Month: December 2022

Grytsai, Oleksandr published the artcileSynthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2020), 104271, database is CAplus and MEDLINE.

Two series of compounds I (R = H, 2-Cl, 3-Br, etc.; X = CH or N) carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivs I (X = N). The biol. results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series I (R = 3-Br; X = CH or N) on several cell lines tested. Moreover, results point out an antiangiogenic activity of these compds I. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vinogradova, L. E. published the artcileProtection of textiles against biodamage, Application In Synthesis of 38146-42-8, the publication is Tekstil’naya Promyshlennost (Moscow, Russian Federation) (1992), 30, database is CAplus.

The protective properties of biocide-impregnated cotton textile packaging were tested during storage of various bleached or dyed cotton textiles under normal conditions and under increased humidity (80-90%) and temperature (20-25°). All the biocides (Ampholan, Katamin AB, Metacid, Decamethoxine, alkyltrimethylammonium chlorides) were effective in normal conditions, but Decamethoxine, alkyltrimethylammonium chlorides failed in textile protection in the humid atm. The best results were obtained with Katamin AB and Metacid.

Tekstil’naya Promyshlennost (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C13H15NO6S, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Epshtein, G. Yu. published the artcileHaloalkyl sulfides. V. Reaction of alkylene sulfides with alkanesulfenyl chlorides and alkyl polythiochlorides, COA of Formula: C4H8Cl2S2, the publication is Zhurnal Obshchei Khimii (1964), 34(7), 2347-9, database is CAplus.

cf. CA 61, 8178c. Addition of RSCl to the appropriate alkylene sulfide in CCl₄ with cooling gave on distillation the indicated disulfides. Ethylene sulfide (I) and ClCH₂CH₂SCl gave (SCH₂CH₂Cl)₂; propylene sulfide (II) gave ClCH₂CH₂SSCH₂CHMeCl; isobutylene sulfide gave ClCH₂CH₂SSCMe₂CH₂Cl (III); I and BrCH₂CH₂SCl gave ClCH₂CH₂SSCH₂CH₂Br, b₄ 129-30°, d₁₉ 1.5683, n¹⁹_D 1.5897; 3-chloro-1,2-propylene sulfide and ClCH₂CH₂SCl gave ClCH₂CH₂SSCH₂CHClCH₂Cl, b₅ 151°, d₂₀ 1.4122, n²⁰_D 1.5752; II and ClSCH₂CHMeBr gave MeCHClCH₂SSCH₂CHMeBr, b₂ 127°, d₁₇ 1.4687, n¹⁷_D 1.5665; II and CCl₃SCl gave CCl₃SSCH₂CHMeCl, b₂ 122°, d₁₈ 1.4726, n¹⁸_D 1.5616; II and MeCHClCH₂SSCl gave (CHMeClCH₂S)₂S, b_1.5 126°, d₁₅ 1.2542, n¹⁵_D 1.5492; I similarly gave ClCH₂CH₂SSSCH₂CHMeCl, b_2.5 125°, d₁₆ 1.3000, n¹⁶_D 1.5634; II and CHMeClCH₂SSSCl gave (MeCHClCH₂SS)₂, undistillable, d₁₇ 1.3560, n¹⁷_D 1.6120; I and CHMeBrCH₂SCl gave ClCH₂CH₂SSCH₂CHMeBr, b_2.5 124°, d₁₇ 1.5462, n¹⁷_D 1.5808; I and CCl₃SCl gave CCl₃SSCH₂CH₂Cl, b₄ 115°, d₁₆ 1.4962, n¹⁶_D 1.4962; II and CHMeClCH₂SCl gave (MeCHClCH₂S)₂, b_2.5 118-26°, d₁₅ 1.2405, n¹⁵_D 1.5408; CHMeClCH₂SCl with 3-chloro-1,2-propylene sulfide gave CHMeClCH₂SSCH₂CHClCH₂Cl, b₁ 128°, d₂₁ 1.3574, n²¹_D 1.5625; isobutylene sulfide gave CHMeClCH₂SSCMe₂CH₂Cl, b_1.5 110°, d₁₆ 1.2153, n¹⁶_D 1.5412. III b_1.5 106-8°, d₁₅ 1.2724, n¹⁵_D 1.5558.

Zhurnal Obshchei Khimii published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Epshtein, G. Yu. published the artcileHaloalkyl sulfides. II. Reaction of alkylene sulfides with halogens and sulfuryl chloride, HPLC of Formula: 1002-41-1, the publication is Zhurnal Obshchei Khimii (1964), 34(6), 1948-50, database is CAplus.

cf. CA 60, 7909h. Chlorination of alkylene sulfides in CCl₄ with ice cooling or treatment with SO₂Cl₂ in CCl₄ gave the following from the indicated starting materials: ClSCH₂CH₂Cl, 46% (from ethylene sulfide); ClSCH₂CH₂Br, 65% [from bis(2-bromoethyl)sulfide]; ClSCH₂CHMeCl, 42% (from propylene sulfide); ClSCH₂CHMeBr, 80% [from bis(2-bromopropyl)sulfide]; 2-chlorocyclohexylsulfenyl chloride, 44% (from cyclohexene sulfide); and (CICH₂CH₂)₂S₂, 63% (from ethylene sulfide and 1:2 proportion of either Cl or SO₂Cl₂). Reaction of appropriate halogens with alkylene sulfides in CCl₄ with ice cooling with 1:2 molar ratio of the reactants gave the following, also obtained similarly with SO₂Cl₂,: (BrCH₂CH₂S)₂, 63% (from ethylene sulfide); (ICH₂CH₂S)₂, 80% (from ethylene sulfide); (MeCHClCH₂S)₂, 63% (from propylene sulfide); (MeCHBrCH₂S)₂, 80% (from propylene sulfide); (MeCHICH₂S)₂, 80% (from propylene sulfide); and bis(2-chlorocyclohexyl) disulfide, 26% (from cyclohexene sulfide). 2-Chloropropylsulfenyl chloride treated with C₂H₄ 15 min. gave 70% ClCH₂CH₂SCH₂CHMeCl, b₅ 88°, d₁₄ 1.2426, n¹⁴_D 1.5221. This and chloramine-T in aqueous EtOH 25 hrs. gave 60% 2-chloroethyl 2-chloropropyl p-toluenesulfilimine, m. 136-7° (Fuson, et al., CA 41, 688d). The following constants were reported: ClSCH₂CH₂Cl, b₁₆ 52-4° d₂₀ 1.3851, n²⁰_D 1.5234; ClSCH₂CH₂Br, b₅ 60°, 1.7875, 1.5776; ClSCH₂CHMeCl, b₁₃ 40°, d₁₄ 1.3040, n¹⁴_D 1.5149; ClSCH₂CHMeBr, b₂ 55°, d₁₅ 1.6885, n¹⁵_D 1.5630; 2-chlorocyclohexylsulfenyl chloride, b₅ 104°, d₂₄ 1.2920, n²⁴_D 1.5455; (ClCH₂CH₂S)₂, b₅ 115° d₂₀ 1.3396, n²⁰_D 1.5662; (BrCH₂CH₂S)₂, m. 25-6°; (ICH₂CH₂S)₂, m. 45-6°; (MeCHClCH₂S)₂, b_2-3 121°, d₁₅ 1.2413, n¹⁵_D 1.5430; (MeCHBrCH₂S)₂, b₂ 137° d₁₆ 1.6602, n¹⁶_D 1.5852; (MeCHICH₂S)₂, undistillable, d₁₇ 1.9962, n¹⁷_D 1.6520; bis(2-chlorocyclohexyl) disulfide, b₂ 177-9°, d₂₈ 1.2280, n²⁸_D 1.5826.

Zhurnal Obshchei Khimii published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, HPLC of Formula: 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gazizov, T. Kh. published the artcileReaction of dialkyl trimethylsilylphosphites with carbon tetrachloride, COA of Formula: C5H10Cl3O3P, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1984), 1830-2, database is CAplus.

The reaction of (EtO)₂POSiMe₃ with CCl₄ gave (EtO)₂P(O)Cl, (EtO)₂P(O)CCl₃, Me₃SiCl, Me₃SiCCl₃, disilacyclobutane I and HCCl₃. (RO)₂POSiMe₃ (R = Me, Pr) reacted similarly.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, COA of Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mayer, W. published the artcileThe pharmaceutical characterization and spectroscopy of AWD 26-06, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Pharmazie (1990), 45(8), 565-7, database is CAplus and MEDLINE.

Data are given on the TLC, stability, assay, and spectroscopic characteristics of the antiulcer drug AWD 26-06 (I). Brief TLC data are also given on 4 other compounds formed during the synthesis (not reported here) of I.

Pharmazie published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rameshbabu, Krishnamurthy published the artcileSynthesis and Characterization of Thermally Irreversible Photochromic Cholesteric Liquid Crystals, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Physical Chemistry B (2011), 115(13), 3409-3415, database is CAplus and MEDLINE.

Three thermally irreversible photochromic chiral liquid crystal dithienylcyclopentenes were found not only to be able to self-organize into a phototunable helical superstructure, i.e., cholesteric phase, but also to be able to induce a photoresponsive helical superstructure in an achiral liquid crystal host. The cholesteric phase in the three chiral compounds went into a glassy phase without crystallization upon cooling. All the materials exhibited reversible photochromism with thermal stability in both solution and thin film, and their fluorescence was shifted to longer wavelength upon UV irradiation while the shifted fluorescence was recovered upon visible light irradiation The enhanced fluorescence emission with the addition of fluoride anions was observed, and its reverse process happened with the addition of an equivalent proton.

Journal of Physical Chemistry B published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yannian published the artcileSynthesis and Characterization of Light-Driven Dithienylcyclopentene Switches with Axial Chirality, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Organic Chemistry (2011), 76(17), 7148-7156, database is CAplus and MEDLINE.

Dithienylcyclopentenes such as I and its enantiomer were prepared as photochem. reversible but thermally stable switches with axial stereochem. All three compounds prepared exhibited photochem. reversible isomerization between their open forms and closed forms and were thermally stable in the open and closed forms both in organic solvents and in a liquid crystal host. Dithienylcyclopentenes such as I acted not only as chiral dopants, inducing helical superstructures in achiral liquid crystal hosts, but also reversibly and dynamically tuned the transmittance and reflection of the resulting chiral phases upon light irradiation The helical twisting powers, transmittance, and reflection spectra of photoswitchable cholesteric liquid crystals were measured. I exhibited an unusually high helical twisting power, which is significantly larger than those of the known chiral diarylethenes reported as chiral dopants so far.

Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Yannian published the artcileReversible Light-Directed Red, Green, and Blue Reflection with Thermal Stability Enabled by a Self-Organized Helical Superstructure, Application In Synthesis of 219537-97-0, the publication is Journal of the American Chemical Society (2012), 134(23), 9573-9576, database is CAplus and MEDLINE.

Adding external, remote, and dynamic control to self-organized superstructures with desired properties is an important leap necessary in leveraging the fascinating mol. subsystems for employment in applications. Here two novel light-driven dithienylethene chiral mol. switches possessing remarkable changes in helical twisting power during photoisomerization as well as very high helical twisting powers were found to experience photochem. reversible isomerization with thermal stability in both isotropic organic solvents and anisotropic liquid crystal media. When doped into a com. available achiral liquid crystal host, the chiral switch was able to either immediately induce an optically tunable helical superstructure or retain an achiral photoresponsive liquid crystal phase whose helical superstructure was induced and tuned reversibly upon light irradiation Moreover, reversible light-directed red, green, and blue reflection colors with thermal stability in a single thin film were demonstrated.

Journal of the American Chemical Society published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application In Synthesis of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jayasundara, Chathurika R. K. published the artcileA Catalytic Borylation/Dehalogenation Route to o-Fluoro Arylboronates, Application of 2-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Organic Letters (2014), 16(23), 6072-6075, database is CAplus and MEDLINE.

A two-step Ir-catalyzed borylation/Pd-catalyzed dehalogenation sequence allows for the net synthesis of fluoroarenes where the boronic ester is ortho to fluorine. Key elements of this approach include the use of a halogen para to the fluorine to block meta Ir-catalyzed borylation and the chemoselective Pd-catalyzed dehalogenation by KF activated polymethylhydrosiloxane (PMHS).

Organic Letters published new progress about 1638847-73-0. 1638847-73-0 belongs to chlorides-buliding-blocks, auxiliary class Boronic acid and ester,Boronic acid and ester, name is 2-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H17BClFO2, Application of 2-(5-Chloro-2-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics