Month: December 2022

Nagiyev, Kh. D. published the artcileSpectrophotometric study of multi-ligand titanium (IV) complexes, Synthetic Route of 38146-42-8, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2003), 46(7), 94-97, database is CAplus.

The formation of titanium (IV) complexes with 2,3,4-trihydroxy-4′-sulfoazobenzene in the presence and absence of 3rd components, such as tri-Ph guanidine, bathophenanthroline, and decamethoxine, has been studied spectrophotometrically. The optimum conditions for the formation of binary and multi-ligand complexes have been found. The influence of pH, temperature, and time, reagent concentration, and the concentration of the 3rd component on the complexation reaction has been studied. Techniques of the photometric determination of titanium microquantities have been developed. These were approved by analyzing titanium in aluminum alloys M207-4 and M-207-5.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Koo published the artcileStructural modification of an orally active thrombin inhibitor, LB30057: replacement of the D-pocket-binding naphthyl moiety, Name: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry (1998), 6(6), 869-876, database is CAplus and MEDLINE.

Amidrazonophenylalanine derivative LB30057 (I) was identified as a potent (K_i=0.38 nM), selective, and orally active thrombin inhibitor. As a continuation of studies into benzamidrazone-based thrombin inhibitors, we have structurally modified I by replacing the naphthyl group with a variety of hydrophobic moieties. This study led to discovery of several compounds with significantly enhanced potency in thrombin inhibition without sacrificing selectivity against trypsin and oral absorption. The highest activity was obtained with benzocycloheptyl derivative II (K_i = 0.045 nM).

Bioorganic & Medicinal Chemistry published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Name: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kitamura, Seiya published the artcileRational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa, Computed Properties of 350-30-1, the publication is Journal of Medicinal Chemistry (2016), 59(10), 4790-4799, database is CAplus and MEDLINE.

The virulence factor cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory factor (Cif) is secreted by Pseudomonas aeruginosa and is the founding member of a distinct class of epoxide hydrolases (EHs) that triggers the catalysis-dependent degradation of the CFTR. We describe here the development of a series of potent and selective Cif inhibitors by structure-based drug design. Initial screening revealed 1a (KB2115), a thyroid hormone analog, as a lead compound with low micromolar potency. Structural requirements for potency were systematically probed, and interactions between Cif and 1a were characterized by X-ray crystallog. On the basis of these data, new compounds were designed to yield addnl. hydrogen bonding with residues of the Cif active site. From this effort, three compounds were identified that are 10-fold more potent toward Cif than our first-generation inhibitors and have no detectable thyroid hormone-like activity. These inhibitors will be useful tools to study the pathol. role of Cif and have the potential for clin. application.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Computed Properties of 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Weijin published the artcileNitromethane-enabled fluorination of styrenes and arenes, Product Details of C12H15ClO3, the publication is CCS Chemistry (2020), 2(6), 566-575, database is CAplus.

Herein, nitromethane (MeNO₂) as an efficient activator of Selectfluor and NFSI, as well as a stabilizer of carbocations was disclosed. Therefore, the fluoro-azidation, fluoroamination, fluoroesterification of styrenes, and C-H fluorination of (hetero)arenes were well realized just by the facilitation of MeNO₂. The mild reaction conditions and practicability made our current method a versatile protocol for accessing organofluorides.

CCS Chemistry published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H10FeO4, Product Details of C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lu, Nan published the artcileDrug repurposing: Discovery of troxipide analogs as potent antitumor agents, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112471, database is CAplus and MEDLINE.

Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clin. drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three cancer cell lines and WPMY-1. Compound 5q(I), especially, could effectively inhibit PC3 with an IC₅₀ value of 0.91μM, which exhibited around 53-fold selectivity toward WPMY-1. Data indicated that 5q effectively inhibited the colony formation, suppressed the cell migration, and induced G1/S phase arrest in PC3 cells. Also, compound 5q induced cell apoptosis by activating the two apoptotic signaling pathways in PC3 cells: death receptor-mediated extrinsic pathway and mitochondria-mediated intrinsic pathway. Compound 5q up-regulated the expression of both pro-apoptotic Bax and P53, while down-regulated anti-apoptotic Bcl-2 expression. Besides, compound 5q significantly increased the expression of cleaved caspase 3/9 and cleaved PARP. Therefore, the successful discovery of compound 5q may further validate the feasibility of this theory, which will encourage researchers to reveal undescribed bioactivities in traditional drugs.

European Journal of Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Application of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sweis, Ramzi F. published the artcile2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy, HPLC of Formula: 18791-02-1, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(6), 1890-1895, database is CAplus and MEDLINE.

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark mol. I. Reversing the connectivity of the central aniline lead to a new class of 2-(4-carbonylphenyl)benzoxazoles. Structure-activity studies at the C-7 and terminal pyridine ring allowed for the optimization of potency and HDLc-raising efficacy in this new class of inhibitors. These efforts lead to the discovery of benzoxazole II, which raised HDLc by 24 mg/dL in the transgenic mouse PD model.

Bioorganic & Medicinal Chemistry Letters published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C10H17N3O2, HPLC of Formula: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wils, E. R. J. published the artcileDetermination of mustard gas and related vesicants in rubber and paint by gas chromatography-mass spectrometry, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Chromatography (1992), 625(2), 382-6, database is CAplus.

The determination of mustard gas (2,2′-dichlorodiethyl sulfide) and some related vesicants in rubber and paint was investigated. The vesicants were isolated by extraction with CH₂Cl₂ or by dynamic headspace anal. at elevated temperatures The latter procedure had the advantage that high-boiling additives did not interfere during the anal. by capillary column gas chromatog.-mass spectrometry. The stability of the vesicants in the materials used proved to be good. No great losses were found after storage for weeks at room temperature

Journal of Chromatography published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C9H12O, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rojas Cabrera, Haydee published the artcileHomochiral L-prolinamido-sulfonamides and their use as organocatalysts in aldol reactions, Computed Properties of 21286-54-4, the publication is Tetrahedron: Asymmetry (2015), 26(4), 163-172, database is CAplus.

The synthesis of new homochiral L-prolinamido-sulfonamides 1-7 from enantiomerically pure (R,R)-11,12-diamino-9,10-dihydro-9,10-ethanoanthracene (R,R)-8 is reported. The L-prolinamido-sulfonamides 1-7 were tested as organocatalysts (10 mol %) in the aldol reaction of p-nitrobenzaldehyde and acetone in dichloromethane at room temperature in the presence of water (1 equiv) and acetic acid (20 mol %) giving good to high yields and enantioselectivities. Catalyst I (10 mol %) afforded the best results in the aldol reaction of acetone with p-substituted-benzaldehydes with electron withdrawing groups (i.e., nitro, cyano, bromo and chloro, up to 97% yield and 90% ee). The origin of the enantioselective induction was modeled using DFT methods. The estimated enantioselectivity for the model system is consistent with the exptl. data.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zheng, Yuxin published the artcileRegiodivergent Desymmetrization Reaction of meso-Azabicycloheptene Providing Two Enantioenriched Structural Isomers, Recommanded Product: Sodium chloro(tosyl)amide trihydrate, the publication is Organic Letters, database is CAplus and MEDLINE.

A novel catalytic asym. reaction uses the regiodivergent desymmetrization of 7-tosyl-7-azabicyclo[4.1.0]hept-3-ene via allylic oxidation using a single chiral copper catalyst to produce two different, enantioenriched structural isomers in high optical purity starting from a single compound The enantioselectivity of the two structurally isomeric compounds was enriched to >99.5%ee after derivatization.

Organic Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C26H26N4O7, Recommanded Product: Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Yanghui published the artcileDiscovery and Optimization of Highly Potent and Selective AT₂R Antagonists to Relieve Peripheral Neuropathic Pain, Formula: C8H6ClF3, the publication is ACS Omega (2021), 6(23), 15412-15420, database is CAplus and MEDLINE.

The angiotensin II type 2 receptor (AT₂R) has attracted much attention as a potential target for the relief of neuropathic pain, which represents an area of unmet clin. need. A series of 1,2,3,4-tetrahydroisoquinolines with a benzoxazole side-chain were discovered as potent AT₂R antagonists. Rational optimization resulted in compound 15, which demonstrated both excellent antagonistic activity against AT₂R in vitro and analgesic efficacy in a rat chronic constriction injury model. Its favorable physicochem. properties and oral bioavailability make it a promising therapeutic candidate for neuropathic pain.

ACS Omega published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics