Month: December 2022

Palii, G. K. published the artcileEffect of decamethoxin on diphtheria exotoxin, Formula: C38H74Cl2N2O4, the publication is Antibiotiki (Moscow) (1975), 20(2), 135-8, database is CAplus.

At the subbacteriostatic concentration of 0.1 μg/ml, decamethoxin [38146-42-8] completely inhibited toxin formation in 4 of 6 Corynebacterium diphtheriae strains tested and decreased it in the other 2. A 2-hr exposure to 10 μg decamethoxin/ml neutralized the activity of diphtheria toxin.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileMicrobiological characteristics and antibiotic sensitivity of decamethoxin-resistant diphtheria causative agents, Application In Synthesis of 38146-42-8, the publication is Antibiotiki (Moscow) (1975), 20(12), 1095-9, database is CAplus.

Resistance of Corynebacterium diphtheriae strains to neomycin [1404-04-2], levomycetin [56-75-7], decamine [522-51-0], and decamethoxin [38146-42-8] increased by 35-, 17-, 20-, and 2-8-fold, resp., after 60 passages through antibiotic-containing media. The decamethoxin-resistant strains were examined for resistance to 9 other antibiotics.

Antibiotiki (Moscow) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application In Synthesis of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Koolpe, Gary A. published the artcileDiastereomeric 6-desoxy-6-spiro-α-methylene-γ-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand, Quality Control of 5034-06-0, the publication is Journal of Medicinal Chemistry (1984), 27(12), 1718-23, database is CAplus and MEDLINE.

The title compounds I and II (R = Me or cyclopropylmethyl) were prepared by sequence reaction starting with direct alkylation of the diacetate ester of the parent ketone by the Reformatskii reagent prepared from Me α–(bromomethyl)acrylate  [4224-69-5], and their affinity for opioid binding sites was determined in crude rat brain membrane preparation by competition against [³H]naltrexone in presence and absence of Na⁺. 6α–(2-Carboxyallyl)-17-(cyclopropylmethyl)-4,5α-epoxy-3,6β,14-trihydroxymorphinan-γ-lactone (II; R = cyclopropylmethyl) [92398-30-6] was the most potent compound showing a 50% inhibition of binding at 5 nM. The data suggest a receptor nucleophile such as SH is located where it can add to the α,β-unsaturated carbonyl system of the above compound

Journal of Medicinal Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Quality Control of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Henderson, LaVell M. published the artcileMammalian enzymes of trimethyllysine conversion to trimethylaminobutyrate, Application In Synthesis of 6249-56-5, the publication is Federation Proceedings (1982), 41(12), 2843-7, database is CAplus and MEDLINE.

The biosynthesis of carnitine proceeds from trimethyllysine (TML) by β-hydroxylation by liver or kidney mitochondrial TML-α-ketoglutarate dioxygenase (referred to as TML hydroxylase) which requires O₂, α-ketoglutarate, Fe²⁺, and ascorbate. TML hydroxylase is rapidly inactivated by preincubation with Fe²⁺, but not Fe³⁺, suggesting that superoxide is involved in the hydroxylation. β-Hydroxyltrimethyllysine undergoes aldol cleavage to glycine and trimethylaminobutyraldehyde under the influence of serum hydroxymethyltransferase and possibly a specific aldolase. The next step, the aldehyde oxidation, is catalyzed by a specific NAD-dependent aldehyde dehydrogenase from liver cytosol. The product, trimethylaminobutyrate, is then hydroxylated by a cytosolic dioxygenase to carnitine. This enzyme, which has the same cofactor requirements as TML hydroxylase, is found in the liver of all species examined, but is absent from the kidney of some species.

Federation Proceedings published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application In Synthesis of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Atthoff, Bjoern published the artcileBiodegradable Ionomers, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Macromolecules (2006), 39(11), 3907-3913, database is CAplus.

Several telechelic anionic or cationic ionomers were synthesized starting from poly(trimethylene carbonate) diols (PTMC) of different mol. weight, ranging from 1000 to 12 000 g/mol. In the synthesis of the anionomer, addition of sulfur trioxide trimethylene complex to the PTMC end-group hydroxyls and subsequent ion exchange afforded a disulfate monoester sodium salt. The cationomer was synthesized in two steps. Acylation of the PTMC diol using 4-chlorobuturyl chloride was followed by displacement of the alkyl chloride with trimethylamine to give a quaternary ammonium salt. These ionomers showed excellent swelling properties, up to around 500% in H₂O, while the unfunctionlized PTMC did not swell at all. The lowest mol. weight ionomers were soluble in both water and chloroform. The phys. properties of the ionomers were analyzed with oscillating rheol. experiments Interestingly, the ionomers displayed “rubbery plateau”. The mech. and swelling properties may be linked to phase separation resulting in ionic aggregates within the bulk, which may function as phys. cross-links. At ambient temperatures, the PTMC starting material behaved like a highly viscous fluid, while the ionomers behaved as elastomers. In a hydrophilic environment, the ionomers displayed a surface rearrangement making the surface of the ionomer hydrophilic by allowing the ionic end groups to appear at the water ionomer interface. In air or vacuum all the ionic groups were found in the bulk of the material as analyzed by XPS or contact angle measurements. Finally, we showed that with the specific ionic groups it was possible to complex specific mols. to the ionomers.

Macromolecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Weixuan published the artcileA [³²P]NAD⁺-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors, Product Details of C6H3ClFNO2, the publication is Analytical Biochemistry (2015), 40-49, database is CAplus and MEDLINE.

The classical methods for quantifying drug-target residence time (t_R) use loss or regain of enzyme activity in progress curve kinetic assays. However, such methods become imprecise at very long residence times, mitigating the use of alternative strategies. Using the NAD(P)H-dependent FabI enoyl-acyl carrier protein (enoyl-ACP) reductase as a model system, we developed a Penefsky column-based method for direct measurement of t_R, where the off-rate of the drug was determined with radiolabeled [adenylate-³²P]NAD(P⁺) cofactor. In total, 23 FabI inhibitors were analyzed, and a math. model was used to estimate limits to the t_R values of each inhibitor based on percentage drug-target complex recovery following gel filtration. In general, this method showed good agreement with the classical steady-state kinetic methods for compounds with t_R values of 10 to 100 min. In addition, we were able to identify seven long t_R inhibitors (100-1500 min) and to accurately determine their t_R values. The method was then used to measure t_R as a function of temperature, an anal. not previously possible using the standard kinetic approach due to decreased NAD(P)H stability at elevated temperatures In general, a 4-fold difference in t_R was observed when the temperature was increased from 25 to 37 °C.

Analytical Biochemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C16H24BF4Ir, Product Details of C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Galatenko, N. A. published the artcileChemical sterilization of polyacrylamide soft contact lenses, Product Details of C38H74Cl2N2O4, the publication is Gigiena i Sanitariya (1991), 67-8, database is CAplus and MEDLINE.

Decamethoxyne solutions (0.01-0.02%) are suitable for the sterilization of polyacrylamide soft contact lenses. No residual decamethoxyne and no toxicity of lenses sterilized by this method were observed

Gigiena i Sanitariya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Product Details of C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gonchar, O. O. published the artcileStudy of antimicrobial qualities of antiseptic remedies, which contain decamethoxin, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Ukrainian Biopharmaceutical Journal (2016), 74-77, database is CAplus.

In the research the effectiveness of antiseptic remedies, which contain decamethoxin (DCM). Microbicidal (Pilot Manufacturing of Institute of Organic Chem. of National Academy of Sciences of Ukraine) and its remedies’ forms (auridexan (AU), horosten (HS), decasan (DS), septefril (SF). The study was carried out on clin. strains of S. aureus (n 85), E. coli (n 22), P. aeruginosa (n 16), C. albicans (n 12) and was compared with museum strains, got from the museum of alive microbe cultures of Vinnytsya National Pirogov Memorial Medical University. Antimicrobial qualities of antiseptics were studied by means of serial dilutions method. The results of antimicrobial activity of remedies was analyzed by minimal cidal concentration (MCC). We found, that DCM (MCC – 3.67 ± 2.71 mkg/mL), HS (3.44 ± 1.60 mkg/mL, DS (3.06 ± 1.95 mkg/mL), SF (4.32 ± 2.47 mkg/mL) had their microbicidal activity against clin. strains of S. aureus. Such remedies of generic DCM as AU, HS, DS were found to have no difference in antimicrobial activity (p < 0.05). Antimicrobial activity of DCM (MCC – 26.8 ± 17.5 mkg/mL) and its remedies horosten, septefril on clin. strains of E. coli was significantly alike antimicrobial activity of museum strain of E. coli ATCC 25922 (MCC – 7.8-31.25 mkg/mL). Clin. strains of P. aeruginosa were resistant to remedies of generic DCM (MCC – 125-250 mkg/mL). C. albicans were sensitive to remedies of DCM in cidal concentrations 3.9-31.25 mkg/mL. Effective antimicrobial qualities of generic decamethoxin and its remedies (auridexan, horosten, decasan, septefril) are advisable to be used in fighting infection, caused by antibiotocresistant strains of S. aureus, E. coli, C. albicans.

Ukrainian Biopharmaceutical Journal published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileStudy of the kinetics of an antimicrobial agent decamethoxine, Category: chlorides-buliding-blocks, the publication is Antibiotiki i Khimioterapiya (2014), 59(3-4), 7-9, database is CAplus.

The kinetics of decamethoxine liberation from medical antimicrobial textiles was studied. The elution of decamethoxine was shown to be a complicated diffusive-kinetic process dependent on the exposure and concentration of decamethoxine.

Antibiotiki i Khimioterapiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileAntimicrobial properties of antiseptic composite with prolonged action, SDS of cas: 38146-42-8, the publication is Antibiotiki i Khimioterapiya (2013), 58(3-4), 14-18, database is CAplus.

Antimicrobial properties of a composite based on decamethoxine and modified polysaccharides (carboxymethylamylum, oxyethyl-cellulose) were studied. The composite was shown to have high antimicrobial activity against Gram-pos. and Gram-neg. bacteria under different conditions of the experiment

Antibiotiki i Khimioterapiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, SDS of cas: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics