Category: chlorides-buliding-blocks

Li, Xiao-Juan published the artcileConvenient and efficient decarboxylative aldol reaction of malonic acid half esters with trifluoromethyl ketones, Formula: C8H4ClF3O, the publication is Tetrahedron Letters (2012), 53(16), 2117-2120, database is CAplus.

A convenient and efficient decarboxylative ketone aldol condensation of malonic acid half esters was reported. In the presence of catalytic amount of triethylamine, a series of aromatic and alkyl trifluoromethyl ketones were transformed into the desired adducts in 61-99% yields. In a preliminary experiment, a moderate stereoselectivity was obtained. Direct reduction of the aldol product with LiAlH₄ afforded trifluoromethylated 1,3-diol.

Tetrahedron Letters published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Formula: C8H4ClF3O.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Zhen published the artcileChiral derivatives of covalent organic framework TpBD (NH₂)₂ used as stationary phases in gas chromatography, Product Details of C10H15ClO3S, the publication is Chirality (2022), 34(3), 462-472, database is CAplus and MEDLINE.

Chiral covalent organic framework materials have many excellent properties, which have received much attention in the field of separation Synthesized the covalent organic framework COF-TpBD (NH₂)₂ modified, resp., by L-valine trifluoroacetyl derivative, L-hydroxyproline, and (1S)-(+)-10-camphorsulfonyl chloride, three capillary columns of chiral covalent organic framework materials were obtained for gas chromatog. Those columns are able to sep. some chiral compounds, positional isomers, n-alkanes, n-alcs., aromatic hydrocarbon mixture, and Grob’s reagents. They are complementary to other chiral capillary columns and are possible for potential applications.

Chirality published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C4H4N2O2, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gao, Donghong Amy published the artcileSAR studies of non-zinc-chelating MMP-13 inhibitors: Improving selectivity and metabolic stability, Quality Control of 6313-54-8, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(17), 5039-5043, database is CAplus and MEDLINE.

SAR studies to improve the selectivity and metabolic stability of a class of recently discovered MMP-13 inhibitors are reported. Improved selectivity was achieved by modifying interactions with the S1′ pocket. Metabolic stability was improved through reduction of inhibitor lipophilicity. This translated into lower in vivo clearance for the preferred compound

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Quality Control of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kong, Xianqiang published the artcileManganese-Catalyzed ortho-C-H Amidation of Weakly Coordinating Aromatic Ketones, Product Details of C10H15ClO3S, the publication is Organic Letters (2018), 20(15), 4495-4498, database is CAplus and MEDLINE.

An efficient manganese-catalyzed ortho-C-H amidation of weakly coordinating aromatic ketones using the readily available sulfonyl azide as the amination reagent is developed. The key step is the ketone directed aromatic metalation using the in situ generated reactive Mn intermediate, MnMe(CO)₅. This method offers excellent chem. yields, high regioselectivities, and good functional group tolerance.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Product Details of C10H15ClO3S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, W. published the artcileMicroscopic and Macroscopic Characterization of Organosilane-Functionalized Nanocrystalline NaZSM-5, Computed Properties of 14799-93-0, the publication is Langmuir (2005), 21(15), 7009-7014, database is CAplus and MEDLINE.

Nanocrystalline NaZSM-5 zeolites with systematically varied particle sizes (15, 60, and 200 nm) were functionalized with organosilanes. Through the systematic variation of particle size and therefore external surface area of NaZSM-5, the extent of functionalization and location of functional groups were spectroscopically verified. ²⁹Si magic-angle spinning (MAS) NMR and Fourier transform IR (FTIR) spectroscopy provided conclusive evidence that the silanol groups located on the external surface of NaZSM-5 were functionalized through reaction with the organosilanes. The ²⁹Si NMR results provided quant. information about the extent of functionalization on NaZSM-5. A nitroxide spin label was adsorbed on the external surface of NaZSM-5 to probe the surface properties by ESR (EPR) spectroscopy. The macroscopic and microscopic properties, such as the behavior of functionalized NaZSM-5 in different solvents, and the sp. surface areas were also investigated. The hydrophobicity of the functionalized NaZSM-5 was found to increase relative to the parent NaZSM-5 as expected for an organic surface coating.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C12H16N2O2, Computed Properties of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gauthier, S. published the artcileThe effect of phase-transfer catalysts on polysilane formation, Quality Control of 14799-94-1, the publication is Macromolecules (1989), 22(5), 2213-18, database is CAplus.

Polysilanes are most often prepared by a Wurtz-type coupling of organodichlorosilanes with Na in refluxing PhMe. The addition of a catalytic amount of crown ether to the reaction mixture increases the rate of disappearance of the monomer with increasing crown ether concentration, suggesting that anionic species are involved in the polymerization mechanism. Higher yields of polymer relative to cyclic material were obtained, and the polymer displays a monomodal distribution. The presence of cryptand has similar effects although some degradation of the polymer upon continued refluxing of the reaction mixture was observed Degradation experiments on poly(n-hexylmethylsilane) with Na in refluxing PhMe showed that the polymer degraded to cyclics in a few minutes with cryptand but not with crown ether.

Macromolecules published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Quality Control of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gauthier, Sylvie published the artcileMechanistic studies of polysilane polymerization, Synthetic Route of 14799-94-1, the publication is Advances in Chemistry Series (1990), 299-307, database is CAplus.

The mechanisms and kinetics of condensation polymerization of dialkyldichlorosilanes were studied. The reactivities of the monomers were different under either concurrent or consecutive monomer addition Block copolymers were formed by sequential addition of monomers to polymer systems. Relative rates of monomer consumption were MePhSiCl₂ > hexylmethyldichlorosilane > Me₂SiCl₂ >> vinylmethyldichlorosilane; relative rates of monomer consumption during copolymerization were in a different order. General schemes were suggested for the reaction pathways, but the kinetics of the reaction were very complex; a kinetic scheme could not be derived.

Advances in Chemistry Series published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Synthetic Route of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jichao published the artcileHexamethyldisilazane Lithium (LiHMDS)-Promoted Hydroboration of Alkynes and Alkenes with Pinacolborane, Application of 4-Chloro-3-fluorostyrene, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Lithium-promoted hydroboration of alkynes and alkenes using com. available hexamethyldisilazane lithium as a precatalyst and HBpin as a hydride source has been developed. This method will be appealing for organic synthesis because of its remarkable substrate tolerance and good yields. Mechanistic studies revealed that the hydroboration proceeds through the in situ-formed BH₃ species, which acts to drive the turnover of the hydroboration of alkynes and alkenes.

Journal of Organic Chemistry published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Application of 4-Chloro-3-fluorostyrene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jing published the artcileMultifunctional Mesoporous Silica Nanoparticles Based on Charge-Reversal Plug-Gate Nanovalves and Acid-Decomposable ZnO Quantum Dots for Intracellular Drug Delivery, Application of 2-Chlorotrityl chloride, the publication is ACS Applied Materials & Interfaces (2015), 7(48), 26666-26673, database is CAplus and MEDLINE.

A novel type of pH-responsive multifunctional mesoporous silica nanoparticle (MSN) was developed for cancerous cells drug delivery and synergistic therapy of tumor. MSNs were covered with a kind of cell-penetrating peptide, deca-lysine sequence (K₁₀), to enhance their escape from the endosomes. After K₁₀‘s primary amines were reacted with citraconic anhydride to form acid-labile β-carboxylic amides, zinc oxide (ZnO) quantum dots (QDs) were introduced to cap MSNs via electrostatic interaction. The obtained ZnO@MSN drug-delivery system (DDS) achieves “zero-premature” drug release under a physiol. environment. However, once the DDS is transferred to the cancerous cells’ acidic endosome, ZnO QDs would rapidly dissolve and the acid-labile amides on the side chain of K₁₀ would hydrolyze to regenerate primary amines, resulting in the uncapping of MSNs and exposure of the cell-penetrating peptide K₁₀. The regenerated K₁₀ could help the DDS escape from the endosome and efficiently release the loaded drugs inside the cells. At the meantime, because of the cytotoxicity of ZnO QDs at their destination, the ZnO@MSN DDS may achieve a synergistic antitumor effect to improve the therapeutic index.

ACS Applied Materials & Interfaces published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C4H6O3, Application of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jing, Lanlan published the artcileIdentification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries, Safety of 3-Chlorobenzylchloride, the publication is European Journal of Medicinal Chemistry (2019), 111696, database is CAplus and MEDLINE.

Cell division cycle 25 (Cdc25) protein phosphatases play key roles in the transition between the cell cycle phases and their association with various cancers has been widely proven, which makes them ideal targets for anti-cancer treatment. Though several Cdc25 inhibitors have been developed, most of them displayed low activity and poor subtype selectivity. Therefore, it is extremely important to discover novel small mol. inhibitors with potent activities and significant selectivity for Cdc25 subtypes, not only served as drugs to treat cancer but also to probe its mechanism in transitions. In this study, miniaturized parallel click chem. synthesis via CuAAC reaction followed by in situ biol. screening were used to discover selective Cdc25 inhibitors. The bioassay results showed that compound M2N12 proved to be the most potent Cdc25 inhibitor, which also act as a highly selective Cdc25C inhibitor and was about 9-fold potent than that of NSC 663284. Moreover, M2N12 showed remarkable anti-growth activity against the KB-VIN cell line, equivalent to that of PXL and NSC 663284. An all-atom mol. dynamics (MD) simulation approach was further employed to probe the significant selectivity of M2N12 for Cdc25C relative to its structural homologs Cdc25A and Cdc25B. Overall, above results make M2N12 a promising lead compound for further investigation and structural modification.

European Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics