Author: Jessica.F

On May 23, 2007, Buschman, Helmut Heinrich published a patent.Electric Literature of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Electric Literature of 4569-86-2

The Article related to diabetes pain analgesic sigma receptor ligand, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Electric Literature of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On February 2, 2006, Baeyens Cabrera, Jose Manuel published a patent.Synthetic Route of 4569-86-2 The title of the patent was Use of compounds active on the sigma receptor for the treatment of mechanical allodynia. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the treatment of mech. allodynia. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Synthetic Route of 4569-86-2

The Article related to mech allodynia treatment sigma receptor modulator, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On March 8, 2007, Buschmann, Helmut H. published a patent.Application of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain. And the patent contained the following:

The invention discloses the use of compounds active on the sigma receptor for the production of a medicament for the treatment of diabetes-associated pain. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Application of 4569-86-2

The Article related to diabetes pain analgesic sigma receptor binding compound, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Application of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On June 10, 2021, Yao, Hong; Uras, Giuseppe; Zhang, Pengfei; Xu, Shengtao; Yin, Ying; Liu, Jie; Qin, Shuai; Li, Xinuo; Allen, Stephanie; Bai, Renren; Gong, Qi; Zhang, Haiyan; Zhu, Zheying; Xu, Jinyi published an article.Formula: C7H6ClNO2 The title of the article was Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease. And the article contained the following:

Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer’s disease (AD). Biol. evaluation results demonstrated that these hybrids exhibited significant inhibitory activities toward acetylcholinesterase (AChE) and glycogen synthase kinase 3 (GSK-3). The optimal compound 27g (I) possessed excellent dual AChE/GSK-3 inhibition both in terms of potency and equilibrium (AChE: IC50 = 51.1 nM; GSK-3β: IC50 = 89.3 nM) and displayed significant amelioration on cognitive deficits in scopolamine-induced amnesia mice and efficient reduction against phosphorylation of tau protein on Ser-199 and Ser-396 sites in glyceraldehyde (GA)-stimulated differentiated SH-SY5Y cells. Furthermore, compound 27g exhibited eligible pharmacokinetic properties, good kinase selectivity, and moderate neuroprotection against GA-induced reduction in cell viability and neurite damage in SH-SY5Y-derived neurons. The multifunctional profiles of compound 27g suggest that it deserves further investigation as a promising lead for the prospective treatment of AD. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Formula: C7H6ClNO2

The Article related to tacrine pyrimidone hybrid ache gsk3 inhibitor alzheimer disease, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Formula: C7H6ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 19, 2017, Kumoi, Hirofumi; Tanaka, Masato published a patent.Formula: C7H6ClF The title of the patent was Production method of phthalocyanine crystals and process for producing electrophotographic photoreceptor using the same. And the patent contained the following:

Title production method of phthalocyanine crystal includes mixing of phthalocyanine compound obtained by the acid pasting method with an organic compound and subjecting it to crystal transformation to obtain phthalocyanine crystal, which comprises a rotatable rotor and a jacket covering the rotor, at least the rotor has a flow path of a coolant or a heat medium therein and a gap between the rotor and the inner wall of the jacket has a portion forming an annular space, the rotor and the inner wall of the jacket both have a smooth surface and a crystal transformation is performed using a disperser having a structure in which a mixture of the phthalocyanine compound and the organic compound passes through the space filled with media particles. Thus, 0.3 parts of hydroxygallium phthalocyanine pigment powder (prepared by reacting chlorogallium phthalocyanine pigment with sulfuric acid), 9.7 parts of N,N-dimethylformamide were mixed in stainless steel container and then the mixed solution was subjected to dispersion treatment using glass beads as media particles and then the mixture was dispersed by using a dispersion machine to obtain hydroxygallium phthalocyanine crystals. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Formula: C7H6ClF

The Article related to phthalocyanine crystal organic compound electrophotog photoreceptor, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Phthalocyanines and other aspects.Formula: C7H6ClF

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 27, 2009, Baeyens-Cabrera, Jose Manuel; Buschmann, Helmut H.; Vela-Hernandez, Jose-Miguel; Zamanillo-Castanedo, Daniel; Nieto-Lopez, Francisco Rafael published a patent.Product Details of 4569-86-2 The title of the patent was Use of compounds binding to the sigma receptor for the treatment of neuropathic pain developing as a consequence of chemotherapy. And the patent contained the following:

The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. The invention discloses the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Product Details of 4569-86-2

The Article related to chemotherapy neuropathic pain treatment sigma receptor ligand analgesic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Product Details of 4569-86-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On August 19, 2009, Baeyens-Cabrera, Jose Manuel; Buschmann, Helmut H.; Vela Hernandez, Jose Miguel; Zamanillo-Castanedo, Daniel; Nieto-Lopez, Francisco Rafael published a patent.Quality Control of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride The title of the patent was Use of compounds binding to the sigma receptor for the treatment of neuropathic pain developing as a consequence of chemotherapy. And the patent contained the following:

The invention discloses the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Quality Control of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

The Article related to chemotherapy neuropathic pain treatment sigma receptor ligand analgesic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Koolpe, Gary A.; Nelson, Wendel L.; Gioannini, T. L.; Angel, Lloyd; Simon, Eric J. published an article in 1984, the title of the article was Diastereomeric 6-desoxy-6-spiro-α-methylene-γ-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand.Quality Control of trimethyloxosulphonium chloride And the article contains the following content:

The title compounds I and II (R = Me or cyclopropylmethyl) were prepared by sequence reaction starting with direct alkylation of the diacetate ester of the parent ketone by the Reformatskii reagent prepared from Me α-(bromomethyl)acrylate  [4224-69-5], and their affinity for opioid binding sites was determined in crude rat brain membrane preparation by competition against [3H]naltrexone in presence and absence of Na+. 6α-(2-Carboxyallyl)-17-(cyclopropylmethyl)-4,5α-epoxy-3,6β,14-trihydroxymorphinan-γ-lactone (II; R = cyclopropylmethyl) [92398-30-6] was the most potent compound showing a 50% inhibition of binding at 5 nM. The data suggest a receptor nucleophile such as SH is located where it can add to the α,β-unsaturated carbonyl system of the above compound The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).Quality Control of trimethyloxosulphonium chloride

The Article related to naltrexone butyrolactone diastereomer preparation, oxymorphone butyrolactone diastereomer preparation, opioid receptor binding morphinanone derivative, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of trimethyloxosulphonium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chen, Jianxia; Namila, E.; Bai, Chaolumen; Baiyin, Menghe; Bao, Agula; Bao, Yong-Sheng published an article in 2018, the title of the article was Transesterification of (hetero)aryl esters with phenols by an Earth-abundant metal catalyst.COA of Formula: C7H4ClNO4 And the article contains the following content:

Readily available and inexpensive Earth-abundant alkali metal species were used as efficient catalysts for the transesterification of aryl or heteroaryl esters with phenols which is a challenging and underdeveloped transformation. The simple conditions and the use of heterogeneous alkali metal catalyst make this protocol very environmentally friendly and practical. This reaction fills in the missing part in transesterification reaction of phenols and provides an efficient approach to aryl esters, which are widely used in the synthetic and pharmaceutical industry. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4

The Article related to aryl ester preparation green chem, ester preparation phenol alkali metal catalyst transesterification, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.COA of Formula: C7H4ClNO4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On October 19, 1987, Fukuoka, Shinsuke published a patent.Quality Control of 4-Chloro-2-fluorotoluene The title of the patent was Preparation of aryl fluoroarenecarboxylates as intermediates for agrochemicals, pharmaceuticals, and polymers. And the patent contained the following:

The title esters, useful as intermediates for agrochems., pharmaceuticals, and heat-stable polymers, are prepared Heating a mixture of p-FC6H4Br 50, PhONa 60, and Ni(acac)2 2.5 mmol in MePh at 250° and 50 kg/cm2 CO gave 82% p-FC6H4CO2Ph. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Quality Control of 4-Chloro-2-fluorotoluene

The Article related to aryl arenecarboxylate intermediate agrochem pharmaceutical, polymer intermediate aryl arenecarboxylate, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Quality Control of 4-Chloro-2-fluorotoluene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics