Month: December 2022

Kim, Tae-Kyung published the artcileSynthesis of a novel bridge compound having hetero-bi-functional reactive groups. Part 1: its adsorption properties, HPLC of Formula: 18791-02-1, the publication is Dyes and Pigments (2005), 65(3), 261-266, database is CAplus.

A novel heterobifunctional compound containing two different reactive groups, α,β-dibromopropionylamino and dichloro-s-triazinyl groups, was synthesized. The α,β-dibromopropionylamino group had considerable reactivity towards amines or amino groups under acidic conditions and high temperature The dichloro-s-triazinyl group had reactivity towards hydroxyl groups under alk. conditions and room temperature The compound was used as a bridge to fix dyes containing amino groups (e.g. 1-amino-4-hydroxyanthraquinone) to cellulosic substrates (e.g. cotton textiles). The effects of temperature, pH, neutral salt, treatment time and concentration on chemisorption of the bridge compound to cotton fibers were investigated. The heterobifunctional compound provided the 1-amino-4-hydroxyanthraquinone-dyed cotton textile with a color strength of 14.73, while the dyed untreated textile had a color strength of 0.78.

Dyes and Pigments published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, B. Vittal published the artcileSynthesis and antifertility activity of 5-oxo-5H-benzofuro(6,5-c)[2]benzopyran and its basic ether derivatives, SDS of cas: 4584-49-0, the publication is Journal of the Indian Chemical Society (1980), 57(8), 837-40, database is CAplus.

Benzofurobenzopyranones I (R = H, aminoalkyl) were prepared from 2-BrC₆H₄CO₂H and benzenediols via 7-hydroxy-3,4-benzocoumarins and cyclization of the corresponding desyl ethers. I caused â‰?3.3% inhibition of fetal implantation at 10 mg/kg i.p. in rats.

Journal of the Indian Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, B. Vittal published the artcileSynthesis of 2,3-diphenyl-6-(p-substituted phenyl)-5H- and (or) -methyl-7H-oxofuro[3,2-g][1]benzopyrans as possible antifertility agents, HPLC of Formula: 4584-49-0, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1980), 19B(3), 232-4, database is CAplus.

Synthesis and antiimplantation activity of benzopyrans I [R = Me₂NCH₂CHMe, 3-piperidinopropyl, 2-morpholinoethyl, 3-piperazinoethyl, 2-(1-pyrrolidinyl)ethyl, Me₂NCH₂CH₂; R¹ = H, Me] are reported. I (R = Me₂NCH₂CHMe; R¹ = Me) shows significant activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, HPLC of Formula: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hamdy, Rania published the artcileDesign and synthesis of new drugs inhibitors of Candida albicans hyphae and biofilm formation by upregulating the expression of TUP1 transcription repressor gene, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Pharmaceutical Sciences (2020), 105327, database is CAplus and MEDLINE.

Here, new compounds were designed to selectively inhibit C. albicans hyphae formation without affecting human cells to afford sufficient safety. The newly designed 5-[3-substitued-4-(4-substituedbenzyloxy)-benzylidene]-2-thioxo-thiazolidin-4-one derivatives, named SR, I (R¹ = 4-Me, 4-CF₃, 3-CF₃; R² = OMe, Cl, Br) showed very specific and effective inhibition activity against C. albicans hyphae formation. SR compounds caused hyphae inhibition activity at concentrations 10-40 fold lower than the concentration required to inhibit Candida yeast and bacterial growths. The anti-hyphae inhibition activities of SR compounds were via activation of the hyphae transcription repressor gene, TUP1. Correlation studies between the expression of TUP1 gene and the activity of SR compounds confirmed that the anti-C. albicans activities of SR compounds were via inhibition of hyphae formation. The newly designed SR compounds showed 10-40% haemolytic activity on human erythrocytes when compared to 100% haemolysis by 0.1% triton employed as pos. control. Furthermore, theor. prediction of absorption, distribution, metabolism, excretion, and toxicity (ADMET) of SR compounds confirmed their safety, efficient metabolism and possible oral bioavailability. With the minimal toxicity and significant activity of the newly-designed SR compounds, a future optimization of pharmaceutical formulation may develop a promising inhibitor of hyphal formation not only for C. albicans but also for other TUP1-dependent dimorphic fungal infections.

European Journal of Pharmaceutical Sciences published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

El-Sakka, Sahar Said published the artcileBehaviour of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid towards nitrogen-containing nucleophiles, SDS of cas: 3696-23-9, the publication is Journal of Chemical Sciences (Bangalore, India) (2014), 126(6), 1883-1891, database is CAplus.

A series of novel amino acid derivatives has been synthesized by the reaction of 4-[4-methoxy-3-methylphenyl]-4-oxobutenoic acid with primary and secondary amines. The treatment of amino acids with hydrazine afforded pyridazine. Phenylhydrazone was obtained from the reaction of the acid with Ph hydrazine in ethanol. On the other hand, the acid underwent heterocyclization upon the treatment with 2-aminopyridine, o-phenylenediamine, aryldithiocarbamates and thiourea derivatives to give the corresponding pyridopyrimidine, quinoxalone, 2-thioxo-1,3-thiazole and 4-hydroxy-1,3-thiazole, resp. The thiazolopyridazine derivatives were obtained from the reaction of 4-hydroxy-1,3-thiazole with hydrazine and phenylhydrazine, resp. The behavior of the 4-hydroxy-1,3-thiazole toward acetic anhydride and bromine was also studied. Some of the synthesized compounds also exhibited anti-microbial activities.

Journal of Chemical Sciences (Bangalore, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hahn, Witold E. published the artcileDicarboxylic acid imides. VI. N-Aminoalkoxyphenyl derivatives of 4-cyclohexene-1,2-dicarboximide, Computed Properties of 4584-49-0, the publication is Acta Poloniae Pharmaceutica (1980), 37(4), 403-8, database is CAplus.

Eighteen imide derivatives (I; n = 2, 3; R = Me, Et, Me₂CH, 1-piperidinyl, 1-pyrrolidinyl) were prepared by reaction of Cl(CH₂)_nNR₂ with the corresponding phenolic compound (II) in Me₂CO in the presence of K₂CO₃. An alternative route of synthesis involved the reaction of II with Br(CH₂)_nBr and subsequent treatment of the thus formed III with R₂NH. Hypotensive and psychotropic activity of several I was claimed.

Acta Poloniae Pharmaceutica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Computed Properties of 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhebentyaev, A. I. published the artcileElectron and infrared spectra of eosin complexes with nitrogen-containing drugs, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Farmatsiya (Moscow, Russian Federation) (1991), 40(6), 28-31, database is CAplus.

The interaction of eosin with some nitrogen-containing drugs decamethoxin and papaverine was examined by using UV, IR, and spectrophotometric methods in the visible region. The OH-group of eosine was implicated in the complex formation. The mechanism responsible for the complex formation is discussed in the study.

Farmatsiya (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C18H20N2O12, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tomashevskii, A. A. published the artcileReaction of (α-haloalkyl)thiiranes with nucleophilic reagents. I. Reaction with morpholine, HPLC of Formula: 18791-02-1, the publication is Zhurnal Organicheskoi Khimii (1994), 30(10), 1528-36, database is CAplus.

D-labeling experiments showed that (chloromethyl)thiirane reacts with morpholine by a mechanism involving initial ring cleavage and subsequent recyclization. In the case of (bromomethyl)thiirane, direct substitution of Br competes with this mechanism. Reactions of morpholine with 2-(chloromethyl)-2-methylthiirane, 3-(chloromethyl)-2,2-dimethylthiirane, and diastereoisomers of (1-chloroethyl)thiirane were also examined

Zhurnal Organicheskoi Khimii published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C5H5BrN2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gotsko, Maxim D. published the artcileTopochemical mechanoactivated phosphonylethynylation of pyrroles with chloroethynylphosphonates on solid Al₂O₃ or K₂CO₃ media, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (2015), 56(32), 4657-4660, database is CAplus.

Dialkyl 2-(1H-pyrrol-2-yl)ethynylphosphonates have been synthesized from their resp. pyrroles by a transition metal-free, topochem. mechanoactivated phosphonylethynylation (room temperature, 24-48 h) using chloroethynylphosphonates on solid Al₂O₃ (40-58% yield) or K₂CO₃ (38-43% yield).

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Skobeeva, V. published the artcileSynthesis of silver nanoparticles and therapeutic films for ophthalmology based on them, Product Details of C38H74Cl2N2O4, the publication is Springer Proceedings in Physics (2020), 179-188, database is CAplus.

This article presents the results of the silver nanoparticles synthesis by a simple and ecol. method of chem. reduction of silver from silver nitrate in an aqueous solution of sodium citrate and their use in the treatment of eye diseases. The technol. conditions that lead to formation of silver nanoparticles with spherical shape and size of 30 nm with an intensive band of surface plasmon resonance are established. The effect of the application of therapeutic films with nanoparticles on the ultrastructure of the epithelium and stroma of the cornea of a rabbit after modeling in animals of moderately severe bacterial keratitis has been studied. It has been established that the application of therapeutic films with silver nanoparticles, as compared with antibiotics, leads to more efficient regeneration of the anterior corneal epithelium, contributes to the rapid restoration of the stroma and active formation of the delicate collagen skeleton typical of healthy corneal tissue.

Springer Proceedings in Physics published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C8H5F3O3, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics