Month: December 2022

Xu, Zhou published the artcileDesign and synthesis of a novel isoxazole derivative, Application In Synthesis of 350-30-1, the publication is Xuzhou Yixueyuan Xuebao (2011), 31(11), 728-730, database is CAplus.

To design and develop a new method for the synthesis of a novel isoxazole derivative I which may had potential bactericidal activity, the product was synthesized with six steps in gram scales using benzaldehyde, 4-fluoro-3-chloronitrobenzene et al as starting materials. The structure of the product was confirmed by ¹H NMR, HRMS and IR spectra. A mild route to synthesize an isoxazole derivative with 35% total yield was reported.

Xuzhou Yixueyuan Xuebao published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C7H10O4, Application In Synthesis of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Lianzhong published the artcileA photochromic dye doped polymeric Mach-Zehnder interferometer for UV light detection, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2019), 7(21), 6257-6265, database is CAplus.

Owing to the compact size, immunity to electromagnetic interference, high sensitivity and real-time monitoring, optical waveguide sensors based on a refractive index change have become an emerging approach for smart sensing in the internet-of-things system. For this purpose, the synergetic efforts in material engineering (sensing materials) and optical engineering (waveguide design and fabrication) are both indispensable. Here we report a Mach-Zehnder interferometer (MZI) waveguide with photochromic dye-doped polymer sensing films for UV light detection. Firstly, UV light induced photochromism of a synthesized dye DAECHO in solution and in the solid state is investigated to understand the relationship between their structure and optical properties, especially the photochromism-induced refractive index change for waveguide sensors. Then the MZI structure is designed and simulated to optimize the performance of refractive index sensing. Following the standard microfabrication process of double photolithog.-development, the device is fabricated with a DAECHO doped polymer as a sensing cladding material for UV light detection. The evanescent sensing of MZI is performed to detect weak UV light from 10 μW cm^-2 to 100 μW cm^-2 at 365 nm. Our demonstration of MZI for UV light detection indicates the potential of portable and highly sensitive UV light waveguide sensors for real-life applications.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Yongguo published the artcileDesign, synthesis and anticancer activity evaluation of diazepinomicin derivatives, Category: chlorides-buliding-blocks, the publication is Letters in Drug Design & Discovery (2013), 10(4), 369-373, 5 pp., database is CAplus.

A series of diazepinomicin derivatives [5,10-dihydro-4,6,8-trihydroxy-10-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-11H-dibenzo[b,e][1,4]diazepin-11-one derivatives] were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds Based on the results, preliminary structure-activity relationships were discussed. The synthesis of the target compounds was achieved using 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one derivatives and (2E,6E)-1-bromo-3,7,11-trimethyl-2,6,10-dodecatriene (trans,trans-farnesyl bromide) as key intermediates. The title compounds thus formed included a diazepinomicin analog (I) and related substances.

Letters in Drug Design & Discovery published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C5H5ClIN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Ravinder published the artcileMonomeric and aggregation emissions of tetraphenylethene in a photo-switchable polymer controlled by cyclization of diarylethene and solvent conditions, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2017), 5(38), 9952-9962, database is CAplus.

A novel photo-switchable polymer P-PHT containing diarylethene (DAE) and tetraphenylethene (TPE) moieties and a triazole linker in the repeating unit was synthesized to study the aggregation-induced emission (AIE) behavior of TPE with both the open and closed forms of DAE in P-PHT with high water contents. The photo-switching phenomena of DAE (from open to closed forms under UV-irradiation) in P-PHT were prominent in organic solvent (THF), high water contents (at 90% H₂O) and acidic conditions. Upon UV-irradiation of P-PHT at 90% water content, the AIE of TPE was completely quenched via an energy transfer event from TPE to cyclized DAE. Interestingly, the rare monomeric emission of TPE was first discovered by the photo-cyclization of DAE in P-PHT compared with the AIE behavior of TPE with the open form of DAE in P-PHT with AIE favorable conditions of high water content (90% H₂O) and acidic conditions.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C16H18Br2ClN3O3, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jing, Lanlan published the artcileIdentification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries, Safety of 3-Chlorobenzylchloride, the publication is European Journal of Medicinal Chemistry (2019), 111696, database is CAplus and MEDLINE.

Cell division cycle 25 (Cdc25) protein phosphatases play key roles in the transition between the cell cycle phases and their association with various cancers has been widely proven, which makes them ideal targets for anti-cancer treatment. Though several Cdc25 inhibitors have been developed, most of them displayed low activity and poor subtype selectivity. Therefore, it is extremely important to discover novel small mol. inhibitors with potent activities and significant selectivity for Cdc25 subtypes, not only served as drugs to treat cancer but also to probe its mechanism in transitions. In this study, miniaturized parallel click chem. synthesis via CuAAC reaction followed by in situ biol. screening were used to discover selective Cdc25 inhibitors. The bioassay results showed that compound M2N12 proved to be the most potent Cdc25 inhibitor, which also act as a highly selective Cdc25C inhibitor and was about 9-fold potent than that of NSC 663284. Moreover, M2N12 showed remarkable anti-growth activity against the KB-VIN cell line, equivalent to that of PXL and NSC 663284. An all-atom mol. dynamics (MD) simulation approach was further employed to probe the significant selectivity of M2N12 for Cdc25C relative to its structural homologs Cdc25A and Cdc25B. Overall, above results make M2N12 a promising lead compound for further investigation and structural modification.

European Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jing published the artcileMultifunctional Mesoporous Silica Nanoparticles Based on Charge-Reversal Plug-Gate Nanovalves and Acid-Decomposable ZnO Quantum Dots for Intracellular Drug Delivery, Application of 2-Chlorotrityl chloride, the publication is ACS Applied Materials & Interfaces (2015), 7(48), 26666-26673, database is CAplus and MEDLINE.

A novel type of pH-responsive multifunctional mesoporous silica nanoparticle (MSN) was developed for cancerous cells drug delivery and synergistic therapy of tumor. MSNs were covered with a kind of cell-penetrating peptide, deca-lysine sequence (K₁₀), to enhance their escape from the endosomes. After K₁₀‘s primary amines were reacted with citraconic anhydride to form acid-labile β-carboxylic amides, zinc oxide (ZnO) quantum dots (QDs) were introduced to cap MSNs via electrostatic interaction. The obtained ZnO@MSN drug-delivery system (DDS) achieves “zero-premature” drug release under a physiol. environment. However, once the DDS is transferred to the cancerous cells’ acidic endosome, ZnO QDs would rapidly dissolve and the acid-labile amides on the side chain of K₁₀ would hydrolyze to regenerate primary amines, resulting in the uncapping of MSNs and exposure of the cell-penetrating peptide K₁₀. The regenerated K₁₀ could help the DDS escape from the endosome and efficiently release the loaded drugs inside the cells. At the meantime, because of the cytotoxicity of ZnO QDs at their destination, the ZnO@MSN DDS may achieve a synergistic antitumor effect to improve the therapeutic index.

ACS Applied Materials & Interfaces published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C4H6O3, Application of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Jichao published the artcileHexamethyldisilazane Lithium (LiHMDS)-Promoted Hydroboration of Alkynes and Alkenes with Pinacolborane, Application of 4-Chloro-3-fluorostyrene, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Lithium-promoted hydroboration of alkynes and alkenes using com. available hexamethyldisilazane lithium as a precatalyst and HBpin as a hydride source has been developed. This method will be appealing for organic synthesis because of its remarkable substrate tolerance and good yields. Mechanistic studies revealed that the hydroboration proceeds through the in situ-formed BH₃ species, which acts to drive the turnover of the hydroboration of alkynes and alkenes.

Journal of Organic Chemistry published new progress about 1263414-46-5. 1263414-46-5 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Alkenyl,Benzene, name is 4-Chloro-3-fluorostyrene, and the molecular formula is C8H6ClF, Application of 4-Chloro-3-fluorostyrene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gauthier, Sylvie published the artcileMechanistic studies of polysilane polymerization, Synthetic Route of 14799-94-1, the publication is Advances in Chemistry Series (1990), 299-307, database is CAplus.

The mechanisms and kinetics of condensation polymerization of dialkyldichlorosilanes were studied. The reactivities of the monomers were different under either concurrent or consecutive monomer addition Block copolymers were formed by sequential addition of monomers to polymer systems. Relative rates of monomer consumption were MePhSiCl₂ > hexylmethyldichlorosilane > Me₂SiCl₂ >> vinylmethyldichlorosilane; relative rates of monomer consumption during copolymerization were in a different order. General schemes were suggested for the reaction pathways, but the kinetics of the reaction were very complex; a kinetic scheme could not be derived.

Advances in Chemistry Series published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Synthetic Route of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gauthier, S. published the artcileThe effect of phase-transfer catalysts on polysilane formation, Quality Control of 14799-94-1, the publication is Macromolecules (1989), 22(5), 2213-18, database is CAplus.

Polysilanes are most often prepared by a Wurtz-type coupling of organodichlorosilanes with Na in refluxing PhMe. The addition of a catalytic amount of crown ether to the reaction mixture increases the rate of disappearance of the monomer with increasing crown ether concentration, suggesting that anionic species are involved in the polymerization mechanism. Higher yields of polymer relative to cyclic material were obtained, and the polymer displays a monomodal distribution. The presence of cryptand has similar effects although some degradation of the polymer upon continued refluxing of the reaction mixture was observed Degradation experiments on poly(n-hexylmethylsilane) with Na in refluxing PhMe showed that the polymer degraded to cyclics in a few minutes with cryptand but not with crown ether.

Macromolecules published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Quality Control of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Song, W. published the artcileMicroscopic and Macroscopic Characterization of Organosilane-Functionalized Nanocrystalline NaZSM-5, Computed Properties of 14799-93-0, the publication is Langmuir (2005), 21(15), 7009-7014, database is CAplus and MEDLINE.

Nanocrystalline NaZSM-5 zeolites with systematically varied particle sizes (15, 60, and 200 nm) were functionalized with organosilanes. Through the systematic variation of particle size and therefore external surface area of NaZSM-5, the extent of functionalization and location of functional groups were spectroscopically verified. ²⁹Si magic-angle spinning (MAS) NMR and Fourier transform IR (FTIR) spectroscopy provided conclusive evidence that the silanol groups located on the external surface of NaZSM-5 were functionalized through reaction with the organosilanes. The ²⁹Si NMR results provided quant. information about the extent of functionalization on NaZSM-5. A nitroxide spin label was adsorbed on the external surface of NaZSM-5 to probe the surface properties by ESR (EPR) spectroscopy. The macroscopic and microscopic properties, such as the behavior of functionalized NaZSM-5 in different solvents, and the sp. surface areas were also investigated. The hydrophobicity of the functionalized NaZSM-5 was found to increase relative to the parent NaZSM-5 as expected for an organic surface coating.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C12H16N2O2, Computed Properties of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics