Month: December 2022

Pasha, Maira published the artcileOrganocatalytic diastereo- and enantioselective oxa-hetero-Diels-Alder reactions of enones with aryl trifluoromethyl ketones for the synthesis of trifluoromethyl-substituted tetrahydropyrans, Quality Control of 21286-54-4, the publication is Organic & Biomolecular Chemistry (2021), 19(42), 9242-9250, database is CAplus and MEDLINE.

Here diastereo- and enantioselective oxa-hetero-Diels-Alder reactions catalyzed by amine-based catalyst systems that afford trifluoromethyl-substituted tetrahydropyranones was reported. Catalyst systems and conditions suitable for the reactions to provide the desired diastereomer products with high enantioselectivities were identified, and various trifluoromethyl-substituted tetrahydropyranones were synthesized with high diastereo- and enantioselectivities. Mechanistic investigation suggested that the reactions involve a [4 + 2] cycloaddition pathway, in which the enamine of the enone acts as the diene and the ketone carbonyl group of the aryl trifluoromethyl ketone acts as the dienophile. In this study, tetrahydropyran derivatives with the desired stereochem. that are difficult to synthesize by previously reported methods were concisely obtained, and the range of tetrahydropyran derivatives that can be synthesized was expanded.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Quality Control of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Reeves, Jonathan T. published the artcileDevelopment of an Enantioselective Hydrogenation Route to (S)-1-(2-(Methylsulfonyl)pyridin-4-yl)propan-1-amine, COA of Formula: C6H4ClNO2, the publication is Organic Process Research & Development (2014), 18(7), 904-911, database is CAplus.

A highly enantioselective enamide hydrogenation route to the title amine was developed. Highlights of the synthesis include an efficient two-step synthesis of a 2-sulfonyl 4-pyridyl Et ketone, a simple enamide synthesis by direct condensation of propionamide with a ketone, catalytic asym. enamide hydrogenation employing the inhouse-developed ligand MeO-BIBOP, and a mild epimerization-free deprotection of a propionamide using Koenig’s procedure.

Organic Process Research & Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, COA of Formula: C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Junji published the artcileSoft mimic gear-shift with a multi-stimulus modified diarylethene, Formula: C15H14Cl2S2, the publication is Journal of Materials Chemistry (2009), 19(32), 5726-5729, database is CAplus.

A novel gated photochromic compound 1,8-naphthalimidepiperazine-tethered dithienylethene (Nap-Pip-DTE) was prepared to mimic a soft gear-shift based on alternative UV/Vis irradiation, protonation/deprotonation and copper(II) ion complexation/dissociation The fluorescence and absorption spectra were used as output signals. Copper(II) ion was introduced to mimic the parking (P) state by complexation with two intramol. piperazine moieties of Nap-Pip-DTE, transforming diarylethene moieties into the photoinactive parallel form.

Journal of Materials Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C17H18N3NaO3S, Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Penghui published the artcileBio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes, Quality Control of 209919-30-2, the publication is Nature Communications (2019), 10(1), 1-9, database is CAplus and MEDLINE.

A bio-inspired iron-catalyzed polymethylhydrosiloxane-promoted aerobic oxidation of methylarenes to arylaldehydes with high yields and selectivities was reported. Notably, this method can tolerate oxidation-labile and reactive boronic acid group, which is normally required to be transformed immediately after its introduction and represents a significant advance in the area of the chem. of organoboronic acids, including the ability to incorporate both aldehyde and ketone functionalities into unprotected arylboronic acids, a class that can be difficult to access by current means. The robustness of this protocol was demonstrated on the late-stage oxidation of complex bioactive mols., including dehydroabietic acid, Gemfibrozil, Tocopherol nicotinate, a complex polyol structure and structurally complex arylboronic acids.

Nature Communications published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Quality Control of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pendem, Venkata Bhavanarushi published the artcileIron-promoted sulfur sequestration for the substituent-dependent regioselective synthesis of tetrazoles and guanidines, SDS of cas: 3696-23-9, the publication is Journal of Sulfur Chemistry (2021), 42(5), 499-509, database is CAplus.

Herein, a facile and versatile synthetic methodol. for the construction of tetrazoles and guanidines in the presence of an eco-friendly, inexpensive and easily available iron reagent were established. Aromatic thioureas with electron-donating substituents produced their resp. target products in quant. yield. In contrast, when electron-withdrawing substituted aromatic thioureas were used, the expected products were obtained in reduced yield. However, the desired products were obtained in good yield at moderate temperature In addition, mechanistic studies revealed that the synthetic route involved iron-based subsequent reactions of addition and removal of sulfur.

Journal of Sulfur Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, SDS of cas: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kiso, Yoshihisa published the artcileSilicon hydrides and nickel complexes. IV. Preparation of silicon-nickel complexes by the reaction of silicon hydrides with σ-alkyl-nickel complexes, Synthetic Route of 14799-93-0, the publication is Journal of Organometallic Chemistry (1974), 76(1), 95-103, database is CAplus.

Three silicon-nickel complexes, Ni(bipy)(SiX3)2 (I,X3 = Cl3; II, X3 = MeCl2, bipy = 2,2′-bipyridyl) and Ni(h1-C5H5 )-(PPh3)(SiCl3) (III, C5H5 = cyclopentadienyl), were prepared by treatment of silicon hydrides with appropriate alkyl-nickel complexes, Ni(bipy)R2 (IV, R = Me, V, R = Et) and Ni(h1-C5H5)(PPh3)Et (VI), resp. Both complexes I and III reacted with HCl or DCl to give the corresponding chlorosilane HSiX3 (or DSiX3) and Ni(bipy)Cl2, in good yields. II reacted with tetracyanoethylene to afford MeCl2SiSiCl2Me, but in low yield. III reacted with MeI to form MeSiCl3 (23.5% yield). The silicon-nickel complex I was inactive as catalyst for hydrosilylation of olefins, whereas the alkyl complexes V and VI were active.

Journal of Organometallic Chemistry published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tanaka, Nobuyuki published the artcileRelationship between Stereochemistry and the β₃-Adrenoceptor Agonistic Activity of 4′-Hydroxynorephedrine Derivative as an Agent for Treatment of Frequent Urination and Urinary Incontinence, Computed Properties of 33697-81-3, the publication is Journal of Medicinal Chemistry (2003), 46(1), 105-112, database is CAplus and MEDLINE.

This report proposes a β₃-adrenoceptor (AR) selective agonist, 2-[2-chloro-4-(2-{[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)phenoxy]acetic acid (I), as a novel agent for treating urinary bladder dysfunction. This compound and its relatives have a unique feature among β₃-AR agonists: two chiral carbons are adjacently structured on the left side of the mol. To study the relationship between the stereoconfiguration of the vicinal chiral carbons in I and β-AR agonistic activity, the four stereoisomers were synthesized via oxazolidinone prepared by intracyclization involving inversion of the β-hydroxy group. The in vitro assays using rat atria for β₁-AR, rat uteri for β₂-AR, and ferret detrusor for β₃-AR showed that I possessed potent β₃-AR agonistic activity (EC₅₀ = 3.85 nM) and 3700- and 1700-fold selectivity for β₃-AR relative to β₁– and β₂-AR, resp. Comparison of the four isomers revealed that the (αS,βR)-compound (I) was not only the most potent agonist but was also the most selective for β₃-AR. In the anesthetized rat, i.v. administration of I brought about a sufficient decrement of the intrabladder pressure (ED₅₀ = 12 μg/kg), and intraduodenal administration of the Et ester of I, led to same result (ED₅₀ = 0.65 mg/kg). Moreover, no effects on the cardiovascular system were observed in either test.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C2H3N3, Computed Properties of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagarajan, K. published the artcileAntiimplantation agents: part I – 1-arylthiosemicarbazides, Formula: C7H6ClF3N2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1984), 23B(12), 1243-57, database is CAplus.

1-Arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines were prepared and examined for their antiimplantation activity in rats. Among the active compounds, MeNHCSNHNHC₆H₃(CF₃)₂-3,5 (C2696-Go) and the corresponding 4,4-di-Me, Et, n-Bu, and allyl derivatives completely inhibit implantation at doses of 10, 3, 20, 20 and 30 mg/kg resp. The 3,4-dichlorophenyl analog is effective at a dose of 30 mg/kg. Hydrazinothiazoline I (n = 1) and the corresponding dihydrothiazine I (n = 2) show a weaker activity. The biol. profile of C2696-Go was determined and it prevents implantation by its antiuretotropic activity and ability to inhibit desiduoma formation.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 1869-22-3. 1869-22-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Hydrazine,Amine,Benzene, name is 1-(2-Chloro-5-(trifluoromethyl)phenyl)hydrazine, and the molecular formula is C7H6ClF3N2, Formula: C7H6ClF3N2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Menn, Jean Christophe published the artcileOrganic electrosynthesis without a potentiostat. Selectivity in the stepwise reduction of trichloromethylphosphonate: a representative experiment, Application In Synthesis of 866-23-9, the publication is Journal of Chemical Education (1991), 68(6), 513-14, database is CAplus.

Two experiments in organic electrosynthesis are presented that involve the stepwise reduction of trichloromethylphosphonate in aqueous solution Safety precautions for performing the experiment are also detailed.

Journal of Chemical Education published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sharapova, T. published the artcileReduced hepatic global hydroxymethylation in mice treated with non-genotoxic carcinogens is transiently reversible with a methyl supplemented diet, Related Products of chlorides-buliding-blocks, the publication is Toxicology and Applied Pharmacology (2021), 115439, database is CAplus and MEDLINE.

Non-genotoxic carcinogens (NGCs) are known to cause perturbations in DNA methylation, which can be an early event leading to changes in gene expression and the onset of carcinogenicity. Phenobarbital (PB) has been shown to alter liver DNA methylation and hydroxymethylation patterns in mice in a time dependent manner. The goals of this study were to assess if clofibrate (CFB), a well-studied rodent NGC, would produce epigenetic changes in mice similar to PB, and if a Me donor supplementation (MDS) would modulate epigenetic and gene expression changes induced by phenobarbital. CByB6F1 mice were treated with 0.5% clofibrate or 0.14% phenobarbital for 7 and 28 days. A subgroup of PB treated and control mice were also fed MDS diet. Liquid Chromatog.-Ionization Mass Spectrometry (LC-MS) was used to quantify global liver 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) levels. Gene expression anal. was conducted using Affymetrix microarrays. A decrease in liver 5hmC but not 5mC levels was observed upon treatment with both CFB and PB with varying time of onset. We observed moderate increases in 5hmC levels in PB-treated mice when exposed to MDS diet and lower expression levels of several phenobarbital induced genes involved in cell proliferation, growth, and invasion, suggesting an early modulating effect of Me donor supplementation. Overall, epigenetic profiling can aid in identifying early mechanism-based biomarkers of non-genotoxic carcinogenicity and increases the quality of cancer risk assessment for candidate drugs. Global DNA methylation assessment by LC-MS is an informative first step toward understanding the risk of carcinogenicity.

Toxicology and Applied Pharmacology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C4H7BN2O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics