Month: December 2022

Rindhe, S. S. published the artcileSynthesis, antimicrobial and antioxidant activity of some oxindoles, Recommanded Product: Coumarin-6-sulfonyl chloride, the publication is Indian Journal of Pharmaceutical Sciences (2011), 73(3), 292-296, database is CAplus and MEDLINE.

The present work describes the synthesis and spectral anal. of several (3Z)-[4-[4-(arylsulfonyl)-1-piperazinyl]benzylidene]-1,3-dihydro-2H-indol-2-one derivatives The title compounds were screened in-vitro against six species of microorganisms, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger and Aspergillus clavatus. Most of the compounds exhibited significant antimicrobial activity. All compounds were also screened in-vitro for the antioxidant activity using DPPH assay. Most of them have shown very significant antioxidant activity. The synthesis of the target compounds was achieved by an amidation (sulfonamidation) of 4-[4-[(2-oxo-3-indolylidene)methylene]phenyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester with sulfonyl halides. The title compounds thus formed included 1,3-dihydro-3-[(3Z)-[4-[4-[[4-(1-methylethyl)phenyl]sulfonyl]-1-piperazinyl]phenyl]methylene]-2H-indol-2-one (I).

Indian Journal of Pharmaceutical Sciences published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Recommanded Product: Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zimina, I. F. published the artcileSorption of some quaternary ammonium salts by ion-exchange materials, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Kolloidnyi Zhurnal (1994), 56(4), 503-8, database is CAplus.

Sorption of various organic electrolytes, having antiseptic properties, was studied on various-structure sorbents. Based on the effects of counter ion, fixed groups, exchange capacity, degree of saturation by H⁺-Na⁺ ions, and matrix permeation, the distribution of organic ions between the phases were determined Sorption mechanism is discussed. Cellulose-based sorbents, carbon fibers, and synthetic sorbents application in a removal of toxic electrolytes from aqueous solutions is proposed for a wide concentration range.

Kolloidnyi Zhurnal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H20O6, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zimina, I. F. published the artcileSorption of bioactive inorganic and organic compounds by cellulosic cation exchangers, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg) (1998), 71(6), 920-924, database is CAplus.

The feasibility of modifying monocarboxy cellulose, CM-cellulose, and cellulose phosphate by a series of antiseptic property-imparting organic or inorganic electrolytes was investigated. The sorption of organic cations by H-form cellulosic cation exchangers increased along the series decamethoxin<septonex<chlorohexidine<ethonium due to increased charge d. and lowered screening of hydrophobic hydrocarbon radicals. A complex-forming sorption of Ag⁺, Zn²⁺, Cu²⁺, Co²⁺, Ni²⁺, and Fe³⁺ by cellulosic cation exchangers in chlorohexidine form was discovered.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H20O6, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shapkin, N. P. published the artcileSynthesis and study of dipotassium derivatives of oligodiorganylsiloxane-α,ω-diols, Related Products of chlorides-buliding-blocks, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1995), 38(3), 24-9, database is CAplus.

Title salts KO(SiRR’O)_nK (R = Bu, R’ = vinyl; n = 1, 2, 4; R = octyl, R’ = Me, n = 1,3) were prepared by treating hydrolysis products of the corresponding dichlorosilanes with KOH. The polydispersion of these salts approaches 1.1 upon lowering the temperature of the reaction mixture to 50° and cooling it to -12° after the cleavage process is completed. Compositions of the salts thus obtained were confirmed by elemental anal., gel chromatog., IR spectral data, and also by reaction of these salts with Me₃SiCl and TiCl₄.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C6H4BBrF2O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cho, Yeon Seok published the artcileNovel Phosphonium Chloride-Catalyzed Dehydrohalogenative Si-C Coupling Reaction of Alkyl Halides with Trichlorosilane, Application of Dichloro(hexyl)(methyl)silane, the publication is Journal of the American Chemical Society (2001), 123(23), 5584-5585, database is CAplus and MEDLINE.

The authors describe a novel catalytic approach to the coupling of both activated and nonactivated alkyl halides with both trichlorosilane and methyldichlorosilane using phosphonium salts as the catalysts. This synthetic approach will now enable the efficient, high-yield synthesis of a wide range of functionalized organosilicon compounds that were previously unavailable by simple means. Thus, RCl (R = CH₂C₆H₄X-p, X = H, F, MeO; CH₂HC:CHX, X = H, (Z)-Me; n-C_nH_2n+1, n = 6, 8, 12, 18; TMS(CH₂)_n, n = 1, 3) when coupled with HSiCl₃ in presence catalytic amounts of phosphonium salts [R¹₄P]Cl (R¹₄ = Bu₄, (PhCH₂)Bu₃) gave RSiCl₃ (R = same as above) in 72-96% yields. The extension of the coupling reaction to other alkyl halides such as secondary and tertiary alkyl halides is currently being studied.

Journal of the American Chemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application of Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lee, Sung-Chan published the artcileDevelopment of a fluorescent chalcone library and its application in the discovery of a mouse embryonic stem cell probe, Recommanded Product: 2-Chloro-6-methoxyisonicotinoyl chloride, the publication is Chemical Communications (Cambridge, United Kingdom) (2012), 48(53), 6681-6683, database is CAplus and MEDLINE.

The authors report the first fluorescent diamino-chalcone library and its application in the discovery of a mouse embryonic stem cell (mESC) probe. CDg4, a novel green fluorescent mESC probe, was discovered through a high-content image based screening of 160 members of the chalcone library. The mol. binding target of CDg4 was identified as the glycogen of the stem cell colony surface, rather than a conventional protein target from an intracellular source.

Chemical Communications (Cambridge, United Kingdom) published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Recommanded Product: 2-Chloro-6-methoxyisonicotinoyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Asano, Shigehiro published the artcileSuzuki-Miyaura cross-coupling reaction of aryl and heteroaryl pinacol boronates for the synthesis of 2-substituted pyrimidines, Application In Synthesis of 6313-54-8, the publication is Tetrahedron (2012), 68(1), 272-279, database is CAplus.

Suzuki-Miyaura cross-coupling reaction with 2-heteroarylboronic acids is generally challenging due to easy decomposition of these acids. To overcome this problem, we developed a coupling method that uses 2-heteroaryl pinacol boronates in the presence of 1.0 mol % Pd(OAc)₂ and 2.0 mol % S-Phos with 4 equiv amount of LiOH in dioxane and H₂O at 80 °C for 30 min. This developed method allowed for the synthesis of a wide variety of 2-heteroaryl pyrimidines from 2-chloropyrimidyl derivatives in high yields, and is also useful in the preparation of various biaryl derivatives from heteroaryl chlorides.

Tetrahedron published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Application In Synthesis of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boodhoo, Nitish published the artcileGlutaminolysis and glycolysis are essential for optimal replication of Marek’s disease virus, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of Virology (2020), 94(4), e01680-19, database is CAplus and MEDLINE.

Marek’s disease virus causes a deadly lymphoproliferative disease in chickens and modulates metabolism of host cells. Metabolic anal. of MDV-infected chicken embryonic fibroblasts identified elevated levels of metabolites involved in glutamine catabolism, such as glutamic acid, alanine, glycine, pyrimidine, and creatine. In addition, our results demonstrate that glutamine uptake is elevated by MDV-infected cells in vitro. Although glutamine, but not glucose, deprivation significantly reduced cell viability in MDV-infected cells, both glutamine and glucose were required for virus replication and spread. In the presence of min. glutamine requirements based on optimal cell viability, virus replication was partially rescued by the addition of the tricarboxylic acid (TCA) cycle intermediate, α-ketoglutarate, suggesting that exogenous glutamine is an essential carbon source for the TCA cycle to generate energy and macromols. required for virus replication. Surprisingly, the inhibition of CPT1a, which is elevated in MDV-infected cells, by chem. (etomoxir) or physiol. (malonyl-CoA) inhibitors, did not reduce MDV replication, indicating that MDV replication does not require fatty acid β-oxidation Taken together, our results demonstrate that MDV infection activates anaplerotic substrate from glucose to glutamine to provide energy and macromols. required for MDV replication, and optimal MDV replication occurs when the cells do not depend on mitochondrial β-oxidation

Journal of Virology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kumar, Gupta Girish published the artcileIsolation of 4-hydroxythiazoline. A solid phase study in Hantzsch thiazole reaction, Computed Properties of 3696-23-9, the publication is Research Journal of Chemistry and Environment (2014), 18(2), 38-44, database is CAplus.

A simple, efficient and rapid practical procedure for the preparation of various thiazole derivatives was developed. The present protocol offered the solid phase reaction of various α-bromo ketones with a wide variety of thioamides/thioureas in the presence of Na₂CO₃ at room temperature (within 3-5 min). More specifically, it also provided an excellent synthetic route to 2-(pyrazol-1-yl)thiazole derivatives that can not be prepared easily using solvent or acidic conditions mediated Hantzsch thiazole reaction due to the exclusive formation of thiocyanatoketones. Increase in amount of solid catalyst led to the formation of 4-hydroxythiazole, a cyclic intermediate which is formed in Hantzsch thiazole reaction. In conclusion, reaction could be stopped either at intermediate state or was directed towards thiazole formation by changing the amount of base.

Research Journal of Chemistry and Environment published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rao, Jyothi N. published the artcileSolvent free microwave-assisted synthesis of some novel pyrimidinones/thiones and their biological studies, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Chemica Sinica (2016), 7(3), 38-42, database is CAplus.

Pyrimidinone derivatives I [R = H; X = O; R¹ = CH₃, C₂H₅] and pyrimidinethione derivatives I [R = H, C₆H₅, 4-MeOC₆H₄, 4-MeC₆H₄, etc.; X = S; R¹ = C₂H₅] were synthesized via reaction of 1-phenyl-3-methyl-5-chloro-pyrazole-4-aldehyde, Et acetoacetate/methyl acetoacetate and urea/thiourea/thiourea derivatives under conventional heating as well as microwave irradiation All the newly synthesized compounds were screened for their antibacterial and antifungal activities. The antimicrobial study revealed that pyrimidinone compound I [R = H; X = O; R¹ = C₂H₅] and pyrimidinethione compounds I [ R = 4-MeOC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄; X = S; R¹ = C₂H₅] showed excellent antibacterial and antifungal activities against all the tested organisms.

Chemica Sinica published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics