Category: chlorides-buliding-blocks

Lei, Ying-jie published the artcileUltrasound assisted synthesis and antibacterial activity of 4-(coumarin-3-yl)-2-arylaminothiazoles, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2018), 40(6), 518-522, 588, database is CAplus.

In this work, 3-(2-bromoacetyl)-2H-chromen-2-ones prepared from 3-acetyl coumarins with tetrabutylammonium tribromide on bromination were used as the raw material. An efficient approach toward the synthesis of 4-(coumarin-3-yl)-2-arylaminothiazoles was carried out by the reaction of the starting compounds with certain Ph thioureas in presence of PEG-400 under ultrasound irradiation at a frequency of 40 kHz in 20âˆ?0 min, with a yield of 81.6%âˆ?3.0%. The structures of target compounds were confirmed by IR, ¹HNMR, ¹³CNMR, MS and elemental anal. Preliminary bioassay results showed that some of them have certain antibacterial activities against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. This method is operationally simple and environmentally benign and the solvent could be reused for several times.

Huaxue Shiji published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Shan published the artcileRegioselective Sulfonylvinylation of the Unactivated C(sp³)-H Bond via a C-Centered Radical-Mediated Hydrogen Atom Transfer (HAT) Process, HPLC of Formula: 21286-54-4, the publication is Organic Letters (2019), 21(12), 4837-4841, database is CAplus and MEDLINE.

Given the similarity of multiple sp³ C-H bonds in electronic properties and bond dissociation energy (BDE), regioselective sp³ C-H bond functionalization remains a paramount challenge. Here, the authors report a C-centered radical-mediated approach for site-specific sulfonylvinylation of the C(sp³)-H bond via the hydrogen atom transfer (HAT) process. The reaction features mild conditions, broad substrate scope, and high regioselectivity and stereoselectivity, manifesting the nontrivial synthetic potential.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C9H9NO6S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Guan-Wu published the artcileMechanochemical aminochlorination of electron-deficient olefins with chloramine-T promoted by (diacetoxyiodo)benzene, Name: Sodium chloro(tosyl)amide trihydrate, the publication is Advanced Synthesis & Catalysis (2007), 349(11+12), 1977-1982, database is CAplus.

A direct and convenient procedure for the solvent-free mechanochem. aminochlorination of electron-deficient olefins promoted by (diacetoxyiodo)benzene [PhI(OAc)₂] was described using com. available and cheap chloramine-T as a nitrogen and chlorine source. The vicinal chloramine derivatives were obtained in high regio- and stereoselectivity with good yields. PhI(OAc)₂ was superior to metal salts for the aminochlorination of electron-deficient olefins.

Advanced Synthesis & Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C10H10O2, Name: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Bin published the artcileGold(I)-Coordination Triggered Multistep and Multiple Photochromic Reactions in Multi-Dithienylethene (DTE) Systems, Computed Properties of 219537-97-0, the publication is Inorganic Chemistry (2012), 51(3), 1933-1942, database is CAplus and MEDLINE.

The preparation, characterization, and photochromic properties of a mononuclear Au(I) complex (100) with two identical DTE-acetylides and a dinuclear Au(I) complex (2000) with both DTE-acetylide and DTE-diphosphine are described. Both Au(I) complexes exhibit multistep and multiple photocyclization/cycloreversion reactions. Particularly, four-state and four-color photochromic switch is successfully achieved for the dinuclear Au(I) complex upon irradiation with appropriate wavelengths of light. In contrast, fully ring-closed form is unattained through multiple photocyclization for the two corresponding model organic compounds coupling with the same DTE units as Au(I) complexes but without Au(I)-participation. It is demonstrated that coordination of Au(I) ion to DTE-acetylides exerts indeed a crucial role in achieving stepwise and selective photocyclization and cycloreversion reactions for both Au(I) complexes, in which the coordinated Au(I) atom acts as an effective “barrier” to prohibit intramol. energy transfer between multi-DTE moieties.

Inorganic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gale, Douglas J. published the artcileFiber-reactive polymethine dyes containing the N-2,3-dibromopropionyl and N-chlorodifluoropyrimidyl groups, COA of Formula: C3H3Br2ClO, the publication is Textile Research Journal (1978), 48(9), 548-50, database is CAplus.

Treatment of 5-amino-1,3,3-trimethyl-2-methyleneindoline [6872-05-5] with 2,3-dibromopropionyl chloride [18791-02-1] or 5-chloro-2,4,6-trifluoropyrimidine [697-83-6] gives I (R = CH₂BrCHBrCO) [68699-06-9] and I (R = A) [68699-07-0], which are treated with 4-(dimethylamino)benzaldehyde [100-10-7], 4-[(2-chloroethyl)methylamino]benzaldehyde [94-31-5], or 1-methyl-2-phenylindole-3-carboxaldehyde [1757-72-8] to give 6 polymethine dyes. The lightfastness of the dyes on wool was significantly greater than that of the corresponding N-chloroacetyl and parent nonreactive dyes. Attempts to prepare the corresponding 2,4-dichloro-s-triazinyl derivative were unsuccessful.

Textile Research Journal published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, COA of Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bhhatarai, Barun published the artcileEvaluation of TOPKAT, Toxtree, and Derek Nexus in Silico Models for Ocular Irritation and Development of a Knowledge-Based Framework To Improve the Prediction of Severe Irritation, Formula: C6H3ClFNO2, the publication is Chemical Research in Toxicology (2016), 29(5), 810-822, database is CAplus and MEDLINE.

Assessment of ocular irritation is an essential component of any risk assessment. A number of (Q)SARs and expert systems have been developed and are described in the literature. Here, the authors focus on three in silico models (TOPKAT, BfR rulebase implemented in Toxtree, and Derek Nexus) and evaluate their performance using 1644 inhouse and 123 European Center for Toxicol. and Ecotoxicol. of Chems. (ECETOC) compounds with existing in vivo ocular irritation classification data. Overall, the in silico models performed poorly. The best consensus predictions of severe ocular irritants were 52 and 65% for the inhouse and ECETOC compounds, resp. The prediction performance was improved by designing a knowledge-based chem. profiling framework that incorporated physicochem. properties and electrophilic reactivity mechanisms. The utility of the framework was assessed by applying it to the same test sets and three addnl. publicly available in vitro irritation data sets. The prediction of severe ocular irritants was improved to 73-77% if compounds were filtered on the basis of AlogP_MR (hydrophobicity with molar refractivity). The predictivity increased to 74-80% for compounds capable of preferentially undergoing hard electrophilic reactions, such as Schiff base formation and acylation. This research highlights the need for reliable ocular irritation models to be developed that take into account mechanisms of action and individual structural classes. It also demonstrates the value of profiling compounds with respect to their chem. reactivity and physicochem. properties that, in combination with existing models, results in better predictions for severe irritants.

Chemical Research in Toxicology published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grabarczyk, Malgorzata published the artcileHydroxy lactones with the gem-dimethylcyclohexane system – Synthesis and antimicrobial activity, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Arabian Journal of Chemistry (2019), 12(8), 2280-2288, database is CAplus.

Two new lactones comprising the gem-dimethylcyclohexane ring: 2-chloro-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one and 2-bromo-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one as well as the already known 2-iodo-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one, were obtained from (6,6-dimethylcyclohex-2-en-1-yl)acetic acid. These lactones were used as substrates for the screening of biotransformation by whole cells of nine fungal strains (Fusarium species, Syncephalastrum racemosum and Cunninghamella japonica). Some of these microorganisms (mainly Fusarium species) transformed all three lactones during the hydrolytic dehalogenation into 2-hydroxy-5,5-dimethyl-9-oxabicyclo[4.3.0]nonan-8-one. It is worth noting that two microorganisms (Fusarium culmorum and Fusarium scirpi) converted iodolactone with very high enantioselectivity (75.1% and 91.6%, resp.). The (+) isomer of hydroxy lactone was preferred. At the last step the hydroxy lactone obtained during biotransformation was examined for its biol. activity against bacteria, yeasts and fungi. It was found that this compound inhibits growth of some tested microorganisms.

Arabian Journal of Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nasim, Muhammad Jawad published the artcilePronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria, SDS of cas: 620-20-2, the publication is New Journal of Chemistry (2019), 43(15), 6021-6031, database is CAplus.

Selenocyanates represent an interesting class of organic selenium compounds Due to their similarity with better known natural (iso-)thiocyanates, they promise high biol. activity and may also be metabolized to other reactive selenium species (RSeS), such as selenols, diselenides, and seleninic acids. Thirteen arylmethyl selenocyanates were synthesized and evaluated for potential antimicrobial, nematicidal, and cytotoxic activity. The compounds exhibit pronounced antimicrobial activity against various strains of Gram-pos. and Gram-neg. bacteria and yeasts, including multidrug resistant strains. The results obtained so far demonstrate that these arylmethyl selenocyanates are also non-mutagenic and have limited cytotoxicity against human cells. Here, benzyl selenocyanate represents the most active anti-ESKAPE agent, with potent activity against multidrug resistant MRSA strains (HEMSA 5) with a competitive MIC value of just 0.76 μg/mL (3.88 μM), whereas it exhibits low(er) cytotoxicity (IC₅₀ = 31 μM) and no mutagenicity against mammalian cells. Due to this selective antimicrobial activity, aromatic selenocyanates may provide an interesting lead in the development of antimicrobial agents, particularly in the context of drug resistance.

New Journal of Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mazurek, M. published the artcileCapillary gas chromatography-atomic emission spectroscopy-mass spectrometry analysis of sulfur mustard and transformation products in a block recovered from the Baltic Sea, Application of 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Chromatography A (2001), 919(1), 133-145, database is CAplus and MEDLINE.

A block of yperite recovered from the Baltic Sea was analyzed by gas chromatog. coupled with at. emission spectrometry and mass spectrometry. In the samples of the block �0 compounds were detected, out of which 30 were identified. The identification of the compounds was performed using the element chromatograms of the studied compounds, and the data obtained by mass spectrometric detection. Thiodiglycol was not found among the compounds in the studied block. The calculations of the contents of S mustard and some products in the block were performed by an external calibration method using bis(2-chloroethyl) sulfide as the standard A satisfactory precision of elements determinations was obtained (RSD 4.4-14.3%).

Journal of Chromatography A published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Application of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mazurek, Mariusz published the artcileGC-MS identification of sulfur mustard transformation products in a mustard block retrieved from the Baltic Sea, Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Biuletyn Wojskowej Akademii Technicznej (2000), 49(8), 89-100, database is CAplus.

The mustard block retrieved from the Baltic Sea has been analyzed using gas chromatog. coupled with mass spectrometry. The mass spectra of the examined samples were determined using electron ionization. In the mustard block have been detected about 36 compounds and 20 of which were identified. Among the identified compounds no thiodiglycols has been detected, which is the main product of sulfur mustard hydrolysis.

Biuletyn Wojskowej Akademii Technicznej published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics