-54-4, the publication is Organic Letters (2015), 17(14), 3572-3575, database is CAplus and MEDLINE.

γ-Sulfonyl-α,β-unsaturated ketones such as I [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr; R² = H] were prepared regioselectively by reaction of dienyl silyl ethers such as II (TBDMS = tert-butyldimethylsilyl) with sulfonyl chlorides RSO₂Cl [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr] in the presence of CuCl in MeCN. Selected sulfonylated unsaturated ketones underwent regioselective alkylation and Michael addition reactions and cyclocondensations to yield products such as I (R = Ph; R² = Me, MeO₂CCH₂CH₂).

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics