New orally active cephalosporin esters was written by Yamada, Hirotada;Ueda, Shinji;Mutoh, Masayuki;Nagata, Hideo;Nouda, Hiroshi;Fukasawa, Masatomo;Okuda, Takao. And the article was included in Journal of Antibiotics in 1990.Electric Literature of C8H7ClO2 This article mentions the following:
The cephalopsorin I [R = 3-methyl-1,2,4-thiadiazol-5-yl(Q), R1 = H] and its esters I [R1 = CO2CH2O2CR2, R2 = CMe3, heterocyclic, Ph) were prepared Esters I (R = 1-methyl-5-tetrazolyl, 5-methyl-1,3,4-thiadiazol-2-yl, 1,2,4-thiadiazol-5-yl, R1 = CO2CH2O2CCMe3) were also prepared I (R = Q, R1 = H) had bactericidal activity comparable to that of cefotaxime and its ester I (R = Q, R1 = CO2CH2O2CCMe3) gave high serum levels. In the experiment, the researchers used many compounds, for example, Chloromethyl benzoate (cas: 5335-05-7Electric Literature of C8H7ClO2).
Chloromethyl benzoate (cas: 5335-05-7) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Electric Literature of C8H7ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics