Month: December 2022

Shi, Feng published the artcileSelective oxidation of naphthalene derivatives with ruthenium catalysts using hydrogen peroxide as terminal oxidant, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Molecular Catalysis A: Chemical (2007), 270(1-2), 68-75, database is CAplus.

The selective oxidation of naphthalene and its derivatives to give naphthoquinones has been investigated in detail. The reaction can be carried out effectively in the presence of a catalytic amount of Ru complexes (0.2 mol %) and phase transfer catalysts using H₂O₂ as the terminal oxidant and water as the solvent. The effects of different ruthenium complexes, phase transfer catalysts, and the concentration of hydrogen peroxide were studied. Compared to previous procedures for this type of reaction, acidic solvents and high concentration of hydrogen peroxide are not necessary, which makes the reaction more environmentally friendly.

Journal of Molecular Catalysis A: Chemical published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C25H34N4O2S, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cho, Jian-Yang published the artcileRemarkably selective iridium catalysts for the elaboration of aromatic C-H bonds, Name: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, the publication is Science (Washington, DC, United States) (2002), 295(5553), 305-308, database is CAplus and MEDLINE.

Arylboron compounds have intriguing properties and are important building blocks for chem. synthesis. A family of Ir catalysts (IndIr(COD), (η⁶-mesitylene)Ir(BPin)₃ (4; HBPin = pinacolborane)) now enables the direct synthesis of arylboron compounds from aromatic hydrocarbons and boranes under solventless conditions. For example, a 98% yield of PhBPin was obtained in 15 h at 150° from benzene and HBPin (16:1 ratio) in the presence of 4 and PMe₃. The Ir catalysts are highly selective for C-H activation and do not interfere with subsequent in situ transformations, including Pd-mediated cross-couplings with aryl halides (e.g. 80% 3,5-dichloro-3′-methylbiphenyl). By virtue of their favorable activities and exceptional selectivities, these Ir catalysts impart the synthetic versatility of arylboron reagents to C-H bonds in aromatic and heteroaromatic hydrocarbons.

Science (Washington, DC, United States) published new progress about 408492-29-5. 408492-29-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ester,Boronate Esters,Boronate Esters,Boronic acid and ester,, name is Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, and the molecular formula is C14H18BClO4, Name: Methyl 3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Minsoo published the artcileStructure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT_2B receptor antagonist scaffold, SDS of cas: 939-99-1, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(21), 127511, database is CAplus and MEDLINE.

Antagonists for the serotonin receptor 2B (5-HT_2B) have clin. applications towards migraine, anxiety, irritable bowl syndrome, and MDMA abuse; however, few selective 5-HT_2B antagonists have been identified. Previous studies from these labs identified a natural product, 5-hydroxy-2-(2-phenylethyl)chromone (5-HPEC, 2) as the first non-nitrogenous ligand for the 5-HT_2B receptor. Studies on 5-HPEC optimization led to the identification of 5-hydroxy-2-(3-phenylpropyl)chromone (5-HPPC, 3), which showed a tenfold improvement in binding affinity over 2 at 5-HT_2B. This study aimed to further improve receptor pharmacol. of this unique scaffold. Guided by mol. modeling studies modifications at the C-3′ and C-4′ positions of 3 were made to probe their effects on ligand binding affinity and efficacy. Among the derivatives synthesized 5-hydroxy-2-(3-(3-cyanophenyl)propyl)chromone (5-HCPC, 3d) showed the most promise with a multifold improvement in binding affinity (pK_i = 7.1 ± 0.07) over 3 with retained antagonism.

Bioorganic & Medicinal Chemistry Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Minsoo published the artcileStructure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT_2B receptor antagonist scaffold, Computed Properties of 620-20-2, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(21), 127511, database is CAplus and MEDLINE.

Antagonists for the serotonin receptor 2B (5-HT_2B) have clin. applications towards migraine, anxiety, irritable bowl syndrome, and MDMA abuse; however, few selective 5-HT_2B antagonists have been identified. Previous studies from these labs identified a natural product, 5-hydroxy-2-(2-phenylethyl)chromone (5-HPEC, 2) as the first non-nitrogenous ligand for the 5-HT_2B receptor. Studies on 5-HPEC optimization led to the identification of 5-hydroxy-2-(3-phenylpropyl)chromone (5-HPPC, 3), which showed a tenfold improvement in binding affinity over 2 at 5-HT_2B. This study aimed to further improve receptor pharmacol. of this unique scaffold. Guided by mol. modeling studies modifications at the C-3′ and C-4′ positions of 3 were made to probe their effects on ligand binding affinity and efficacy. Among the derivatives synthesized 5-hydroxy-2-(3-(3-cyanophenyl)propyl)chromone (5-HCPC, 3d) showed the most promise with a multifold improvement in binding affinity (pK_i = 7.1 ± 0.07) over 3 with retained antagonism.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zaitsev, O. I. published the artcileBuilding a mathematical model of ion exchange of NaA zeolite with decametoxin and its technological optimization, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Farmatsevtichnii Zhurnal (Kiev) (2001), 78-81, database is CAplus.

Full (three-factor) math. model of ion exchange process of NaA zeolite with decametoxin was built, its anal. was carried out, on which base the technol. optimum was received. The most considerable parameter, which exerts an essential influence on technol. process, was determined The following exptl. check of calculated optimum allowed to received a preparation with level of ion exchange which exceeds an exptl. result.

Farmatsevtichnii Zhurnal (Kiev) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C42H63O3P, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Volyanskii, Yu. L. published the artcileEffect of prodigiosan in combination with decamethoxine on experimental septicemia in albino mice, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Antibiotiki (Moscow) (1971), 16(5), 441-3, database is CAplus.

Treatment of mice with a combination of prodigiosan (1 mg/kg) and decamethoxine (10 mg/kg) at 7 or 4 days and again 12 hr before or 1 day after infection with a 3-fold lethal dose of Staphylococcus aureus prevented or greatly reduced the development of infection.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C6H10O7, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Etlis, V. S. published the artcileChlorination of some alkene sulfides, Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Zhurnal Obshchei Khimii (1965), 35(3), 475-9, database is CAplus.

Ethylene sulfide and dry Cl₂ in CCl₄ under ultraviolet light at -5-0° 45-50 min. gave only (ClCH₂CH₂S)₂, b_1.5 87-8°, n²⁰_D 1.5655, d₂₀ 1.3381. Propylene sulfide similarly gave (ClCH₂CHMeS)₂, b₅ 128-9°, 1.5402, 1.2563; thioepichlorohydrin in a similar reaction gave [(ClCH₂)₂CHS]₂, m. 69°. Ethylene sulfide treated under N atm. with 0.125 mole Me₃COCl under ultraviolet light at -15° to -10° gave a mixture of Me₃COSCH₂CH₂Cl, b_1.5 37-8°, 1.4698, 1.0560, (ClCH₂CH₂S)₂, and some Me₃CO₂SCH₂CH₂Cl, b₁ 58-60°, 1.4853, 1.1510. Similar reaction of propylene sulfide gave Me₃COSCHMeCH₂Cl, b₁ 34°, 1.4641, 1.0269, and some (ClCH₂CHMeS)₂.

Zhurnal Obshchei Khimii published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kuhn, Richard published the artcileTrimethylsulfoxonium ion, COA of Formula: C3H9ClOS, the publication is Justus Liebigs Annalen der Chemie (1958), 117-21, database is CAplus.

Me₂SO (I) (16 g.) and 30 ml. MeI refluxed 3 days gave 25 g. octagonal plates of trimethylsulfoxonium iodide, Me₃S⁺OI^– (II), m. 200° (H₂O), insoluble in C₆H₆, Et₂O, CHCl₃, petr. ether, sparingly soluble in MeOH, soluble in H₂O (1.5 g. in 100 ml. at 20°). II shaken with an aqueous suspension of AgCl gave the H₂O-soluble chloride, long needles, (MeOH-C₆H₆); picrate, decompose 210° (H₂O); tetraphenylborate, m. 195° (aqueous EtOH). The reineckate, phosphomolybdate, and phosphotungstate are very little soluble Thermal decomposition of II gave I. II shaken with aqueous CO₂-free Ag₂O gave the oily hydroxide, which in the presence of air crystallized to the bicarbonate or carbonate. Reduction of II with HI gave blue-black crystals of the periodide, Me₃S⁺I₃^–, which on boiling with H₂O yielded iodine and Me₃S⁺I^–, identical with an authentic specimen. II (1 g.) and 5 ml. pyridine (III), refluxed 15 min., or the chloride and III refluxed 240 min. at 115°, gave quant. yields of III.MeI and III.MeCl, resp. Similarly II and quinoline gave the corresponding MeI derivative, m. 70-2° (monohydrate) (EtOH). II (2.2 g.), 0.7 g. p-O₂NC₆H₄OH, and 10 g. Ag₂O in Me₂NCHO shaken 2 days at 20°, CHCl₃ added, the mixture filtered, washed with 2N NaOH and H₂O, dried, and concentrated gave 78% p-O₂NC₆H₄OMe, m. 55°, b_0.1 100-5°.

Justus Liebigs Annalen der Chemie published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, COA of Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Molander, Gary A. published the artcileA modified procedure for the palladium catalyzed borylation/Suzuki-Miyaura cross-coupling of aryl and heteroaryl halides utilizing bis-boronic acid, Synthetic Route of 116850-28-3, the publication is Tetrahedron (2015), 71(35), 5758-5764, database is CAplus and MEDLINE.

A modified Pd-catalyzed method of forming aryl- and heteroarylboron species and a two-step, one-pot borylation/Suzuki-Miyaura cross coupling using the atom economical tetrahydroxydiboron (bis-boronic acid, BBA) is reported. By using ethylene glycol as an additive, the new method results in increased yields, lower BBA loading, faster reaction times, and a broader reaction scope, including previously problematic substrates such as heterocycles e. g., I.

Tetrahedron published new progress about 116850-28-3. 116850-28-3 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzene, name is 2-Chloro-1-fluoro-3-methylbenzene, and the molecular formula is C7H6ClF, Synthetic Route of 116850-28-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kobelev, Aleksandr I. published the artcileFacile regiodivergent synthesis of spiro pyrrole-substituted pseudothiohydantoins and thiohydantoins via reaction of [e]-fused 1H-pyrrole-2,3-diones with thiourea, Application In Synthesis of 3696-23-9, the publication is Beilstein Journal of Organic Chemistry (2019), 2864-2871, database is CAplus and MEDLINE.

A highly divergent synthesis of regioisomeric thiohydantoins and pseudothiohydantoins spiro-fused to a pharmacol. valuable pyrrole-2-one fragment involving the reaction of [e]-fused 1H-pyrrole-2,3-diones with thioureas was developed. The obtained spiro pseudothiohydantoin derivatives were found to undergo a pseudothiohydantoin-thiohydantoin rearrangement. The reactions were shown to proceed under catalyst-free conditions in good yields, and the products were isolated without applying preparative chromatog. methods.

Beilstein Journal of Organic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics