Month: December 2022

Kovtun, E. A. published the artcileStability of coated polycaproamide sutures during radiation sterilization, HPLC of Formula: 38146-42-8, the publication is Fibre Chemistry (Translation of Khimicheskie Volokna) (1999), 31(6), 455-459, database is CAplus.

The studies showed that the radiation sterilization, recommended by the State Pharmacopeia, does not cause degradation of polycaproamide-based sutures and has almost no effect on their physicomech. properties and capillarity. The optimum sterilizing dose was 2.5 Mrad for suture based on BF-6 phenol-polyvinylacetal adhesive coatings, SKTN-G dimethylsiloxane rubber, and a composite with addition of an antimicrobial agent Decametoxin.

Fibre Chemistry (Translation of Khimicheskie Volokna) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, HPLC of Formula: 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yong-Kang published the artcileNovel synthesis of isoxazoline indolizine amides for potential application to tropical diseases, Related Products of chlorides-buliding-blocks, the publication is Tetrahedron Letters (2014), 55(11), 1936-1938, database is CAplus.

Synthetically challenging isoxazoline indolizine amide compounds were designed and prepared for potential application to tropical diseases. Indolizine core structures were synthesized strategically as common intermediates for efficient derivatization. The chem. for the syntheses of 8-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)indolizine-5-carboxamide and 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-indolizine-8-carboxamide is described in this Letter.

Tetrahedron Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C44H28ClFeN4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Yong-Kang published the artcileDiscovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(23), 5589-5593, database is CAplus and MEDLINE.

A novel series of isoxazoline benzoxaborole small mols. was designed and synthesized for a structure-activity relationship (SAR) investigation to assess the ectoparasiticide activity against ticks and fleas. The study identified an orally bioavailable mol., (S)-3,3-dimethyl-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)benzo[c][1,2]oxaborol-1(3H)-ol (38, AN8030), which was long lasting in dogs (t_1/2 = 22 days). Compound 38 demonstrated 97.6% therapeutic effectiveness within 24 h of treatment, with residual efficacy of 95.3% against American dog ticks (Dermacentor variabilis) on day 30% and 100% against cat fleas (Ctenocephalides felis) on day 32 after a single oral dose at 50 mg/kg in dogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C10H10O2, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Millet, Antoine published the artcileDiscovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells, COA of Formula: C9H5ClO4S, the publication is Journal of Medicinal Chemistry (2016), 59(18), 8276-8292, database is CAplus and MEDLINE.

Cancer is the second cause of deaths worldwide and is forecast to affect more that 22 million people in 2020. Despite dramatic improvement in its care over the last two decades, the treatment of resistant forms of cancer is still an unmet challenge. Thus, innovative and efficient treatments are still needed. In this context, the authors report herein the synthesis and evaluation of a new class of bioactive mols. belonging to the N-(4-(3-aminophenyl)thiazol-2-yl)acetamide family. Structure-activity relationships could be driven and resulted in the discovery of lead compound I.. The latter display high in vitro potency against both sensitive and resistant cancer cell lines on three models: melanoma, pancreatic cancer, and chronic myeloid leukemia (CML). I leads to cell death by concomitant induction of apoptosis and autophagy, shows good pharmacokinetic properties, and demonstrates a significant reduction of tumor growth in vivo on A375 xenograft model in mice.

Journal of Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pattison, Graham published the artcileEnantioselective Rhodium-catalyzed addition of arylboronic acids to alkenylheteroarenes, Synthetic Route of 480438-56-0, the publication is Journal of the American Chemical Society (2010), 132(41), 14373-14375, database is CAplus and MEDLINE.

In the presence of a rhodium complex containing a newly developed chiral diene ligand, alkenes activated by a range of π-deficient or π-excessive heteroarenes engage in highly enantioselective conjugate additions with various arylboronic acids.

Journal of the American Chemical Society published new progress about 480438-56-0. 480438-56-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Synthetic Route of 480438-56-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Xi published the artcileEffects of dietary anaplerotic and ketogenic energy sources on renal fatty acid oxidation induced by clofibrate in suckling neonatal pigs, Computed Properties of 637-07-0, the publication is International Journal of Molecular Sciences (2020), 21(3), 726, database is CAplus and MEDLINE.

Maintaining an active fatty acid metabolism is important for renal growth, development, and health. We evaluated the effects of anaplerotic and ketogenic energy sources on fatty acid oxidation during stimulation with clofibrate, a pharmacol. peroxisome proliferator-activated receptor α (PPARα) agonist. Suckling newborn pigs (n = 72) were assigned into 8 dietary treatments following a 2 x 4 factorial design: ± clofibrate (0.35%) and diets containing 5% of either (1) glycerol-succinate (GlySuc), (2) tri-valerate (TriC5), (3) tri-hexanoate (TriC6), or (4) tri-2-methylpentanoate (Tri2MPA). Pigs were housed individually and fed the iso-caloric milk replacer diets for 5 d. Renal fatty acid oxidation was measured in vitro in fresh tissue homogenates using [1-14C]-labeled palmitic acid. The oxidation was 30% greater in pig received clofibrate and 25% greater (p < 0.05) in pigs fed the TriC6 diet compared to those fed diets with GlySuc, TriC5, and Tri2MPA. Addition of carnitine also stimulated the oxidation by twofold (p < 0.05). The effects of TriC6 and carnitine on palmitic acid oxidation were not altered by clofibrate stimulation. However, renal fatty acid composition was altered by clofibrate and Tri2MPA. In conclusion, modification of anaplerosis or ketogenesis via dietary substrates had no influence on in vitro renal palmitic acid oxidation induced by PPARα activation.

International Journal of Molecular Sciences published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Computed Properties of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corallo, Marcel published the artcileStudy of the reaction of α-chlorinated alkylphosphonyl dichlorides with alcohols and amines, Product Details of C5H10Cl3O3P, the publication is Phosphorus and Sulfur and the Related Elements (1978), 4(1), 19-25, database is CAplus.

Condensation reactions of alcs. and amines with Cl₃CP(O)Cl₂ and with α,α-dichlorinated alkylphosphonyl dichlorides were investigated. The best results were obtained in solution with Et₃N as HCl trapping agent. Thus, reaction of Cl₃CP(O)Cl₂ with MeOH at -20° gave Cl₃P(O)(OMe)Cl. Several side reactions occur, one leading to triethylammonium phosphonates. The exptl. conditions for the stepwise esterification of α-chlorinated phosphonyl dichlorides were also given.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Product Details of C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Davis, Rohan A. published the artcileSynthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide, Related Products of chlorides-buliding-blocks, the publication is Magnetic Resonance in Chemistry (2007), 45(5), 442-445, database is CAplus and MEDLINE.

Parallel solution-phase chem. has yielded a series of secondary amide analogs of the fungal natural product 3-chloro-4-hydroxyphenylacetamide. 3-Chloro-4-hydroxyphenylacetic acid was coupled to a variety of primary amines using 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride. The desired products were obtained in good yield and high purity following rapid silica purification All analogs were spectroscopically characterized using NMR, UV, IR and MS data. One compound displayed moderate cytotoxicity against the human melanoma and prostate cell lines, MM96L and DU145.

Magnetic Resonance in Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Borah, Arun Jyoti published the artcileBromamine-T as an efficient amine source for Sharpless asymmetric aminohydroxylation of olefins, Quality Control of 7080-50-4, the publication is Tetrahedron Letters (2014), 55(3), 713-715, database is CAplus.

Asym. aminohydroxylation of various olefins was carried out using bromamine-T as nitrogen source in the presence of (DHQ)₂PHAL ligand. The new nitrogen source was effective in terms of yield and reaction time. The optical purities of the products could be obtained with ≤99% ee.

Tetrahedron Letters published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Quality Control of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Esteva-Font, Cristina published the artcileStructure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Biochimica et Biophysica Acta, Biomembranes (2015), 1848(5), 1075-1080, database is CAplus and MEDLINE.

Small-mol. inhibitors of urea transporter (UT) proteins in kidney have potential application as novel salt-sparing diuretics. The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa recta endothelium) with IC₅₀ of 2-3 mM, and was shown to have diuretic action when administered to rats. Here, we measured UT-A1 and UT-B inhibition activity of 36 thiourea analogs, with the goal of identifying more potent and isoform-selective inhibitors, and establishing structure-activity relationships. The analog set systematically explored modifications of substituents on the thiourea including alkyl, heterocycles and Ph rings, with different steric and electronic features. The analogs had a wide range of inhibition activities and selectivities. The most potent inhibitor, 3-nitrophenyl-thiourea, had an IC₅₀ of ∼ 0.2 mM for inhibition of both UT-A1 and UT-B. Some analogs such as 4-nitrophenyl-thiourea were relatively UT-A1 selective (IC₅₀ 1.3 vs. 10 mM), and others such as thioisonicotinamide were UT-B selective (IC₅₀ > 15 vs. 2.8 mM).

Biochimica et Biophysica Acta, Biomembranes published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics