Month: December 2022

Hu, Wenbin published the artcileSuper-microporous silica-supported platinum catalyst for highly regioselective hydrosilylation, Formula: C9H20Cl2Si, the publication is Catalysis Communications (2017), 51-55, database is CAplus.

Super-microporous micelle-templated platinum on silica catalysts were successfully prepared by an improved one-pot procedure, using a water/acetonitrile/n-dodecylamine mixture The catalyst showed high surface area and narrow pore size and was further characterized by powder X-ray diffraction and inductively coupled plasma mass spectrometry. The unique super-microporous materials were proven to be highly active for the microwave-assisted hydrosilylation reaction of terminal alkenes or alkynes using dichloromethylsilane as silicon source. The super-microporous structure was beneficial for the control of hydrosilylation regioselectivity, as the selectivity to the β-adduct reached 99%. Moreover, the catalyst could be easily recovered by simple filtration and re-used seven times without appreciable loss of activity and selectivity.

Catalysis Communications published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Che, Chao published the artcileStudies on Pyridine Derivatives. IX. Synthesis and Herbicidal Activities of N-(1-carbomethoxy)-ethyl-N-[5-(2-chloropyrid-4-yl)-1,3,4-thiodiazol-2-yl] Amides, COA of Formula: C6H4ClNO2, the publication is Nongyaoxue Xuebao (2004), 6(3), 15-20, database is CAplus.

In order to investigate the structure-activity relationship and improve the activity of herbicidal lead compound 2-sec-butylamino-5-(2-chloropyrid-4-yl)-1,3,4-thiodiazole (BCPT), which was found in previous work on pyridine derivatives, a novel series of N-(1-carbomethoxy) ethyl-N-[5-(2-chloropyrid-4-yl)-1,3,4-thiodiazol-2-yl] amides were synthesized and subjected to post-emergence herbicidal tests. All the compounds showed much weaker herbicidal activity than BCPT itself. The results suggested that BCPT might act to herbs in different way to amide herbicides.

Nongyaoxue Xuebao published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Zhiguo published the artcileModulation of the Photochromic Property in an Organoboron-Based Diarylethene by a Fluoride Ion, Category: chlorides-buliding-blocks, the publication is Organic Letters (2006), 8(18), 3911-3914, database is CAplus and MEDLINE.

Organoboron-based diarylethene was successfully synthesized and exhibited photochromic property. Furthermore, its photochromic property can be modulated by a fluoride ion. The absorption maximum of the photostationary state shifted from 655 to 490 nm upon addition of a fluoride ion. The modulation mechanism is attributed to the special Lewis acid-base interaction between a trivalent boron atom and a fluoride ion.

Organic Letters published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H15OP, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Yan-Xia published the artcileThe small auxin-up RNA OsSAUR45 affects auxin synthesis and transport in rice, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Plant Molecular Biology (2017), 94(1-2), 97-107, database is CAplus and MEDLINE.

Key message: This research is the first to demonstrate that OsSAUR45 is involved in plant growth though affecting auxin synthesis and transport by repressing OsYUCCA and OsPIN gene expression in rice. Abstract: Small auxin-up RNAs (SAURs) comprise a large multigene family and are rapidly activated as part of the primary auxin response in plants. However, little is known about the role of SAURs in plant growth and development, especially in monocots. Here, we report the biol. function of OsSAUR45 in the model plant rice (Oryza sativa). OsSAUR45 is expressed in a tissue-specific pattern and is localized to the cytoplasm. Rice lines overexpressing OsSAUR45 displayed pleiotropic developmental defects including reduced plant height and primary root length, fewer adventitious roots, narrower leaves, and reduced seed setting. Auxin levels and transport were reduced in the OsSAUR45 overexpression lines, potentially because of decreased expression of Flavin-binding monooxygenase family proteins (OsYUCCAs) and PIN-FORMED family proteins (OsPINs). Exogenous auxin application rapidly induced OsSAUR45 expression and partially restored the phenotype of rice lines overexpressing OsSAUR45. These results demonstrate that OsSAUR45 is involved in plant growth by affecting auxin synthesis and transport through the repression of OsYUCCA and OsPIN gene expression in rice.

Plant Molecular Biology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C12H16N2O2, Safety of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ye, Jiao published the artcileSynthesis and Cytotoxicity in Vitro of N-Aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine, Name: 1-(4-Chlorophenyl)thiourea, the publication is Journal of the Chinese Chemical Society (Weinheim, Germany) (2015), 62(7), 627-631, database is CAplus.

A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines I [R = H, 4-Me, 2-F, etc.] were synthesized in a green way. H₂O₂-NaBr brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. Structures of the target compounds were confirmed by ¹H NMR and elemental anal. and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound I [R = 3-F₃C] was the most potent compound with the IC₅₀ values of 9μM against Hela cells and 15μM against Bel-7402 cells resp.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C10H16Br3N, Name: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Haihua published the artcileControllable access to multi-substituted imidazoles via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions, Formula: C9H12BClO3, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(70), 9745-9748, database is CAplus and MEDLINE.

A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles I [R¹ = Me, CF₃, Ph, etc.; R² = H, Ph, Bn; R³ = H, Me; R⁴ = Ph, 4-FC₆H₄, 2-MeC₆H₄, etc.] via cascade palladium catalyzed C-C coupling followed by intramol. C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield. The protocol was the first report to prepare multi-substituted imidazoles from readily accessible aminoacetonitrile and boronic acid.

Chemical Communications (Cambridge, United Kingdom) published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C19H21N3O3S, Formula: C9H12BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Zhifei published the artcileSynthesis of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one from maltol and its taste identification, Application In Synthesis of 21286-54-4, the publication is Food Chemistry (2021), 130052, database is CAplus and MEDLINE.

2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) exists in many foods, and its effect on taste is controversial. The aim of this study was to clarify whether DDMP has bitter taste or not. For this purpose, DDMP was synthesized from maltol instead of from glucose for the first time. In contrast, DDMP derived from glucose was also prepared and further purified. Their structures were identified by NMR and MS, and considered to be the same substance. The sensory anal. showed that DDMP derived from maltol was tasteless. Further studies indicated that some impurities in Maillard reaction made DDMP derived from glucose taste bitter.

Food Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Matralis, Alexios N. published the artcileMolecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2018), 26(20), 5547-5554, database is CAplus and MEDLINE.

Lamin A contributes to the structure of nuclei in all mammalian cells and plays an important role in cell division and migration. Mature lamin A is derived from a farnesylated precursor protein, known as prelamin A, which undergoes posttranslational cleavage catalyzed by the zinc metalloprotease STE24 (ZPMSTE24). Accumulation of farnesylated prelamin A in the nuclear envelope compromises cell division, impairs mitosis and induces an increased expression of inflammatory gene products. ZMPSTE24 has been proposed as a potential therapeutic target in oncol. A library of peptidomimetic compounds were synthesized and screened for their ability to induce accumulation of prelamin A in cancer cells and block cell migration in pancreatic ductal adenocarcinoma cells. The results of this study suggest that inhibitors of lamin A maturation may interfere with cell migration, the biol. process required for cancer metastasis.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Downie, Ian M. published the artcileA high yield route to ethyl esters of carboxylic acids, Safety of Diethyltrichloromethylphosphonate, the publication is Tetrahedron (1982), 38(10), 1457, database is CAplus.

On treatment with (EtO)₂POCCl₃ (I), aromatic and aliphatic carboxylic acids gave the corresponding Et esters in good-to-high yield through transesterification. E.g., treatment of PhCO₂H with I, prepared in 92% yield from (EtO)₃P and CCl₄, at 120° for 1 day gave 96% PhCO₂Et. 2,4,6-Me₃C₆H₂CO₂H was esterified in 93% yield.

Tetrahedron published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tian, Yazhen published the artcileStudies on the NMR and configuration of derivatives of aziridine, COA of Formula: C3H3Br2ClO, the publication is Bopuxue Zazhi (1990), 7(3), 269-80, database is CAplus.

Cyclocondensation of 4-NaO₃SC₆H₄NHCOCBr:CH₂ with amino acids under basic conditions gave aziridine derivatives I [R = CH₂CO₂Na, CH₂CH₂CO₂Na, L-CHMeCO₂Na, DL-CH(CH₂Ph)CO₂Na]. The configurations of I were determined by ¹H and ¹³C NMR; the latter two I were 1:1 mixtures of diastereomers.

Bopuxue Zazhi published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C9H10N2O, COA of Formula: C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics