Synthesis, Nematicidal Evaluation, and 3D-QSAR Analysis of Novel 1,3,4-Oxadiazole-Cinnamic Acid Hybrids was written by Chen, Jixiang;Chen, Yongzhong;Gan, Xiuhai;Song, Baojing;Hu, Deyu;Song, Baoan. And the article was included in Journal of Agricultural and Food Chemistry in 2018.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
A series of novel 1,3,4-oxadiazole-cinnamic acid hybrids were synthesized. The bioassays results indicated that the compounds (I), (II), (III), and (IV) showed excellent nematicidal activities against Tylenchulus semipenetrans with LC50/48 h values of 9.7 ± 1.6, 15.6 ± 2.8, 8.0 ± 0.5, and 19.8 ± 2.9 mg/L, resp., which were higher than avermectin (32.6 ± 4.5 mg/L) and fosthiazate (67.8 ± 1.7 mg/L). The low toxicity compound 26 with excellent nematicidal activity in vitro (LC50/48 h = 8.2 ± 1.2 mg/L) was designed based on the predictive CoMFA (q2 = 0.795, r2 = 0.921) and CoMSIA (q2 = 0.762, r2 = 0.912) models. The control effect of compound (V) was 69.8% at an ED of 1.0 g/plant in field experiment, which effect was superior to fosthiazate (67.2%). This work indicated 1,3,4-oxadiazole-cinnamic acid hybrids may be used as potential nematicides. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Recommanded Product: 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics