Month: December 2022

Rhee, Hee-Kyung published the artcileSynthesis, cytotoxicity and topoisomerase II inhibitory activity of benzonaphthofurandiones, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Bulletin of the Korean Chemical Society (2011), 32(7), 2391-2396, database is CAplus.

Benzonaphthofurandiones containing 4 coplanar fused aromatic rings were synthesized and evaluated for their cytotoxicity against human cancer cell lines and for their inhibitory activity on topoisomerases. These benzonaphthofurandiones were prepared by condensation of 2,3-dichloronaphthoquinone and aromatic diols with base catalysts in alc. The synthesized compounds were O-alkylated with (dialkylamino)alkyl halides. The resulting hydroxy derivatives exhibited relatively potent cytotoxicity among the prepared compounds These compounds were evaluated as excellent inhibitors against topoisomerase II (topo II). Especially, a hydroxy analog with a branched Me side chain showed high cytotoxicity against cancer cell lines and good inhibitory activity on topo II.

Bulletin of the Korean Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kim, Jonghoon published the artcileFabrication of biodegradable nanofibers of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) via electrospinning, COA of Formula: C19H34ClN, the publication is Journal of Nanoscience and Nanotechnology (2009), 9(2), 914-918, database is CAplus and MEDLINE.

For the first time, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) nanofibrous membrane has been fabricated via electrospinning method. To improve the electrospinnability and reduce the diameter of fibers, the solvent and salt additives were used that affected on the parameters including such as the viscosity and the conductivity of the electrospinning solution for poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). Since the addnl. salts should be removed, it could be inferred that the co-solvent system was predominant to prepare the nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) membrane. This biodegradable nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) membrane has a great potential to be used in the various application fields such as tissue engineering, implants, packaging materials, agriculture, and so on.

Journal of Nanoscience and Nanotechnology published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Reisinger, Bernd published the artcileExploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2014), 53(2), 595-598, database is CAplus and MEDLINE.

The activity of the metabolic branch-point enzyme PriA from Mycobacterium tuberculosis (mtPriA) can be controlled reversibly by light. Two-pronged inhibitors based on the dithienylethene scaffold were designed utilizing mtPriA’s natural rotational symmetry. Switching from the flexible, ring-open to the rigid, ring-closed isomer reduces inhibition activity by one order of magnitude.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Name: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lipatova, I. P. published the artcileElectron-donor capability of the phosphoryl group of some trichloromethyl derivatives of phosphorus(V) studied by an ir spectroscopic method, Name: Diethyltrichloromethylphosphonate, the publication is Zhurnal Obshchei Khimii (1975), 45(2), 287-9, database is CAplus.

Heats of the H bonding of 16 title compounds, e.g., EtPhP(O)CCl3, p-MeC6H4P(CCl3)(O)OPr, and CCl3P(O)(OBu)2, with PhOH were determined via ir and correlated with resonance and inductive effects of the substituents.

Zhurnal Obshchei Khimii published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdildinova, Aizhan published the artcileHeterocycles as a peptidomimetic scaffold: solid-phase synthesis strategies, Name: 2-Chlorotrityl chloride, the publication is Pharmaceuticals (2021), 14(5), 449, database is CAplus and MEDLINE.

A review. Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochem. and biol. properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of mols. from small mols. to biopolymers and also is widely used for the synthesis of peptidomimetics. Small mols. including heterocycles serve as a core for hundreds of drugs, including peptidomimetic mols. This review covers solid-phase synthesis strategies for peptidomimetics mols. based on heterocycles.

Pharmaceuticals published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Name: 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vashi, D. M. published the artcileSynthesis and characterizations of substituted 1, 3, 5-triazine -2, 4, 6-triamines as biological potent agents, Application In Synthesis of 3696-23-9, the publication is Journal of Applicable Chemistry (Lumami, India) (2016), 5(4), 871-876, database is CAplus.

Some novel 1, 3, 5-triazine-2, 4, 6- triamines have been synthesized and characterized by elemental analyses, IR and NMR. The products have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria.

Journal of Applicable Chemistry (Lumami, India) published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C4H4N2O2, Application In Synthesis of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdeen, Sanofar published the artcileSulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA), Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Journal of Medicinal Chemistry (2018), 61(16), 7345-7357, database is CAplus and MEDLINE.

Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-sym. bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asym. analogs of this scaffold against a panel of bacteria known as the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). While GroEL/ES inhibitors were largely ineffective against K. pneumoniae, A. baumannii, P. aeruginosa, and E. cloacae (Gram-neg. bacteria), many analogs were potent inhibitors of E. faecium and S. aureus proliferation (Gram-pos. bacteria – EC₅₀ values of the most potent analogs were in the 1-2 μM range). Furthermore, even though some compounds inhibit human HSP60/10 biochem. functions in vitro (IC₅₀ values in the 1-10 μM range), many of these exhibited moderate to low cytotoxicity to human liver and kidney cells (CC₅₀ values >20 μM).

Journal of Medicinal Chemistry published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Recommanded Product: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Abdeen, Sanofar published the artcileSulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA), Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2018), 61(16), 7345-7357, database is CAplus and MEDLINE.

Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-sym. bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asym. analogs of this scaffold against a panel of bacteria known as the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). While GroEL/ES inhibitors were largely ineffective against K. pneumoniae, A. baumannii, P. aeruginosa, and E. cloacae (Gram-neg. bacteria), many analogs were potent inhibitors of E. faecium and S. aureus proliferation (Gram-pos. bacteria – EC₅₀ values of the most potent analogs were in the 1-2 μM range). Furthermore, even though some compounds inhibit human HSP60/10 biochem. functions in vitro (IC₅₀ values in the 1-10 μM range), many of these exhibited moderate to low cytotoxicity to human liver and kidney cells (CC₅₀ values >20 μM).

Journal of Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Korvorapun, Korkit published the artcileLate-Stage Diversification by Selectivity Switch in meta-C-H Activation: Evidence for Singlet Stabilization, Product Details of C8H6ClF3, the publication is ACS Catalysis (2020), 10(1), 435-440, database is CAplus.

The full control of site selectivity in C-H activation is paramount for the programmed late-stage functionalization of structurally complex structures. During the past decade, directing groups have revolutionized mol. synthesis in terms of ortho-selective C-H activation. In sharp contrast, a selectivity switch that guides the typical ortho- to remote meta-C-H activation has thus far proven elusive. Herein, we describe the realization of such a concept for a robust selectivity control in ruthenium catalysis. The distal C-H transformation was guided by key mechanistic insights into the mild, synergistic action of carboxylates and phosphines in ruthenium(II) catalysis. Our findings allowed remote selectivity in broadly effective late-stage diversification of structurally complex drugs and natural product mols., tolerating sensitive fluorescent dyes, drugs, lipids, peptides, nucleosides and carbohydrates.

ACS Catalysis published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Product Details of C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dey, Sandip published the artcileStructural variety and multiple isomerism in 1-(dimethylamino)propyl-2-chalcogenolate and 2-(dimethylamino)propyl-1-chalcogenolate complexes of palladium(II) and platinum(II): Synthesis, spectroscopy and structures, SDS of cas: 4584-49-0, the publication is European Journal of Inorganic Chemistry (2004), 4510-4520, database is CAplus.

Isomeric dichalcogenides [Me₂NCH(Me)CH₂E]₂ [(N^{âˆ?/sup>E**)₂] and [Me₂NCH₂CH(Me)E]₂ [(Nâˆ?/sup>E*)₂] (E = S, Se, Te) were obtained by the reactions of NaSH or M’₂E₂ (M’ = Na or K) with Me₂NCH₂CHMeCl. The former reaction affords mainly (Nâˆ?/sup>E**)₂ (E = S) while from the latter mixtures of (Nâˆ?/sup>E**)₂ and (Nâˆ?/sup>E*)₂ [referred to as (Nâˆ?/sup>E)₂, E = S, Se, Te] were isolated, the ratios in the mixtures depending on the chalcogen. Reactions of (Nâˆ?/sup>E)Na with [M₂Cl₂(μ-Cl)₂(PR₃)₂] gave [MCl(Nâˆ?/sup>E)(PR₃)] (M = Pd or Pt). These chiral, mixed-ligand complexes were characterized by elemental anal., IR, UV/visible and NMR (1H, 13C, 31P, 77Se, 125Te, 195Pt) spectroscopy, and, in part, by x-ray structure anal. The complexes display a typical pattern of mutually trans-oriented neutral (P and N) and anionic (Cl and E) donor atoms in an approx. square-planar environment. In contrast to the Pt(II) analogs, the x-ray structures of [PdCl(Nâˆ?/sup>E)(PMePh₂)] (E = S or Se) revealed both a conformational isomerism of the five-membered chelate ring and, for Se, the co-crystallization of complexes with both the Nâˆ?/sup>E* and Nâˆ?/sup>E** isomeric ligands. The thermal behavior of some complexes was studied.}

European Journal of Inorganic Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics