Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2106-04-9, name is 3-Chloro-2-fluoroaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloro-2-fluoroaniline
General procedure: N,N-Carbonyldiimidazole (0.17 g, 1.2 mmo1) was added to a solution of 8 (0.21 g, 1 mmo1) in anhydrous tetrahydrofuran (THF) and the mixture was stirred for 10 min at room temperature under a nitrogen atmosphere. Subsequently, substituted aniline or phenylethylamine (1.2 mmol) was slowly added to the mixture. The mixture was stirred at 80 oC overnight, then filtrated. The filtrate was evaporated under reduced pressure to give an oil or colored solid, which was purified by column chromatography with petroleum ether/ethyl acetate (7 : 1) to obtain the desired product 9a-9g.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Liu, Yang; Li, Yijing; Liu, Jianzhen; Yang, Limin; Li, Pengzhan; Zhao, Guisen; Letters in drug design and discovery; vol. 13; 4; (2016); p. 314 – 323;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics