Month: December 2022

Jiang, Wanlong published the artcileArylpropionylpiperazines as antagonists of the human melanocortin-4 receptor, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(17), 4674-4678, database is CAplus and MEDLINE.

A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was increased by replacing the α-Me substituent of the initial lead with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or β-alanine was incorporated onto the benzylamine. Some compounds demonstrated good potency, moderate selectivity, and oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, Recommanded Product: 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileVisible Light-Promoted Synthesis of β-Keto Sulfoximines from N-Tosyl-Protected Sulfoximidoyl Chlorides, Related Products of chlorides-buliding-blocks, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Under visible light, N-tosyl-protected sulfoximidoyl chlorides RSO(NTs)Cl (R = 4-CH₃C₆H₄, 4-CH₃OC₆H₅, 1-naphthyl, etc.) react with aryl alkynes R¹C₆H₄CC (R¹ = 4-Cl, 3-Br, 3-Me, etc.) to give β-keto sulfoximines I. The reaction is characterized by a high functional group tolerance and good yields. It can be improved by the presence of a ruthenium photocatalyst. Air is the source of the ketonic oxygen in the products.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H10BNO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Peng published the artcileRegio- and Stereoselective Chloro Sulfoximidations of Terminal Aryl Alkynes Enabled by Copper Catalysis and Visible Light, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Advanced Synthesis & Catalysis (2021), 363(10), 2552-2556, database is CAplus.

By visible-light photoredox catalysis with copper complexes, sulfoximidoyl chlorides add to terminal aryl alkynes to gave the corresponding (E)-β-chlorovinyl sulfoximines I [R = 2-thienyl, Ph, 2-naphthyl, etc.; R¹ = n-Pr, Ph, 4-MeC₆H₄, etc.] with exclusive regio- and stereoselectivities in high yields. Two representative products I [R = 4-BrC₆H₄, 4-t-BuC₆H₄; R¹ = Ph] had been characterized by X-ray crystal structure anal. Radicals appear was decisive intermediates. As demonstrated by two subsequent reactions, the products could be derivatized.

Advanced Synthesis & Catalysis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C9H21NO3, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qi, Gang published the artcileSynthesis of coumarin-propanedioic acid dimethyl esters, Synthetic Route of 10543-42-7, the publication is Hecheng Huaxue (2007), 15(4), 466-467, 470, database is CAplus.

Three new coumarin-propanedioic acid di-Me esters were designed and synthesized by matching principle from coumarin and propanedioic acid di-Me ester. The structures were identified by ¹H NMR, IR and MS.

Hecheng Huaxue published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Synthetic Route of 10543-42-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Han, Ying published the artcileSynthesis and Bioactivity of Coumarin-6-sulfonylureas, Category: chlorides-buliding-blocks, the publication is Zhongguo Yaoke Daxue Xuebao (2002), 33(2), 93-97, database is CAplus.

Twenty-one coumarin-6-sulfonylureas {N-[4-R¹-7-R²-benzopyran-2(2H)-one-6-sulfonyl]-N’-R³-urea; R¹ and/or R² = H or methyl; R³ = cyclohexyl, allyl, Pr, heptyl, iso-Pr, Bu, or isobutyl} were synthesized to search for new antidiabetic drugs. Sulfonylurea functional groups were introduced into the structure of coumarin, and the hypoglycemic activity of the target compounds was measured. Their structures were identified by IR, ¹H NMR, and MS spectra. The pharmacol. study showed that compounds SU-1 (R¹ = R² = H, R³ = cyclohexyl), SU-8 (R¹ = H, R² = Me, R³ = cyclohexyl), SU-11 (R¹ = H, R² = Me, R³ = butyl), SU-12 (R¹ = H, R² = Me, R³ = heptyl), and SU-13 (R¹ = H, R² = Me, R³ = isopropyl) exhibited evident hypoglycemic activities (P <0.01) at the dose of 50 mg kg^-1.

Zhongguo Yaoke Daxue Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Haraguchi, Naoki published the artcileAsymmetric transfer hydrogenation of imines catalyzed by a polymer-immobilized chiral catalyst, COA of Formula: C19H34ClN, the publication is Organic & Biomolecular Chemistry (2009), 7(1), 69-75, database is CAplus and MEDLINE.

The asym. transfer hydrogenation of imines was performed with the use of a polymer-immobilized chiral catalyst. The chiral catalyst, prepared from crosslinked polystyrene-immobilized chiral 1,2-diamine monosulfonamide, was effective in the asym. transfer hydrogenation of N-benzyl imines in CH₂Cl₂ to give a chiral amine in high yield and good enantioselectivity. Furthermore, an amphiphilic polymeric catalyst prepared from crosslinked polystyrene containing sulfonated groups successfully catalyzed the asym. transfer hydrogenation of cyclic imines in water. Enantioenriched secondary amines with up to 94% ee were obtained by using a polymeric catalyst.

Organic & Biomolecular Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ohya, K. published the artcileThin-layer chromatography of methyl N-trimethyl-γ-aminobutyrate chloride and related compounds, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Journal of Chromatography (1974), 90(1), 230-2, database is CAplus.

The best separation of trimethylaminobutyrate derivatives[Me3N+(CH2)3CO2RCl-] came when a plate was heated for 1 hr at 120°. Sharp spots free from tailing were found in the solvent system EtOAc-HCO2H-water. Increasing the HCO2H concentration gave higher Rf values, but did not improve separation The Rst values were applied using crystal violet as the standard and the results were better in terms of reproducibility.

Journal of Chromatography published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seno, Manabu published the artcilePreparation, properties, and x-ray photoelectron spectra of palladium(II) and platinum(II) complexes of amine imides aminimides and sulfur ylides, Recommanded Product: trimethyloxosulphonium chloride, the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) (1977), 751-7, database is CAplus.

Amine imides RMe2N+N-COR1 (R = PhCH2, p-O2NC6H4CH2; R1 = Me, Et, Ph) and the S ylides Me2S+(O)C-HCOPh with Pd(II) and Pt(II) halides gave ylide-metal complexes PdCl2L2 (L = amine imide), PtCl2[Me2S+(O)C-HCOPh]SEt2, and MCl2[Me2S+(O)C-HCOPh]2 (M = Pd, Pt). IR, 1H and 13C NMR, and x-ray photoelectron spectra indicated that the coordination of the ylide to the metal was through the nucleophilic N+ or C- atom as simple terminal ligands. Cis-PtCl2[Me2S+(O)C-HCOPh]SEt2 released SEt2 in Me2SO giving PtCl2[Me2S+(O)C-HCOPh] which was chelated through the carbanion C and the sulfonium O of the ylide. The thermal properties of the complexes were examined by thermal gravimetric anal. and the nature of the bonding was discussed.

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C4H5NS2, Recommanded Product: trimethyloxosulphonium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stergiopoulos, Chrysanthos published the artcileThe use of biomimetic chromatography to predict acute aquatic toxicity of pharmaceutical compounds, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Toxicological & Environmental Chemistry (2022), 104(1), 1-19, database is CAplus.

The potential of biomimetic chromatog. to predict ecotoxicol. endpoints of pharmaceutical compounds was investigated. For this purpose, a data set of previously and newly measured chromatog. retention data for 36 structurally diverse drugs was used. Standardized retention times were measured on the immobilized artificial membrane, human serum albumin, and alpha-1-acid glycoprotein stationary phases. As ecotoxicol. endpoints, half-maximal lethal concentration values of fish and half-maximal effective concentration (immobilization) values of a water flea (Daphnia magna spp.) determined with a two-day static method were considered. Ecotoxicity values correlated with octanol-water partitioning and the pos. charge of compounds contributed even more to the toxicity. Models based on membrane partition exhibited the best statistics and predictive performance, attributed to lipophilicity and membrane electrostatic interactions. Alpha-1-acid glycoprotein binding led to satisfactory models, owing to its function as a binder of neutral and basic lipophilic compounds Albumin binding, however, did not result in sound models, as it is governed by lipophilicity and the neg. charge of compounds, contrary to the mechanism of toxicity. Both membrane and alpha-1-acid glycoprotein models were superior statistically from those derived from the octanol-water system. Overall, membrane and alpha-1-acid glycoprotein retention can be suggested as promising indexes to assess the ecotoxicol. risk of drugs.

Toxicological & Environmental Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C7H5BClNO2, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shi, Feng published the artcileA novel and convenient process for the selective oxidation of naphthalenes with hydrogen peroxide, SDS of cas: 23616-79-7, the publication is Advanced Synthesis & Catalysis (2007), 349(3), 303-308, database is CAplus.

A practical Ru phase-transfer catalyst (Ru-PTC) system for the oxidation of naphthalene derivatives was developed. Substituted 1,4-quinones were obtained in good selectivity and yield in H₂O without the addition of any organic solvent and acid. By applying the optimized conditions the feed additive menadione (vitamin K₃) was obtained from 2-methylnaphthalene with 64% yield and 73% selectivity. Oxidation of phenanthrene is also described.

Advanced Synthesis & Catalysis published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C10H20O2, SDS of cas: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics