Author: Jessica.F

Takahashi, Hidehiko published the artcileRelation between pharmacological actions on the mammalian ileum and chemical structure of γ-aminobutyric acid (GABA), Computed Properties of 6249-56-5, the publication is Japan J. Physiol. (1961), 229-37, database is CAplus.

The effects of GABA, its derivatives and related compounds on the isolated ileum of the guinea-pig, rabbit, and cat were investigated. GABA caused sustained tone-increasing, or relaxing or transient tone-increasing one followed by relaxation, whereas other ω-amino-acids, such as glycine, δ-aminovaleric acid, and ε-aminocaproic acid had no effect; β-alanine (10^-2M) sometimes produced a slight relaxation. α-Aminobutyric acid and β-aminoisobutyric acid had no effect. 4-Aminobutanol and N-methyl-4-aminobutanol at very high concentrations had a slight stimulant action, although BuOH had none. N-Substitution by Ac, Ph, Bu, or M group reduced the relaxing activity of GABA. Methyl esterification of GABA increased its stimulant activity, but these stimulant effects were antagonized by atropine. As the chem. structure of GABA became more like that of acetylcholine (Ach) its stimulant activity increased; however, even N,N,N-trimethyl-GABA methyl ester, the strongest methyl ester stimulant, was far weaker than Ach. N-Ethylation and N-butylation lessened the stimulant effect of GABA methyl ester and N-phenylation reversed it to a relaxing effect. N-Methyl-GABA ethyl ester had less stimulant effect than N-methyl-GABA methyl ester. N-Methyl-GABA butyl ester and N-methyl-GABA benzyl ester had a marked relaxing effect. N-Methyl-GABA ethyl ester had a weak relaxing action in lower concentrations but a stimulant effect in higher concentrations On the contrary, N-methyl-GABA butyl ester had a weak stimulant effect in lower concentration, but a strong relaxing one in higher concentrations The effects of the β-hydroxy derivative of GABA (GABOB) and its Me ester were similar to that of GABA and its methyl ester but were weaker. Nicotinic acid, isonicotinic acid, and their methyl esters produced a slight relaxation. The rabbit ileum and cat ileum responded in similar manner, but were less sensitive than the guinea-pig ileum.

Japan J. Physiol. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C23H43NP2, Computed Properties of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mizuno, Noritaka published the artcileA Flexible Nonporous Heterogeneous Catalyst for Size-Selective Oxidation through a Bottom-Up Approach, HPLC of Formula: 23616-79-7, the publication is Angewandte Chemie, International Edition (2010), 49(51), 9972-9976, S9972/1-S9972/19, database is CAplus and MEDLINE.

The nonporous ([(Bu)₄N]₄[γ-SiW₁₀O₃₄(H₂O)₂]·H₂O, 1.H₂O) synthesized through a bottom-up approach sorbs EtOAc, which is highly mobile in the solid bulk of the compound, probably contributing to the easy co-sorption of olefins and H₂O₂. 1 Heterogeneously catalyzes size-selective oxidation (small olefins are much more preferentially epoxidized than large olefins) of various organic substances including olefins, sulfides, and silanes with aqueous H₂O₂ in EtOAc. 1 Can easily be separated by filtration and reused several times with retention of its high catalytic activity and is the 1st example for the heterogeneously catalyzed size-selective liquid-phase oxidation with H₂O₂ by a POM-based catalyst.

Angewandte Chemie, International Edition published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Akazawa, Masako published the artcilePhotoresponsive dithienylethene-urea-based organogels with “reversed” behavior, HPLC of Formula: 219537-97-0, the publication is Organic & Biomolecular Chemistry (2008), 6(9), 1544-1547, database is CAplus and MEDLINE.

Dithienylperhydrocyclopentene-bisurea-based low mol. weight gelators are described that function as photoresponsive organogels that show a remarkable gel-to-liquid transition upon irradiation The two series of derivatives, with and without alkyl spacers between the urea hydrogen bonding groups and the photochromic unit, show different gelation behavior. Upon UV irradiation of the gels, a gel liquefied at only 1.4% conversion of the photochromic unit. Transmission electron microscopy (TEM) shows that the gel fibers consist of thin ribbons. Semi-empirical (PM3) calculations indicate that the hydrogen bonding between the open-ring isomer (o) mols. is weak, and that formation of the closed-ring isomer (c) destabilizes the hydrogen bonding further. The results indicate that a small amount of the closed-ring isomer will disrupt the intermol. hydrogen-bonding, leading to disintegration of the gel fiber ribbons and hence reversible liquefication.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Birgul, Kaan published the artcileSynthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents, Recommanded Product: 3-Chlorobenzylchloride, the publication is Journal of Molecular Structure (2022), 132739, database is CAplus.

New thiosemicarbazides, 1,2,4-triazoles and thioethers I (R¹ = Ph, 4-FC₆H₄, Bn, etc.; R² = Bn, 3-FC₆H₄CH₂, 4-MeOC₆H₄CH₂, etc.) from derived (S)-Naproxen were synthesized in this study. The mol. binding of the compounds on MetAP-2 was performed. Anticancer effects of the synthesized compounds were studied by using MTT assay method on MCF-7 (includes estrogen and progesterone receptors) and MDA-MB-231 (lacks estrogen and progesterone receptors) adenocarcinoma cell lines at 0, 10, 25, 50, 75 and 100μM concentrations for 24 h. The IC₅₀ values of novel (S)-Naproxen derivatives were determined between from 5 to 100μM on MCF-7 breast cancer cell line and MDA-MB-231 cell lines. The apoptotic activity of selected compounds I (R¹ = 4-ClC₆H₄; R² = 3-FC₆H₄CH₂) and I (R¹ = Ph; R² = 4-MeC₆H₄CH₂) were first analyzed by Annexin V staining using Tali Image-Based Cytometer. Mitochondrial membrane potential changes determined in fluorescence plate reader following JC-1 stain for compounds I (R¹ = 4-ClC₆H₄; R² = 3-FC₆H₄CH₂) and I (R¹ = Ph; R² = 4-MeC₆H₄CH₂) in MCF-7 and MDA-MB-231 cells. The effect of these compounds on the cell viability 4T1 mouse mammary tumor cell line was tested at 1 to 5 times of calculated IC₅₀ value (IC₅₀x1, IC₅₀x2, IC₅₀x3, IC₅₀x4, and IC₅₀x5). Next in order to determine the toxicity of the combination of compound I (R¹ = Bn; R² = 3-FC₆H₄CH₂) and Docetaxel, WST-1 cell viability and proliferation assay was performed with 4T1.

Journal of Molecular Structure published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Murphy, Jaclyn M. published the artcileOne-Pot Synthesis of Arylboronic Acids and Aryl Trifluoroborates by Ir-Catalyzed Borylation of Arenes, HPLC of Formula: 929626-16-4, the publication is Organic Letters (2007), 9(5), 757-760, database is CAplus and MEDLINE.

The synthesis of arylboronic acids and aryl trifluoroborates in a one-pot sequence by Ir-catalyzed borylation of arenes is reported. To prepare the arylboronic acids, the Ir-catalyzed borylation is followed by oxidative cleavage of the boronic ester with NaIO₄ and to prepare the aryltrifluoroborate, the Ir-catalyzed borylation is followed by displacement of pinacol by KHF₂. These two-step sequences give products that are more reactive toward subsequent chem. than the initially formed pinacol boronates.

Organic Letters published new progress about 929626-16-4. 929626-16-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronate Esters, name is 2-(3-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO3, HPLC of Formula: 929626-16-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ferrier, Robert J. published the artcileUnsaturated carbohydrates, part 28. Synthesis and photolysis of some carbohydrate 1,6-dienes, Related Products of chlorides-buliding-blocks, the publication is Carbohydrate Research (1985), 249-58, database is CAplus.

Several attempts to abbreviate author’s earlier syntheses of the prostaglandin intermediates I and II by photocyclization of carbohydrate-based 1,6-dienes III [R = R¹ = Cl, Br; RR¹ = S(CH₂)₃S; R = cyano, R¹ = NEt₂] and IV (R² = Me, OEt) did not yield the required bicyclo[3.2.0]heptane derivatives Photolysis of IV caused migration of the conjugated alkene bond.

Carbohydrate Research published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zawadowski, Teodor published the artcileSynthesis of the 2-[4-hydroxy-7-methyl-5-oxo-5H-furo[3,2-g][1]benzopyran-9-yloxy]acetic and -propionic acid derivatives with expected activity on the circulatory system, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Acta Poloniae Pharmaceutica (1989), 46(4), 305-12, database is CAplus and MEDLINE.

Etherification of 4,9-didemethylkhellin (I) with ClCH₂CO₂Et and MeCHClCO₂Et in Me₂CO containing K₂CO₃ gave the furobenzopyranyloxyacetic acid derivatives II (R = H, R² = OEt, R¹ = H, Me, resp.), subsequently hydrolyzed with H₂SO₄ to the corresponding II (R² = OH, III). II (R = H, R² = OR³; R¹ = H, Me, R³ = 2-(1-piperidinyl)ethyl and 2-(4-morpholinyl)ethyl; R¹ = Me, R³ = Me₂NCH₂CHMe) were prepared in the reaction of III with appropriate R³Cl.HCl in a MeOH-Me₂CHOH solution of NaOH. II (R = R¹ = H, R² = NH₂, 2-pyridylamino, IV) were prepared by direct etherification of I with the corresponding ClCH₂COR²; further reaction with MeI gave II (R = Me, R¹ = H, R² = 2-pyridylamino), and with 2-chloroacetylaminopyridine, the ethers V (R¹ = H, R⁴ = H₂NCO and 2-pyridylcarbamoyl). In a similar reaction, 4-demethylkhellin gave V (R¹ = R⁴ = H). IV was comparable with propranolol in antiarrhythmic activity and effect on heart bioelec. action with LD₅₀ as low as 250 mg/kg i.v.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C6H8O6, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Wanlong published the artcileArylpropionylpiperazines as antagonists of the human melanocortin-4 receptor, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(17), 4674-4678, database is CAplus and MEDLINE.

A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was increased by replacing the α-Me substituent of the initial lead with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or β-alanine was incorporated onto the benzylamine. Some compounds demonstrated good potency, moderate selectivity, and oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileVisible Light-Promoted Synthesis of β-Keto Sulfoximines from N-Tosyl-Protected Sulfoximidoyl Chlorides, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Under visible light, N-tosyl-protected sulfoximidoyl chlorides RSO(NTs)Cl (R = 4-CH₃C₆H₄, 4-CH₃OC₆H₅, 1-naphthyl, etc.) react with aryl alkynes R¹C₆H₄CC (R¹ = 4-Cl, 3-Br, 3-Me, etc.) to give β-keto sulfoximines I. The reaction is characterized by a high functional group tolerance and good yields. It can be improved by the presence of a ruthenium photocatalyst. Air is the source of the ketonic oxygen in the products.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H10BNO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileRegio- and Stereoselective Chloro Sulfoximidations of Terminal Aryl Alkynes Enabled by Copper Catalysis and Visible Light, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Advanced Synthesis & Catalysis (2021), 363(10), 2552-2556, database is CAplus.

By visible-light photoredox catalysis with copper complexes, sulfoximidoyl chlorides add to terminal aryl alkynes to gave the corresponding (E)-β-chlorovinyl sulfoximines I [R = 2-thienyl, Ph, 2-naphthyl, etc.; R¹ = n-Pr, Ph, 4-MeC₆H₄, etc.] with exclusive regio- and stereoselectivities in high yields. Two representative products I [R = 4-BrC₆H₄, 4-t-BuC₆H₄; R¹ = Ph] had been characterized by X-ray crystal structure anal. Radicals appear was decisive intermediates. As demonstrated by two subsequent reactions, the products could be derivatized.

Advanced Synthesis & Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C9H21NO3, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics