Month: December 2022

Gottardi, Waldemar published the artcileThe Integral Method, a new approach to quantify bactericidal activity, Application In Synthesis of 7080-50-4, the publication is Journal of Microbiological Methods (2015), 71-78, database is CAplus and MEDLINE.

The bactericidal activity (BA) of antimicrobial agents is generally derived from the results of killing assays. A reliable quant. characterization and particularly a comparison of these substances, however, are impossible with this information. We here propose a new method that takes into account the course of the complete killing curve for assaying BA and that allows a clear-cut quant. comparison of antimicrobial agents with only one number The new Integral Method, based on the reciprocal area below the killing curve, reliably calculates an average BA [log₁₀ CFU/min] and, by implementation of the agent’s concentration C, the average specific bactericidal activity SBA = BA / C [log₁₀ CFU/min/mM]. Based on exptl. killing data, the pertaining BA and SBA values of exemplary active halogen compounds were established, allowing quant. assertions. N-chlorotaurine (NCT), chloramine T (CAT), monochloramine (NH₂Cl), and iodine (I₂) showed extremely diverging SBA values of 0.0020 ± 0.0005, 1.11 ± 0.15, 3.49 ± 0.22, and 291 ± 137 log₁₀ CFU/min/mM, resp., against Staphylococcus aureus. This immediately demonstrates an approx. 550-fold stronger activity of CAT, 1730-fold of NH₂Cl, and 150,000-fold of I₂ compared to NCT. The inferred quant. assertions and conclusions prove the new method suitable for characterizing bactericidal activity. Its application comprises the effect of defined agents on various bacteria, the consequence of temperature shifts, the influence of varying drug structure, dose-effect relationships, ranking of isosteric agents, comparison of competing com. antimicrobial formulations, and the effect of additives.

Journal of Microbiological Methods published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wondraczek, Holger published the artcileWater soluble photoactive cellulose derivatives: synthesis and characterization of mixed 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetic acid-(3-carboxypropyl)trimethylammonium chloride esters of cellulose, COA of Formula: C7H16ClNO2, the publication is Cellulose (Dordrecht, Netherlands) (2012), 19(4), 1327-1335, database is CAplus.

Photoactive derivatives of cellulose were prepared by a mild esterification of the biopolymer with 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetic acid via the activation of the carboxylic acid with N,N’-carbonyldiimidazole. Subsequently, modification with the cationic carboxylic acid (3-carboxypropyl)trimethylammonium chloride was carried out. Thus, water soluble polyelectrolytes decorated with high amounts of photochem. active chromene moieties were obtained. The structures of the novel polysaccharide esters and the polyelectrolytes were evaluated by means of NMR and IR spectroscopy. Moreover, the light triggered photodimerization of the chromene moieties of the photoactive polyelectrolytes was studied by means of UV-Vis spectroscopy in the dissolved state. The photochem. observed may be used to control the properties of the new polysaccharide derivatives and are thus of interest in the design of smart materials.

Cellulose (Dordrecht, Netherlands) published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H8BClO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vega, B. published the artcileStudies on the fibre surfaces modified with xylan polyelectrolytes, HPLC of Formula: 6249-56-5, the publication is Carbohydrate Polymers (2012), 89(3), 768-776, database is CAplus and MEDLINE.

Xylan was isolated from birch wood chips by using pressurized hot water extraction (PHWE). The extracted xylan was chem. modified yielding three different xylan derivatives (XDs): xylan sulfate (XS), carboxymethyl xylan (CMX) and xylan-4-[N,N,N-trimethylammonium]butyrate chloride (XTMAB). The structure and mol. weight of XDs was determined by using NMR spectroscopy and size exclusion chromatog. (SEC). The potential utilization of xylan polyelectrolytes for modifying fiber surfaces was assessed by sorption experiments using bleached pine Kraft pulp as substrate. Polyelectrolyte titration method was chosen for estimating the amount of sorbed XDs onto the fibers. The cationic xylan derivative XTMAB had a strong interaction with fibers while the anionic derivatives did not show any sorption. XPS and time of flight secondary ion mass spectrometry (ToF-SIMS) were selected as advanced surface analyses for studying the amount of surface anionic groups and the surface distribution of the XTMAB. XPS and polyelectrolyte titration results suggested that the XTMAB is sorbed onto the fiber surfaces. ToF-SIMS imaging showed that XTMAB was evenly distributed on fiber surfaces.

Carbohydrate Polymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C44H58NO5PPdS, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

da Rocha, Caroline O. published the artcileMethylene violet 3 RAX dye as a new reagent for the determination of nitrite in cured meats and vegetables, SDS of cas: 4569-86-2, the publication is Journal of the Brazilian Chemical Society (2017), 28(8), 1528-1533, database is CAplus.

In this contribution we propose, for the first time, the use of Methylene Violet 3 RAX dye for the detection and determination of nitrite in cured meats and vegetables. Quantification is based on the decrease in absorbance of the dye, which is proportional to the nitrite concentration The proposed method presents linear response (r > 0.99) in the range from 1.8 to 9 μmol L-1 of nitrite, with a limit of detection of 0.14 μmol L-1. Satisfactory accuracy with the official Association of Official Agricultural Chemists (AOAC) method was achieved, and the method was successfully applied to a wide range of cured meats and vegetables. The proposed method offers similar or superior performance to other optical methods used for the determination of nitrite in different matrixes, with advantage in terms of reduction of chem. waste for each anal., by minimizing amounts of reagents and products.

Journal of the Brazilian Chemical Society published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C22H23ClN4, SDS of cas: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hancock, James R. published the artcileRetention index monitoring of compounds of chemical defense interest using thermal desorption gas chromatography, Synthetic Route of 1002-41-1, the publication is Journal of Chromatography (1991), 538(2), 249-57, database is CAplus.

Retention index monitoring using thermal desorption gas chromatog. anal. was developed as method for the verification of compounds of chem. defense interest in environmental matrixes. Gas chromatog. retention indexes were determined by loading solid adsorbent packed sampling tubes initially with the target compounds and subsequently with a series of n-alkane probes. The resulting chromatog. performance and gas chromatog. retention indexes were independent of the tube loading method. A data base of gas chromatog. retention indexes for chem. warfare agents and simulants was compiled and, in conjunction with simultaneous flame ionization and flame photometric detection, applied to the identification of tri-Et phosphate, tri-Bu phosphate, and di-Et malonate in water and soil samples.

Journal of Chromatography published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Synthetic Route of 1002-41-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Florvall, Lennart published the artcilePotential neuroleptic agents. 2. Synthesis and dopamine blocking activity of some new 2,6-dimethoxybenzamide derivatives, COA of Formula: C9H9ClO4, the publication is Acta Pharmaceutica Suecica (1983), 20(5), 365-70, database is CAplus and MEDLINE.

A series of 14 novel 2,6-dimethoxybenzamides related to the parent drug (S)-(-)-3-bromo-2,6-dimethoxy-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide, were synthesized by chlorination and amination of the corresponding dimethoxybenzaldehydes, and were evaluated for the ability to block the apomorphine syndrome in rats. Four of the compounds, dimethoxybenzamides I (R = R¹ = Cl, Br; R = Br, R¹ = H) and II, were potent but the activity was lower than that of the parent compound None of the new amides showed any notable separation between apomorphine-induced hyperactivity and stereotypes.

Acta Pharmaceutica Suecica published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, COA of Formula: C9H9ClO4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, Jean published the artcileα-Chloroenolates; VI. Diethyl 1-chloro-1-lithio-2-oxoalkanephosphonates; synthesis of α-chloro-α,β-unsaturated ketones, Category: chlorides-buliding-blocks, the publication is Synthesis (1978), 29-31, database is CAplus.

1-Chloro-2-oxoalkanephosphonates RCOCHClP(O)(OEt)₂ (I; R = Pr, iso-Pr, tert-Bu) were prepared in 60-85% yield by treating LiCCl₂P(O)(OEt)₂ with BuLi at -90° followed by acylation with RCOCl at -125 and hydrolysis. In situ reaction of I α-Li derivatives with aldehydes R¹CHO (R¹ = Ph, 2- or 4-ClC₆H₄, Bu) gave α,β-unsaturated ketones (E)-R¹CH:CClCOR.

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C7H8BNO4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, Jean published the artcileα-Haloenolates; VII. Diethyl 1-chloro-1-ethoxycarbonyl-1-lithiomethanephosphonate; a convenient one-step preparation of α-chloro-α,β-unsaturated esters from diethyl trichloromethanephosphonate, Quality Control of 866-23-9, the publication is Synthesis (1978), 31-3, database is CAplus.

α,β-Unsaturated esters (E)- and (Z)-RCH:CClCO₂Et (R = n-C₉H₁₉, BuCHEt, 3-cyclohexenyl, Cl₃C, Ph, 2-ClC₆H₄, 4-MeOC₆H₄) and I (n = 0, 1) were prepared by treating Cl₃CP(O)(OEt)₂ with BuLi at -90°, ClCO₂Et at -125°, and RCHO or the cycloalkanone at -60 to +20°. Hydrolysis of the intermediate Li enolate formed in the above reactions gave EtO₂CCHClP(O)(OEt)₂.

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C6H4ClNO2, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Villieras, J. published the artcileSimple route from aldehydes to alkynes and 1-chloro-1-alkynes, SDS of cas: 866-23-9, the publication is Synthesis (1975), 458-61, database is CAplus.

Reaction of RCHO (R = e.g., Et2CH, cyclohexyl, MeCH:CH, PhCH:CH, substituted phenyl) with LiCCl2P(O)(OEt)2 in THF-ether gave 85-90% RCH:CCl2 which 1) with LiNEt2 in THF-ether gave RCCCl and 2) with EtLi or BuLi in THF-ether at -10 to -70° gave RCCLi which was hydrolyzed with aqueous H2SO4 to RCCH or alkylated with chlorodimethyl ether to give methoxymethyl derivatives (e.g., 1-cyclohexyl-3-methoxy-1-propyne).

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C18H35NO, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chantler, Thomas published the artcileProximity effects in the electron impact mass spectra of 2-substituted benzazoles, SDS of cas: 51656-68-9, the publication is International Journal of Mass Spectrometry (2004), 236(1-3), 65-80, database is CAplus.

The 70 eV electron impact mass spectra of a wide range of 2-substituted benzazoles are reported and discussed. Particular attention is paid to the mechanistic significance and anal. utility of [M-H]⁺ and [M-X]⁺ signals in the spectra of benzazoles in which the 2-substituent contains a terminal aryl group with one or more substituents, X. Loss of H^• or X^• occurs preferentially from an ortho-position from ionized 2-benzylbenzimidazoles, 2-phenethylbenzimidazoles, 2-styrylbenzimidazoles, 2-styrylbenzoxazoles and 2-styrylbenzothiazoles. In the three styrylbenzazole series, the [M-H]⁺ and/or [M-X]⁺ signals dominate the spectra. This unusually facile loss of H^• or X^• may be attributed to a proximity effect, in which cyclization of the ionized mol. is followed by elimination of an ortho-substituent to give an exceptionally stable polycyclic ion. Formation of a new five- or six-membered ring by the proximity effect occurs rapidly; cyclization to a seven-membered ring takes place rather less readily; but formation of a ring with only four atoms or more than seven atoms is not observed to a significant extent. The proximity effect competes effectively with loss of a Me radical by simple cleavage of an Et, iso-Pr and even a t-Bu group in the pendant aromatic ring of ionized 2-(4-alkylstyryl)benzazoles.

International Journal of Mass Spectrometry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C9H8Cl2O2, SDS of cas: 51656-68-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics