Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 367-22-6, name is 4-Chloro-3-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H5ClFN
Step 1 : tert-butyl (4-chloro-3-fluorophenyl)carbamate. To a solution of 4-chloro-3-fluoroaniline (7.50 g, 51.50 mmol) in DCM (150 mL) was added di-tert-butyl dicarbonate (11.96 mL, 51.5 mmol) dropwise. The reaction mixture was stirred at 25C for 16 h under N2 atmosphere (balloon). TLC showed a new spot and the SM was consumed. The mixture was diluted with water (200 mL) and extracted with EtOAc (150 mL x2). The combined organic layers were dried over Na2S04, filtered and the filtrate was concentrated. The residue was purified by flash silica gel chromatography (0-18% EtOAc/PE gradient) to afford the title compound.
According to the analysis of related databases, 367-22-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MERTZ, Eric; EDMONDSON, Scott, D.; SO, Sung-Sau; SUN, Wanying; LIU, Weiguo; NEELAMKAVIL, Santhosh, F.; GAO, Ying-Duo; HRUZA, Alan; ZANG, Yi; ALI, Amjad; MAL, Rudrajit; HE, Jiafang; KUANG, Rongze; WU, Heping; OGAWA, Anthony, K.; NOLTING, Andrew, F.; (152 pag.)WO2016/168098; (2016); A1;,
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