Category: chlorides-buliding-blocks

Su, Yuan-Hsiao published the artcileSolution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries, Synthetic Route of 33697-81-3, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(5), 1320-1324, database is CAplus and MEDLINE.

The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid Bu amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs, e.g. I, II and III, were found to have a good anti-tumor activity comparable to cisplatin.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C14H12N2S, Synthetic Route of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Arakawa, Yukihiro published the artcileAsymmetric transfer hydrogenation of aromatic ketones in water using a polymer-supported chiral catalyst containing a hydrophilic pendant group, Computed Properties of 23616-79-7, the publication is Advanced Synthesis & Catalysis (2008), 350(14+15), 2295-2304, database is CAplus.

Hydrophilic polymers having pendant groups of carboxylates or sulfonates have been used as a polymer support for chiral 1,2-diamine monosulfonamides. The polymeric chiral complex prepared from the polymer-supported chiral ligand with ruthenium dichloride p-cymene was used in the asym. transfer hydrogenation of prochiral ketones in water. The balance between hydrophilicity and hydrophobicity of the polymer support influenced both the reactivity and the enantioselectivity of the reaction in water. The chiral polymeric complex having a quaternary ammonium salt structure as the pendant group worked well in water. In most cases the polymer-supported catalyst having a quaternary ammonium sulfonate pendant group showed superior enantioselectivity compared to the corresponding nonsupported model catalyst in the solution system. The polymeric catalysts can be reused without loss of catalytic activity.

Advanced Synthesis & Catalysis published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Computed Properties of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vilceanu, R. published the artcileStructure-activity correlations for the toxicity of organic phosphorus compounds of the Schrader type, Quality Control of 866-23-9, the publication is Analele Universitatii din Timisoara, Stiinte Fizice-Chimice (1977), 15(1), 61-77, database is CAplus.

The toxicity in mice of 71 phosphororg. compounds of the Schrader type, R¹R²PO₂R³, was correlated with parameters for intermol. forces [number of atoms with lone electron pairs (HA), molar refractions (R), Hammett constants of the R³ groups (H), number of aromatic cycles (AR), electron attracting character in charge transfer (CT)] and minimal steric difference (MSD), with respect to acetylcholine. The best linear correlational equation obtained (71 compounds, 6 parameters) was: A = 0.555 + 0.476(HA)-0.017(R) + 0.343(H)-0.402(AR) + 0.611(CT)-0.063(MSD), where A = -lgLD₅₀. This correlation was obtained for a very wide range of chem. structures with the R¹, R² and R³ groups.

Analele Universitatii din Timisoara, Stiinte Fizice-Chimice published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C3H6O2, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Garcia-Barrantes, Pedro M. published the artcileLead optimization of the VU0486321 series of mGlu₁ PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs, Recommanded Product: 3-Chloro-4-fluoronitrobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(8), 1869-1872, database is CAplus and MEDLINE.

This Letter describes the further lead optimization of the VU0486321 series of mGlu₁ pos. allosteric modulators (PAMs), focused on addressing the recurrent issue of plasma instability of the phthalimide moiety. Here, the authors evaluated a number of phthalimide bioisosteres, and ultimately identified isoindolinones as the ideal replacement that effectively address plasma instability, while maintaining acceptable mGlu₁ PAM potency, DMPK profile, CNS penetration and mGluR selectivity.

Bioorganic & Medicinal Chemistry Letters published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Recommanded Product: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, Ho-Taek published the artcileSurface Modulation of Magnetic Nanocrystals in the Development of Highly Efficient Magnetic Resonance Probes for Intracellular Labeling, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of the American Chemical Society (2005), 127(28), 9992-9993, database is CAplus and MEDLINE.

High-quality biocompatible magnetic iron oxide (Fe₃O₄) nanocrystals were developed through a ligand exchange process of hydrophobically capped nanocrystals with hydrophilic mols. By simple modulation of the nanocrystal surface ligand charge properties, the authors have been able to prepare magnetic nanocrystals with excellent intracellular labeling capabilities that efficiently label a variety of cell types without the need for addnl. transport facilitating agents. The excellent intracellular labeling capability of the newly developed cationic WSIO has further led to successful MRI monitoring of the migration of neural stem cells in rat spinal cord. The magnetic nanocrystals developed here have great potential in applications for labeling of various cell types and also the monitoring of cell-based medical treatments and cancer metastasis.

Journal of the American Chemical Society published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C2H3N3, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kucherenko, Ludmila published the artcileTheoretical study of the possibility of decamethoxin complexes with thiotriazoline to be formed, COA of Formula: C38H74Cl2N2O4, the publication is ScienceRise: Pharmaceutical Science (2021), 37-42, database is CAplus.

Over the last decade, much attention has been paid to the prevention and treatment of chronic diseases of the oral mucosa. This is primarily due to the increase in the number of patients who seek dental care for diseases of the oral muco-sa (DOM). Currently, due to the lack of special epidemiol. studies, information on the pathol. of the oral mucosa in the literature is almost non-existent. The etiol. and pathogenesis have not been definitively elucidated. It is established that a significant role in the pathogenesis of chronic inflammatory processes belongs to the state of the microbiocenosis of the oral mucosa. One of the most striking examples of domestic drugs of the antioxidant group is thiotriazoline, developed by the staff of the NGO ‘Pharmatron’, as well as specialists of the Department of Pharmaceutical Chem. of Zaporozhye State Medical University under the leadership of professor Mazur I. This drug has an antioxidant and membrane-stabilizing effect. The combined use of several drugs can be complicated by the formation of their supramol. complexes. Therefore, before the introduction of several substances in it is necessary to model the possibility of intermol. interactions between them. For this purpose, methods of quantum chem. are used. We examined the structures and energy characteristics of the complexes, formed thiotriazoline and decamethoxin, also carried out anal. and established at what temperature the formation of a substance from two active components was possible. As a result, the probability of the formation of intermol. hydrogen bonds is reduced, which is very well seen in the trend of interactions between acid and morpholine. Quantum chem. study of a two-component system consisting of thiotriazoline and decamethoxine showed that the most energetically advantageous three-component complexes have a sufficiently low interaction energy of thiotriazoline and decamethoxine. In addition, the data that are provided in the anal. of the tree diagram suggest that in the technol. process in the manufacture of dosage forms, it is advisable to use a temperature not higher than 115°C.

ScienceRise: Pharmaceutical Science published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Miller, Susanne L. published the artcileC-H Borylation Catalysts that Distinguish Between Similarly Sized Substituents Like Fluorine and Hydrogen, Related Products of chlorides-buliding-blocks, the publication is Organic Letters (2019), 21(16), 6388-6392, database is CAplus and MEDLINE.

By modifying ligand steric and electronic profiles it is possible to C-H borylate ortho or meta to substituents in aromatic and heteroaromatic compounds, where steric differences between accessible C-H sites are small. Dramatic effects on selectivities between reactions using B₂pin₂ or 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (HBpin) are described for the 1st time. Judicious ligand and borane combinations give highly regioselective C-H borylations on substrates where typical borylation protocols afford poor selectivities.

Organic Letters published new progress about 765917-27-9. 765917-27-9 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronate Esters, name is 2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C12H15BClFO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ni, Nanting published the artcileInhibition of quorum sensing in Vibrio harveyi by boronic acids, Safety of (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, the publication is Chemical Biology & Drug Design (2009), 74(1), 51-56, database is CAplus and MEDLINE.

Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chems. called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathol. relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. Here, the authors describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC₅₀ values in the low to sub-micromolar range in whole cell assays.

Chemical Biology & Drug Design published new progress about 1072952-42-1. 1072952-42-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, Safety of (5-Chloro-2-fluoro-4-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jahan, Humera published the artcileAnthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes, Computed Properties of 60091-87-4, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2018), 14(5), 516-523, database is CAplus and MEDLINE.

Anthranilic acid derivatives are important pharmacophores in drug discovery. Several of them are currently being used, such as mefenamic acid and meclofenamates, possess analgesic, anti-inflammatory and antipyretic activities. Some anthranilic acid-based scaffolds have also been reported for the management of metabolic disorders. The aim of the current study was to investigate the antiglycation potential of 2-anilino benzoic acid derivatives against (N-phenylanthranilic acid) fructose- human serum albumin (HSA) glycation. The study also analyzed the effects of newly identified antiglycation inhibitors on AGEs-mediated intracellular reactive oxygen species production, and associated impaired proliferation of the hepatocytes. The present study focuses on the antiglycation activity of 2- anilinobenzoic acid derivatives 1-18 in in-vitro human serum albumin (HSA)- fructose model. These derivatives were also identified as non-toxic to 3T3 mouse fibroblast cell-line using metabolic assay. The effect of the most promising derivative 1, 2- (2, 4- dinitroanilino)benzoic acid, was studied in a dose dependent manner, co-incubated with fructose-derived AGEs (0- 200 μg/mL), on rat hepatocytes proliferation and associated intracellular generation of ROS via MTT assay and DCFH-DA technique, resp. We found that derivative 1 ameliorates the elevated intracellular oxidative stress and associated diminished proliferation of the hepatocytes in response to AGEs. In conclusion, we identify novel 2- anilino benzoic acid derivatives as antiglycation agents through in-vitro and cellular-based models.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Computed Properties of 60091-87-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wall, Joseph S. published the artcileSpectrophotometric determination of betaines and other quaternary compounds as their periodides, HPLC of Formula: 6249-56-5, the publication is Anal. Chem. (1960), 870-4, database is CAplus.

The method of Appleton, et al. (CA 48, 3437a), for the determination of choline, through the absorbance of its periodide at 365 mμ, was modified for the determination of other quaternary N compounds (e.g. betaine, trigonelline, carnitine, stachydrine, and γ-butyrobetaine) as each was separated from an extract of corn grain by ion-exchange chromatography (cf. following abstract). Certain N compounds (such as nicotinic acid, histidine, adenine, and thiamine), which give precipitates with I, may occur in some eluates but they do not interfere in this method. As many as 50 tubes of anal. samples containing 10-100 γ of a compound can be handled. The roles of pH, I concentration, temperature, time, and presence of chloride ions on the yield of the isolated periodide were studied.

Anal. Chem. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C4Br2N2O4S, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics