Month: December 2022

Chotana, Ghayoor A. published the artcileIridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C-H functionalization, Category: chlorides-buliding-blocks, the publication is Tetrahedron (2008), 64(26), 6103-6114, database is CAplus and MEDLINE.

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, addnl. functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed High regioselectivities were observed in borylation of 3- and 2,5-di-substituted thiophenes. Electrophilic aromatic C-H/C-Si bromination on thiophene boronate esters is shown to take place without breaking the C-B bond, and one-pot C-H borylation/Suzuki-Miyaura cross-coupling has been accomplished on 2- and 3-borylated thiophenes.

Tetrahedron published new progress about 942070-02-2. 942070-02-2 belongs to chlorides-buliding-blocks, auxiliary class Thiophene,Chloride,Bromide,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is 2-(4-Bromo-5-chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C10H13BBrClO2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hrinovets, I. S. published the artcileJustification of formulation of dental films with decamethoxine as medicinal preparation for treatment of mucous membrane diseases, Computed Properties of 38146-42-8, the publication is Farmatsevtichnii Zhurnal (Kiev, Ukraine) (2008), 99-103, database is CAplus.

Therapeutic drug delivery systems in the form of dental medicinal films with pharmacol. ingredients with prolonged wound-healing, antibacterial, anti-inflammatory, and regenerative activities for use in stomatol. practice were studied. The mucosa-adhesive films containing 0.02% of the antiseptic and disinfecting agent decamethoxine were prepared from methylcellulose, polyvinyl alc., polyvinylpyrrolidone, and gelatin; the auxiliary components were propylene glycol, PEO-400, Tween-80, saccharin, and water. The medicinal films were evaluated for sensory, taste, physicochem., microbiol., and biopharmaceutical properties, including thickness, adhesivity, UV absorption spectra, solubility and drug release in water and in mouth. The decamethoxine levels were determined by spectrophotometry at 540 nm. The antimicrobial activity was examined against test strains of Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Candida albicans at 37°. The films had pronounced antibacterial effects on G-pos. and less on G-neg. bacteria. The films were also tested in patients with mouth mucosa inflammation and ulcerative damage. The dry films were stable during 24-mo storage.

Farmatsevtichnii Zhurnal (Kiev, Ukraine) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Computed Properties of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kuramochi, Takahiro published the artcileDiscovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry (2005), 13(12), 4022-4036, database is CAplus and MEDLINE.

Ca²⁺ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca²⁺ overload, because NCX inhibitors can directly inhibit the influx of Ca²⁺ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives We have discovered a novel NCX inhibitor (I) with an IC₅₀ value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P 450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of I are discussed.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grob, Cyril A. published the artcilePolar effects. Part II. The transmission of polar effects, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Helvetica Chimica Acta (1977), 60(2), 391-9, database is CAplus.

Comparison of pKa values for the ammonia acids Me3N+(CH2)nCO2H ClO4- (n = 1, 2, 3), I (R = 2-, 3-, 4-CO2H), and II (same R) with the pKa values for the homomorphous acids Me3C(CH2)nCO2H (n = 1, 2, 3), III (R = 2-, 3-, 4-CO2H) and IV (same R) permits an evaluation of the steric effect of the Me3N+ group. The pKa values, corrected for the steric effect, correlate with the reciprocal distance between the pos. N atom and the dissociable proton. Thus, the acidity of these acids is determined by the field effect, not the inductive effect, of the Me3N+ groups.

Helvetica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mayer, Bernhard X. published the artcileA 50% n-octylmethyl, 50% diphenyl-polysiloxane as stationary phase with unique selectivity for gas chromatography, Name: Dichloro(methyl)(octyl)silane, the publication is Analyst (Cambridge, United Kingdom) (2003), 128(10), 1238-1242, database is CAplus and MEDLINE.

An n-octylmethyl, diphenyl-polysiloxane called SOP-50-Octyl was prepared by a condensation reaction of bis(dimethylamino) n-octylmethylsilane with diphenylsilanediol. The resulting copolymer was a gum with high mol. weight and was obtained with a yield of 80%. ¹H and ²⁹Si NMR spectroscopy revealed that the copolymer was a 52% octylmethyl, 48% diphenyl-polysiloxane with random microstructure. Small cyclic impurities could be almost quant. removed via a purification step. SOP-50-Octyl was used as stationary phase for the preparation of wall coated open tubular fused silica capillary columns for gas-liquid chromatog. The capillary columns exhibited high separation efficiency and high inertness. The stationary phase offered a unique selectivity due to its unique composition The Rohrschneider-McReynolds constants indicated a low overall polarity in spite of the high Ph content, as the polarity was distinctly decreased by the octyl substituent. Also, the octyl substituent was responsible for a high column bleed, reducing the maximum allowable operating temperature to 280°. The elution temperatures of apolar compounds were increased due to increased interaction of the octyl substituent with the analytes. Some applications with volatile and semi-volatile organic compounds illustrate that SOP-50-Octyl is an excellent choice for confirmational analyses.

Analyst (Cambridge, United Kingdom) published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Name: Dichloro(methyl)(octyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kalindjian, S. Barret published the artcileA New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease, HPLC of Formula: 32333-53-2, the publication is Journal of Medicinal Chemistry (2016), 59(7), 3098-3111, database is CAplus and MEDLINE.

Chemokine receptor 9 (CCR9), a cell surface chemokine receptor which belongs to the G protein-coupled receptor, 7-trans-membrane superfamily, is expressed on lymphocytes in the circulation and is the key chemokine receptor that enables these cells to target the intestine. It has been proposed that CCR9 antagonism represents a means to prevent the aberrant immune response of inflammatory bowel disease in a localized and disease specific manner and one which is accessible to small mol. approaches. One possible reason why clin. studies with vercirnon, a prototype CCR9 antagonist, were not successful may be due to a relatively poor pharmacokinetic (PK) profile for the mol. We wish to describe work aimed at producing new, orally active CCR9 antagonists based on the 1,3-dioxoisoindoline skeleton. This study led to a number of compounds that were potent in the nanomolar range and which, on optimization, resulted in several possible preclin. development candidates with excellent PK properties.

Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, HPLC of Formula: 32333-53-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abhishek, Verma published the artcileMechanistic aspect of Iridium(III) catalyzed oxidation of ethylene glycol by Chloramine-T in aqueous acidic medium: a kinetic model, Formula: C7H13ClNNaO5S, the publication is G P Globalize Research Journal of Chemistry (2018), 1(2), 107-115, database is CAplus.

The kinetic investigation of homogeneously Ir(III) chloride catalyzed oxidation of Ethylene glycol by Chloramine- T [CAT] in perchloric acid medium has been carried out in the temperature range of 30 to 45°C. The reaction was carried out in the presence of mercuric acetate as a scavenger for chloride ion. The reaction exhibits first order kinetics with respect to the oxidant [CAT] and catalyst [Ir(III)] while zero order with respect to substrate, i.e., Ethylene glycol (EG) was observed The reaction shows negligible effect of [Hg(OAc)₂], [H⁺] and ionic strength of the medium. Chloride ion pos. influenced the rate of reaction. The various activation parameters have been calculated from the rate measurements at different temperatures (30 to 45°C). The product of the reaction has been identified as the corresponding monocarboxylic acid. The reaction between Chloramine-T and Ethylene glycol in acid medium shows 2:1 stoichiometry. On the basis of kinetic studies, reaction stoichiometry and product anal., a suitable mechanism has been proposed and rate law has been derived.

G P Globalize Research Journal of Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jurga, S. published the artcileNMR study of molecular motion in solid trimethyloxosulfonium halides, Formula: C3H9ClOS, the publication is Journal of Physics C: Solid State Physics (1981), 14(30), 4433-46, database is CAplus.

NMR 2nd moments M₂ and spin-lattice relaxation times in the laboratory and rotating frame (T₁ and T_1ρ) for Me₃SOF, Me₃SOCl, Me₃SOBr, and Me₃SOI were measured over a wide temperature range. The variations of M₂, T₁, and T_1ρ for each of these salts were interpreted in terms of Me group reorientation about its C₃ axis and reorientation of the trimethyloxosulfonium ion about its C₃‘ symmetry axis; the resp. activation parameters were also estimated (CH₃)₃SOCl contains 2 types of Me groups statistically weighted in the ratio 2:1, reorienting with different frequencies about their C₃ axes.

Journal of Physics C: Solid State Physics published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Koo published the artcileFluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption, Application In Synthesis of 61551-49-3, the publication is Bioorganic & Medicinal Chemistry Letters (1999), 9(17), 2483-2486, database is CAplus and MEDLINE.

LB30057 (I, R = H) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound I (R = H) and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound I (R = F) demonstrated a 3-fold increase in absorption.

Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Application In Synthesis of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bakkas, Salem published the artcileReactivity of triethyl phosphite with tetrachloromethane: electron transfer versus ionic substitution on positive halogen, SDS of cas: 866-23-9, the publication is Tetrahedron (1987), 43(3), 501-12, database is CAplus.

The mechanism of the reaction of P(OEt)₃ (I) with CCl₄ (II) was studied. I reacts at 80° with II to form mostly (EtO)₂P(O)CCl₃ and EtCl. Trichloromethyl radical is trapped by BHT. The reaction is initiated by UV light (254 nm) and a charge-transfer complex is formed between I and II, and the reaction is inhibited by TCNQ. Tris(cyclopropylmethyl) phosphite and tri(1-hexene-6-yl) phosphite are used as potential radical clocks in these reactions. The first leads to CH₂:CHCHClMe and the second to CH₂:CHCH₂CH₂CHClMe. The first suggests a radical mechanism (but also may be rationalized by an ionic mechanism), but not the second. Electrochem. oxidation of I with added CCl₄ does not account for a radical chain process as the main pathway. Marcus anal. of the reaction viewed as an electron transfer gives a calculated rate constant in the range of 10^-20 M^-1s^-1. Thus, the thermal reaction is in fact an S_NCl⁺ substitution. The radical intermediates are derived from the electron-transfer reaction between CCl₃^– and CCl₄. The reaction of I with II is an example where the observed paramagnetic species during a donor (D)/acceptor (A) interaction suggests an electron-transfer between D and A where in fact they originate from an interaction between A and an electron donor formed after or during the first step of the reaction.

Tetrahedron published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics