Month: December 2022

Li, Ridong published the artcileDiscovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators, Product Details of C9H5ClO4S, the publication is European Journal of Medicinal Chemistry (2018), 48-65, database is CAplus and MEDLINE.

Pyruvate kinase M2 isoform (PKM2) is a crucial protein responsible for aerobic glycolysis of cancer cells. Activation of PKM2 may alter aberrant metabolism in cancer cells. In this study, we discovered a 4-hydroxy-thiazolidine-2-thione compound 2 as a novel PKM2 activator from a random screening of an inhouse compound library. Then a series of novel 4-hydroxy-thiazolidine-2-thione derivatives were designed and synthesized for screening as potent PKM2 activators. Among these, some compounds showed higher PKM2 activation activity than lead compound 2 and also exhibited significant anti-proliferative activities on human cancer cell lines at nanomolar concentration The compound 5w was identified as the most potent antitumor agent, which showed excellent anti-proliferative effects with IC₅₀ values from 0.46 μM to 0.81 μM against H1299, HCT116, Hela and PC3 cell lines. 5w also showed less cytotoxicity in non-tumor cell line HELF compared with cancer cells. In addition, Preliminary pharmacol. studies revealed that 5w arrests the cell cycle at the G2/M phase in HCT116 cell line. The best PKM2 activation by compound 5t was rationalized through docking studies.

European Journal of Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Product Details of C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Berte-Verrando, Sylvie published the artcileGeneral synthesis of α,α-dideuteriated phosphonic esters, Product Details of C5H10Cl3O3P, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1994), 821-4, database is CAplus.

A range of α,α-dideuteriated phosphonic esters has been prepared by deuteriolysis of α-silylated α-phosphonylated carbanions with D₂O as deuterium source. In most cases, incorporation of deuterium is greater than 95% and the yields are good to excellent. The title products are potential trace compounds in many biol. and industrial applications.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lesniak, Robert K. published the artcileDiscovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors, Category: chlorides-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2022), 13(6), 981-988, database is CAplus and MEDLINE.

G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson’s disease, as well as for some forms of cancer, and is a shared risk allele for Crohn’s disease. GS-LRRK2 has a hyperactive kinase, and although numerous drug discovery programs have targeted LRRK2 kinase, few have reached clin. development. We report the discovery and preliminary development of an entirely novel structural class of potent and selective GS-LRRK2 kinase inhibitors: biaryl-1H-pyrazoles.

ACS Medicinal Chemistry Letters published new progress about 1030832-75-7. 1030832-75-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronate Esters,Boronic acid and ester, name is 2-(4-Chloro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Junjie published the artcileSemicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, SDS of cas: 939-99-1, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(4), 351-360, database is CAplus and MEDLINE.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R¹ = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R² = t-Bu, H, prop-2-en-1-yl; R³ = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R¹ H, R² = R³ = t-Bu; (II) R = Et, R¹ H, R² = R³ = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC₅₀ values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ma, Junjie published the artcileSemicarbazone derivatives bearing phenyl moiety: synthesis, anticancer activity, cell cycle, apoptosis-inducing and metabolic stability study, Safety of 3-Chlorobenzylchloride, the publication is Chemical & Pharmaceutical Bulletin (2019), 67(4), 351-360, database is CAplus and MEDLINE.

A series of semicarbazone derivatives bearing Ph moiety I [R = Me, Et; R¹ = H, benzyloxidanyl, 2-(2H-1,3-benzodioxol-5-ylmethyl)-(1,3-thiazol-4-yl)-methyloxy, [(4-chlorophenyl)methyl]oxidanyl, etc.; R² = t-Bu, H, prop-2-en-1-yl; R³ = H, t-Bu] was synthesized and evaluated for the vitro anticancer activities in four human cancer cell lines (human colon cancer (HT29), human neuroblastoma (SK-N-SH), human breast cancer (MDA-MB-231), and human gastric cancer (MKN45)). Biol. evaluation led to the identification of I [(I) R = Me, R¹ H, R² = R³ = t-Bu; (II) R = Et, R¹ H, R² = R³ = t-Bu], which showed excellent anticancer activities against tested cancer cell lines with IC₅₀ values ranging from 0.32 to 1.57 μM, resp., while exhibiting weak cytotoxicity on the normal cells (human umbilical vein endothelial cell (HUVEC)). Flow cytometric assay for cell cycle and apoptosis revealed that (I) and (II) caused an arrest in the Sub-G1 cell cycle and inhibited proliferation of cancer cells by inducing apoptosis in a dose-dependent manner. Further enzymic assay suggested that (I) and (II) could significantly activated procaspase-3 to caspase-3. Metabolic stability study indicated that (I) and (II) showed moderate stability in vitro in human and rat liver microsomes. In view of promising pharmacol. activities of (I) and (II), which had emerged as the valuable lead for further development in the treatment for cancer.

Chemical & Pharmaceutical Bulletin published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhou, Xin published the artcileElectrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes, Formula: C9H5Cl2F3, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(70), 8750-8753, database is CAplus and MEDLINE.

Radical fluoroalkylation of alkenes has been developed by electrochem. reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily underwent hydrofluoroalkylation in good to excellent yields. This chem. represents the first example of electrochem. generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds

Chemical Communications (Cambridge, United Kingdom) published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C8H13NO3, Formula: C9H5Cl2F3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wagare, Devendra S. published the artcileHighly efficient microwave-assisted one-pot synthesis of 4-aryl-2-aminothiazoles in aqueous medium, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Environmental Chemistry Letters (2017), 15(3), 475-479, database is CAplus.

A one-pot protocol for the synthesis of 4-aryl-2-aminothiazoles from the reaction of aromatic ketones, NBS (N-bromosuccinimide) and thioureas under microwave irradiation at 80-85° in PEG (polyethylene glycol)-400 and water as a green reaction medium was developed. The products were obtained in 84-89% yields in 28-32 min. The method had several advantages such as use of green solvent, easy work-up, excellent yield and avoiding use of lachrymatory α-haloketones.

Environmental Chemistry Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C8H7N3, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Freidlina, R. Kh. published the artcileThermal telomerization of olefins with silicon hydrides, HPLC of Formula: 14799-94-1, the publication is Khim. i Prakt. Primenenie Kremneorgan. Soedin., Tr. Konf., Leningrad (1961), 1958(6), 72-82, database is CAplus.

Compounds containing Si-H bonds undergo addition reactions with olefins in a steel autoclave at temperatures of 260-300° and at 100-560 atm. with no other catalyst or initiator. Products are of the type Si(olefin)_nH (I), where n = 1-6. The autoclave itself does not appear to act as an initiator by reacting with Cl in chlorosilanes to give metal chlorides, since a similar reaction takes place when no Cl is present in the Si compound The reaction appears to proceed by a free radical route. The influence of temperature and olefin concentration on the product mixture was investigated. With increasing C₂H₄ concentration, where n = 1, the yield of I decreases; where n = 2 or 3, remains the same; where n >3, increases. Increasing temperature in range 285°-400°, with constant (2:1) excess of olefin in mixture, increased the yield of I where n = 1 at expense of n >3; where n = 2 or 3, the yield varied little. For comparison, the reaction was carried out in the presence of certain metallic chlorides. H₂PtCl₆ catalyzes addition reaction at room temperature, but chlorides of Zr, Ti, and Sn, require temperatures ≃200° and give less satisfactory conversion. This reaction appears to proceed via polar intermediates.

Khim. i Prakt. Primenenie Kremneorgan. Soedin., Tr. Konf., Leningrad published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brasca, Maria Gabriella published the artcilePyrrole-3-carboxamides as potent and selective JAK2 inhibitors, Safety of (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid, the publication is Bioorganic & Medicinal Chemistry (2014), 22(17), 4998-5012, database is CAplus and MEDLINE.

We report herein the discovery, structure guided design, synthesis and biol. evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor (I; NMS-P953). I displayed significant tumor growth inhibition in SET-2 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile.

Bioorganic & Medicinal Chemistry published new progress about 1195945-67-5. 1195945-67-5 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid, and the molecular formula is C7H5BClF3O2, Safety of (5-Chloro-2-(trifluoromethyl)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileSensitivity of Bacillus pyocyaneus to antimicrobial preparations, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Veterinariya (Moscow, Russian Federation) (1975), 80-2, database is CAplus.

B. pyocyaneus (Pseudomonas aeruginosa) was more sensitive to oleomorphocycline [18353-77-0], polymyxin M sulfate [54988-04-4], neomycin [1404-04-2], monomycin [7542-37-2], kanamycin [8063-07-8], and decamethoxin [38146-42-8] than to other disinfectants and antibiotics tested.

Veterinariya (Moscow, Russian Federation) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics