Synthetic Route of 7006-52-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7006-52-2 as follows.
Sodium hydride (4.89 g, 73.4 mmol, 60percent in oil) was added portionwise to an ice-cooled solution of N-methyl-3-chloroaniline (8 g, 56.5 mmol) in DMF (40 ml). This mixture was5 then added to an ice-cooled solution of 2,4-dichloropyrimidine (16.8 g, 113 mmol) in DMF (40 ml). The resulting mixture was heated at 700C for 18 hrs. Additional sodium hydride (large excess) was added and the mixture was heated at 1000C for 2 hrs.. After cooling, the mixture was poured in saturated aqueous sodium bicarbonate and extracted with DCM. The organic layer was dried over magnesium sulfate and filtered. After evaporation of the o solvents, the residue was purified by chromatography on silica gel (eluant: 0 to 20percent EtOAc in DCM, then 10percent methanol in EtOAc ) to give 4-[(3-chlorophenyl)-methyl- ammo]-lH-pyrimidin-2-one as a light brown solid (4 g, 30percent). NMR Spectrum: (DMSOd6 and CF3CO2D) 3.53 (s, 3H), 7.46 (m, IH), 7.67-7.60 (m, 3H), 7.78 (m, IH); Mass spectrum: MH+ 236
According to the analysis of related databases, 7006-52-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/104754; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics