Author: Jessica.F

Qi, Gang published the artcileSynthesis of coumarin-propanedioic acid dimethyl esters, Synthetic Route of 10543-42-7, the publication is Hecheng Huaxue (2007), 15(4), 466-467, 470, database is CAplus.

Three new coumarin-propanedioic acid di-Me esters were designed and synthesized by matching principle from coumarin and propanedioic acid di-Me ester. The structures were identified by ¹H NMR, IR and MS.

Hecheng Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Ying published the artcileSynthesis and Bioactivity of Coumarin-6-sulfonylureas, Category: chlorides-buliding-blocks, the publication is Zhongguo Yaoke Daxue Xuebao (2002), 33(2), 93-97, database is CAplus.

Twenty-one coumarin-6-sulfonylureas {N-[4-R¹-7-R²-benzopyran-2(2H)-one-6-sulfonyl]-N’-R³-urea; R¹ and/or R² = H or methyl; R³ = cyclohexyl, allyl, Pr, heptyl, iso-Pr, Bu, or isobutyl} were synthesized to search for new antidiabetic drugs. Sulfonylurea functional groups were introduced into the structure of coumarin, and the hypoglycemic activity of the target compounds was measured. Their structures were identified by IR, ¹H NMR, and MS spectra. The pharmacol. study showed that compounds SU-1 (R¹ = R² = H, R³ = cyclohexyl), SU-8 (R¹ = H, R² = Me, R³ = cyclohexyl), SU-11 (R¹ = H, R² = Me, R³ = butyl), SU-12 (R¹ = H, R² = Me, R³ = heptyl), and SU-13 (R¹ = H, R² = Me, R³ = isopropyl) exhibited evident hypoglycemic activities (P <0.01) at the dose of 50 mg kg^-1.

Zhongguo Yaoke Daxue Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haraguchi, Naoki published the artcileAsymmetric transfer hydrogenation of imines catalyzed by a polymer-immobilized chiral catalyst, COA of Formula: C19H34ClN, the publication is Organic & Biomolecular Chemistry (2009), 7(1), 69-75, database is CAplus and MEDLINE.

The asym. transfer hydrogenation of imines was performed with the use of a polymer-immobilized chiral catalyst. The chiral catalyst, prepared from crosslinked polystyrene-immobilized chiral 1,2-diamine monosulfonamide, was effective in the asym. transfer hydrogenation of N-benzyl imines in CH₂Cl₂ to give a chiral amine in high yield and good enantioselectivity. Furthermore, an amphiphilic polymeric catalyst prepared from crosslinked polystyrene containing sulfonated groups successfully catalyzed the asym. transfer hydrogenation of cyclic imines in water. Enantioenriched secondary amines with up to 94% ee were obtained by using a polymeric catalyst.

Organic & Biomolecular Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, K. published the artcileThin-layer chromatography of methyl N-trimethyl-γ-aminobutyrate chloride and related compounds, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Chromatography (1974), 90(1), 230-2, database is CAplus.

The best separation of trimethylaminobutyrate derivatives[Me3N+(CH2)3CO2RCl-] came when a plate was heated for 1 hr at 120°. Sharp spots free from tailing were found in the solvent system EtOAc-HCO2H-water. Increasing the HCO2H concentration gave higher Rf values, but did not improve separation The Rst values were applied using crystal violet as the standard and the results were better in terms of reproducibility.

Journal of Chromatography published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seno, Manabu published the artcilePreparation, properties, and x-ray photoelectron spectra of palladium(II) and platinum(II) complexes of amine imides aminimides and sulfur ylides, Recommanded Product: trimethyloxosulphonium chloride, the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) (1977), 751-7, database is CAplus.

Amine imides RMe2N+N-COR1 (R = PhCH2, p-O2NC6H4CH2; R1 = Me, Et, Ph) and the S ylides Me2S+(O)C-HCOPh with Pd(II) and Pt(II) halides gave ylide-metal complexes PdCl2L2 (L = amine imide), PtCl2[Me2S+(O)C-HCOPh]SEt2, and MCl2[Me2S+(O)C-HCOPh]2 (M = Pd, Pt). IR, 1H and 13C NMR, and x-ray photoelectron spectra indicated that the coordination of the ylide to the metal was through the nucleophilic N+ or C- atom as simple terminal ligands. Cis-PtCl2[Me2S+(O)C-HCOPh]SEt2 released SEt2 in Me2SO giving PtCl2[Me2S+(O)C-HCOPh] which was chelated through the carbanion C and the sulfonium O of the ylide. The thermal properties of the complexes were examined by thermal gravimetric anal. and the nature of the bonding was discussed.

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C4H5NS2, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stergiopoulos, Chrysanthos published the artcileThe use of biomimetic chromatography to predict acute aquatic toxicity of pharmaceutical compounds, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Toxicological & Environmental Chemistry (2022), 104(1), 1-19, database is CAplus.

The potential of biomimetic chromatog. to predict ecotoxicol. endpoints of pharmaceutical compounds was investigated. For this purpose, a data set of previously and newly measured chromatog. retention data for 36 structurally diverse drugs was used. Standardized retention times were measured on the immobilized artificial membrane, human serum albumin, and alpha-1-acid glycoprotein stationary phases. As ecotoxicol. endpoints, half-maximal lethal concentration values of fish and half-maximal effective concentration (immobilization) values of a water flea (Daphnia magna spp.) determined with a two-day static method were considered. Ecotoxicity values correlated with octanol-water partitioning and the pos. charge of compounds contributed even more to the toxicity. Models based on membrane partition exhibited the best statistics and predictive performance, attributed to lipophilicity and membrane electrostatic interactions. Alpha-1-acid glycoprotein binding led to satisfactory models, owing to its function as a binder of neutral and basic lipophilic compounds Albumin binding, however, did not result in sound models, as it is governed by lipophilicity and the neg. charge of compounds, contrary to the mechanism of toxicity. Both membrane and alpha-1-acid glycoprotein models were superior statistically from those derived from the octanol-water system. Overall, membrane and alpha-1-acid glycoprotein retention can be suggested as promising indexes to assess the ecotoxicol. risk of drugs.

Toxicological & Environmental Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C7H5BClNO2, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Feng published the artcileA novel and convenient process for the selective oxidation of naphthalenes with hydrogen peroxide, SDS of cas: 23616-79-7, the publication is Advanced Synthesis & Catalysis (2007), 349(3), 303-308, database is CAplus.

A practical Ru phase-transfer catalyst (Ru-PTC) system for the oxidation of naphthalene derivatives was developed. Substituted 1,4-quinones were obtained in good selectivity and yield in H₂O without the addition of any organic solvent and acid. By applying the optimized conditions the feed additive menadione (vitamin K₃) was obtained from 2-methylnaphthalene with 64% yield and 73% selectivity. Oxidation of phenanthrene is also described.

Advanced Synthesis & Catalysis published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C10H20O2, SDS of cas: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Feng published the artcileSelective oxidation of naphthalene derivatives with ruthenium catalysts using hydrogen peroxide as terminal oxidant, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Molecular Catalysis A: Chemical (2007), 270(1-2), 68-75, database is CAplus.

The selective oxidation of naphthalene and its derivatives to give naphthoquinones has been investigated in detail. The reaction can be carried out effectively in the presence of a catalytic amount of Ru complexes (0.2 mol %) and phase transfer catalysts using H₂O₂ as the terminal oxidant and water as the solvent. The effects of different ruthenium complexes, phase transfer catalysts, and the concentration of hydrogen peroxide were studied. Compared to previous procedures for this type of reaction, acidic solvents and high concentration of hydrogen peroxide are not necessary, which makes the reaction more environmentally friendly.

Journal of Molecular Catalysis A: Chemical published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C25H34N4O2S, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cho, Jian-Yang published the artcileRemarkably selective iridium catalysts for the elaboration of aromatic C-H bonds, Name: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, the publication is Science (Washington, DC, United States) (2002), 295(5553), 305-308, database is CAplus and MEDLINE.

Arylboron compounds have intriguing properties and are important building blocks for chem. synthesis. A family of Ir catalysts (IndIr(COD), (η⁶-mesitylene)Ir(BPin)₃ (4; HBPin = pinacolborane)) now enables the direct synthesis of arylboron compounds from aromatic hydrocarbons and boranes under solventless conditions. For example, a 98% yield of PhBPin was obtained in 15 h at 150° from benzene and HBPin (16:1 ratio) in the presence of 4 and PMe₃. The Ir catalysts are highly selective for C-H activation and do not interfere with subsequent in situ transformations, including Pd-mediated cross-couplings with aryl halides (e.g. 80% 3,5-dichloro-3′-methylbiphenyl). By virtue of their favorable activities and exceptional selectivities, these Ir catalysts impart the synthetic versatility of arylboron reagents to C-H bonds in aromatic and heteroaromatic hydrocarbons.

Science (Washington, DC, United States) published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, Name: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Minsoo published the artcileStructure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT_2B receptor antagonist scaffold, SDS of cas: 939-99-1, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(21), 127511, database is CAplus and MEDLINE.

Antagonists for the serotonin receptor 2B (5-HT_2B) have clin. applications towards migraine, anxiety, irritable bowl syndrome, and MDMA abuse; however, few selective 5-HT_2B antagonists have been identified. Previous studies from these labs identified a natural product, 5-hydroxy-2-(2-phenylethyl)chromone (5-HPEC, 2) as the first non-nitrogenous ligand for the 5-HT_2B receptor. Studies on 5-HPEC optimization led to the identification of 5-hydroxy-2-(3-phenylpropyl)chromone (5-HPPC, 3), which showed a tenfold improvement in binding affinity over 2 at 5-HT_2B. This study aimed to further improve receptor pharmacol. of this unique scaffold. Guided by mol. modeling studies modifications at the C-3′ and C-4′ positions of 3 were made to probe their effects on ligand binding affinity and efficacy. Among the derivatives synthesized 5-hydroxy-2-(3-(3-cyanophenyl)propyl)chromone (5-HCPC, 3d) showed the most promise with a multifold improvement in binding affinity (pK_i = 7.1 ± 0.07) over 3 with retained antagonism.

Bioorganic & Medicinal Chemistry Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics