Month: December 2022

Rehak, Vladimir published the artcileComparison of linear and branched nonpolar chemically bonded stationary phases in high-performance liquid chromatography, Application In Synthesis of 14799-93-0, the publication is Journal of Chromatography (1980), 191(1), 71-9, database is CAplus.

Nonpolar chem. bonded stationary phases with branched or unbranched structure were synthesized, and their sp. surface areas, pore size distributions, and C contents were estimated Based on these data the number of silane mols. bonded to unit surface area of the original silica gel was calculated for each phase. Retentions of selected solute groups were measured in 4 mobile phases of various elution strength, prepared from MeOH-H₂O mixtures at various ratios. Dependence of k‘ on the length of the “bristle”, on the size and structure of the solute mol., and the elution strength of the mobile phase were plotted. Results are compared for pairs of phases having different structures but either the same total number of C atoms in the bonded mol. or the same length of the “bristle”. The synthesis of several halosilanes used for preparation of the bonded phases is described.

Journal of Chromatography published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Application In Synthesis of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hwang, Jong Yeon published the artcileOptimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei, COA of Formula: C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(14), 4127-4131, database is CAplus and MEDLINE.

We previously reported the phenylchloronitrobenzamides (PCNBs), a novel class of compounds active against the species of trypanosomes that cause Human African Trypanosomiasis (HAT). Herein, we explored the potential to adjust the reactivity of the electrophilic chloronitrobenzamide core. These studies identified compound 7d that potently inhibited the growth of trypanosomes (EC₅₀ = 120 nM for Trypanosoma b. brucei, 18 nM for Trypanosoma b. rhodesiense, and 38 nM for Trypanosoma b. gambiense) without significant cytotoxicity against mammalian cell lines (EC₅₀ > 25 μM for HepG2, HEK293, Raji, and BJ cell lines) and also had good stability in microsomal models (t_1/2 > 4 h in both human and mouse). Overall these properties indicate the compound 7d and its analogs are worth further exploration as potential leads for HAT.

Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lankova, Martina published the artcileAuxin influx inhibitors 1-NOA, 2-NOA, and CHPAA interfere with membrane dynamics in tobacco cells, Product Details of C8H7ClO3, the publication is Journal of Experimental Botany (2010), 61(13), 3589-3598, database is CAplus and MEDLINE.

The phytohormone auxin is transported through the plant body either via vascular pathways or from cell to cell by specialized polar transport machinery. This machinery consists of a balanced system of passive diffusion combined with the activities of auxin influx and efflux carriers. Synthetic auxins that differ in the mechanisms of their transport across the plasma membrane together with polar auxin transport inhibitors have been used in many studies on particular auxin carriers and their role in plant development. However, the exact mechanism of action of auxin efflux and influx inhibitors has not been fully elucidated. In this report, the mechanism of action of the auxin influx inhibitors (1-naphthoxyacetic acid (1-NOA), 2-naphthoxyacetic acid (2-NOA), and 3-chloro-4-hydroxyphenylacetic acid (CHPAA)) is examined by direct measurements of auxin accumulation, cellular phenotypic anal., as well as by localization studies of Arabidopsis thaliana auxin carriers heterologously expressed in Nicotiana tabacum, cv. Bright Yellow cell suspensions. The mode of action of 1-NOA, 2-NOA, and CHPAA has been shown to be linked with the dynamics of the plasma membrane. The most potent inhibitor, 1-NOA, blocked the activities of both auxin influx and efflux carriers, whereas 2-NOA and CHPAA at the same concentration preferentially inhibited auxin influx. The results suggest that these, previously unknown, activities of putative auxin influx inhibitors regulate overall auxin transport across the plasma membrane depending on the dynamics of particular membrane vesicles.

Journal of Experimental Botany published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Waszkowycz, Bohdan published the artcileCell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides, Name: 2-(Chloromethyl)-5-methyl-1,3,4-thiadiazole, the publication is Journal of Medicinal Chemistry (2018), 61(23), 10767-10792, database is CAplus and MEDLINE.

DNA damage repair enzymes are promising targets in the development of new therapeutic agents for a wide range of cancers and potentially other diseases. The enzyme poly(ADP-ribose) glycohydrolase (PARG) plays a pivotal role in the regulation of DNA repair mechanisms; however, the lack of potent drug-like inhibitors for use in cellular and in vivo models has limited the investigation of its potential as a novel therapeutic target. Using the crystal structure of human PARG in complex with the weakly active and cytotoxic anthraquinone 8a, novel quinazolinedione sulfonamides PARG inhibitors have been identified by means of structure-based virtual screening and library design. 1-Oxetan-3-ylmethyl derivatives 33d and 35d were selected for preliminary investigations in vivo. X-ray crystal structures help rationalize the observed structure-activity relationships of these novel inhibitors.

Journal of Medicinal Chemistry published new progress about 75341-23-0. 75341-23-0 belongs to chlorides-buliding-blocks, auxiliary class Thiadiazole,Chloride, name is 2-(Chloromethyl)-5-methyl-1,3,4-thiadiazole, and the molecular formula is C15H20O6, Name: 2-(Chloromethyl)-5-methyl-1,3,4-thiadiazole.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gourdet, Benoit published the artcileRhodium-catalyzed carbometalation of ynamides with organoboron reagents, Product Details of C9H12BClO3, the publication is Tetrahedron (2010), 66(32), 6026-6031, database is CAplus.

In the presence of catalytic [Rh(cod)(MeCN)₂]BF₄, ynamides undergo carbometalation with boronic acids, arylboronic esters, and triarylboroxines. These reactions enable the regio- and stereocontrolled synthesis of multisubstituted enamides. E.g., reaction of 3-(2-phenylethynyl)oxazolidin-2-one with 4-chlorophenylboronic acid gave 65% 3-[(E)-2-(4-chlorophenyl)-2-phenylvinyl]oxazolidin-2-one (I).

Tetrahedron published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Product Details of C9H12BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Van Tilborg, W. J. M. published the artcileThe electrochemical Wittig-Horner reaction; evidence of a stepwise cleavage of a four-membered ring Wittig intermediate, Application In Synthesis of 866-23-9, the publication is Recueil des Travaux Chimiques des Pays-Bas (1980), 99(6), 202-6, database is CAplus.

Electroreduction of diethyl(trichloromethyl)phosphonate in the presence of aldehydes or ketones replaces the O atom of the carbonyl group by a dichloromethylene group. The yield of 1,1-dichloroethene product decreases substantially if the carbonyl compound carries strongly acidic hydrogen. In several cases the conversion of the 4-membered ring Wittig intermediate into its corresponding carbanion by heterolytic P-C bond cleavage was observed The intermediate carbanion is sufficiently stable to be intercepted by proton abstraction. These observations suggest that the decomposition of the Wittig 4-membered ring intermediate occurs along a 2-step pathway.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C24H20Ge, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Timmers, Peer H. A. published the artcileImproved drinking water quality after adding advanced oxidation for organic micropollutant removal to pretreatment of river water undergoing dune infiltration near The Hague, Netherlands, SDS of cas: 637-07-0, the publication is Journal of Hazardous Materials (2022), 128346, database is CAplus and MEDLINE.

Introduction of AOP decreased the number and concentration of OMP that were introduced during MARR, which decreased the risk of neg. impacts on ecol. and groundwater. The many uncertainties, such as seasonal and annual fluctuations of the intake water and in the infltration ponds, made it diffcult to determine if factors were directly affected by the AOP introduction. However, AOP did increase the amount of easily biol. degradable compounds, but these were diluted with non-AOP treated infltration water and degraded during transport to the dunes, making the effects on MARR negligible. Several OMP that were not removed during AOP, were removed during MARR. The overall OMP concentrations in resulting drinking water therefore decreased after introduction of AOP, without showing a measurable neg. effect on other water quality parameters.

Journal of Hazardous Materials published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C16H12N2O2, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Allgeier, Alan M. published the artcileElectrochemically Controlling Ligand Binding Affinity for Transition Metals via RHLs: The Importance of Electrostatic Effects, HPLC of Formula: 1002-41-1, the publication is Journal of the American Chemical Society (1997), 119(3), 550-559, database is CAplus.

Redox-switchable hemilabile ligands (RHLs) were synthesized that incorporates ferrocene as the redox group and phosphine ether or phosphine thioether moieties as binding groups. These ligands, which complex to Rh(I) and Pd(II), yield electrochem. control over ligand binding affinity for transition metals in complexes of the following type: [M(η⁴-(η⁵-C₅H₄XCH₂CH₂PR₂)₂Fe)]^y+ (I: M = Rh, X = O, R = Ph (phenyl), y = 1; II: M = Rh, X = O, R = Cy (cyclohexyl), y = 1; III: M = Rh, X = S, R = Ph, y = 1; IV: M = Pd, X = O, R = Ph, y = 2; V: M = Pd, X = O, R = Cy, y = 2). In the case of V, ligand based oxidation decreases the ligand to metal binding constant by nearly ten orders of magnitude. An examination of the crystal structures of I, III, IV, and V and the electrochem. behavior of RHL-complexes and isoelectronic model complexes reveals that electrostatic effects play a significant role in the charge dependent behaviors of these complexes. Addnl., there is a correlation between the phosphine substituents and RHL-complex stability. As a general rule cyclohexyl groups stabilize the complexes in their oxidized states over Ph groups. RHLs provide a viable means of electrochem. controlling ligand binding affinity and thus the steric and electronic environment of bound transition metals.

Journal of the American Chemical Society published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

van der Maaden, Koen published the artcileFluorescent Nanoparticle Adhesion Assay: a Novel Method for Surface pK_a Determination of Self-Assembled Monolayers on Silicon Surfaces, Related Products of chlorides-buliding-blocks, the publication is Langmuir (2012), 28(7), 3403-3411, database is CAplus and MEDLINE.

Since the computer industry enables one to generate smaller and smaller structures, silicon surface chem. is becoming increasingly important for (bio-)anal. and biol. applications. For controlling the binding of charged biomacromols. such as DNA and proteins on modified silicon surfaces, the surface pK_a is an important factor. Here the authors present a fluorescent nanoparticle adhesion assay as a novel method to determine the surface pK_a of silicon surfaces modified with weak acids or bases. This method is based upon electrostatic interactions between the modified silicon surface and fluorescent nanoparticles with an opposite charge. Silicon slides were modified with 3-aminopropyltriethoxysilane (APTES) and were further derivatized with succinic anhydride. Layer thickness of these surfaces was determined by ellipsometry. After incubating the surfaces with an amine-reactive fluorescent dye, fluorescence microscopy revealed that the silicon surfaces were successfully modified with amine- and carboxyl-groups. Two surface pK_a values were found for APTES surfaces by the fluorescent nanoparticle adhesion assay. The 1st surface pK_a (6.55 ± 0.73) was comparable with the surface pK_a obtained by contact angle titration (7.3 ± 0.8), and the 2nd surface pK_a (9.94 ± 0.19) was only found by using the fluorescent nanoparticle adhesion assay. The surface pK_a of the carboxyl-modified surface by the fluorescent nanoparticle adhesion assay (4.37 ± 0.59) did not significantly differ from that found by contact angle titration (5.7 ± 1.4). In conclusion, the authors have developed a novel method to determine the surface pK_a of modified silicon surfaces: the fluorescent nanoparticle adhesion assay. This method may provide a useful tool for designing pH-dependent electrostatic protein and particle binding/release and to design surfaces with a pH-dependent surface charge for (bio-)anal. lab-on-a-chip devices or drug delivery purposes.

Langmuir published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C23H28N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zolnowska, Beata published the artcileN-(2-Arylmethylthio-4-chloro-5-methylbenzenesulfonyl)amide derivatives as potential antimicrobial agents-synthesis and biological studies, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is International Journal of Molecular Sciences (2020), 21(1), 210, database is CAplus and MEDLINE.

A series of N-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)amides I [R = Ph, 3-F₃CC₆H₄, 4–F₃CC₆H₄, 1-naphthyl, 2-naphthyl] and II was synthesized. The antimicrobial activity of compounds I and II was evaluated on Gram-pos., Gram-neg. bacteria and fungal species. Experiments took into account investigation of antibacterial activity against planktonic cells as well as biofilms. Compounds I and II showed high bacteriostatic activity against staphylococci, with the most active mols. I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] presenting low MIC values of 4-8μg/mL against reference methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains as well as clin. isolates. Compounds I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] also showed an ability to inhibit biofilms formed by MRSA and MSSA. The potential of I [R = 3-F₃CC₆H₄] and II [R = 3-F₃CC₆H₄] as antibiofilm agents was supported by cytotoxicity assays that indicated no cytotoxic effect either on normal cells of human keratinocytes or on human cancer cells, including cervical, colon, and breast cancer lines.

International Journal of Molecular Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H9NOS, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics