Marino, Joseph P. published the artcileThe discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages, COA of Formula: C8H4ClF3O, the main research area is tertiary amine preparation reductive amination nucleophilic substitution; liver X receptor LXR agonist cholesterol efflux macrophage pharmacokinetics; structure activity coronary heart disease cholesterol homeostasis lipid metabolism.
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism SAR studies around tertiary-amine lead mol. I, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.
Bioorganic & Medicinal Chemistry Letters published new progress about Liver X receptor β Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (agonists). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, COA of Formula: C8H4ClF3O.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics