Author: Jessica.F

Vashchenko, O. V. published the artcileInvestigation of combined effect of quaternary ammonium compounds and organic acid on model phospholipid membranes, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Biofizichnii Visnik (2010), 55-72, database is CAplus.

Effects caused by combined inclusion of two membranotropic agents (MTA) of different nature into model phospholipid membranes have been examined An effect of significant change in activity of individual M1IA based on quaternary and bisquaternary ammonium compounds (QAC, BQAC) – decamethoxinum. aethonium. tetramethylammonium – and organic 2.5-dihydroxybcnzoic acid (DHB) on their combined incorporation into model multibilayer structures of hydrated dipalmitoylphosphatidycholine (DPPC) is revealed. Differential scanning calorimetry (DSC) data have shown that, when both types of MTA are jointly present in the system. significant deviations from additivity values are noted for the measured calorimetry parameters. This shows that it is the MTA complexes. rather than individual MTAs. affect the model membrane properties. Mass-spectrometric and quantum chem. calculations data have demonstrated a possibility of formation of stable noncovalent complexes including (di)cations of quaternary ammonium bases and anions of organic DHB acid. Plotting of “membrane melting temperature (T_m) vs. MTA composition” quasi-binary diagrams permitted us to determine the optimal stoichiometry of the BQAC-DHB membrane-incorporated complexes. It was revealed by means of DSC that incorporation into membranes of individual ionic BQAC and DHB as well as their complexes with stoichiometry providing preservation of the ionic (charged) state of the MTAs causes decrease of T_m and correspondingly, disordering of the membrane structure. At the same time, under MTA concentrations providing neutral complexes of BQAC and DHB. some increase in T_m is observed corresponding to an ordering of membrane structure. which can be interpreted as deactivation of BQAC. i.e. modulation of their activity in the presence of the organic acid. The ascertained possibility of suppression of membranotropic activity of antimicrobial BQAC on their combined use with an organic acid is to be taken into account in design of multi-component antimicrobial drugs.

Biofizichnii Visnik published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C9H17NO, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kosevich, M. V. published the artcileStability of the dication of decamethoxin as revealed by secondary ion mass spectrometry, Synthetic Route of 38146-42-8, the publication is Visnik Kharkivs’kogo Universitetu (1998), 15-22, database is CAplus.

Stability of the dication of the antimicrobial drug decamethoxin under the influence of various phys. factors was studied. Significant differences in the pathways of transformation of decamethoxin under the influence of heating and upon long-term storage were revealed by means of the secondary ion mass spectrometry; it was shown that the changes in the medicine with time upon neglect of storage rules are connected, obviously, with the deleting of chlorine counterions from the crystalline sample with preservation of the structure of the dication, while upon thermal treatment a dequaternization of the quaternary nitrogens of decamethoxin with formation of tertiary amines takes place.

Visnik Kharkivs’kogo Universitetu published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Neatu, Stefan published the artcileM/TiO₂/SiO₂ (M = Fe, Mn, and V) catalysts in photodecomposition of sulfur mustard, Quality Control of 1002-41-1, the publication is Applied Catalysis, B: Environmental (2009), 91(1-2), 546-553, database is CAplus.

The photocatalytic decomposition of Sulfur mustard (bis(2-chloroethyl)sulfide) has been examined on Fe-, Mn- and V-doped dispersed TiO₂-SiO₂ catalysts. The catalysts were prepared by successive incipient wetness impregnation. They have been characterized by means of vibrational (FTIR) and optical (UV-vis-NIR in the DRS mode) spectroscopy. Powder XRD, XPS, and BET were used to characterize the structural morphol. and texture. The reaction was carried out in two different types of reactors under both UV- and visible light irradiation The parent TiO₂-SiO₂ catalyst showed activity only under UV irradiation, while the doped ones were active in the decontamination of the persistent Sulfur mustard even under visible light irradiation

Applied Catalysis, B: Environmental published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Quality Control of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Neatu, Stefan published the artcilePhotodegradation of yperite over V, Fe and Mn-doped titania-silica photocatalysts, Name: 1,2-Bis(2-chloroethyl)disulfane, the publication is Physical Chemistry Chemical Physics (2008), 10(43), 6562-6570, database is CAplus and MEDLINE.

The photocatalytic decomposition of Yperite (bis(2-chloroethyl)sulfide), a chem. warfare agent, was achieved by using titania-silica catalysts doped with several transition metal ions. The preparation of these catalysts was achieved by impregnation of a titania-silica mixed oxide previously synthesized using a sol-gel route with salts of the doping elements (vanadium, iron, manganese). The above catalysts were characterized using several spectroscopic techniques: FTIR, Raman, DR-UV-Vis, and XPS. The band gap energy was measured for each photocatalytic system. The reaction was carried out in two different types of reactors, i.e. naturally aerated and a closed quartz tube aerated under a constant flow, and using two types of irradiation, UV-Vis and Vis. The investigated systems proved to be extremely active, leading to an almost complete degradation of yperite in 2 h of irradiation An excellent correlation between the photocatalytic performances and the band gap has been found. Based on the characterization data and on the temporal evolution of the reaction products, a reaction mechanism has been suggested. This mechanism considers two distinct pathways for the decomposition of yperite, namely the C-S bond cleavage and the S oxidation

Physical Chemistry Chemical Physics published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Name: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tam, Eugenia S. published the artcileSingle-Molecule Conductance of Pyridine-Terminated Dithienylethene Switch Molecules, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is ACS Nano (2011), 5(6), 5115-5123, database is CAplus and MEDLINE.

The authors have studied the conductance of individual optically switchable dithienylethene mols. in both their conducting closed configuration and nonconducting open configuration, using the technique of repeatedly formed break-junctions. The authors employed pyridine groups to link the mols. to gold electrodes to achieve relatively well-defined mol. contacts and stable conductance. For the closed form of each mol., the authors observed a peak in the conductance histogram constructed without any data selection, allowing the authors to determine the conductance of the fully stretched mols. For two different dithienylethene derivatives, these closed-configuration conductances were (3.3 ± 0.5) × 10^-5G₀ and (1.5 ± 0.5) × 10^-6G₀, where G₀ is the conductance quantum. For the open configuration of the mols., the existence of elec. conduction via the mol. was evident in traces of conductance vs. junction displacement, but the conductance of the fully stretched mols. was less than the noise floor of the authors’ measurement. The authors can set a lower limit of 30 for the on/off ratio for the simplest dithienylethene derivative the authors have studied. D. functional theory calculations predict an on/off ratio consistent with this result.

ACS Nano published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C17H14F3N3O2S, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jianbo published the artcileSynthesis of N-trifluoromethyl amides from carboxylic acids, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Chem (2021), 7(8), 2245-2255, database is CAplus and MEDLINE.

Here, the synthesis of N-trifluoromethyl amides R¹C(O)NCF₃(R²) [R¹ = Et, cyclohexyl, CH₂CH₂Ph, etc.; R² = Me, allyl, CH₂CH₂Ph, etc.] from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature was reported. Through this strategy, isothiocyanates were desulfurized with AgF, and then the formed derivative was acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method showed broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners and should find application in the modification of advanced intermediates.

Chem published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yun, Seung Beom published the artcileSynthesis and properties of poly(carbomethyloctylsiloxane)s by melt copolymerization of bis(diethylamino)methyloctylsilane and aryldiol derivatives, HPLC of Formula: 14799-93-0, the publication is Bulletin of the Korean Chemical Society (2008), 29(12), 2373-2378, database is CAplus.

We carried out the melt copolymerizations of bis(diethylamino)methyloctylsilane with several aryldiols to afford poly(carbomethyloctylsiloxane)s containing fluorescent aromatic chromophore groups in the polymer main chain: poly(oxybiphenyloxymethyloctyl silane), poly(oxy(4,4′-isopropylidene)diphenyleneoxymethyloctylsilane), poly(oxy(4,4′-hexafluoroisopropylidene)diphenyleneoxymethyloctylsilane),poly(oxy-2,6-naphthalenediyloxymethyloctylsilane),and poly(oxyphenyleneoxymethyloctylsilane). These materials are soluble in common organic solvents such as CHCl₃ and THF. FTIR spectra of all the polymeric materials show the characteristic Si-O-C stretching frequencies at 1051-1082 cm^-1. The polymers in THF solution exhibit strong maximum absorption peaks at 263-341 nm with the strong maximum excitation peaks at 253-325 nm, and strong maximum fluorescence emission bands at 300-420 nm. According to TGA all the polymers are stable up to 200 °C with weight loss of less than 9% in nitrogen.

Bulletin of the Korean Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C7H8BBrO3, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Ji Ho published the artcileOxidative coupling polymerization of diethynylsilane derivatives and 1,2-diethynyl-1,1,2,2-tetramethyldisilane, Category: chlorides-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2006), 27(6), 869-874, database is CAplus.

The Glaser oxidative coupling polymerizations was performed on diethynyldiphenylsilane, diethynylmethylphenylsilane, diethynylmethyloctylsilane, and 1,2-diethynyl-1,1,2,2-tetramethyldisilane to afford polycarbosilanes containing diethynyl and organosilane groups in the main chain, such as poly(diethynyldiphenylsilane), poly(diethynylmethylphenylsilane), poly(diethynylmethyloctylsilane), and poly(1,2-diethynyl-1,1,2,2-tetramethyldisilane), resp. These obtained materials are almost insoluble in common organic solvents such as CHCl₃ and THF probably due to the presence of a rigid rod diacetylene group along the polymer main chain. Therefore, the polymers were characterized using several spectroscopic methods in solid state. FTIR spectra of all the polymeric materials show that the characteristic CC stretching frequencies appear at 2147-2154 cm^-1, in particular. The polymers in the solid state exhibit that the strong maximum excitation peaks appear at 260-283 nm and the strong maximum fluorescence emission bands at 367-412 nm, especially Thermogravimetric anal. of the materials shows that about 55-68% of the initial polymer weights remain at 400°C in nitrogen.

Bulletin of the Korean Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jung, Eun Ae published the artcileSynthesis and photoelectronic properties of thermally stable poly[oxy(2,7-fluoren-9-onenylene)oxy(diorganosilylene)]s, HPLC of Formula: 14799-93-0, the publication is Bulletin of the Korean Chemical Society (2012), 33(6), 2031-2036, database is CAplus.

Melt copolymerization reactions of several bis(diethylamino)silane derivatives, bis(diethylamino)methylphenylsilane, bis(diethylamino)methyloctylsilane, 1,2-bis(diethylamino)tetramethyldisilane, and 1,3-bis(diethylamino)tetramethyldisiloxane, with 2,7-dihydroxyfluoren-9-one were carried out to yield poly[oxy(2,7-fluoren-9-onenylene)oxy(diorganosilylene)]s bearing the fluoren-9-one fluorescent aromatic group in the polymer main chain: poly[oxy(2,7-fluoren-9-onenylene)oxy(methylphenylsilylene)], poly[oxy(2,7-fluoren-9-onenylene)oxy(methyloctylsilylene)], poly[oxy(2,7-fluoren-9-onenylene)oxy(tetramethyldisilylene)], and poly[oxy(2,7-fluoren-9-onenylene)oxy(tetramethyldisiloxanylene)]. These polymeric materials are soluble in common organic solvents such as CHCl₃ and THF. FTIR spectra of all the materials reveal characteristic Si-O-C stretching frequencies at 1012-1018 cm^-1. In the THF solution, the prepared materials show strong maximum absorption peaks at 258-270 nm, strong maximum excitation peaks at 260-280 nm, and strong maximum fluorescence emission bands at 310-420 nm. TGA thermograms suggest that most of the polymers are essentially stable to 200° without any weight loss and up to 300° with only a weight loss of less than 5% in nitrogen.

Bulletin of the Korean Chemical Society published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, HPLC of Formula: 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Soo-Yeon published the artcileField-based rational design of p300 histone acetyltransferase inhibitor and systematic evaluation as an anti-fibrotic agent, Recommanded Product: 3-Chlorobenzylchloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(68), 9795-9798, database is CAplus and MEDLINE.

(E)-3-(3-(4-((3-Carbamoylbenzyl)oxy)-3-iodo-5-methoxyphenyl) acryloyl)benzamide (A6) was found to be a potent p300 inhibitor (IC₅₀ = 870 nM) showing a similar binding mode to that of acetyl-CoA, a p300 substrate, and effective anti-fibrotic activity in both TGF-β1-stimulated lung fibroblast cells and bleomycin-induced in vivo lung fibrosis mice.

Chemical Communications (Cambridge, United Kingdom) published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics