Adding a certain compound to certain chemical reactions, such as: 13334-71-9, name is 4-Chloro-3-methylanisole, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13334-71-9, category: chlorides-buliding-blocks
To a solution of the l-chloro-4-methoxy-2-methylbenzene (2.0 g, 12.77 mmol) in anhydrous carbon tetrachloride (50 mL), NBS (2.29 g, 12.98 mmol) and benzoyl peroxide (0.154 g, 0.64 mmol) was added. The reaction mixture was heated to reflux overnight. Then, the reaction mixture was cooled to room temperature and filtered. The filtrate was evaporated to provide crude 2-(bromomethyl)-l-chloro-4- methoxybenzene, which was used for the next step without any further purification; 1H NMR (400 MHz, DMSO-J6): delta 3.74 (s, 3H), 4.66 (s, 2H), 7.01 (d, J = 8.9 Hz, IH), 7.19 (s, IH), 7.38 (d, J = 8.9 Hz, IH).
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Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics