Month: December 2022

Bala, Renu published the artcilePhthaloyl Dichloride-DMF Mediated Synthesis of Benzothiazole-based 4-Formylpyrazole Derivatives: Studies on Their Antimicrobial and Antioxidant Activities, Product Details of C7H7ClN2S, the publication is Journal of Heterocyclic Chemistry (2018), 55(11), 2507-2515, database is CAplus.

Benzothiazole-based pyrazole derivatives were prepared by a mol. hybridization approach with an aim to influence the biol. activity significantly. Efficient conversion of hydrazones I (R = H, OMe, Cl, etc.; R’ = H, F; R” = H, Me, Br, Cl) derived from their corresponding Me ketones to 4-formylpyrazoles II was carried out at 60° in dioxane, using the Vilsmeier-Haack reagent isolated from phthaloyl dichloride and N,N-dimethylformamide. The newly synthesized compounds II and hydrazones I were screened in vitro for their antimicrobial activities using the broth macrodilution method. The compounds I were also screened for their antioxidant activities using the DPPH radical scavenging assay. Some of the synthesized compounds showed significant antibacterial and antifungal activities as evident from their min. inhibitory concentrations Compound II (R = R’ = H; R” = Br) showed remarkable antioxidant activity.

Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Product Details of C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yadav, Sanjay Kumar published the artcileCounterion-specific clouding in aqueous anionic surfactant: a case of Hofmeister-like series, Formula: C19H34ClN, the publication is Colloid and Polymer Science (2017), 295(5), 869-876, database is CAplus.

Two ionic surfactants (sodium dodecylsulfate (SDS) and sodium dodecylbenzenesuphonate (SDBS)) are chosen, and effect of addition of quaternary bromide or chloride (tetra-n-butylammonium bromide, tetra-n-butylphosphonium bromide, tetraphenylphosphonium bromide, tetra-npentylammonium bromide and benzyl tributylammonium chloride) has been studied on the cloud point (CP) behavior in aqueous solution CP behavior was observed due to dehydration of headgroup region in presence of quaternary counterion. Order of counterion to decrease CP is as follows: TPeA⁺ > BTA⁺ > TBP⁺ > TPhP⁺ > TBA⁺ for SDS and TPeA⁺ > TPhP⁺ > BTA⁺ > TBP⁺ > TBA⁺ for SDBS. CP data have been used to select surfactant + salt system. Effect of additives (carbohydrate, amino acid or vitamin), on the CP, has been seen on above such selected systems. Additive may either decrease or increase the CP, depending upon the structure of counterion and/or the additive. Counterion (cations) can be arranged in an order like Hofmeister series.

Colloid and Polymer Science published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C6H11BF3KO, Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Singh, Rahul published the artcileSynthesis and exploration of configurational dynamics in equilibrating E/Z 2-aryliminothiazolidin-4-ones using NMR and estimation of thermodynamic parameters, Safety of 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2022), 46(11), 5012-5025, database is CAplus.

In the present study, 2-aryliminothiazolidin-4-ones I [R¹ = H, OMe, NMe₂, NO₂; R² = H, Me, MeO, Cl, NO₂] were utilized as dynamic chem. systems, whose different states were modulated in a reversible fashion through specific chem. stimuli. The in-depth NMR investigation revealed that the magnitude of rotational energy barrier ΔG^{â€?/sup> was affected markedly by (1) the solvent polarity; (2) the electronic nature of the ring system present on the exocyclic CQN bond and (3) the temperature of the system. The derivatives of I exist in two isomeric forms at room temperature in DMSO-d₆: (2E,5Z,7E) (2Z,5Z,7E). The stereodynamics of the synthesized derivatives I were investigated using variable temperature dynamic 1H-NMR (VT DNMR). The ΔGâ€?/sup> values (â‰?5 kcal mol-1) estimated for the dynamic process depicted a significant barrier between two forms in solution at ambient temperature To go a step further, line shape anal. were also performed to get a clear understanding of the equilibration mechanism.}

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C17H16O2, Safety of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Prasad, Y. Rajendra published the artcileSynthesis and antimicrobial activity of some novel chalcones of 2-hydroxy-1-acetonaphthone and 3-acetylcoumarin, COA of Formula: C7H4BrClO2, the publication is E-Journal of Chemistry (2006), 3(13), 236-241, database is CAplus.

Five novel chalcones were synthesized by condensing 2-hydroxy-1-acetonaphthone with aldehydes and another five novel chalcones were prepared by refluxing 3-acetylcoumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were characterized by means of their IR, ¹H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

E-Journal of Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, COA of Formula: C7H4BrClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kumar, Sourav published the artcilePyrazine Based Type-I Sensitizing Assemblies for Photoreduction of Cu(II) in ‘One-Pot Three-Component’ CuAAC Reaction Under Aerial Conditions, Category: chlorides-buliding-blocks, the publication is Chemistry – An Asian Journal (2021), 16(23), 3944-3950, database is CAplus and MEDLINE.

Photosensitizing assemblies of pyrazine derivative PDA have been developed which exhibit a high photostability, ‘lighted’ excited state, balanced redox potential, high transportation potential and activate oxygen via type-I pathway only. These PDA assemblies in combination with Cu(II) ions catalyze the CuAAC reaction via in situ reduction of Cu(II) ions without any reducing or stabilizing agent. The present protocol has wide substrate scope with recyclability of the catalytic system up to six catalytic cycles and is applicable to gram-scale synthesis.

Chemistry – An Asian Journal published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Saha, Ishita published the artcilePhenazinium dyes methylene violet 3RAX and indoine blue bind to DNA by intercalation: Evidence from structural and thermodynamic studies, Computed Properties of 4569-86-2, the publication is Dyes and Pigments (2013), 96(1), 81-91, database is CAplus.

The structural and energetic aspects of the interaction of two important phenazinium dyes methylene violet 3RAX and indoine blue with DNA were studied by spectroscopic and thermochem. techniques. The binding affinity values of both the dyes were of the order of 10⁵ M^-1 but methylene violet 3RAX bound to DNA more strongly. Both dyes bound DNA by intercalation but methylene violet 3RAX bound stronger than indoine blue. The DNA binding of both the dyes was exothermic and favored by a small neg. enthalpy and pos. entropy contributions. The effect of ionic strength indicated that electrostatic attraction is an important component of the dye-DNA interaction although the major contribution comes from hydrophobic forces. The temperature dependence of enthalpy changes yielded neg. heat capacity value which was higher for methylene violet 3RAX compared to indoine blue suggesting higher contribution from hydrophobic forces in the interaction of the former. Enthalpy-entropy compensation phenomenon was observed for the binding of both dyes to DNA.

Dyes and Pigments published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, Computed Properties of 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Srikrishna, Devulapally published the artcilePEG-600 mediated one-pot reaction of 3-acetyl-2H-chromen-2-one with heterylthiols and phenylthioureas using tetrabutylammonium tribromide as an efficient green reagent, Application of 1-(4-Chlorophenyl)thiourea, the publication is New Journal of Chemistry (2017), 41(12), 5168-5175, database is CAplus.

A simple method for the one-pot reaction of 3-acetyl-2H-chromen-2-one with different heterylthiols and phenylthioureas under green conditions using tetrabutylammonium tribromide (TBATB) as an efficient reagent has been described. 3-Acetyl-2H-chromen-2-one was reacted with TBATB in acetic acid to give 3-(2-bromoacetyl)-2H-chromen-2-one. Poly(ethylene glycol) 600 (PEG-600) was found to be the effective solvent for this reaction. Thus, a one-pot reaction of equimolar amounts of 3-acetyl-2H-chromen-2-one, TBATB and heterylthiols or phenylthioureas, resulted in the formation of heterylthioacetylcoumarins I (X = NH, O, S) or coumarinylthiazoles II (Ar = C₆H₅, 4-FC₆H₄, 2-Cl-4-FC₆H₃, etc.), resp. The effect of the solvent on these reactions was studied. The merits of this preparation are the mild reaction conditions, easy workup, good yields and use of PEG-600 as a green reaction medium.

New Journal of Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C9H9NO, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Suzuki, Keiko published the artcileA novel macroreticular-type fluorous polystyrene resin and its application to the synthesis of a 3-amino-β-carboline derivative with N-methyl-N-nitrosourea conjugation via fluorous solid-phase reaction: a comparative study of fluorous solid-, solid-, and liquid-phase reactions, SDS of cas: 42074-68-0, the publication is Tetrahedron (2015), 71(30), 4999-5012, database is CAplus.

A novel fluorous polystyrene (FPS) MR-resin was applied to a fluorous solid-phase (FSP) reaction. The MR-FPS resin actually was developed previously and possessed excellent chem. resistance to acids and alkalis, and a fluorous-tagged compound was homogeneously and loosely immobilized on the resin. The synthesis of an antitumor drug, an N-methyl-N-nirosourea conjugated 3-amino-β-carboline derivative, was accomplished with a high yield by using this new fluorous reaction system. Using only filtration, the fluorous 3-amino-β-carboline derivatives immobilized on the MR-FPS resin were easily recovered from the reaction mixtures As an extention of this approach, a diversity synthesis of 3-amino-9-benzyl-β-carboline derivatives was applied to the FSP method giving high yields. Finally, the FSP synthesis was compared with the corresponding conventional solid- and liquid-phase methods of synthesis. The FSP reaction was superior in terms of the reactivity of the substrate and the ease of product separation

Tetrahedron published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C9H9ClN2, SDS of cas: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Klovak, Viktoriia published the artcileFluorescent detection of decamethoxine by reaction with eosin Y in medicines, Category: chlorides-buliding-blocks, the publication is Journal of Chemical Sciences (Berlin, Germany) (2021), 133(4), 117, database is CAplus.

The influence of cationic, anionic, and nonionic surfactant solutions on the nature of the fluorescence spectra of reagents of different charges and hydrophobicity in aqueous solutions has been studied. The increase in the surfactant anal. signal with increasing contribution of the role of electrostatic interactions between the reagent particle and ionic surfactant has been shown. The observed effect is explained by the implementation of charge matching in the interaction of surfactants with the reagents. Hydrophobic binding of oppositely charged reagent particles and surfactants further enhances the effect of charge matching. The elimination of the detected effect for reagents that exhibit weak solvatochromic properties has been shown. The conditions for detecting the content of hydrophobic organic substances of cationic nature by reaction with eosin Y have been proposed.

Journal of Chemical Sciences (Berlin, Germany) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Andersson, Lars published the artcilePreparation of 3-carboxy-N,N,N-trimethylpropanaminium chloride (γ-butyrobetaine hydrochloride), Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Synthesis (1981), 468-9, database is CAplus.

Me₃N⁺(CH₂)₃CO₂H Cl^– was prepared in 18% yield by treatment of Me₂N(CH₂)₃CO₂H with RNHC(OMe):NR (R = cyclohexyl) (I) followed by HCl. I was prepared from N,N‘-dicyclohexylcarbodiimide and MeOH with a CuCl catalyst.

Synthesis published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics