Category: 7079-48-3

Pal, Manojit published the artcileSynthesis and cyclooxygenase-2 (COX-2) inhibiting properties of 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (-SO2NH2) moiety, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is cyclooxygenase inhibitor aryl pyrazole sulfonamide preparation; anti inflammatory agent; inflammation inhibitor; synthetase prostaglandin endoperoxide COX inhibitor benzisothiazole pyrazole preparation.

A number of novel 1,5-diarylpyrazoles possessing N-substitution on the sulfonamide (SO2NH2) moiety were synthesized and tested for COX-1/COX-2 inhibition in vitro. Many of these 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles, where the SO2NH2 group was a part of the fused ring, showed COX inhibitory activity. Few of them were identified as selective COX-2 inhibitors. A structure-activity relationship study within the series are discussed. Compounds prepared for this study included derivatives of 5-[3-(difluoromethyl)-5-[2-fluoro-4-(methylthio)phenyl]-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide and 5-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,3-dihydro-1,2-benzisothiazole dioxide (i.e., cyclic benzenesulfonamide analogs).

Letters in Drug Design & Discovery published new progress about Anti-inflammatory agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Name: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Calzaferri, Francesco published the artcileSynthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is purine preparation antiinflammatory activity mol docking pharmacokinetic study; xanthine preparation antiinflammatory activity mol docking pharmacokinetic study.

In this work, novel blood-brain barrier (BBB)-permeable derivatives, e.g., I as potential P2X7 antagonists were designed and synthesized. They comprise purine or xanthine cores linked to an aryl group through different short spacers. Compounds were tested in YO-PRO-1 uptake assays and intracellular calcium dynamics in a human P2X7-expressing HEK293 cell line, two-electrode voltage-clamp in Xenopus laevis oocytes, and in interleukin 1β release assays in mouse peritoneal macrophages. BBB permeability was assessed by parallel artificial membrane permeability assays and P-glycoprotein ATPase activity. Dichloroarylpurinylethanones featured a certain P2X7 blockade, being compound (2-(6-chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)ethan-1-one) (I), named ITH15004, the most potent, selective, and BBB-permeable antagonist. Compound I can be considered as a first non-nucleotide purine hit for future drug optimizations.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Rui published the artcileDiscovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA, HPLC of Formula: 7079-48-3, the main research area is spirocyclic sulfonamide preparation Akt inhibitor SAR.

We describe the design and synthesis of novel bicyclic spiro sulfonamides, e.g. I, as potent Akt inhibitors. Through structure-based rational design, we have successfully improved PKA selectivity of previously disclosed spirochromanes. Representative compounds showed favorable Akt potency while exhibiting up to 1000-fold selectivity against PKA.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, HPLC of Formula: 7079-48-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Madaiah, Malavalli published the artcileSynthesis and evaluation of 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives as potential anticonvulsants, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is oxotriazaspiroundecylmethylbenzonitrile preparation anticonvulsant.

New 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives were synthesized and their pharmacol. activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by maximal electroshock seizure (MES) and pentylenetetrazole (PTZ) test. Four compounds showed significant and protective effect on seizure, when compared with the standard drug valproate. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug. From this study, it is quite apparent that there are at least three parameters for the activity of anticonvulsant drugs, i.e., a lipophilic domain, a hydrophobic center, and a two-electron donor. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pecic, Stevan published the artcileDesign, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase, Synthetic Route of 7079-48-3, the main research area is sulfonylpiperidinecarboxamide preparation soluble epoxide hydrolase inhibitor antiinflammation antihypertensive.

Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor I having potency comparable to urea-based inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent) (aromatic). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Synthetic Route of 7079-48-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Follows, Bruce published the artcileDiscovery of novel biaryl sulfonamide based Mcl-1 inhibitors, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is Mcl 1 Bid sulfonamide crystal structure; BH3-mimetic; Inhibitors; Mcl-1; Myeloid cell leukemia-1; Small molecule.

Mcl-1 is an anti-apoptotic protein overexpressed in hematol. malignancies and several human solid tumors. Small mol. inhibition of Mcl-1 would offer an effective therapy to Mcl-1 mediated resistance. Subsequently, it has been the target of extensive research in the pharmaceutical industry. The discovery of a novel class of Mcl-1 small mol. inhibitors is described beginning with a simple biaryl sulfonamide hit derived from a high through put screen. A medicinal chem. effort aided by SBDD generated compounds capable of disrupting the Mcl-1/Bid protein-protein interaction in vitro. The crystal structure of the Mcl-1 bound ligand represents a unique binding mode to the BH3 binding pocket where binding affinity is achieved, in part, through a sulfonamide oxygen/Arg263 interaction. The work highlights the some of the key challenges in designing effective protein-protein inhibitors for the Bcl-2 class of proteins.

Bioorganic & Medicinal Chemistry Letters published new progress about Bid proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kas’yan, L. I. published the artcile2-(1-Aminoethyl)bicyclo[2.2.1]heptane. Sulfonamides, ureas, and thioreas on its base, Recommanded Product: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is aminoethylbicycloheptane conformation electron density nucleophilic reactivity; sulfonamide aminoethylbicycloheptane preparation; urea aminoethylbicycloheptane preparation; thiourea aminoethylbicycloheptane preparation.

The known antiviral drug, 2-(1-aminoethyl)bicyclo[2.2.1]heptane, has been studied by mol. mechanics and quantum-chem. methods. The structure of both exo and endo isomers has been examined by the MMX procedure. Conformational compositions of the isomers and barriers to rotation about the C2-C8 bond have been compared with corresponding parameters of stereoisomeric 2-aminomethylbicyclo[2.2.1]heptanes which also exhibit antiviral activity. The electron d. distribution in the amines has been calculated by the semiempirical AM1 method, and their reactivity has been estimated on the basis of the calculated proton affinities and energies of localized MOs. Nucleophilic properties of the title compound have been studied in reactions with phenylmethane- and arenesulfonyl chlorides and alicyclic and aromatic isocyanates and isothiocyanates. The structure of sulfonamides, ureas, and thioureas thus obtained has been proved by IR and 1H spectroscopy.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about Amines Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent) (cage). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Recommanded Product: 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Hao published the artcileMicroarray-Assisted High-Throughput Identification of a Cell-Permeable Small-Molecule Binder of 14-3-3 Proteins, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is cell permeable peptide library preparation microarray screening protein binding.

The authors have used a small-mol. microarray (SMM) technique to identify cell-permeable small mol.-peptide hybrids that are capable of binding to all 14-3-3 proteins and thus inhibiting protein-protein interactions (PPI). Phosphoserine-containing peptide libraries were constructed on solid-phase using 243 different carboxylic acids for conjugation with N-terminus of individual peptides in one library, and 50 different amines for conjugation with C-terminus of individual peptides in the second library. For both libraries, biotin and GlyGly linkers were introduced at either N- or C-terminus of each peptide to facilitate subsequent immobilization onto avidin-functionalized glass slides. All the peptide conjugates were characterized by liquid chromatog./mass spectrometry and most were shown to be the correct mol. weight and of sufficient purity for direct microarray applications.

Angewandte Chemie, International Edition published new progress about 14-3-3 Proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Application of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xu, Liang published the artcileOxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives, HPLC of Formula: 7079-48-3, the main research area is ortho methylarenesulfonamide oxidative cyclization saccharin derivative synthesis; benzisothiazole dioxide synthesis oxidative cyclization ortho methylarenesulfonamide.

Various biol. important saccharin skeletons and their N-alkyl derivatives were efficiently prepared by Cr(VI) oxide-catalyzed H5IO6 oxidation of N-alkyl-o-methyl-arenesulfonamides in MeCN. N-tert-Bu saccharin skeletons were easily prepared by H5IO6-CrO3 oxidation of N-tert-butyl-o-Me arenesulfonamides in the presence of acetic anhydride. The method that furnished the novel fluoro- and trifluoromethyl-substituted saccharin skeletons was characterized by two steps, a simple work-up procedure, a single purification and good overall yields from substituted toluene derivatives For example, 58 % 2-tert-butyl-6-trifluoromethyl-1,2-benzisothiazol-3-one 1,1-dioxide was obtained from 1-methyl-4-(trifluoromethyl)benzene.

Tetrahedron published new progress about Heterocyclization (oxidative). 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, HPLC of Formula: 7079-48-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pal, Manojit published the artcileSynthesis and Cyclooxygenase-2 Inhibiting Property of 1,5-Diarylpyrazoles with Substituted Benzenesulfonamide Moiety as Pharmacophore: Preparation of Sodium Salt for Injectable Formulation, Category: chlorides-buliding-blocks, the main research area is diarylpyrazole containing benzenesulfonamide pharmacophore preparation cyclooxygenase 2 inhibitor; sulfamoylphenylpyrazole preparation cyclooxygenase 2 inhibitor; pyrazolylbenzenesulfonamide preparation cyclooxygenase 2 inhibitor.

A series of 1,5-diarylpyrazoles having a substituted benzenesulfonamide moiety as pharmacophore, e.g. (I; Ar = 2 or 3-fluoro-4-sulfamoylphenyl, 3-methyl-4-sulfamoylphenyl; R = OMe, SMe) and (II; R1 = 4-methoxyphenyl, 4-methylthiophenyl, 4-fluorophenyl; R2= propanoyl, butyryl) was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Through SAR and mol. modeling, it was found that fluorine substitution on the benzenesulfonamide moiety along with an electron-donating group at the 4-position of the 5-aryl ring yielded selectivity as well as potency for COX-2 inhibition in vitro. Among such compounds 3-fluoro-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide 3 displayed interesting pharmacokinetic properties along with antiinflammatory activity in vivo. Among the sodium salts tested in vivo, 10, the propionyl analog of 3, showed excellent antiinflammatory activity and therefore represents a new lead structure for the development of injectable COX-2 specific inhibitors.

Journal of Medicinal Chemistry published new progress about Pharmacokinetics. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Category: chlorides-buliding-blocks.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics