Month: December 2022

Kim, Hun Young published the artcileReversal of Enantioselectivity Approach to BINOLs via Single and Dual 2-Naphthol Activation Modes, Quality Control of 21286-54-4, the publication is Organic Letters (2017), 19(14), 3867-3870, database is CAplus and MEDLINE.

A mechanism-driven enantiodivergent approach to chiral 1,1′-bi-2-naphthols via catalytic asym. oxidative coupling of 2-naphthol derivatives is described for the first time. By utilizing 2-naphthol derivatives with low oxidation potential, the substrates were activated by either chiral mononuclear or dinuclear vanadium(V) catalyst to promote distinctively different asym. reaction pathways: single vs. dual substrate activation mechanisms.

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shigano, Miyuki published the artcileThe effect of aging on the repeated-dose liver micronucleus assay, SDS of cas: 637-07-0, the publication is Genes and Environment (2021), 43(1), 37, database is CAplus and MEDLINE.

Abstract: Background: The liver micronucleus (MN) assay is an effective and important in vivo test for detecting genotoxic compounds In particular, the repeated-dose liver MN (RDLMN) assay which greatly facilitates incorporation of the liver MN assay into the general toxicity study has been developed. Usefulness of the RDLMN assay was appraised highly in the 7th International Workshops on Genotoxicity Testing (2017 in Tokyo) in that sufficient numbers and types of chems. were studied and easy integration into the general toxicity study is preferred from the 3Rs point of view. However, it was pointed out that it is necessary to evaluate the effect of age at the start of 4-wk repeated administration, since there are limited data, where only those of rats of 6 wk of age at the start of administration are available. In this study, we conducted the 4-wk RDLMN assay using rats of 6 and 8 wk of age (at the start of administration) to investigate the effect of age on the liver MN inducibility. Clofibrate, a weak inducer of liver MN, was used in this study to detect the slight difference in the liver MN induction. Results: The liver MN induced by clofibrate was detected in both rats of 6 and 8 wk of age at the start of administration. However, the liver MN induction was lower in rats of 8 wk of age compared to rats of 6 wk of age at the start of administration. Conclusion: These results suggest that the liver MN inducibility decreases with age. Therefore, we recommend the use of rats of 6 wk of age at start of administration to reliably detect the liver MN induction in the RDLMN assay.

Genes and Environment published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H17NS2, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ishiyama, Tatsuo published the artcileIridium-catalyzed C-H borylation of arenes and heteroarenes: 1-chloro-3-iodo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene and 2-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)indole, Computed Properties of 408492-29-5, the publication is Organic Syntheses (2005), 126-133, database is CAplus.

High yield C-H borylation of arenes and heteroarenes using pinacolborane or bis(pinacolato)diboron catalyzed by [Ir(OMe)(COD)]₂ and 4,4′-di-tert-butyl-2,2′-bipyridine occurs at room temperature

Organic Syntheses published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, Computed Properties of 408492-29-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ishiyama, Tatsuo published the artcileA stoichiometric aromatic C-H borylation catalyzed by iridium(i)/2,2′-bipyridine complexes at room temperature, Formula: C14H18BClO4, the publication is Angewandte Chemie, International Edition (2002), 41(16), 3056-3058, database is CAplus and MEDLINE.

Room-temperature C-H borylation using a stoichiometric amount of arenes and bis(pinacolato)diboron (pin₂B₂) is efficiently catalyzed by iridium(I) complexes generated from [{Ir(OMe)(cod)}₂] (cod = 1,5-cyclooctadiene) and 4,4′-di-tert-butyl-2,2′-bipyridine (dtbpy) in hexane, and provides the corresponding arylboronates in excellent yields. Thus, [{Ir(OMe)(cod)}₂]/dtbpy catalyzed C-H borylation of 1,2-dichlorobenzene with pin₂B₂ in hexane at 25° for 8h gave 82% 3,4-Cl₂C₆H₃Bpin.

Angewandte Chemie, International Edition published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, Formula: C14H18BClO4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aspin, Samuel J. published the artcile9-Silafluorenyl dichlorides as chemically ligating coupling agents and their application in peptide synthesis, Related Products of chlorides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2016), 55(44), 13833-13837, database is CAplus and MEDLINE.

A fundamentally simple, mild, and practical procedure for peptide bond formation is reported that employs a stoichiometric amount of easy-to-access 9-silafluorenyl dichlorides as the coupling agent. Without initial preactivation or elaboration of the carboxylic acid or amine termini of the amino acids, the developed reagent is proposed to act through an unprecedented chem. ligation mechanism, bringing the two coupling partners together before being subsequently eliminated. The desired amides or peptide bonds are thus furnished in good yields and with low to no epimerization.

Angewandte Chemie, International Edition published new progress about 1451393-45-5. 1451393-45-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (2-Bromo-4-chlorophenyl)boronic acid, and the molecular formula is C6H5BBrClO2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yoshihira, Kunitoshi published the artcileStereochemistry. XL. Rearrangement and trans-elimination contrary to the Chugaev reaction rule. 4. Thermal treatment on thionobenzoates, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Yakugaku Zasshi (1969), 89(9), 1225-35, database is CAplus and MEDLINE.

Thermal treatment of xanthates bearing an anchimeric group causes rearrangement to dithiocarbonates or trans elimination depending on their conformation (contrary to the Chugaev reaction). Thiobenzoates, e.g. I, were similarly treated and the analogous conclusion was reached concerning results and mechanisms. The identification of 2-(dialkylamino)alkanethiols produced in this series was reexamined and Hansen’s report on the same problem was corrected with respect to isothiuronium salt formation and desulfurization by Raney Ni.

Yakugaku Zasshi published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C11H11BFNO4, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hideo, Endo published the artcileAntitumor activity of phenazine derivatives against S 180 and C 63 in mice I, Product Details of C22H23ClN4, the publication is Sci. Rept. Res. Inst., Tohoku Univ., Ser. C (1965), 12(1), 53-7, database is CAplus.

Phenazine and 68 derivatives of phenazine were screened for their antitumor activity against Sarcoma 180 and Carcinoma 63, transplanted in mice. The ratio of the average weights of tumors in the treated and the controls, and the ratio of body weight changes in the 2 groups were recorded for each compound 2-Methoxyphenazine, 3,7-diamino-2-methylphenazine and 3-morpholino-1,2-benzophenazine at doses of 50 mg./kg.-body weight/day, brought down the tumor weight to less than half in the carcinoma infected mice and 3-acetamido-7-amino-5-phenylphenazonium chloride at the same dosage caused a similar effect in the sarcoma-infected animals. No correlation was observed between tumor weight change and the change in body weight in the treated animals.

Sci. Rept. Res. Inst., Tohoku Univ., Ser. C published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Product Details of C22H23ClN4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corpas-Lopez, Victoriano published the artcileO-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(11), 5734-5751, database is CAplus and MEDLINE.

Leishmania (L.) infantum causes visceral, cutaneous, and mucosal leishmaniasis in humans and canine leishmaniasis in dogs. Herein, we describe that O-alkyl hydroxamate derivatives displayed potent and selective in vitro activity against the amastigote stage of L. infantum while no activity was observed against promastigotes. Compound PhNHCO(CH₂)₆CONHOCPh₃ (I)showed potent in vivo activity against L. infantum. Moreover, the combination of compound 5 supported on gold nanoparticles and meglumine antimoniate was also effective in vivo and improved the activity of these compounds compared to that of the individual treatment. Docking studies showed that compound 5 did not reach highly conserved pocket C and established interactions with the semiconserved residues V44, A45, R242, and E243 in pocket A of LiSIR2rp1. The surface space determined by these four amino acids is not conserved in human sirtuins. Compound I represents a new class of selective ligands with antileishmanial activity.

Journal of Medicinal Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Matsuo, Y. published the artcilePreparation and characterization of silylated graphite oxide, Quality Control of 14799-93-0, the publication is Carbon (2005), 43(14), 2875-2882, database is CAplus.

Graphite oxide was silylated by various alkylchlorosilanes in the presence of butylamine and toluene, and new intercalation compounds were obtained. The silylating reagents with two or three Cl atoms at Si in them reacted with graphite oxide, while no reaction occurred when silylating reagents with only one Cl atom was used. The silylating reagent mainly reacted with hydroxyl group of graphite oxide, forming Si-O bonding. The role of butylamine was not only exfoliating graphite oxide layer but also scavenging HCl mol. which caused the decomposition of silylated graphite oxide. The Si content was almost constant �.6 mol/graphite oxide for the samples silylated by alkyltrichlorosilane with shorter alkyl chain lengths. It increased with the increase of alkyl chain length and reached 1.7 mol/graphite oxide. The higher Si content could be ascribed to further silylation on hydroxyl groups formed at Si atoms of silylating reagent bonded to graphite oxide, bridging two silylating reagents.

Carbon published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Quality Control of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wyrebska, Lucja published the artcileSynthesis and characterization of new polisher agent used in electroplating, Synthetic Route of 4569-86-2, the publication is Technologia i Jakosc Wyrobow (2012), 56(1-2), 30-35, database is CAplus.

The paper presents results of research on the preparation of polisher agent used in copper electroplating (electropolisher) and intermediate required for the synthesis of N,N-diethylphenosafranine (I). The multi-step synthesis of the intermediate I comprises the nitrosation of N,N-diethylaniline, reduction of p-nitroso-N,N-diethylaniline, oxidation of the resulting N,N-diethyl-p-phenylenediamine and its condensation with aniline. The polisher agent was obtained by diazotization of N,N-diethylphenosafranine and by reacting the resulting diazo compound with N,N-dimethylaniline, to obtain the product with absorption maximum λ_max = 584 (300) nm. The usage tests of the newly developed product have shown very good application properties.

Technologia i Jakosc Wyrobow published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C7H7IN2O, Synthetic Route of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics